| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jaishree Jalewa, Alok Joshi, T Martin McGinnity, Girijesh Prasad, KongFatt Wong-Lin, Christian Hölsche. Neural circuit interactions between the dorsal raphe nucleus and the lateral hypothalamus: an experimental and computational study. PloS one. vol 9. issue 2. 2015-01-13. PMID:24516577. |
orexinergic/hypocretinergic (ox) neurotransmission plays an important role in regulating sleep, as well as in anxiety and depression, for which the serotonergic (5-ht) system is also involved in. |
2015-01-13 |
2023-08-12 |
mouse |
| Young-Min Par. Relationship between SSRI-induced sexual dysfunction and central serotonergic activity based on the loudness dependence of auditory evoked potentials. Psychopharmacology. vol 231. issue 3. 2015-01-07. PMID:24005532. |
it has been hypothesized that selective serotonin reuptake inhibitor (ssri)-induced sexual dysfunction can occur more frequently in patients with higher central serotonergic activity, and that this higher serotonergic activity can induce inhibition of sexual desire, ejaculation, and orgasm. |
2015-01-07 |
2023-08-12 |
Not clear |
| Jennifer A Sumner, Suzanne Vrshek-Schallhorn, Susan Mineka, Richard E Zinbarg, Michelle G Craske, Eva E Redei, Kate Wolitzky-Taylor, Emma K Ada. Effects of the serotonin transporter polymorphism and history of major depression on overgeneral autobiographical memory. Cognition & emotion. vol 28. issue 5. 2015-01-05. PMID:24341893. |
there is preliminary evidence that a genetic serotonergic vulnerability coupled with depressive symptoms may be associated with other memory impairments, and experimental research suggests a role for serotonin in ogm. |
2015-01-05 |
2023-08-12 |
Not clear |
| Rani K Vasudeva, Barry D Waterhous. Cellular profile of the dorsal raphe lateral wing sub-region: relationship to the lateral dorsal tegmental nucleus. Journal of chemical neuroanatomy. vol 57-58. 2015-01-05. PMID:24704911. |
as one of the main serotonergic (5ht) projections to the forebrain, the dorsal raphe nucleus (drn) has been implicated in disorders of anxiety and depression. |
2015-01-05 |
2023-08-13 |
human |
| Dennis R Sparta, Garret D Stube. Cartography of serotonergic circuits. Neuron. vol 83. issue 3. 2014-12-29. PMID:25102556. |
serotonin is an essential neuromodulator, but the precise circuit connectivity that regulates serotonergic neurons has not been well defined. |
2014-12-29 |
2023-08-13 |
Not clear |
| Brandon Weissbourd, Jing Ren, Katherine E DeLoach, Casey J Guenthner, Kazunari Miyamichi, Liqun Lu. Presynaptic partners of dorsal raphe serotonergic and GABAergic neurons. Neuron. vol 83. issue 3. 2014-12-29. PMID:25102560. |
the major source of forebrain serotonergic innervation is from the dorsal raphe nucleus (dr), which contains both serotonin and gaba neurons. |
2014-12-29 |
2023-08-13 |
Not clear |
| Jonas Waider, Florian Proft, Georg Langlhofer, Esther Asan, Klaus-Peter Lesch, Lise Gutknech. GABA concentration and GABAergic neuron populations in limbic areas are differentially altered by brain serotonin deficiency in Tph2 knockout mice. Histochemistry and cell biology. vol 139. issue 2. 2014-12-17. PMID:23052836. |
while tryptophan hydroxylase-2 (tph2) null mutant (tph2(-/-)) mice are completely deficient in brain serotonin (5-ht) synthesis, the formation of serotonergic neurons and pathfinding of their projections are not impaired. |
2014-12-17 |
2023-08-12 |
mouse |
| Ju-Wei Hsu, Jiing-Feng Lirng, Shyh-Jen Wang, Chun-Lung Lin, Kai-Chun Yang, Mei-Hsiu Liao, Yuan-Hwa Cho. Association of thalamic serotonin transporter and interleukin-10 in bipolar I disorder: a SPECT study. Bipolar disorders. vol 16. issue 3. 2014-12-17. PMID:24372850. |
although many studies have demonstrated reciprocal relationships between serotonin metabolism and immune-inflammatory pathways that occur in depression, studies linking serotonergic function and cytokines are still limited concerning bd. |
2014-12-17 |
2023-08-12 |
Not clear |
| Georg F Weber, Bethann N Johnson, Bryan K Yamamoto, Gary A Gudelsk. Effects of stress and MDMA on hippocampal gene expression. BioMed research international. vol 2014. 2014-12-16. PMID:24511526. |
on the other hand, repeated administration of mdma results in persistent deficits in markers of serotonergic (5-ht) nerve terminals that have been viewed as indicative of 5-ht neurotoxicity. |
2014-12-16 |
2023-08-12 |
rat |
| Maria Lidia Gerra, Carlo Marchesi, Jose A Amat, Pierre Blier, David J Hellerstein, Jonathan W Stewar. Does negative affectivity predict differential response to an SSRI versus a non-SSRI antidepressant? The Journal of clinical psychiatry. vol 75. issue 9. 2014-12-15. PMID:25295437. |
this work tested the hypothesis that patients with high negative affectivity (na) would have a better response to a serotonergic agent (escitalopram) than to one not thought to act directly on serotonin (bupropion). |
2014-12-15 |
2023-08-13 |
Not clear |
| Deepak Verma, Barnali Chakraborti, Arijit Karmakar, Tirthankar Bandyopadhyay, Asem Surindro Singh, Swagata Sinha, Anindita Chatterjee, Saurabh Ghosh, Kochupurackal P Mohanakumar, Kanchan Mukhopadhyay, Usha Rajamm. Sexual dimorphic effect in the genetic association of monoamine oxidase A (MAOA) markers with autism spectrum disorder. Progress in neuro-psychopharmacology & biological psychiatry. vol 50. 2014-12-11. PMID:24291416. |
serotonin as modulator of behavior and implication of serotonergic dysfunction in asd etiology corroborates that serotonergic system genes are potential candidates for autism susceptibility. |
2014-12-11 |
2023-08-12 |
human |
| Cheuk Ka Tong, Jiadong Chen, Arantxa Cebrián-Silla, Zaman Mirzadeh, Kirsten Obernier, Cristina D Guinto, Laurence H Tecott, Jose Manuel García-Verdugo, Arnold Kriegstein, Arturo Alvarez-Buyll. Axonal control of the adult neural stem cell niche. Cell stem cell. vol 14. issue 4. 2014-12-11. PMID:24561083. |
we show that serotonergic (5ht) axons originating from a small group of neurons in the raphe form an extensive plexus on most of the ventricular walls. |
2014-12-11 |
2023-08-12 |
Not clear |
| Giuseppe Musumeci, Carla Loreto, Francesca Maria Trovato, Salvatore Giunta, Rosa Imbesi, Paola Castrogiovann. Serotonin (5HT) expression in rat pups treated with high-tryptophan diet during fetal and early postnatal development. Acta histochemica. vol 116. issue 2. 2014-12-10. PMID:24071520. |
serotonin (5ht) is a neurotransmitter synthesized in serotonergic neurons of the central nervous system and in the enterochromaffin cells of the gastrointestinal tract. |
2014-12-10 |
2023-08-12 |
human |
| Giuseppe Musumeci, Carla Loreto, Francesca Maria Trovato, Salvatore Giunta, Rosa Imbesi, Paola Castrogiovann. Serotonin (5HT) expression in rat pups treated with high-tryptophan diet during fetal and early postnatal development. Acta histochemica. vol 116. issue 2. 2014-12-10. PMID:24071520. |
hyperserotonemia results in an excess of serotonin in the brain where it has a negative influence on development of serotonergic neurons and consequently on growth hormone production. |
2014-12-10 |
2023-08-12 |
human |
| Anchalee Prasansuklab, Yong Poovorawan, Tewin Tencomna. Modulation of human serotonin transporter expression by 5-HTTLPR in colon cells. International journal of molecular sciences. vol 12. issue 10. 2014-11-28. PMID:22072907. |
known as a primary target for psychoactive drug development, the 5-ht transporter (5-htt, sert) plays a critical role in the regulation of serotonergic function by reuptaking 5-ht. |
2014-11-28 |
2023-08-12 |
human |
| Sören Enge, Monika Fleischhauer, Klaus-Peter Lesch, Andreas Reif, Alexander Strobe. Variation in key genes of serotonin and norepinephrine function predicts gamma-band activity during goal-directed attention. Cerebral cortex (New York, N.Y. : 1991). vol 24. issue 5. 2014-11-28. PMID:23258345. |
recent evidence shows that genetic variations in key regulators of serotonergic (5-ht) signaling explain variance in executive tasks, which suggests modulatory actions of 5-ht on goal-directed selective attention as one possible underlying mechanism. |
2014-11-28 |
2023-08-12 |
human |
| T Okamoto, M J Barton, G W Hennig, G C Birch, N Grainger, R D Corrigan, S D Koh, K M Sanders, T K Smit. Extensive projections of myenteric serotonergic neurons suggest they comprise the central processing unit in the colon. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 26. issue 4. 2014-11-26. PMID:24460867. |
5-hydroxytryptamine (5-ht, serotonin) is an important regulator of colonic motility and secretion; yet the role of serotonergic neurons in the colon is controversial. |
2014-11-26 |
2023-08-12 |
Not clear |
| Beverley Greenwood-Van Meerveld, Ehsan Mohammadi, Karl Tyler, Claudio Pietra, Lucy A Bee, Anthony Dickenso. Synergistic effect of 5-hydroxytryptamine 3 and neurokinin 1 receptor antagonism in rodent models of somatic and visceral pain. The Journal of pharmacology and experimental therapeutics. vol 351. issue 1. 2014-11-25. PMID:25077526. |
synergistic activity has been observed between serotonergic 5-hydroxytryptamine 3 (5-ht3) and tachykinergic neurokinin 1 (nk1) receptor-mediated responses. |
2014-11-25 |
2023-08-13 |
rat |
| Mari Gabrielsen, Rafał Kurczab, Agata Siwek, Małgorzata Wolak, Aina W Ravna, Kurt Kristiansen, Irina Kufareva, Ruben Abagyan, Gabriel Nowak, Zdzisław Chilmonczyk, Ingebrigt Sylte, Andrzej J Bojarsk. Identification of novel serotonin transporter compounds by virtual screening. Journal of chemical information and modeling. vol 54. issue 3. 2014-11-24. PMID:24521202. |
the serotonin (5-hydroxytryptamine, 5-ht) transporter (sert) plays an essential role in the termination of serotonergic neurotransmission by removing 5-ht from the synaptic cleft into the presynaptic neuron. |
2014-11-24 |
2023-08-12 |
Not clear |
| Johanna Nyffeler, Susanne Walitza, Elise Bobrowski, Ronnie Gundelfinger, Edna Grünblat. Association study in siblings and case-controls of serotonin- and oxytocin-related genes with high functioning autism. Journal of molecular psychiatry. vol 2. issue 1. 2014-11-21. PMID:25408912. |
the serotonergic and oxytocinergic systems are of interest in autism for several reasons: (i) both systems are implicated in social behavior, and abnormal levels of serotonin and oxytocin have been found in people with asd; (ii) treatment with selective serotonin reuptake inhibitors and oxytocin can yield improvements; and (iii) previous association studies have linked the serotonin transporter (sert; slc6a4), serotonin receptor 2a (htr2a), and oxytocin receptor (oxtr) genes with asd. |
2014-11-21 |
2023-08-13 |
Not clear |