| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mariana Pizarro, Leonardo F Fontenelle, Daniel C Paravidino, Murat Yücel, Eurípedes C Miguel, Gabriela B de Meneze. An updated review of antidepressants with marked serotonergic effects in obsessive-compulsive disorder. Expert opinion on pharmacotherapy. vol 15. issue 10. 2014-11-18. PMID:24766145. |
since the recognition of the effectiveness of clomipramine in treating obsessive-compulsive disorder (ocd), a number of recent empirical studies have confirmed a key role of the serotonergic (5-ht) system in the pathophysiology of ocd. |
2014-11-18 |
2023-08-13 |
Not clear |
| M E Haahr, P M Fisher, C G Jensen, V G Frokjaer, B Mc Mahon, K Madsen, W F C Baaré, S Lehel, A Norremolle, E A Rabiner, G M Knudse. Central 5-HT4 receptor binding as biomarker of serotonergic tonus in humans: a [11C]SB207145 PET study. Molecular psychiatry. vol 19. issue 4. 2014-11-17. PMID:24189342. |
identification of a biomarker that can inform on extracellular serotonin (5-ht) levels in the brains of living humans would enable greater understanding of the way brain circuits are modulated by serotonergic neurotransmission. |
2014-11-17 |
2023-08-12 |
human |
| Nathalie Bock, Emre Koc, Hannah Alter, Veit Roessner, Andreas Becker, Aribert Rothenberger, Till Manzk. Chronic fluoxetine treatment changes S100B expression during postnatal rat brain development. Journal of child and adolescent psychopharmacology. vol 23. issue 7. 2014-11-14. PMID:24024533. |
s100b is a glia-derived calcium-binding protein, which may influence the development of serotonergic fibers and, vice versa, serotonin may influence the expression of s100b. |
2014-11-14 |
2023-08-12 |
rat |
| Wai Kin D Ko, Qin Li, Erwan Bezar. Effects of L-tryptophan on L-DOPA-induced dyskinesia in the L-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated macaque model of Parkinson's disease. Neuroscience letters. vol 566. 2014-11-11. PMID:24572591. |
in animal models of parkinson's disease (pd), the serotonergic (5-hydroxytryptamine, 5-ht) system is thought to play an important pathophysiological role in the development and expression of l-3,4-dihydroxyphenylalanine (l-3,4-dihydroxyphenylalanine-dopa)-induced dyskinesia (lid). |
2014-11-11 |
2023-08-12 |
monkey |
| Wai Kin D Ko, Qin Li, Erwan Bezar. Effects of L-tryptophan on L-DOPA-induced dyskinesia in the L-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated macaque model of Parkinson's disease. Neuroscience letters. vol 566. 2014-11-11. PMID:24572591. |
these behavioural data further support the role of the serotonergic system in expression of lid, highlighting the difficult challenge of targeting 5-ht neurons for alleviating dyskinesia and maintaining the therapeutic response of l-dopa. |
2014-11-11 |
2023-08-12 |
monkey |
| Huma Ikram, Foqia Mushtaq, Darakhshan Jabeen Halee. Dose-dependent effects of tryptophan on learning and memory. Pakistan journal of pharmaceutical sciences. vol 27. issue 5. 2014-11-10. PMID:25176356. |
the concentration of 5-hydroxytryptamine (5-ht, serotonin) varies as a result of physiological changes in the availability of its precursor tryptophan to the serotonergic neurons in the brain. |
2014-11-10 |
2023-08-13 |
rat |
| Julian Macovean. Serotonergic modulation of reward and punishment: evidence from pharmacological fMRI studies. Brain research. vol 1556. 2014-11-06. PMID:24508910. |
the new findings may have implications in understanding psychiatric disorders such as major depression which is characterized by abnormal serotonergic function and reward-related processing and may also provide a neural correlated for the emotional blunting observed in the clinical treatment of psychiatric disorders with selective serotonin reuptake inhibitors. |
2014-11-06 |
2023-08-12 |
human |
| Carlos D Silva, Ana F Neves, Ana I Dias, Hugo J Freitas, Sheena M Mendes, Inês Pita, Sofia D Viana, Paulo A de Oliveira, Rodrigo A Cunha, Carlos A Fontes Ribeiro, Rui D Prediger, Frederico C Pereir. A single neurotoxic dose of methamphetamine induces a long-lasting depressive-like behaviour in mice. Neurotoxicity research. vol 25. issue 3. 2014-11-05. PMID:24072398. |
this depressive-like profile induced by meth was accompanied by a marked depletion of frontostriatal dopaminergic and serotonergic neurotransmission, indicated by a reduction in the levels of dopamine, dopac and hva, tyrosine hydroxylase and serotonin, observed at both 3 and 49 days post-administration. |
2014-11-05 |
2023-08-12 |
mouse |
| Jorge J Pérez Maceira, María J Mancebo, Manuel Aldegund. The involvement of 5-HT-like receptors in the regulation of food intake in rainbow trout (Oncorhynchus mykiss). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 161. 2014-10-29. PMID:24365333. |
it is known that in fish the serotonergic system is part of the neural network that controls feeding and that a pharmacologically induced increase in the brain 5-ht inhibits food intake. |
2014-10-29 |
2023-08-12 |
Not clear |
| Nobuyuki Obara, Haruyuki Kamiya, Satoshi Fukud. Serotonergic modulation of inhibitory synaptic transmission in mouse inferior colliculus. Biomedical research (Tokyo, Japan). vol 35. issue 1. 2014-10-28. PMID:24573204. |
to identify the cellular target for the serotonergic modulation in the ic, we examined the effect of serotonin as well as selective serotonin reuptake inhibitor (ssri) fluvoxamine on spontaneous gabaergic and glycinergic inhibitory postsynaptic currents (sipscs) recorded with whole-cell recordings.consistent with earlier studies, we confirmed that serotonin robustly enhanced the frequency, but not amplitude, of gabaergic sipscs. |
2014-10-28 |
2023-08-12 |
mouse |
| Nobuyuki Obara, Haruyuki Kamiya, Satoshi Fukud. Serotonergic modulation of inhibitory synaptic transmission in mouse inferior colliculus. Biomedical research (Tokyo, Japan). vol 35. issue 1. 2014-10-28. PMID:24573204. |
the differential sensitivity of the gabaergic and glycinergic sipscs to serotonin implies that serotonergic input plays a specific role in auditory information processing.moreover, it suggests that the serotonergic input may contribute to pathological conditions such as tinnitus. |
2014-10-28 |
2023-08-12 |
mouse |
| Claus-Jürgen Scholz, Susanne Jungwirth, Walter Danielczyk, Heike Weber, Ildiko Wichart, Karl Heinz Tragl, Peter Fischer, Peter Riederer, Jürgen Deckert, Edna Grünblat. Investigation of association of serotonin transporter and monoamine oxidase-A genes with Alzheimer's disease and depression in the VITA study cohort: a 90-month longitudinal study. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 165B. issue 2. 2014-10-16. PMID:24443391. |
several genetic variations have been suggested to associate with ad and de, particularly in genes involved in the serotonergic system such as the serotonin transporter (sert/slc6a4), responsible for the removal from the synaptic cleft, and the monoamine-oxidase-a (maoa), responsible for the presynaptic degradation of serotonin. |
2014-10-16 |
2023-08-12 |
human |
| Mohammad Seyedabadi, Gohar Fakhfouri, Vahid Ramezani, Shahram Ejtemaei Mehr, Reza Rahimia. The role of serotonin in memory: interactions with neurotransmitters and downstream signaling. Experimental brain research. vol 232. issue 3. 2014-10-14. PMID:24430027. |
in addition, there has been an alteration in the density of serotonergic receptors in aging and alzheimer's disease, and serotonin modulators are found to alter the process of amyloidogenesis and exert cognitive-enhancing properties. |
2014-10-14 |
2023-08-12 |
Not clear |
| Hong-xia Chen, Zeng-liang Jin, Li-ming Zhang, Rui Xue, Xiao-dan Xu, Nan Zhao, Zhi-kun Qiu, Xian-wang Wang, You-zhi Zhang, Ri-fang Yang, Yun-feng L. Antidepressant-like activity of YL-0919: a novel combined selective serotonin reuptake inhibitor and 5-HT1A receptor agonist. PloS one. vol 8. issue 12. 2014-10-13. PMID:24367588. |
these findings suggest that yl-0919, a novel structure compound, exerts dual effect on the serotonergic system, as both 5-ht1a receptor agonist and 5-ht uptake blocker, showing remarkable antidepressant effects in animal models. |
2014-10-13 |
2023-08-12 |
mouse |
| F L Wright, R J Rodger. On the behavioural specificity of hypophagia induced in male rats by mCPP, naltrexone, and their combination. Psychopharmacology. vol 231. issue 4. 2014-10-10. PMID:24114428. |
serotonergic (5-hydroxytryptamine, 5-ht) and opioidergic mechanisms are intimately involved in appetite regulation. |
2014-10-10 |
2023-08-12 |
rat |
| Alvaro L Garcia-Garcia, Adrian Newman-Tancredi, E David Leonard. 5-HT(1A) [corrected] receptors in mood and anxiety: recent insights into autoreceptor versus heteroreceptor function. Psychopharmacology. vol 231. issue 4. 2014-10-10. PMID:24337875. |
serotonin (5-ht) neurotransmission is intimately linked to anxiety and depression and a diverse body of evidence supports the involvement of the main inhibitory serotonergic receptor, the serotonin-1a (5-ht(1a)) subtype, in both disorders. |
2014-10-10 |
2023-08-12 |
Not clear |
| Yun-Fang Jia, Ning-Ning Song, Rong-Rong Mao, Jin-Nan Li, Qiong Zhang, Ying Huang, Lei Zhang, Hui-Li Han, Yu-Qiang Ding, Lin X. Abnormal anxiety- and depression-like behaviors in mice lacking both central serotonergic neurons and pancreatic islet cells. Frontiers in behavioral neuroscience. vol 8. 2014-10-08. PMID:25294992. |
mice lacking either 5-ht or central serotonergic neurons were generated by conditional deletion of tph2 or lmx1b respectively. |
2014-10-08 |
2023-08-13 |
mouse |
| Fionn E O'Brien, Richard M O'Connor, Gerard Clarke, Maria D Donovan, Timothy G Dinan, Brendan T Griffin, John F Crya. The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram. Behavioural brain research. vol 261. 2014-10-06. PMID:24280122. |
csa pre-treatment exacerbated the severity of behaviours in an escitalopram-induced mouse model of serotonin syndrome, a potentially life-threatening adverse drug reaction associated with serotonergic drugs. |
2014-10-06 |
2023-08-12 |
mouse |
| Jessica L Hanson, Laura M Hurle. Context-dependent fluctuation of serotonin in the auditory midbrain: the influence of sex, reproductive state and experience. The Journal of experimental biology. vol 217. issue Pt 4. 2014-09-30. PMID:24198252. |
there was no effect of female estrous phase on the serotonergic change for either context, but serotonin was related to behavioral activity in females interacting with males. |
2014-09-30 |
2023-08-12 |
mouse |
| O Giotako. [Aggressive behavior: theoretical and biological aspects]. Psychiatrike = Psychiatriki. vol 24. issue 2. 2014-09-29. PMID:24200542. |
it is known that serotonin facilitates prefrontal inhibition and insufficient serotonergic activity may increase aggression levels. |
2014-09-29 |
2023-08-12 |
Not clear |