| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paula L Jacobsen, Atul R Mahableshwarkar, Yinzhong Chen, Lambros Chrones, Anita H Clayto. Effect of Vortioxetine vs. Escitalopram on Sexual Functioning in Adults with Well-Treated Major Depressive Disorder Experiencing SSRI-Induced Sexual Dysfunction. The journal of sexual medicine. vol 12. issue 10. 2016-04-18. PMID:26331383. |
sexual dysfunction is common with serotonergic antidepressants, including selective serotonin reuptake inhibitors (ssris) and serotonin-norepinephrine reuptake inhibitors (snris), and does not resolve in most patients. |
2016-04-18 |
2023-08-13 |
Not clear |
| Ranjithkumar Chellian, Vijayapandi Pandy, Zahurin Mohame. Biphasic Effects of α-Asarone on Immobility in the Tail Suspension Test: Evidence for the Involvement of the Noradrenergic and Serotonergic Systems in Its Antidepressant-Like Activity. Frontiers in pharmacology. vol 7. 2016-04-12. PMID:27065863. |
moreover, pretreatment of mice with noradrenergic neuromodulators such as ampt (100 mg/kg, i.p., a catecholamine synthesis inhibitor), prazosin (1 mg/kg, i.p., an α1-adrenoceptor antagonist), yohimbine (1 mg/kg, i.p., an α2-adrenoceptor antagonist) and with serotonergic neuromodulators such as pcpa (100 mg/kg, i.p., once daily for four consecutive days, a serotonin synthesis inhibitor,) and way100635 (0.1 mg/kg, s.c., a selective 5-ht1a receptor antagonist) significantly reversed the anti-immobility effect of α-asarone (20 mg/kg, i.p.). |
2016-04-12 |
2023-08-13 |
mouse |
| Kai-Lin Huang, Wan-Chen Lu, Ying-Yue Wang, Gwo-Chi Hu, Chien-Hung Lu, Wei-Ying Lee, Chien-Chi Hs. Comparison of agomelatine and selective serotonin reuptake inhibitors/serotonin-norepinephrine reuptake inhibitors in major depressive disorder: A meta-analysis of head-to-head randomized clinical trials. The Australian and New Zealand journal of psychiatry. vol 48. issue 7. 2016-04-08. PMID:24604920. |
agomelatine is a new antidepressant with unique melatonin receptor type 1a (mtnr1a) and 1b ( mtnr1b) agonism and serotonergic receptor 5-hydroxytryptamine receptor 2c (5-ht-2c) antagonism. |
2016-04-08 |
2023-08-12 |
Not clear |
| Adrian G Fischer, Tanja Endrass, Ingrid Goebel, Martin Reuter, Christian Montag, Christian Kubisch, Markus Ullsperge. Interactive effects of citalopram and serotonin transporter genotype on neural correlates of response inhibition and attentional orienting. NeuroImage. vol 116. 2016-04-08. PMID:25957993. |
the brain's serotonergic (5-ht) system has been implicated in controlling impulsive behavior and attentional orienting and linked to impulse control and anxiety related disorders. |
2016-04-08 |
2023-08-13 |
human |
| Vincent Beliveau, Claus Svarer, Vibe G Frokjaer, Gitte M Knudsen, Douglas N Greve, Patrick M Fishe. Functional connectivity of the dorsal and median raphe nuclei at rest. NeuroImage. vol 116. 2016-04-08. PMID:25963733. |
the dorsal raphe (dr) and median raphe (mr) nuclei are the source of most serotonergic neurons projecting throughout the brain and thus provide a compelling target for a seed-based probe of resting-state activity related to 5-ht. |
2016-04-08 |
2023-08-13 |
human |
| Vincent Beliveau, Claus Svarer, Vibe G Frokjaer, Gitte M Knudsen, Douglas N Greve, Patrick M Fishe. Functional connectivity of the dorsal and median raphe nuclei at rest. NeuroImage. vol 116. 2016-04-08. PMID:25963733. |
our results provide evidence for a resting-state network related to dr and mr and comprising regions receiving serotonergic innervation and centrally involved in 5-ht related behaviors including emotion, cognition and reward processing. |
2016-04-08 |
2023-08-13 |
human |
| L I Khozha. [EXPRESSION OF SEROTONIN TRANSPORTER IN THE VENTROLATERAL PART OF THE NUCLEUS OF THE SOLITARY TRACT IN RATS IN THE EARLY POSTNATAL PERIOD IN NORM AND FOLLOWING SEROTONERGIC SYSTEM DEFICIENCY IN THE PRENATAL PERIOD OF DEVELOPMENT]. Morfologiia (Saint Petersburg, Russia). vol 148. issue 5. 2016-04-08. PMID:26987216. |
[expression of serotonin transporter in the ventrolateral part of the nucleus of the solitary tract in rats in the early postnatal period in norm and following serotonergic system deficiency in the prenatal period of development]. |
2016-04-08 |
2023-08-13 |
rat |
| Perdita Cheshire, Scott Ayton, Kelly L Bertram, Helen Ling, Abi Li, Catriona McLean, Glenda M Halliday, Sean S O'Sullivan, Tamas Revesz, David I Finkelstein, Elsdon Storey, David R William. Serotonergic markers in Parkinson's disease and levodopa-induced dyskinesias. Movement disorders : official journal of the Movement Disorder Society. vol 30. issue 6. 2016-04-07. PMID:25649148. |
we obtained brain tissue from 44 pd cases and 17 age-matched controls and assessed monoamine levels and the serotonin and dopamine transporters in the striatum, and the extent of dopaminergic and serotonergic cell preservation in the substantia nigra (sn) and the dorsal raphe nuclei (drn), respectively. |
2016-04-07 |
2023-08-13 |
Not clear |
| Perdita Cheshire, Scott Ayton, Kelly L Bertram, Helen Ling, Abi Li, Catriona McLean, Glenda M Halliday, Sean S O'Sullivan, Tamas Revesz, David I Finkelstein, Elsdon Storey, David R William. Serotonergic markers in Parkinson's disease and levodopa-induced dyskinesias. Movement disorders : official journal of the Movement Disorder Society. vol 30. issue 6. 2016-04-07. PMID:25649148. |
marked serotonin loss was observed in the caudate (but not putamen) in pd patients compared with controls (p < 0.001), but no difference was found in the levels of the serotonin transporter in the striatum or density of serotonergic neurons in the drn between these groups, suggesting a functional but not structural change in the serotonergic system in pd. |
2016-04-07 |
2023-08-13 |
Not clear |
| Perdita Cheshire, Scott Ayton, Kelly L Bertram, Helen Ling, Abi Li, Catriona McLean, Glenda M Halliday, Sean S O'Sullivan, Tamas Revesz, David I Finkelstein, Elsdon Storey, David R William. Serotonergic markers in Parkinson's disease and levodopa-induced dyskinesias. Movement disorders : official journal of the Movement Disorder Society. vol 30. issue 6. 2016-04-07. PMID:25649148. |
the absence of a correlation between striatal serotonin markers and the incidence and severity of l-dopa-induced dyskinesias suggests that an intact and functioning serotonergic system is not a risk factor for developing dyskinesias in pd. |
2016-04-07 |
2023-08-13 |
Not clear |
| Pia Baldinger, Christoph Kraus, Christina Rami-Mark, Gregor Gryglewski, Georg S Kranz, Daniela Haeusler, Andreas Hahn, Marie Spies, Wolfgang Wadsak, Markus Mitterhauser, Dan Rujescu, Siegfried Kasper, Rupert Lanzenberge. Interaction between 5-HTTLPR and 5-HT1B genotype status enhances cerebral 5-HT1A receptor binding. NeuroImage. vol 111. 2016-04-07. PMID:25652393. |
thereby, they are involved in the regulation of extracellular serotonin concentrations and the extent of serotonergic effects in respective projection areas. |
2016-04-07 |
2023-08-13 |
human |
| Pia Baldinger, Christoph Kraus, Christina Rami-Mark, Gregor Gryglewski, Georg S Kranz, Daniela Haeusler, Andreas Hahn, Marie Spies, Wolfgang Wadsak, Markus Mitterhauser, Dan Rujescu, Siegfried Kasper, Rupert Lanzenberge. Interaction between 5-HTTLPR and 5-HT1B genotype status enhances cerebral 5-HT1A receptor binding. NeuroImage. vol 111. 2016-04-07. PMID:25652393. |
this finding suggests that the interaction between two major serotonergic structures involved in serotonin release, specifically the sert and 5-ht1b receptor, results in a modification of the inhibitory serotonergic tone mediated via 5-ht1a receptors. |
2016-04-07 |
2023-08-13 |
human |
| Ying-Chih Cheng, Chun-Mao Liang, Hsing-Cheng Li. Serotonin syndrome after electroconvulsive therapy in a patient on trazodone, bupropion, and quetiapine: a case report. Clinical neuropharmacology. vol 38. issue 3. 2016-04-07. PMID:25970280. |
serotonin syndrome is a potentially fatal complication that usually occurs in the combination use of several serotonergic agents. |
2016-04-07 |
2023-08-13 |
Not clear |
| Preeti Jaiswal, Kochupurackal P Mohanakumar, Usha Rajamm. Serotonin mediated immunoregulation and neural functions: Complicity in the aetiology of autism spectrum disorders. Neuroscience and biobehavioral reviews. vol 55. 2016-04-04. PMID:26021727. |
serotonergic system has long been implicated in the aetiology of autism spectrum disorders (asd), since platelet hyperserotonemia is consistently observed in a subset of autistic patients, who respond well to selective serotonin reuptake inhibitors. |
2016-04-04 |
2023-08-13 |
Not clear |
| Tillmann Weber, Miriam A Vogt, Sarah E Gartside, Stefan M Berger, Rafael Lujan, Thorsten Lau, Elke Herrmann, Rolf Sprengel, Dusan Bartsch, Peter Gas. Adult AMPA GLUA1 receptor subunit loss in 5-HT neurons results in a specific anxiety-phenotype with evidence for dysregulation of 5-HT neuronal activity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 6. 2016-03-29. PMID:25547714. |
both the glutamatergic and serotonergic (5-ht) systems are implicated in the modulation of mood and anxiety. |
2016-03-29 |
2023-08-13 |
mouse |
| Tillmann Weber, Miriam A Vogt, Sarah E Gartside, Stefan M Berger, Rafael Lujan, Thorsten Lau, Elke Herrmann, Rolf Sprengel, Dusan Bartsch, Peter Gas. Adult AMPA GLUA1 receptor subunit loss in 5-HT neurons results in a specific anxiety-phenotype with evidence for dysregulation of 5-HT neuronal activity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 6. 2016-03-29. PMID:25547714. |
to analyze the functional role of glua1-containing ampa receptors in serotonergic neurons, we used the cre-ert2/loxp-system for the conditional inactivation of the glua1-encoding gria1 gene selectively in 5-ht neurons of adult mice. |
2016-03-29 |
2023-08-13 |
mouse |
| Wenjing Law, Leah M Wuescher, Amanda Ortega, Vera M Hapiak, Patricia R Komuniecki, Richard Komunieck. Heterologous Expression in Remodeled C. elegans: A Platform for Monoaminergic Agonist Identification and Anthelmintic Screening. PLoS pathogens. vol 11. issue 4. 2016-03-29. PMID:25928899. |
monoamines, such as 5-ht and tyramine (ta), paralyze both free-living and parasitic nematodes when applied exogenously and serotonergic agonists have been used to clear haemonchus contortus infections in vivo. |
2016-03-29 |
2023-08-13 |
human |
| Andrea E Corcoran, George B Richerson, Michael B Harri. Functional link between the hypocretin and serotonin systems in the neural control of breathing and central chemosensitivity. Journal of neurophysiology. vol 114. issue 1. 2016-03-28. PMID:25878157. |
although the impact of hypocretin on 5-ht neuronal sensitivity to acidosis is still unclear, hypocretins did appear to mediate the burst duration response to acidosis via serotonergic mechanisms. |
2016-03-28 |
2023-08-13 |
mouse |
| Nozomi Asaoka, Kazuki Nagayasu, Naoya Nishitani, Mayumi Yamashiro, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kanek. Olanzapine augments the effect of selective serotonin reuptake inhibitors by suppressing GABAergic inhibition via antagonism of 5-HT₆ receptors in the dorsal raphe nucleus. Neuropharmacology. vol 95. 2016-03-24. PMID:25863120. |
among many serotonergic agents, the 5-ht6 receptor antagonist sb399885 (1-100 μm) mimicked the effects of olanzapine by enhancing the ssri-induced increase in extracellular 5-ht levels, which was not further augmented by bicuculline or olanzapine. |
2016-03-24 |
2023-08-13 |
mouse |
| N N Kudryavtsev. [Serotonergic Control of Aggressive Behavior: Novel Approaches--New Interpretations (Review)]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 65. issue 5. 2016-03-24. PMID:26859999. |
ealier, experimental studies have demonstrated reduced metabolism in brain serotonergic system and specific changes in pharmacological sensitivity of 5-ht(1a) receptors in male mice with repeated experience of aggression. |
2016-03-24 |
2023-08-13 |
mouse |