| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Swen Hesse, Franziska Moeller, David Petroff, Donald Lobsien, Julia Luthardt, Ralf Regenthal, Georg-Alexander Becker, Marianne Patt, Eva Thomae, Anita Seese, Philipp M Meyer, Florian Then Bergh, Osama Sabr. Altered serotonin transporter availability in patients with multiple sclerosis. European journal of nuclear medicine and molecular imaging. vol 41. issue 5. 2015-02-09. PMID:24562640. |
modulation of the immune system by the cns may involve serotonergic regulation via the brain serotonin transporters (sert). |
2015-02-09 |
2023-08-12 |
Not clear |
| M Filaferro, V Ruggieri, C Novi, G Calò, C Cifani, M V Micioni Di Bonaventura, M Sandrini, G Vital. Functional antagonism between nociceptin/orphanin FQ and corticotropin-releasing factor in rat anxiety-related behaviors: involvement of the serotonergic system. Neuropeptides. vol 48. issue 4. 2015-02-09. PMID:24894718. |
in pons, n/ofq induced no change in serotonergic activity while crf significantly decreased 5-ht levels and increased 5-hiaa content. |
2015-02-09 |
2023-08-13 |
rat |
| Alonzo Whyte, Tammy Jessen, Seth Varney, Ana M D Carneir. Serotonin transporter and integrin beta 3 genes interact to modulate serotonin uptake in mouse brain. Neurochemistry international. vol 73. 2015-02-02. PMID:24083985. |
convergent evidence from genetic analyses of human subjects has implicated the integrin β3 subunit gene (itgb3) as a modulator of serotonergic systems via genetic interactions with the 5-ht transporter gene (slc6a4, sert). |
2015-02-02 |
2023-08-12 |
mouse |
| Alonzo Whyte, Tammy Jessen, Seth Varney, Ana M D Carneir. Serotonin transporter and integrin beta 3 genes interact to modulate serotonin uptake in mouse brain. Neurochemistry international. vol 73. 2015-02-02. PMID:24083985. |
our findings provide evidence that integrin αvβ3 is involved in the regulation of serotonergic systems in some, but not all 5-ht synapses, revealing novel contributions to synaptic specificity within the central nervous system. |
2015-02-02 |
2023-08-12 |
mouse |
| Sylvia Montañez, Jaclyn L Munn, W Anthony Owens, Rebecca E Horton, Lynette C Daw. 5-HT1B receptor modulation of the serotonin transporter in vivo: studies using KO mice. Neurochemistry international. vol 73. 2015-02-02. PMID:24246466. |
the serotonin transporter (sert) controls the strength and duration of serotonergic neurotransmission by the high-affinity uptake of serotonin (5-ht) from extracellular fluid. |
2015-02-02 |
2023-08-12 |
mouse |
| Trine Nygaard Jørgensen, Peter Møller Christensen, Ulrik Gethe. Serotonin-induced down-regulation of cell surface serotonin transporter. Neurochemistry international. vol 73. 2015-02-02. PMID:24462583. |
the serotonin transporter (sert) terminates serotonergic signaling and enables refilling of synaptic vesicles by mediating reuptake of serotonin (5-ht) released into the synaptic cleft. |
2015-02-02 |
2023-08-12 |
Not clear |
| Trine Nygaard Jørgensen, Peter Møller Christensen, Ulrik Gethe. Serotonin-induced down-regulation of cell surface serotonin transporter. Neurochemistry international. vol 73. 2015-02-02. PMID:24462583. |
moreover, preincubation with 5-ht lowered the vmax for 5-ht uptake in cultured raphe serotonergic neurons, indicting that endogenous cell-surface resident sert likewise is down-regulated in the presence of substrate. |
2015-02-02 |
2023-08-12 |
Not clear |
| Blandine Bellot, Julie Peyronnet-Roux, Catherine Gire, Umberto Simeoni, Laurent Vinay, Jean-Charles Viemar. Deficits of brainstem and spinal cord functions after neonatal hypoxia-ischemia in mice. Pediatric research. vol 75. issue 6. 2015-02-02. PMID:24618565. |
dysfunctions of neuromodulatory systems, such as the serotonergic (5-ht) projections, critical for the development of neural networks, have been postulated to underlie behavioral and motor deficits, as well as metabolic changes. |
2015-02-02 |
2023-08-12 |
mouse |
| Tamaki Ishima, Yuko Fujita, Kenji Hashimot. Interaction of new antidepressants with sigma-1 receptor chaperones and their potentiation of neurite outgrowth in PC12 cells. European journal of pharmacology. vol 727. 2015-01-29. PMID:24508523. |
first, we examined the effects of selective serotonin reuptake inhibitors (ssris) (fluvoxamine, paroxetine, sertraline, citalopram and escitalopram), serotonin and noradrenaline reuptake inhibitors (snris) (duloxetine, venlafaxine, milnacipran), and mirtazapine, a noradrenaline and specific serotonergic antidepressant (nassa), on [(3)h](+)-pentazocine binding to rat brain membranes. |
2015-01-29 |
2023-08-12 |
rat |
| Claudia Rangel-Barajas, Maninder Malik, Suwanna Vangveravong, Robert H Mach, Robert R Luedtk. Pharmacological modulation of abnormal involuntary DOI-induced head twitch response in male DBA/2J mice: I. Effects of D2/D3 and D2 dopamine receptor selective compounds. Neuropharmacology. vol 83. 2015-01-29. PMID:24680675. |
this observation suggests a functional interaction between dopaminergic and serotonergic systems through d2 dopamine receptors and the 5-ht2a serotonin receptors in vivo. |
2015-01-29 |
2023-08-12 |
mouse |
| Christopher M Ciarleglio, Holly E S Resuehr, John C Axley, Evan S Deneris, Douglas G McMaho. Pet-1 deficiency alters the circadian clock and its temporal organization of behavior. PloS one. vol 9. issue 5. 2015-01-29. PMID:24831114. |
previous work on the interaction between these two systems suggests that serotonin modulates photic input to the central circadian clock (the suprachiasmatic nuclei; scn) from the retina and serves as a signal for locomotor activity, novelty, and arousal to shift the scn clock, but effects of disruption of serotonergic signaling from the raphe nuclei on circadian behavior and on scn function are not fully characterized. |
2015-01-29 |
2023-08-13 |
mouse |
| Francesca Megiorni, Serena Resta, Deliar Yazdanian, Gabriele Cavaggioni, Claudia Lia, Pierluigi Benedetti Panici, Antonio Pizzuti, Maria Grazia Porpor. Lack of association between serotonin transporter 5-HTT gene polymorphism and endometriosis in an Italian patient population. Journal of negative results in biomedicine. vol 13. issue 1. 2015-01-26. PMID:24925205. |
the aim of this study was to determine whether the serotonin transporter gene (5-htt), a key component in the control of the serotonergic system, is associated with endometriosis in an italian population. |
2015-01-26 |
2023-08-13 |
Not clear |
| Christian Scharinger, Ulrich Rabl, Christian H Kasess, Bernhard M Meyer, Tina Hofmaier, Kersten Diers, Lucie Bartova, Gerald Pail, Wolfgang Huf, Zeljko Uzelac, Beate Hartinger, Klaudius Kalcher, Thomas Perkmann, Helmuth Haslacher, Andreas Meyer-Lindenberg, Siegfried Kasper, Michael Freissmuth, Christian Windischberger, Matthäus Willeit, Rupert Lanzenberger, Harald Esterbauer, Burkhard Brocke, Ewald Moser, Harald H Sitte, Lukas Pezawa. Platelet serotonin transporter function predicts default-mode network activity. PloS one. vol 9. issue 3. 2015-01-22. PMID:24667541. |
a blood-brain relationship between platelet and synaptosomal 5-ht reuptake has been suggested, but it is unknown today, if platelet 5-ht uptake can predict neural activation of human brain networks that are known to be under serotonergic influence. |
2015-01-22 |
2023-08-12 |
human |
| Deepali Gupta, Mahesh Radhakrishnan, Devadoss Thangaraj, Yeshwant Kurh. Antidepressant and anti-anxiety like effects of 4i (N-(3-chloro-2-methylphenyl) quinoxalin-2-carboxamide), a novel 5-HT3 receptor antagonist in acute and chronic neurobehavioral rodent models. European journal of pharmacology. vol 735. 2015-01-22. PMID:24747753. |
furthermore, synergistic effect of 4i with fluoxetine (a selective serotonin reuptake inhibitor) and inhibitory effect of 1-(m-chlorophenyl)-biguanide (a 5-ht3 receptor agonist) revealed serotonergic modulation by 4i mediated 5-ht3 receptor antagonism, which was further confirmed by potentiation of 5-hydroxytryptophan (a serotonin synthesis precursor) induced head twitch response. |
2015-01-22 |
2023-08-13 |
rat |
| Daniela Baptista-de-Souza, Lorenzo Di Cesare Mannelli, Matteo Zanardelli, Laura Micheli, Ricardo Luiz Nunes-de-Souza, Azair Canto-de-Souza, Carla Ghelardin. Serotonergic modulation in neuropathy induced by oxaliplatin: effect on the 5HT2C receptor. European journal of pharmacology. vol 735. 2015-01-22. PMID:24786153. |
besides to increase serotonin levels in the synaptic cleft, fluoxetine is able to block the serotonergic 5-ht2c receptor subtype, which in turn has been involved in the modulation of neuropathic pain. |
2015-01-22 |
2023-08-13 |
rat |
| Øyvind Øverli, Janicke Nordgreen, Cecilie M Mejdell, Andrew M Janczak, Silje Kittilsen, Ida B Johansen, Tor E Horsber. Ectoparasitic sea lice (Lepeophtheirus salmonis) affect behavior and brain serotonergic activity in Atlantic salmon (Salmo salar L.): Perspectives on animal welfare. Physiology & behavior. vol 132. 2015-01-21. PMID:24792663. |
one mediator of such variation is the brain serotonergic (5-hydroxytryptamine, 5-ht) system, which conveys physiological and behavioral responses to stress and sub-optimal rearing conditions. |
2015-01-21 |
2023-08-13 |
human |
| Bryon Silva, Nicolás I Goles, Rodrigo Varas, Jorge M Campusan. Serotonin receptors expressed in Drosophila mushroom bodies differentially modulate larval locomotion. PloS one. vol 9. issue 2. 2015-01-20. PMID:24586928. |
data obtained in the mutants and in animals exposed to the serotonergic drugs, suggest that 5ht systems are important regulators of motor programs in fly larvae. |
2015-01-20 |
2023-08-12 |
drosophila_melanogaster |
| Bryon Silva, Nicolás I Goles, Rodrigo Varas, Jorge M Campusan. Serotonin receptors expressed in Drosophila mushroom bodies differentially modulate larval locomotion. PloS one. vol 9. issue 2. 2015-01-20. PMID:24586928. |
studies carried out in animals pan-neuronally expressing the rnai for each of the serotonergic receptors, support this idea and further suggest that cns 5ht pathways play a role in motor control. |
2015-01-20 |
2023-08-12 |
drosophila_melanogaster |
| J Daniel Hothersall, Amy Alexander, Andrew J Samson, Christopher Moffat, Karen A Bollan, Christopher N Connoll. 5-Hydroxytryptamine (5-HT) cellular sequestration during chronic exposure delays 5-HT3 receptor resensitization due to its subsequent release. The Journal of biological chemistry. vol 289. issue 46. 2015-01-20. PMID:25281748. |
the serotonergic synapse is dynamically regulated by serotonin (5-hydroxytryptamine (5-ht)) with elevated levels leading to the down-regulation of the serotonin transporter and a variety of 5-ht receptors, including the 5-ht type-3 (5-ht3) receptors. |
2015-01-20 |
2023-08-13 |
Not clear |
| Heidi Kaastrup Müller, Marie Kragballe, Anja Winther Fjorback, Ove Wibor. Differential regulation of the serotonin transporter by vesicle-associated membrane protein 2 in cells of neuronal versus non-neuronal origin. PloS one. vol 9. issue 5. 2015-01-15. PMID:24878716. |
the serotonin transporter (sert) is a key regulator of serotonergic signalling as it mediates the re-uptake of synaptic serotonin into nerve terminals, thereby terminating or modulating its signal. |
2015-01-15 |
2023-08-13 |
rat |