| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Catharina E van Ewijk, Gabriel E Jacobs, Armand R J Girbe. Unsuspected serotonin toxicity in the ICU. Annals of intensive care. vol 6. issue 1. 2016-09-03. PMID:27589986. |
the purpose of the present study is to determine the number of patients admitted to the icu or mcu who are diagnosed with delirium and who show characteristics of serotonin toxicity in association with the administration of serotonergic drugs. |
2016-09-03 |
2023-08-13 |
Not clear |
| María Dolores Picouto, Francisco Villar, María Dolores Braquehai. The role of serotonin in adolescent suicide: theoretical, methodological, and clinical concerns. International journal of adolescent medicine and health. vol 27. issue 2. 2016-08-29. PMID:25411983. |
serotonergic (5-ht) dysfunction has extensively been studied in adults and has been postulated as a biological marker for suicide. |
2016-08-29 |
2023-08-13 |
Not clear |
| Giuseppe Musumeci, Paola Castrogiovanni, Sergio Castorina, Rosa Imbesi, Marta Anna Szychlinska, Soraya Scuderi, Carla Loreto, Salvatore Giunt. Changes in serotonin (5-HT) and brain-derived neurotrophic factor (BDFN) expression in frontal cortex and hippocampus of aged rat treated with high tryptophan diet. Brain research bulletin. vol 119. issue Pt A. 2016-08-29. PMID:26444078. |
altogether, these finding provide evidence that enhanced trp intake and the consequent increase in 5-ht neurotransmission may act as a modulator of bdnf system suggesting a possible mechanism for the protective role of serotonergic system on memory impairment occurring along normal aging process. |
2016-08-29 |
2023-08-13 |
rat |
| Brice Le François, Jeremy Soo, Anne M Millar, Mireille Daigle, Anne-Marie Le Guisquet, Samuel Leman, Frédéric Minier, Catherine Belzung, Paul R Alber. Chronic mild stress and antidepressant treatment alter 5-HT1A receptor expression by modifying DNA methylation of a conserved Sp4 site. Neurobiology of disease. vol 82. 2016-08-24. PMID:26188176. |
the serotonin 1a receptor (5-ht1a), a critical regulator of the brain serotonergic tone, is implicated in major depressive disorder (mdd) where it is often found to be dys-regulated. |
2016-08-24 |
2023-08-13 |
mouse |
| Helene Blanchard, Lisa Chang, Amir H Rezvani, Stanley I Rapoport, Ameer Y Tah. Brain Arachidonic Acid Incorporation and Turnover are not Altered in the Flinders Sensitive Line Rat Model of Human Depression. Neurochemical research. vol 40. issue 11. 2016-08-24. PMID:26404538. |
increased brain serotonin concentrations and disturbed serotonergic neurotransmission have been reported in the flinders sensitive line (fsl) rat model of depression, suggesting that brain aa metabolism may be elevated. |
2016-08-24 |
2023-08-13 |
human |
| Helene Blanchard, Lisa Chang, Amir H Rezvani, Stanley I Rapoport, Ameer Y Tah. Brain Arachidonic Acid Incorporation and Turnover are not Altered in the Flinders Sensitive Line Rat Model of Human Depression. Neurochemical research. vol 40. issue 11. 2016-08-24. PMID:26404538. |
in summary, brain aa metabolism did not change in fsl rats despite reported increased levels of serotonin concentrations, suggesting possible post-synaptic dampening of serotonergic neurotransmission involving aa. |
2016-08-24 |
2023-08-13 |
human |
| Hyung-Mun Yun, Kyung-Ran Park, Eun-Cheol Kim, Sanghyeon Kim, Jin Tae Hon. Serotonin 6 receptor controls Alzheimer's disease and depression. Oncotarget. vol 6. issue 29. 2016-08-22. PMID:26449188. |
it was found that the reduction of serotonin level was significantly recovered by sb271036, which was mediated by an indirect regulation of serotonergic neurons via gaba. |
2016-08-22 |
2023-08-13 |
mouse |
| Boris Mlinar, Alberto Montalbano, Lukasz Piszczek, Cornelius Gross, Renato Corradett. Firing Properties of Genetically Identified Dorsal Raphe Serotonergic Neurons in Brain Slices. Frontiers in cellular neuroscience. vol 10. 2016-08-18. PMID:27536220. |
tonic spiking of serotonergic neurons establishes serotonin levels in the brain. |
2016-08-18 |
2023-08-13 |
mouse |
| E Tronci, C Fidalgo, R Stancampiano, M Cart. Effect of selective and non-selective serotonin receptor activation on L-DOPA-induced therapeutic efficacy and dyskinesia in parkinsonian rats. Behavioural brain research. vol 292. 2016-08-17. PMID:26119238. |
conversely, we recently found that increasing the serotonergic tone with chronic administration of the serotonin precursor 5-hydroxy-tryptophan (5-htp) can reduce lid in 6-ohda-lesioned rats, without affecting l-dopa efficacy. |
2016-08-17 |
2023-08-13 |
rat |
| M H Mohajeri, J Wittwer, K Vargas, E Hogan, A Holmes, P J Rogers, R Goralczyk, E L Gibso. Chronic treatment with a tryptophan-rich protein hydrolysate improves emotional processing, mental energy levels and reaction time in middle-aged women. The British journal of nutrition. vol 113. issue 2. 2016-08-15. PMID:25572038. |
common pharmacological treatments of mood disorders aim to modulate serotonergic neurotransmission and enhance serotonin levels in the brain. |
2016-08-15 |
2023-08-13 |
human |
| Karlene T Barrett, Ryan T Dosumu-Johnson, J Andrew Daubenspeck, Rachael D Brust, Vasileios Kreouzis, Jun Chul Kim, Aihua Li, Susan M Dymecki, Eugene E Natti. Partial Raphe Dysfunction in Neurotransmission Is Sufficient to Increase Mortality after Anoxic Exposures in Mice at a Critical Period in Postnatal Development. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 14. 2016-08-15. PMID:27053202. |
sudden infant death syndrome (sids) cases often have abnormalities of the brainstem raphe serotonergic (5-ht) system. |
2016-08-15 |
2023-08-13 |
mouse |
| Gary E Pickard, Kwok-Fai So, Mingliang P. Dorsal raphe nucleus projecting retinal ganglion cells: Why Y cells? Neuroscience and biobehavioral reviews. vol 57. 2016-08-09. PMID:26363667. |
we propose that in addition to its role in visual perception, the y-alpha retinal ganglion cell provides concurrent signals via axon collaterals to the drn, the major source of serotonergic afferents to the forebrain, to dramatically inhibit 5-ht activity during orientation or alerting/escape responses, which dis-facilitates ongoing tonic motor activity while dis-inhibiting sensory information processing throughout the visual system. |
2016-08-09 |
2023-08-13 |
mouse |
| Meiju Zhu, Hongzhu Zhu, Ninghua Tan, Hui Wang, Hongbiao Chu, Chonglin Zhan. Central anti-fatigue activity of verbascoside. Neuroscience letters. vol 616. 2016-08-04. PMID:26827721. |
in this study, the effects of verbascoside on treadmill exercise endurance, 5-hydroxytryptamine (5-ht) concentrations, the second isoforms of tryptophan hydroxylase (tph2) and serotonergic type 1b inhibitory autoreceptors (5-ht1b) protein expression in the caudate putamen of exercised rats were investigated. |
2016-08-04 |
2023-08-13 |
rat |
| Adelina Petrova, David Franklin Moffet. Comprehensive Immunolocalization Studies of a Putative Serotonin Receptor from the Alimentary Canal of Aedes aegypti Larvae Suggest Its Diverse Roles in Digestion and Homeostasis. PloS one. vol 11. issue 1. 2016-07-26. PMID:26808995. |
lack of information on serotonin receptors associated with the alimentary canal impedes the understanding of the serotonergic role in insect physiology. |
2016-07-26 |
2023-08-13 |
Not clear |
| Karolina Pytka, Maria Walczak, Agnieszka Kij, Anna Rapacz, Agata Siwek, Grzegorz Kazek, Adrian Olczyk, Adam Gałuszka, Anna Waszkielewicz, Henryk Marona, Jacek Sapa, Barbara Filipe. The antidepressant-like activity of 6-methoxy-2-[4-(2-methoxyphenyl)piperazin-1-yl]-9H-xanthen-9-one involves serotonergic 5-HT(1A) and 5-HT(2A/C) receptors activation. European journal of pharmacology. vol 764. 2016-07-21. PMID:26210317. |
the antidepressant-like activity of 6-methoxy-2-[4-(2-methoxyphenyl)piperazin-1-yl]-9h-xanthen-9-one involves serotonergic 5-ht(1a) and 5-ht(2a/c) receptors activation. |
2016-07-21 |
2023-08-13 |
mouse |
| Jennifer S Yokoyama, Luke W Bonham, Virginia E Sturm, Babu Adhimoolam, Anna Karydas, Giovanni Coppola, Bruce L Miller, Katherine P Ranki. The 5-HTTLPR variant in the serotonin transporter gene modifies degeneration of brain regions important for emotion in behavioral variant frontotemporal dementia. NeuroImage. Clinical. vol 9. 2016-07-21. PMID:26509115. |
5-httlpr-s modifies the serotonergic systems that support emotion and behavioral regulation by reducing gene expression, which slows the reuptake of serotonin, and is associated with distinct morphological and functional effects. |
2016-07-21 |
2023-08-13 |
Not clear |
| Priyoneel Basu, Naomi Ie, Adrienne L Wensel, Joelle D Baskerville, Victoria M Smith, Michael C Antl. Triptans attenuate circadian responses to light. The European journal of neuroscience. vol 42. issue 7. 2016-07-20. PMID:26228801. |
these responses to light can be modified by serotonergic drugs, such as serotonin 5ht1b receptor agonists. |
2016-07-20 |
2023-08-13 |
Not clear |
| Alan L Pehrson, Theepica Jeyarajah, Connie Sanche. Regional distribution of serotonergic receptors: a systems neuroscience perspective on the downstream effects of the multimodal-acting antidepressant vortioxetine on excitatory and inhibitory neurotransmission. CNS spectrums. vol 21. issue 2. 2016-07-19. PMID:26250622. |
previous work from this laboratory hypothesized that the multimodal antidepressant vortioxetine enhances cognitive function through a complex mechanism, using serotonergic (5-hydroxytryptamine, 5-ht) receptor actions to modulate gamma-butyric acid (gaba) and glutamate neurotransmission in key brain regions like the prefrontal cortex (pfc) and hippocampus. |
2016-07-19 |
2023-08-13 |
Not clear |
| N L Baganz, K M Lindler, C B Zhu, J T Smith, M J Robson, H Iwamoto, E S Deneris, W A Hewlett, R D Blakel. A requirement of serotonergic p38α mitogen-activated protein kinase for peripheral immune system activation of CNS serotonin uptake and serotonin-linked behaviors. Translational psychiatry. vol 5. 2016-07-19. PMID:26529424. |
a requirement of serotonergic p38α mitogen-activated protein kinase for peripheral immune system activation of cns serotonin uptake and serotonin-linked behaviors. |
2016-07-19 |
2023-08-13 |
mouse |
| N L Baganz, K M Lindler, C B Zhu, J T Smith, M J Robson, H Iwamoto, E S Deneris, W A Hewlett, R D Blakel. A requirement of serotonergic p38α mitogen-activated protein kinase for peripheral immune system activation of CNS serotonin uptake and serotonin-linked behaviors. Translational psychiatry. vol 5. 2016-07-19. PMID:26529424. |
to establish a role of serotonergic p38α mapk signaling in lps/il-1β-induced sert regulation and attendant behavioral responses, we pursued studies in mice that afford conditional elimination of p38α mapk in 5-ht neurons (p38α(5ht-)). |
2016-07-19 |
2023-08-13 |
mouse |