| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiamei Lian, Xu-Feng Huang, Nagesh Pai, Chao Den. Chronic betahistine co-treatment reverses olanzapine's effects on dopamine D₂ but not 5-HT2A/2C bindings in rat brains. Progress in neuro-psychopharmacology & biological psychiatry. vol 56. 2015-07-31. PMID:25149912. |
this study investigated the effects of chronic treatment of olanzapine and/or betahistine on the binding density of the serotonergic 5-ht2a (5-ht2ar) and 5-ht2c (5-ht2cr) receptors, 5-ht transporter (5-htt), and dopaminergic d₂ receptors (d₂r) in the brain regions involved in antipsychotic efficacy, including the prefrontal cortex (pfc), cingulate cortex (cg), nucleus accumbens (nac), and caudate putamen (cpu). |
2015-07-31 |
2023-08-13 |
rat |
| Hao Li, Jamie L Scholl, Wenyu Tu, James E Hassell, Michael J Watt, Gina L Forster, Kenneth J Renne. Serotonergic responses to stress are enhanced in the central amygdala and inhibited in the ventral hippocampus during amphetamine withdrawal. The European journal of neuroscience. vol 40. issue 11. 2015-07-31. PMID:25234335. |
during amphetamine withdrawal, the absence of stress-induced increases in ventral hippocampal 5-ht levels combined with enhanced stress-induced serotonergic responses in the central amygdala may contribute to drug relapse by decreasing stress-coping ability and heightening stress responsiveness. |
2015-07-31 |
2023-08-13 |
rat |
| Mousumi Ghosh, Damien D Pears. The role of the serotonergic system in locomotor recovery after spinal cord injury. Frontiers in neural circuits. vol 8. 2015-07-30. PMID:25709569. |
following spinal cord injury (sci) there is a disruption of descending serotonergic projections to spinal motor areas, which results in a subsequent depletion in 5-ht, the dysregulation of 5-ht transporters as well as the elevated expression, super-sensitivity and/or constitutive auto-activation of specific 5-ht receptors. |
2015-07-30 |
2023-08-13 |
Not clear |
| Mousumi Ghosh, Damien D Pears. The role of the serotonergic system in locomotor recovery after spinal cord injury. Frontiers in neural circuits. vol 8. 2015-07-30. PMID:25709569. |
these strategies have included pharmacological modulation of serotonergic receptors, through the administration of specific 5-ht receptor agonists, or by elevating the 5-ht precursor 5-hydroxytryptophan, which produces a global activation of all classes of 5-ht receptors. |
2015-07-30 |
2023-08-13 |
Not clear |
| Mousumi Ghosh, Damien D Pears. The role of the serotonergic system in locomotor recovery after spinal cord injury. Frontiers in neural circuits. vol 8. 2015-07-30. PMID:25709569. |
another approach has been to employ cell therapeutics to replace the loss of descending serotonergic input to the cpg, either through transplanted fetal brainstem 5-ht neurons at the site of injury that can supply 5-ht to below the level of the lesion or by other cell types to provide a substrate at the injury site for encouraging serotonergic axon regrowth across the lesion to the caudal spinal cord for restoring locomotion. |
2015-07-30 |
2023-08-13 |
Not clear |
| César Augusto Brüning, Bibiana Mozzaquatro Gai, Suelen Mendonça Soares, Franciele Martini, Cristina Wayne Nogueir. Serotonergic systems are implicated in antinociceptive effect of m-trifluoromethyl diphenyl diselenide in the mouse glutamate test. Pharmacology, biochemistry, and behavior. vol 125. 2015-07-28. PMID:25135115. |
considering that serotonin (5-ht) plays an important role in the descending control of pain, this study further investigated the role of serotonergic systems in the antinociceptive action of (m-cf3-phse)2 in the glutamate-induced licking behavior model in mice. |
2015-07-28 |
2023-08-13 |
mouse |
| Rachael D Brust, Andrea E Corcoran, George B Richerson, Eugene Nattie, Susan M Dymeck. Functional and developmental identification of a molecular subtype of brain serotonergic neuron specialized to regulate breathing dynamics. Cell reports. vol 9. issue 6. 2015-07-24. PMID:25497093. |
these findings show that serotonergic regulation of the respiratory chemoreflex is mediated by a specialized molecular subtype of 5ht neuron harboring unique physiological, biophysical, and hodological properties specified developmentally and demonstrate that the serotonergic system contains specialized modules contributing to its collective functional breadth. |
2015-07-24 |
2023-08-13 |
Not clear |
| Jeyaganesh Rajamanickam, Balasubramaniam Annamalai, Troels Rahbek-Clemmensen, Santhanalakshmi Sundaramurthy, Ulrik Gether, Lankupalle D Jayanthi, Sammanda Ramamoorth. Akt-mediated regulation of antidepressant-sensitive serotonin transporter function, cell-surface expression and phosphorylation. The Biochemical journal. vol 468. issue 1. 2015-07-20. PMID:25761794. |
the serotonin [5-ht (5-hydroxytryptamine)] transporter (sert) controls serotonergic neurotransmission in the brain by rapid clearance of 5-ht from the synaptic cleft into presynaptic neurons. |
2015-07-20 |
2023-08-13 |
Not clear |
| Jeyaganesh Rajamanickam, Balasubramaniam Annamalai, Troels Rahbek-Clemmensen, Santhanalakshmi Sundaramurthy, Ulrik Gether, Lankupalle D Jayanthi, Sammanda Ramamoorth. Akt-mediated regulation of antidepressant-sensitive serotonin transporter function, cell-surface expression and phosphorylation. The Biochemical journal. vol 468. issue 1. 2015-07-20. PMID:25761794. |
thus any changes in the activation of akt and/or gsk3α/β could alter sert-mediated 5-ht clearance and subsequently serotonergic neurotransmission. |
2015-07-20 |
2023-08-13 |
Not clear |
| Katherine M Nautiyal, Kenji F Tanaka, Mary M Barr, Laurent Tritschler, Yannick Le Dantec, Denis J David, Alain M Gardier, Carlos Blanco, René Hen, Susanne E Ahmar. Distinct Circuits Underlie the Effects of 5-HT1B Receptors on Aggression and Impulsivity. Neuron. vol 86. issue 3. 2015-07-20. PMID:25892302. |
impulsive and aggressive behaviors are both modulated by serotonergic signaling, specifically through the serotonin 1b receptor (5-ht1br). |
2015-07-20 |
2023-08-13 |
mouse |
| Evan D Paul, Philip L Johnson, Anantha Shekhar, Christopher A Lowr. The Deakin/Graeff hypothesis: focus on serotonergic inhibition of panic. Neuroscience and biobehavioral reviews. vol 46 Pt 3. 2015-07-17. PMID:24661986. |
evidence supporting this panic inhibition system comes from the following observations: (1) serotonergic neurons located in the 'ventrolateral dorsal raphe nucleus' (drvl) as well as the ventrolateral periaqueductal gray (vlpag) inhibit dorsal periaqueductal gray-elicited panic-like responses; (2) chronic, but not acute, antidepressant treatment potentiates serotonin's panicolytic effect; (3) contextual fear activates a central nucleus of the amygdala-drvl/vlpag circuit implicated in mediating freezing and inhibiting panic-like escape behaviors; (4) drvl/vlpag serotonergic neurons are central chemoreceptors and modulate the behavioral and cardiorespiratory response to panicogenic agents such as sodium lactate and co2. |
2015-07-17 |
2023-08-12 |
Not clear |
| Henriette Bjerregaard, Kasper Severinsen, Saida Said, Ove Wiborg, Steffen Sinnin. A dualistic conformational response to substrate binding in the human serotonin transporter reveals a high affinity state for serotonin. The Journal of biological chemistry. vol 290. issue 12. 2015-07-02. PMID:25614630. |
serotonergic neurotransmission is modulated by the membrane-embedded serotonin transporter (sert). |
2015-07-02 |
2023-08-13 |
human |
| Senka Sabolovic Rudman, Maja Mustapic, Vesna Kosec, Nela Pivac, Franjo Rudman, Dorotea Muck-Sele. Serotonin risk factors for the development of hypertension in pregnancy. Archives of gynecology and obstetrics. vol 291. issue 4. 2015-07-01. PMID:25223859. |
to determine platelet serotonin (5-ht) concentrations and genotype and allele frequencies of serotonergic type 2a receptor gene (htr2a) and 5-ht transporter gene (slc6a4) in women with pre-eclampsia, gestational hypertension without proteinuria (pih) and in control normotensive pregnant women. |
2015-07-01 |
2023-08-13 |
Not clear |
| Troels H Lunn, Vibe G Frokjaer, Torben B Hansen, Per W Kristensen, Thomas Lind, Henrik Kehle. Analgesic effect of perioperative escitalopram in high pain catastrophizing patients after total knee arthroplasty: a randomized, double-blind, placebo-controlled trial. Anesthesiology. vol 122. issue 4. 2015-06-24. PMID:25782644. |
serotonergic signaling may be involved in pain processing, but the effect of selective serotonin reuptake inhibitors on well-defined postoperative pain has not previously been investigated. |
2015-06-24 |
2023-08-13 |
Not clear |
| Sandra M W van de Wiel, Michel M Verheij, Judith R Homber. Designing modulators of 5-hydroxytryptamine signaling to treat abuse disorders. Expert opinion on drug discovery. vol 9. issue 11. 2015-06-22. PMID:25217125. |
brain-derived neurotropic factor (bdnf) is an important modulator of the serotonergic system and 5-ht modulates bdnf expression. |
2015-06-22 |
2023-08-13 |
Not clear |
| Suman Kushwaha, Akhila Kumar Panda, Hardeep Singh Malhotra, Manmeet Kau. Serotonin syndrome following levodopa treatment in diffuse Lewy body disease. BMJ case reports. vol 2014. 2015-06-22. PMID:25246451. |
this case highlights the difficulty in diagnosis and management of cases with serotonin syndrome in the absence of history of a known serotonergic drug and the fact that levodopa can contribute to its occurrence. |
2015-06-22 |
2023-08-13 |
Not clear |
| Anderson Manoel Herculano, Caio Maximin. Serotonergic modulation of zebrafish behavior: towards a paradox. Progress in neuro-psychopharmacology & biological psychiatry. vol 55. 2015-06-16. PMID:24681196. |
due to the fish-specific genome duplication event (~320-350 mya), some genes which code for serotonin proteins were duplicated in teleosts; this duplication event was preceded by a reorganization of the serotonergic system, with the appearance of the raphe nuclei (dependent on the isthmus organizer) and prosencephalic nuclei, including the paraventricular and pretectal complexes. |
2015-06-16 |
2023-08-12 |
zebrafish |
| Anderson Manoel Herculano, Caio Maximin. Serotonergic modulation of zebrafish behavior: towards a paradox. Progress in neuro-psychopharmacology & biological psychiatry. vol 55. 2015-06-16. PMID:24681196. |
however, many different behavioral functions of serotonin, as well as the effects of drugs which affect the serotonergic system, seem to be conserved among species. |
2015-06-16 |
2023-08-12 |
zebrafish |
| Anderson Manoel Herculano, Caio Maximin. Serotonergic modulation of zebrafish behavior: towards a paradox. Progress in neuro-psychopharmacology & biological psychiatry. vol 55. 2015-06-16. PMID:24681196. |
in this article, we will expose this paradox, reviewing the chemical neuroanatomy of the zebrafish serotonergic system, followed by an analysis of the role of serotonin in zebrafish fear/anxiety, stress, aggression and the effects of psychedelic drugs. |
2015-06-16 |
2023-08-12 |
zebrafish |
| Ryan R Gaffney, Ian R Schreibma. Serotonin Syndrome in a Patient on Trazodone and Duloxetine Who Received Fentanyl following a Percutaneous Liver Biopsy. Case reports in gastroenterology. vol 9. issue 2. 2015-06-16. PMID:26078731. |
serotonin syndrome is a rare but potentially life-threatening adverse drug reaction resulting from the use or overuse of serotonergic medications alone or in combination. |
2015-06-16 |
2023-08-13 |
Not clear |