| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Iderberg, A C McCreary, M A Varney, M S Kleven, W Koek, L Bardin, R Depoortère, M A Cenci, A Newman-Tancred. NLX-112, a novel 5-HT1A receptor agonist for the treatment of L-DOPA-induced dyskinesia: Behavioral and neurochemical profile in rat. Experimental neurology. vol 271. 2015-12-22. PMID:26037043. |
in microdialysis experiments, nlx-112 profoundly decreased striatal 5-ht extracellular levels, indicative of inhibition of serotonergic function. |
2015-12-22 |
2023-08-13 |
rat |
| R K Mahaseth, S Kumar, Shagun Dutta, Ratika Sehgal, Preety Rajora, Rajani Mathu. Pharmacodynamic Study of Interaction of Aqueous Leaf Extract of Psidium Guajava Linn. (Myrtaceae) with Receptor Systems Using Isolated Tissue Preparations. Indian journal of pharmaceutical sciences. vol 77. issue 4. 2015-12-15. PMID:26664068. |
the concentration-dependent contractile response of aqueous leaf extract of psidium guajava was parallel and rightward of standard agonists, ach and 5-ht indicating agonistic activity on muscarinic and serotonergic receptor systems. |
2015-12-15 |
2023-08-13 |
rat |
| Agorastos Agorastos, Michael Kellner, Oliver Stiedl, Christoph Muhtz, Klaus Wiedemann, Cüneyt Demirala. Blunted autonomic reactivity to pharmacological panic challenge under long-term escitalopram treatment in healthy men. The international journal of neuropsychopharmacology. vol 18. issue 5. 2015-12-08. PMID:25522396. |
selective serotonin reuptake inhibitors (ssris) affect multiple serotonergic pathways, including central autonomic pathways. |
2015-12-08 |
2023-08-13 |
Not clear |
| Christoph Kraus, Pia Baldinger, Christina Rami-Mark, Gregor Gryglewski, Gregor Gryglewsky, Georg S Kranz, Daniela Haeusler, Andreas Hahn, Wolfgang Wadsak, Markus Mitterhauser, Dan Rujescu, Siegfried Kasper, Rupert Lanzenberge. Exploring the impact of BDNF Val66Met genotype on serotonin transporter and serotonin-1A receptor binding. PloS one. vol 9. issue 9. 2015-12-07. PMID:25188405. |
the brain-derived neurotrophic factor (bdnf) val66met polymorphism (rs6265) may impact on the in-vivo binding of important serotonergic structures such as the serotonin transporter (5-htt) and the serotonin-1a (5-ht1a) receptor. |
2015-12-07 |
2023-08-13 |
Not clear |
| Eszter Kirilly, Xénia Gonda, György Bagd. [Antidepressants, stressors and the serotonin 1A receptor]. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 17. issue 2. 2015-12-04. PMID:26192901. |
5-ht(1a) receptors on serotonergic neurons can be found in the somatodendritic area and play a significant role in delaying the effects of antidepressants which is an obvious disadvantage. |
2015-12-04 |
2023-08-13 |
human |
| Eszter Kirilly, Xénia Gonda, György Bagd. [Antidepressants, stressors and the serotonin 1A receptor]. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 17. issue 2. 2015-12-04. PMID:26192901. |
therefore the newest serotonergic antidepressants including vilazodone and vortioxetine have been designed to possess 5-ht(1a) receptor partial agonist properties. |
2015-12-04 |
2023-08-13 |
human |
| Angelika Marsic, Mitchell E Berman, Tammy D Barry, Michael S McCloske. The relationship between intentional self-injurious behavior and the loudness dependence of auditory evoked potential in research volunteers. Journal of clinical psychology. vol 71. issue 3. 2015-12-03. PMID:25327536. |
serotonergic (5-ht) functioning has been shown to be inversely associated with intentional self-injurious behaviors. |
2015-12-03 |
2023-08-13 |
human |
| Phillip D Kronstein, Eiji Ishida, Ni A Khin, Eric Chang, H M James Hung, Robert J Temple, Peiling Yan. Summary of findings from the FDA regulatory science forum on measuring sexual dysfunction in depression trials. The Journal of clinical psychiatry. vol 76. issue 8. 2015-12-03. PMID:26335083. |
sexual dysfunction is a significant treatment-emergent adverse reaction to the serotonergic antidepressants (selective serotonin reuptake inhibitors [ssris] and serotonin-norepinephrine reuptake inhibitors [snris]). |
2015-12-03 |
2023-08-13 |
Not clear |
| Barbara Pelosi, Sara Migliarini, Giulia Pacini, Marta Pratelli, Massimo Pasqualett. Generation of Pet1210-Cre transgenic mouse line reveals non-serotonergic expression domains of Pet1 both in CNS and periphery. PloS one. vol 9. issue 8. 2015-11-30. PMID:25098329. |
in the mouse, pet1 mrna expression appears between 10 and 11 days post coitum (dpc) in serotonergic post-mitotic precursors and persists in serotonergic neurons up to adulthood, where it promotes the expression of genes defining the mature serotonergic phenotype such as tryptophan hydroxylase 2 (tph2) and serotonin transporter (sert). |
2015-11-30 |
2023-08-13 |
mouse |
| A Giacosa, P Morazzoni, E Bombardelli, A Riva, G Bianchi Porro, M Rondanell. Can nausea and vomiting be treated with ginger extract? European review for medical and pharmacological sciences. vol 19. issue 7. 2015-11-27. PMID:25912592. |
these effects are mainly due to the presence of gingerols and shogaols and their activity on cholinergic m receptors and serotonergic 5-ht and 5-ht receptors. |
2015-11-27 |
2023-08-13 |
human |
| Pei Jiang, Li-Hong Zhang, Hua-Lin Cai, Huan-De Li, Yi-Ping Liu, Mi-Mi Tang, Rui-Li Dang, Wen-Ye Zhu, Ying Xue, Xin H. Neurochemical effects of chronic administration of calcitriol in rats. Nutrients. vol 6. issue 12. 2015-11-25. PMID:25533012. |
however, the concentrations of the metabolites of dopamine and serotonin were increased and the drug use also resulted in a significant rise of monoamine oxidase a (maoa) expression, which might be responsible to maintain the homeostasis of dopaminergic and serotonergic neurotransmission. |
2015-11-25 |
2023-08-13 |
rat |
| Ichiro Kaneko, Marya S Sabir, Christopher M Dussik, G Kerr Whitfield, Amitis Karrys, Jui-Cheng Hsieh, Mark R Haussler, Mark B Meyer, J Wesley Pike, Peter W Jurutk. 1,25-Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin genes: implication for behavioral influences of vitamin D. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 9. 2015-11-25. PMID:26071405. |
brain tph2 mrna, encoding the rate-limiting enzyme in serotonin synthesis, was induced 2.2-fold by 10 nm 1,25d in human u87 glioblastoma cells and 47.8-fold in rat serotonergic rn46a-b14 cells. |
2015-11-25 |
2023-08-13 |
mouse |
| Seshadri Sekhar Chatterjee, Sayantanava Mitra, Nitu Malli. Emerging Hyperprolactinemic Galactorrhea in Obsessive Compulsive Disorder with a Stable Dose of Fluoxetine. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology. vol 13. issue 3. 2015-11-24. PMID:26598592. |
while fluoxetine (fxt) is a frequently prescribed selective serotonin reuptake inhibitor (ssri), with few major side-effects; altered serotonergic transmissions in hypothalamic pathways might lead to a distressing, and often embarrassing, manifestation of galactorrhea by altering prolactin release in those on fxt. |
2015-11-24 |
2023-08-13 |
Not clear |
| Jill S Carmody, Nadia N Ahmad, Sriram Machineni, Scott Lajoie, Lee M Kapla. Weight Loss After RYGB Is Independent of and Complementary to Serotonin 2C Receptor Signaling in Male Mice. Endocrinology. vol 156. issue 9. 2015-11-17. PMID:26066076. |
activation of serotonin 2c receptors (5-ht2cr) by serotonergic drugs causes wl in humans and animal models. |
2015-11-17 |
2023-08-13 |
mouse |
| Katharine M Koury, Becky Tsui, Padma Gulu. Incidence of serotonin syndrome in patients treated with fentanyl on serotonergic agents. Pain physician. vol 18. issue 1. 2015-11-16. PMID:25675067. |
incidence of serotonin syndrome in patients treated with fentanyl on serotonergic agents. |
2015-11-16 |
2023-08-13 |
Not clear |
| Katharine M Koury, Becky Tsui, Padma Gulu. Incidence of serotonin syndrome in patients treated with fentanyl on serotonergic agents. Pain physician. vol 18. issue 1. 2015-11-16. PMID:25675067. |
there has been a recent surge in the literature highlighting the association of fentanyl as precipitating serotonin syndrome in patients on a serotonergic agent. |
2015-11-16 |
2023-08-13 |
Not clear |
| Maude Beaudoin-Gobert, Justine Epinat, Elise Météreau, Sandra Duperrier, Sara Neumane, Bénédicte Ballanger, Franck Lavenne, François Liger, Christian Tourvielle, Frédéric Bonnefoi, Nicolas Costes, Didier Le Bars, Emmanuel Broussolle, Stéphane Thobois, Léon Tremblay, Véronique Sgambato-Faur. Behavioural impact of a double dopaminergic and serotonergic lesion in the non-human primate. Brain : a journal of neurology. vol 138. issue Pt 9. 2015-11-16. PMID:26117365. |
serotonergic (5-ht) neurons degenerate in parkinson's disease. |
2015-11-16 |
2023-08-13 |
monkey |
| Marta Krzyżanowska, Johann Steiner, Ralf Brisch, Christian Mawrin, Stefan Busse, Katharina Braun, Zbigniew Jankowski, Hans-Gert Bernstein, Bernhard Bogerts, Tomasz Go. Ribosomal DNA transcription in the dorsal raphe nucleus is increased in residual but not in paranoid schizophrenia. European archives of psychiatry and clinical neuroscience. vol 265. issue 2. 2015-11-12. PMID:25091423. |
the central serotonergic system is implicated in the pathogenesis of schizophrenia, where the imbalance between dopamine, serotonin and glutamate plays a key pathophysiological role. |
2015-11-12 |
2023-08-13 |
Not clear |
| Matthew O Parker, Alistair J Brock, Ari Sudwarts, Muy-Teck Teh, Fraser J Combe, Caroline H Brenna. Developmental role of acetylcholinesterase in impulse control in zebrafish. Frontiers in behavioral neuroscience. vol 9. 2015-11-03. PMID:26528153. |
assessment of expression of cholinergic (nachr), serotonergic (5-ht), and dopamine (dr) receptor mrna in both adult and larval (9 dpf) ache (sb55/+) revealed significant downregulation of chrna2, chrna5, and drd2 mrna in ache (sb55/+) larvae, but no differences in adults. |
2015-11-03 |
2023-08-13 |
zebrafish |
| Cheng Liu, Tao-Tao Liu, Zhi-Gang He, Bin Shu, Hong-Bing Xian. Inhibition of itch-related responses by selectively ablated serotonergic signals at the rostral ventromedial medulla in mice. International journal of clinical and experimental pathology. vol 7. issue 12. 2015-10-30. PMID:25674265. |
here we investigated the contribution of serotonergic (5-ht) pathway at the rvm to pruritic behavior. |
2015-10-30 |
2023-08-13 |
mouse |