| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Snjezana Lelas, Yu-Wen Li, Tanya L Wallace-Boone, Matthew T Taber, Amy E Newton, Rick L Pieschl, Carl D Davis, Thaddeus F Molski, Kimberly S Newberry, Michael F Parker, Kevin W Gillman, Joanne J Bronson, John E Macor, Nicholas J Lodg. NK1 receptor antagonism lowers occupancy requirement for antidepressant-like effects of SSRIs in the gerbil forced swim test. Neuropharmacology. vol 73. 2014-08-13. PMID:23770339. |
the known interactions between the serotonergic and neurokinin systems suggest that serotonin reuptake inhibitor (ssris) efficacy may be improved by neurokinin-1 receptor (nk1r) antagonism. |
2014-08-13 |
2023-08-12 |
Not clear |
| Andrew E Arrant, Elizabeth Coburn, Jacob Jacobsen, Cynthia M Kuh. Lower anxiogenic effects of serotonin agonists are associated with lower activation of amygdala and lateral orbital cortex in adolescent male rats. Neuropharmacology. vol 73. 2014-08-13. PMID:23774134. |
we investigated serotonergic modulation of anxiety-like behavior in adolescent (pn28-32) and adult (pn67-73) male rats using the ssri fluoxetine, the 5-ht(1a) agonist 8-oh dpat, and the 5-ht₂ agonist mcpp. |
2014-08-13 |
2023-08-12 |
rat |
| Shay Bracha, Austin Viall, Cheri Goodall, Bernadette Stang, Craig Ruaux, Bernard Seguin, Patrick E Chappel. The expression and role of serotonin receptor 5HTR2A in canine osteoblasts and an osteosarcoma cell line. BMC veterinary research. vol 9. 2014-08-13. PMID:24330646. |
the significance of the serotonergic system in bone physiology and, more specifically, the importance of the five hydroxytryptamine receptor 2a (5htr2a) in normal osteoblast proliferation have been previously described; however the role of serotonin in osteosarcoma remains unclear. |
2014-08-13 |
2023-08-12 |
Not clear |
| J Yang, H B Bae, H G Ki, J M Oh, W M Kim, H G Lee, M H Yoon, J I Cho. Different role of spinal 5-HT(hydroxytryptamine)7 receptors and descending serotonergic modulation in inflammatory pain induced in formalin and carrageenan rat models. British journal of anaesthesia. vol 113. issue 1. 2014-08-12. PMID:24129596. |
different role of spinal 5-ht(hydroxytryptamine)7 receptors and descending serotonergic modulation in inflammatory pain induced in formalin and carrageenan rat models. |
2014-08-12 |
2023-08-12 |
rat |
| Cristián Vela Hinojosa, Miguel Angel León Galván, Miguel Tapia Rodríguez, Gerardo López Ortega, Marco Antonio Cerbón Cervantes, Carmen Adriana Mendoza Rodríguez, Patricia Padilla Cortés, Luis Antonio Martínez Méndez, Francisco Javier Jiménez Trej. Differential expression of serotonin, tryptophan hydroxylase and monoamine oxidase A in the mammary gland of the Myotis velifer bat. PloS one. vol 8. issue 9. 2014-08-07. PMID:24086437. |
current research on non-chiropteran mammals indicates that serotonin (5-ht) plays a major role in the intraluminal volume homeostasis of the mammary gland during lactation; however, an analysis of both the expression and localization of the main components of the serotonergic system in the bat mammary gland is lacking. |
2014-08-07 |
2023-08-12 |
Not clear |
| Cristián Vela Hinojosa, Miguel Angel León Galván, Miguel Tapia Rodríguez, Gerardo López Ortega, Marco Antonio Cerbón Cervantes, Carmen Adriana Mendoza Rodríguez, Patricia Padilla Cortés, Luis Antonio Martínez Méndez, Francisco Javier Jiménez Trej. Differential expression of serotonin, tryptophan hydroxylase and monoamine oxidase A in the mammary gland of the Myotis velifer bat. PloS one. vol 8. issue 9. 2014-08-07. PMID:24086437. |
thus, the objectives of the present study were: to describe the gross and histological anatomy of the mammary gland of m. velifer to establish the lactation period for this species; to analyze the distribution and expression of the main serotonergic components in the mammary tissues of these bats under the physiological conditions of lactation, involution and the resting phase; and to provide information on the involvement of 5-ht in the regulation of the physiological function of this organ. |
2014-08-07 |
2023-08-12 |
Not clear |
| David Baumeister, Georgina Barnes, Giovanni Giaroli, Derek Trac. Classical hallucinogens as antidepressants? A review of pharmacodynamics and putative clinical roles. Therapeutic advances in psychopharmacology. vol 4. issue 4. 2014-08-01. PMID:25083275. |
these drugs appear to exert their psychedelic effects through their agonist or partial agonist activity at the serotonergic 5-ht2a receptor, though they also have affinity for other metabotropic serotonin receptors. |
2014-08-01 |
2023-08-13 |
Not clear |
| Arnold E Egger. An explanation of why schizophrenia begins with excitotoxic damage to the hippocampus. Medical hypotheses. vol 81. issue 6. 2014-07-28. PMID:24139723. |
the serotonin theory predicts that schizophrenia begins with stress-induced overdrive of serotonergic pacemaker cells in the dorsal raphe nucleus. |
2014-07-28 |
2023-08-12 |
mouse |
| María Noel Meikle, José Pedro Prieto, Jessika Urbanavicius, Ximena López, Juan Andrés Abin-Carriquiry, Giselle Prunell, María Cecilia Scorz. Anti-aggressive effect elicited by coca-paste in isolation-induced aggression of male rats: influence of accumbal dopamine and cortical serotonin. Pharmacology, biochemistry, and behavior. vol 110. 2014-07-15. PMID:23891757. |
the dopaminergic (da) neurotransmission in the nucleus accumbens (nacc) and serotonergic (5-ht) activity in the frontal cortex were explored. |
2014-07-15 |
2023-08-12 |
rat |
| M A Fox, M G Panessiti, P R Moya, T J Tolliver, K Chen, J C Shih, D L Murph. Mutations in monoamine oxidase (MAO) genes in mice lead to hypersensitivity to serotonin-enhancing drugs: implications for drug side effects in humans. The pharmacogenomics journal. vol 13. issue 6. 2014-07-14. PMID:22964922. |
these findings provide a second genetic mouse model suggestive of possible human vulnerability to the serotonin syndrome in individuals with lesser-expressing mao or sert polymorphisms that confer serotonergic system changes. |
2014-07-14 |
2023-08-12 |
mouse |
| Pau Celada, Laia Lladó-Pelfort, N Santana, L Kargieman, Eva Troyano-Rodriguez, M S Riga, Francesc Artiga. Disruption of thalamocortical activity in schizophrenia models: relevance to antipsychotic drug action. The international journal of neuropsychopharmacology. vol 16. issue 10. 2014-07-01. PMID:23809188. |
likewise, serotonergic hallucinogens, acting on 5-ht(2a) receptors, induce perceptual and behavioural alterations possibly related to psychotic symptoms. |
2014-07-01 |
2023-08-12 |
Not clear |
| Kazuki Nagayasu, Maiko Kitaichi, Naoya Nishitani, Nozomi Asaoka, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kanek. Chronic effects of antidepressants on serotonin release in rat raphe slice cultures: high potency of milnacipran in the augmentation of serotonin release. The international journal of neuropsychopharmacology. vol 16. issue 10. 2014-07-01. PMID:23920436. |
recently, we reported that sustained exposure of rat organotypic raphe slice cultures containing abundant serotonergic neurons to selective serotonin (5-ht) reuptake inhibitors (citalopram, fluoxetine and paroxetine) caused the augmentation of exocytotic serotonin release. |
2014-07-01 |
2023-08-12 |
rat |
| Kazuki Nagayasu, Maiko Kitaichi, Naoya Nishitani, Nozomi Asaoka, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kanek. Chronic effects of antidepressants on serotonin release in rat raphe slice cultures: high potency of milnacipran in the augmentation of serotonin release. The international journal of neuropsychopharmacology. vol 16. issue 10. 2014-07-01. PMID:23920436. |
in this study, we investigated the sustained actions of two tricyclic antidepressants (imipramine and desipramine), one tetracyclic antidepressant (mianserin), three 5-ht and noradrenaline reuptake inhibitors (milnacipran, duloxetine and venlafaxine) and one noradrenergic and specific serotonergic antidepressant (mirtazapine) on serotonin release in the slice cultures. |
2014-07-01 |
2023-08-12 |
rat |
| Adam L Halberstadt, Mark A Geye. Serotonergic hallucinogens as translational models relevant to schizophrenia. The international journal of neuropsychopharmacology. vol 16. issue 10. 2014-07-01. PMID:23942028. |
one of the oldest models of schizophrenia is based on the effects of serotonergic hallucinogens such as mescaline, psilocybin, and (+)-lysergic acid diethylamide (lsd), which act through the serotonin 5-ht(2a) receptor. |
2014-07-01 |
2023-08-12 |
Not clear |
| Herbert Y Meltzer, Lakshmi Rajagopal, Mei Huang, Yoshihiro Oyamada, Sunoh Kwon, Masakuni Horiguch. Translating the N-methyl-D-aspartate receptor antagonist model of schizophrenia to treatments for cognitive impairment in schizophrenia. The international journal of neuropsychopharmacology. vol 16. issue 10. 2014-07-01. PMID:24099265. |
serotonergic mechanisms, including, but not limited to serotonin (5-ht)2a and 5-ht7 antagonism, 5-ht(1a), and gaba(a) agonism, contribute to the efficacy of the aapds in the scnmdar antagonist rodent models, which are relevant to the loss of gaba interneuron/hyperglutamate hypothesis of the etiology of cis. |
2014-07-01 |
2023-08-12 |
human |
| Anderson Iuras, Mônica M Telles, Iracema S Andrade, Gianni M S Santos, Lila M Oyama, Cláudia M O Nascimento, Vera L F Silveira, Eliane B Ribeir. L-arginine abolishes the hypothalamic serotonergic activation induced by central interleukin-1β administration to normal rats. Journal of neuroinflammation. vol 10. 2014-06-25. PMID:24314273. |
it is suggested that, although serotonin participates in il-1β anorexia, other mechanisms recruited by il-1β in normal rats are able to override the absence of the serotonergic hypophagic influence. |
2014-06-25 |
2023-08-12 |
rat |
| Pia Koudouovoh-Tripp, Barbara Sperner-Unterwege. Influence of mental stress on platelet bioactivity. World journal of psychiatry. vol 2. issue 6. 2014-06-24. PMID:24175179. |
they display different serotonergic markers which seem to reflect the central nervous serotonin metabolism. |
2014-06-24 |
2023-08-12 |
human |
| Marta Sadkowski, Brittany Dennis, Robert C Clayden, Wala Elsheikh, Sumathy Rangarajan, Jane Dejesus, Zainab Samaa. The role of the serotonergic system in suicidal behavior. Neuropsychiatric disease and treatment. vol 9. 2014-06-24. PMID:24235834. |
these genes - tph1, tph2, slc6a4, slc18a2, htr1a, htr1b, htr2a, ddc, maoa, and maob - encode proteins that are vital to serotonergic function: tryptophan hydroxylase; the serotonin transporter 5-htt; the vesicular transporter vmat2; the htr1a, htr1b, and htr2a receptors; the l-amino acid decarboxylase; and the monoamine oxidases. |
2014-06-24 |
2023-08-12 |
Not clear |
| Jacqueline Volpi-Abadie, Adam M Kaye, Alan David Kay. Serotonin syndrome. The Ochsner journal. vol 13. issue 4. 2014-06-24. PMID:24358002. |
serotonin syndrome is a potentially life-threatening syndrome that is precipitated by the use of serotonergic drugs and overactivation of both the peripheral and central postsynaptic 5ht-1a and, most notably, 5ht-2a receptors. |
2014-06-24 |
2023-08-12 |
Not clear |
| Jacqueline Volpi-Abadie, Adam M Kaye, Alan David Kay. Serotonin syndrome. The Ochsner journal. vol 13. issue 4. 2014-06-24. PMID:24358002. |
serotonin syndrome can occur via the therapeutic use of serotonergic drugs alone, an intentional overdose of serotonergic drugs, or classically, as a result of a complex drug interaction between two serotonergic drugs that work by different mechanisms. |
2014-06-24 |
2023-08-12 |
Not clear |