| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jerrold S Meye. 3,4-methylenedioxymethamphetamine (MDMA): current perspectives. Substance abuse and rehabilitation. vol 4. 2014-06-24. PMID:24648791. |
these neurotoxic effects may reflect either a drug-induced degeneration of serotonergic fibers or a long-lasting downregulation in 5-ht and sert biosynthesis. |
2014-06-24 |
2023-08-12 |
Not clear |
| Katharina Spoida, Olivia A Masseck, Evan S Deneris, Stefan Herlitz. Gq/5-HT2c receptor signals activate a local GABAergic inhibitory feedback circuit to modulate serotonergic firing and anxiety in mice. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 17. 2014-06-24. PMID:24733892. |
our results demonstrate that precise temporal control of gq signals in 5-ht2c-r domains in gabaergic neurons upstream of 5-ht neurons provides negative feedback regulation of serotonergic firing to modulate anxiety-like behavior in mice. |
2014-06-24 |
2023-08-13 |
mouse |
| Jeremy D Coplan, Srinath Gopinath, Chadi G Abdallah, Benjamin R Berr. A neurobiological hypothesis of treatment-resistant depression - mechanisms for selective serotonin reuptake inhibitor non-efficacy. Frontiers in behavioral neuroscience. vol 8. 2014-06-24. PMID:24904340. |
this calls for "stacked" interventions, with an ssri base, targeting, if necessary, the glutamatergic, serotonergic, noradrenergic, and histaminergic systems, thereby successively eliminating the inhibitory effects each are capable of exerting on serotonin neurons. |
2014-06-24 |
2023-08-13 |
Not clear |
| Naotaka Horiguchi, Yukio Ago, Shigeru Hasebe, Kosuke Higashino, Kazuki Asada, Yuki Kita, Kazuhiro Takuma, Toshio Matsud. Isolation rearing reduces mechanical allodynia in a mouse model of chronic inflammatory pain. Pharmacology, biochemistry, and behavior. vol 113. 2014-06-23. PMID:24161684. |
social isolation rearing in mice after weaning reduces pain sensitivity to acute pain, and this hypoalgesia is mediated by the descending serotonergic pain inhibitory system in which the spinal serotonin (5-ht)1a receptor is involved. |
2014-06-23 |
2023-08-12 |
mouse |
| Rebecca L Miller, Arthur D Loew. 5-HT neurons of the area postrema become c-Fos-activated after increases in plasma sodium levels and transmit interoceptive information to the nucleus accumbens. American journal of physiology. Regulatory, integrative and comparative physiology. vol 306. issue 9. 2014-06-19. PMID:24598462. |
serotonergic (5-hydroxytryptamine, 5-ht) neurons of the area postrema (ap) represent one neuronal phenotype implicated in the regulation of salt appetite. |
2014-06-19 |
2023-08-12 |
rat |
| Pinkhas Sirota, Reuben Benhato. Eight-year follow-up of olanzapine therapy in a previous treatment-refractory schizophrenic patient: a case report. International journal of psychiatry in clinical practice. vol 6. issue 4. 2014-06-19. PMID:24937114. |
olanzapine, a thienobenzodiazapine, is an antipsychotic drug with high affinity for the serotonergic receptors 5-ht 2 and 5-ht 6 and high affinity for dopaminergic receptors, mainly d2, d3 and d4, and with a lower propensity to cause extrapyramidal symptoms or increasing prolactin levels. |
2014-06-19 |
2023-08-13 |
Not clear |
| Erin V Paulus, Eric M Mint. Photic and nonphotic responses of the circadian clock in serotonin-deficient Pet-1 knockout mice. Chronobiology international. vol 30. issue 10. 2014-06-18. PMID:24059871. |
in these mice, the serotonergic system suffers a developmental loss of 70% of serotonin neurons, with the remaining neurons being deficient in serotonergic function as well. |
2014-06-18 |
2023-08-12 |
mouse |
| Kerri A Pierz, Michael E Thas. A review of vilazodone, serotonin, and major depressive disorder. The primary care companion for CNS disorders. vol 16. issue 1. 2014-06-18. PMID:24940527. |
to review the mechanism of selective serotonin reuptake inhibitor (ssri)-mediated serotonergic neurotransmission, focusing on serotonin 1a (5-ht1a) autoreceptors, which are proposed to be involved in delaying therapeutic efficacy. |
2014-06-18 |
2023-08-13 |
Not clear |
| Pierre Blier, Mostafa El Mansar. The importance of serotonin and noradrenaline in anxiety. International journal of psychiatry in clinical practice. vol 11 Suppl 2. 2014-06-17. PMID:24926868. |
the therapeutics of obsessive-compulsive disorder (ocd) involves the serotonergic system in the brain; the selective serotonin reuptake inhibitors (ssris) are the only class of drugs to be consistently effective for this disorder. |
2014-06-17 |
2023-08-13 |
Not clear |
| Eric Hollande. Obsessive-compulsive disorder and spectrum across the life span. International journal of psychiatry in clinical practice. vol 9. issue 2. 2014-06-17. PMID:24930787. |
thus, in common with ocds, in bdd there is increased activity in the limbic regions; in pg there is evidence of deficiencies in 5-ht function and receptors; and in autism there are restricted interests and repetitive behaviours which may be influenced by serotonergic mechanisms. |
2014-06-17 |
2023-08-13 |
Not clear |
| David S Baldwi. Serotonin noradrenaline reuptake inhibitors: A new generation of treatment for anxiety disorders. International journal of psychiatry in clinical practice. vol 10 Suppl 2. 2014-06-14. PMID:24921677. |
the probable role of disturbed serotonergic neurotransmission in anxiety is widely accepted and is the theoretical basis for the use of serotonergic agents such as the 5-ht1a receptor partial agonist, buspirone, and the selective serotonin reuptake inhibitors (ssri), such as sertraline and paroxetine, which have largely replaced the earlier antidepressants. |
2014-06-14 |
2023-08-13 |
Not clear |
| J K Abrams Caroline J Bell David J Nut. Tryptophan depletion as a clinical tool: Current status and future directions. International journal of psychiatry in clinical practice. vol 5. issue 4. 2014-06-14. PMID:24921691. |
over the past 10 years, tryptophan depletion (td) studies of 5-ht function have emerged as an important clinical tool for studying brain serotonergic systems, and their relevance to practising psychiatrists has grown steadily. |
2014-06-14 |
2023-08-13 |
Not clear |
| Tomas Richter, Zoltan Paluch, Stefan Alusi. The non-antidepressant effects of citalopram: a clinician's perspective. Neuro endocrinology letters. vol 35. issue 1. 2014-06-12. PMID:24625921. |
finally, the authors provide a brief overview of the latest findings on osteoporosis and the serotonergic mechanism inducing it in individuals treated with a selective serotonin reuptake inhibitor. |
2014-06-12 |
2023-08-12 |
Not clear |
| Takeshi Inoue, Yuji Kitaichi, Tsukasa Koyam. SSRIs and conditioned fear. Progress in neuro-psychopharmacology & biological psychiatry. vol 35. issue 8. 2014-06-09. PMID:21925230. |
among drugs that act on serotonergic neurotransmission, selective serotonin (5-ht) reuptake inhibitors (ssris) are now the gold standard for the treatment of anxiety disorders. |
2014-06-09 |
2023-08-12 |
Not clear |
| Takeshi Inoue, Yuji Kitaichi, Tsukasa Koyam. SSRIs and conditioned fear. Progress in neuro-psychopharmacology & biological psychiatry. vol 35. issue 8. 2014-06-09. PMID:21925230. |
microinjection studies revealed the amygdala as the target brain region of both classes of serotonergic drugs, and the hippocampus as the target of 5-ht(1a) receptor agonists. |
2014-06-09 |
2023-08-12 |
Not clear |
| Takeshi Inoue, Yuji Kitaichi, Tsukasa Koyam. SSRIs and conditioned fear. Progress in neuro-psychopharmacology & biological psychiatry. vol 35. issue 8. 2014-06-09. PMID:21925230. |
these findings highlight the contribution of post-synaptic 5-ht receptors, especially 5-ht(1a) receptors, to the anxiolytic-like effects of serotonergic drugs. |
2014-06-09 |
2023-08-12 |
Not clear |
| Ana P Abdala, John M Bissonnette, Adrian Newman-Tancred. Pinpointing brainstem mechanisms responsible for autonomic dysfunction in Rett syndrome: therapeutic perspectives for 5-HT1A agonists. Frontiers in physiology. vol 5. 2014-06-09. PMID:24910619. |
a promising new symptomatic strategy currently focuses on regulation of serotonergic function using highly selective serotonin type 1a (5-ht1a) "biased agonists." |
2014-06-09 |
2023-08-13 |
Not clear |
| L Tran, B K Lasher, K A Young, N B Keel. Depletion of serotonin in the basolateral amygdala elevates glutamate receptors and facilitates fear-potentiated startle. Translational psychiatry. vol 3. 2014-06-05. PMID:24002084. |
bilateral infusions of 5,7-dihydroxytryptamine (4 μg per side) into the la produced a regional reduction of serotonergic fibers, resulting in decreased 5-ht concentrations. |
2014-06-05 |
2023-08-12 |
Not clear |
| Tallie Noble, Jonathan Stieglitz, Supriya Srinivasa. An integrated serotonin and octopamine neuronal circuit directs the release of an endocrine signal to control C. elegans body fat. Cell metabolism. vol 18. issue 5. 2014-06-05. PMID:24120942. |
here, we decipher the serotonergic neural circuit for body fat loss in c. elegans and show that the effects of 5-ht require signaling from octopamine, the invertebrate analog of adrenaline, to sustain body fat loss. |
2014-06-05 |
2023-08-12 |
caenorhabditis_elegans |
| Christine Norra, Johanna Feilhauer, Gerhard Andreas Wiesmüller, Hanns Jürgen Kuner. Differential effects of endogenous lithium on neurobehavioural functioning: a study on auditory evoked potentials. Psychiatry research. vol 178. issue 1. 2014-06-03. PMID:20452041. |
low environmental concentrations in drinking water are associated with mental illnesses and behavioural offences, and at therapeutic dosages it is used to treat psychiatric (especially affective) disorders, partly by facilitating serotonergic (5-ht) neurotransmission. |
2014-06-03 |
2023-08-12 |
human |