| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jonathan A Coleman, Evan M Green, Eric Gouau. X-ray structures and mechanism of the human serotonin transporter. Nature. vol 532. issue 7599. 2016-05-10. PMID:27049939. |
the serotonin transporter (sert) terminates serotonergic signalling through the sodium- and chloride-dependent reuptake of neurotransmitter into presynaptic neurons. |
2016-05-10 |
2023-08-13 |
human |
| Eran Lottem, Magor L Lörincz, Zachary F Maine. Optogenetic Activation of Dorsal Raphe Serotonin Neurons Rapidly Inhibits Spontaneous But Not Odor-Evoked Activity in Olfactory Cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 1. 2016-05-09. PMID:26740645. |
these results identify a new role for serotonergic modulation in dynamically regulating the balance between different sources of neural activity in sensory systems, suggesting a possible role for 5-ht in perceptual inference. |
2016-05-09 |
2023-08-13 |
mouse |
| Jose Amat, Samuel D Dolzani, Scott Tilden, John P Christianson, Kenneth H Kubala, Kristi Bartholomay, Katherine Sperr, Nicholas Ciancio, Linda R Watkins, Steven F Maie. Previous Ketamine Produces an Enduring Blockade of Neurochemical and Behavioral Effects of Uncontrollable Stress. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 1. 2016-05-09. PMID:26740657. |
is induces increased anxiety, which is dependent on activation of serotonergic (5-ht) dorsal raphe nucleus (drn) neurons that project to the basolateral amygdala (bla). |
2016-05-09 |
2023-08-13 |
rat |
| Anna Castañé, Lucila Kargieman, Pau Celada, Analía Bortolozzi, Francesc Artiga. 5-HT2A receptors are involved in cognitive but not antidepressant effects of fluoxetine. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 8. 2016-05-06. PMID:25914158. |
it contains a rich serotonergic (serotonin, 5-ht) innervation and a high density of 5-ht receptors. |
2016-05-06 |
2023-08-13 |
mouse |
| Hamed Shafaroodi, Simin Oveisi, Mahsa Hosseini, Hossein Niknahad, Leila Moez. The effect of acute aripiprazole treatment on chemically and electrically induced seizures in mice: The role of nitric oxide. Epilepsy & behavior : E&B. vol 48. 2016-05-05. PMID:26037847. |
dopaminergic and serotonergic systems relate to nitric oxide, and aripiprazole also has effects on dopamine and serotonin receptors. |
2016-05-05 |
2023-08-13 |
mouse |
| Mariana Angoa-Pérez, Donald M Kuh. Neuroanatomical dichotomy of sexual behaviors in rodents: a special emphasis on brain serotonin. Behavioural pharmacology. vol 26. issue 6. 2016-05-05. PMID:26110223. |
the use of serotonergic pharmacological interventions, mouse strains with genetic polymorphisms causing alterations in the levels of brain serotonin, and animal models with genetic manipulations of various serotonin effectors has helped delineate the fundamental role of this neurotransmitter in the regulation of sexual behavior. |
2016-05-05 |
2023-08-13 |
mouse |
| D Keszthelyi, F J Troost, D M Jonkers, H M van Eijk, J Dekker, W A Buurman, A A M Mascle. Visceral hypersensitivity in irritable bowel syndrome: evidence for involvement of serotonin metabolism--a preliminary study. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 27. issue 8. 2016-05-03. PMID:26031193. |
altered serotonergic (5-ht) metabolism and visceral perception have been associated with the pathogenesis of irritable bowel syndrome (ibs). |
2016-05-03 |
2023-08-13 |
Not clear |
| Jingjing Song, Xintong Hou, Xinyu Hu, Chengyu Lu, Chungang Liu, Juan Wang, Wei Liu, Lirong Teng, Di Wan. Not only serotonergic system, but also dopaminergic system involved in albiflorin against chronic unpredictable mild stress-induced depression-like behavior in rats. Chemico-biological interactions. vol 242. 2016-05-03. PMID:26475043. |
compared to non-treated depression-like rats, the increased levels of 5-hydroxytryptamine (5-ht) and 5-hydroxyindoleacetic acid (5-htaa) in serum and hypothalamus, and the reduced expressions of 5-ht1a receptor and 5-ht2a receptor in hypothalamus were observed after af and fluoxetine oral administration indicating that af-mediated antidepressant-like effect may be related to the normalization of serotonergic system. |
2016-05-03 |
2023-08-13 |
rat |
| Pragathi Priyadharsini Balasubramani, V Srinivasa Chakravarthy, Manal Ali, Balaraman Ravindran, Ahmed A Moustaf. Identifying the Basal Ganglia network model markers for medication-induced impulsivity in Parkinson's disease patients. PloS one. vol 10. issue 6. 2016-05-02. PMID:26042675. |
a neural network model of the basal ganglia (bg) that has the capacity to predict the dysfunction of both the dopaminergic (da) and the serotonergic (5ht) neuromodulator systems was developed and used to facilitate the interpretation of experimental results. |
2016-05-02 |
2023-08-13 |
human |
| Shawn P Alter, Kristen A Stout, Kelly M Lohr, Tonya N Taylor, Kennie R Shepherd, Minzheng Wang, Thomas S Guillot, Gary W Mille. Reduced vesicular monoamine transport disrupts serotonin signaling but does not cause serotonergic degeneration. Experimental neurology. vol 275 Pt 1. 2016-04-29. PMID:26428905. |
reduced vesicular monoamine transport disrupts serotonin signaling but does not cause serotonergic degeneration. |
2016-04-29 |
2023-08-13 |
mouse |
| Shawn P Alter, Kristen A Stout, Kelly M Lohr, Tonya N Taylor, Kennie R Shepherd, Minzheng Wang, Thomas S Guillot, Gary W Mille. Reduced vesicular monoamine transport disrupts serotonin signaling but does not cause serotonergic degeneration. Experimental neurology. vol 275 Pt 1. 2016-04-29. PMID:26428905. |
collectively, these data indicate that reduced vesicular monoamine transport significantly disrupts serotonergic signaling, but does not drive degeneration of serotonin neurons. |
2016-04-29 |
2023-08-13 |
mouse |
| Gianfranco Bellipanni, Elke Rink, Laure Bally-Cui. Cloning of two tryptophan hydroxylase genes expressed in the diencephalon of the developing zebrafish brain. Mechanisms of development. vol 119 Suppl 1. 2016-04-23. PMID:14516688. |
the monoamine serotonin (5-ht) exerts key neuromodulatory activities in all animal phyla, but the development and function of the serotonergic system is still incompletely understood. |
2016-04-23 |
2023-08-12 |
zebrafish |
| Gianfranco Bellipanni, Elke Rink, Laure Bally-Cui. Cloning of two tryptophan hydroxylase genes expressed in the diencephalon of the developing zebrafish brain. Mechanisms of development. vol 119 Suppl 1. 2016-04-23. PMID:14516688. |
in order to characterize the organization of serotonergic neurons in the zebrafish we cloned two cdnas encoding distinct forms of tryptophan hydroxylase (tph), the rate-limiting enzyme in serotonin synthesis. |
2016-04-23 |
2023-08-12 |
zebrafish |
| Noah H Green, Chad R Jackson, Hideki Iwamoto, Michael C Tackenberg, Douglas G McMaho. Photoperiod programs dorsal raphe serotonergic neurons and affective behaviors. Current biology : CB. vol 25. issue 10. 2016-04-21. PMID:25959961. |
the serotonergic raphe nuclei of the midbrain are principal centers from which serotonin neurons project to innervate cortical and sub-cortical structures. |
2016-04-21 |
2023-08-13 |
mouse |
| Noah H Green, Chad R Jackson, Hideki Iwamoto, Michael C Tackenberg, Douglas G McMaho. Photoperiod programs dorsal raphe serotonergic neurons and affective behaviors. Current biology : CB. vol 25. issue 10. 2016-04-21. PMID:25959961. |
dysregulation of serotonin neurotransmission is implicated in neurobehavioral disorders, such as depression and anxiety, and alterations in the serotonergic phenotype of raphe neurons have dramatic effects on affective behaviors in rodents. |
2016-04-21 |
2023-08-13 |
mouse |
| Steven C Leiser, Yan Li, Alan L Pehrson, Elena Dale, Gennady Smagin, Connie Sanche. Serotonergic Regulation of Prefrontal Cortical Circuitries Involved in Cognitive Processing: A Review of Individual 5-HT Receptor Mechanisms and Concerted Effects of 5-HT Receptors Exemplified by the Multimodal Antidepressant Vortioxetine. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25746856. |
serotonergic regulation of prefrontal cortical circuitries involved in cognitive processing: a review of individual 5-ht receptor mechanisms and concerted effects of 5-ht receptors exemplified by the multimodal antidepressant vortioxetine. |
2016-04-19 |
2023-08-13 |
Not clear |
| Rodrigo Andrade, Daniel Huereca, Joseph G Lyons, Elaine M Andrade, Kelly M McGrego. 5-HT1A Receptor-Mediated Autoinhibition and the Control of Serotonergic Cell Firing. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25913021. |
activity-dependent release of serotonin within serotonergic nuclei is thought to activate these autoreceptors, thus completing an autoinhibitory feedback loop. |
2016-04-19 |
2023-08-13 |
Not clear |
| Cornelia Hainer, Valentina Mosienko, Stella Koutsikou, Jonathan J Crook, Bernd Gloss, Sergey Kasparov, Bridget M Lumb, Natalia Alenin. Beyond Gene Inactivation: Evolution of Tools for Analysis of Serotonergic Circuitry. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:26132472. |
in this review, we summarize findings on genetic animal models that enable control of 5-ht neuronal activity or mapping of the serotonergic system. |
2016-04-19 |
2023-08-13 |
mouse |
| Erik Studer, Jakob Näslund, Erik Andersson, Staffan Nilsson, Lars Westberg, Elias Eriksso. Serotonin depletion-induced maladaptive aggression requires the presence of androgens. PloS one. vol 10. issue 5. 2016-04-18. PMID:25978464. |
whereas these results suggest the pro-aggressive effect of testosterone to be independent of serotonin, and not caused by an inhibition of serotonergic activity, the pcpa-induced induction of maladaptive aggression appears to require the presence of the hormone. |
2016-04-18 |
2023-08-13 |
mouse |
| Erik Studer, Jakob Näslund, Erik Andersson, Staffan Nilsson, Lars Westberg, Elias Eriksso. Serotonin depletion-induced maladaptive aggression requires the presence of androgens. PloS one. vol 10. issue 5. 2016-04-18. PMID:25978464. |
we conclude that androgenic deficiency does not dampen aggression by unleashing an anti-aggressive serotonergic influence; instead serotonin seems to modulate aggressive behavior by exerting a parallel-coupled inhibitory role on androgen-driven aggression, which is irrelevant in the absence of the hormone, and the arresting of which leads to enhanced maladaptive aggression. |
2016-04-18 |
2023-08-13 |
mouse |