| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Satoshi Ansai, Hiroshi Hosokawa, Shingo Maegawa, Kiyoshi Naruse, Youhei Washio, Kenji Sato, Masato Kinoshit. Deficiency of Serotonin in Raphe Neurons and Altered Behavioral Responses in Tryptophan Hydroxylase 2-Knockout Medaka (Oryzias latipes). Zebrafish. vol 14. issue 6. 2018-01-05. PMID:28933662. |
teleost fish species have serotonergic neurons in the raphe nuclei of the brainstem; however, the role of 5-ht in the raphe neurons in teleost fish remains largely unknown. |
2018-01-05 |
2023-08-13 |
Not clear |
| William T Donnelly, Donald Bartlett, J C Leite. Serotonin in the solitary tract nucleus shortens the laryngeal chemoreflex in anaesthetized neonatal rats. Experimental physiology. vol 101. issue 7. 2018-01-02. PMID:27121960. |
thus, endogenous 5-ht released within the nts may curtail the respiratory depression that is part of the lcr, and serotonergic shortening of the lcr may be attributed to activation of 5-ht3 receptors within the nts. |
2018-01-02 |
2023-08-13 |
rat |
| Marc Fakhour. Revisiting the Serotonin Hypothesis: Implications for Major Depressive Disorders. Molecular neurobiology. vol 53. issue 5. 2017-12-22. PMID:25823514. |
the 5-ht membrane transporter protein (sert), which helps regulate the serotonergic transmission, is also implicated in mdd and is one of the main targets of antidepressant therapy. |
2017-12-22 |
2023-08-13 |
mouse |
| Marc Fakhour. Revisiting the Serotonin Hypothesis: Implications for Major Depressive Disorders. Molecular neurobiology. vol 53. issue 5. 2017-12-22. PMID:25823514. |
the overarching goal of this review is to present recent findings from studies examining the serotonergic pathway in mdd, with a focus on sert and the serotonin 1a (5-ht1a), serotonin 1b (5-ht1b), and serotonin 2a (5-ht2a) receptors. |
2017-12-22 |
2023-08-13 |
mouse |
| Grzegorz Satała, Beata Duszyńska, Katarzyna Stachowicz, Anna Rafalo, Bartlomiej Pochwat, Christine Luckhart, Paul R Albert, Mireille Daigle, Kenji F Tanaka, René Hen, Tomasz Lenda, Gabriel Nowak, Andrzej J Bojarski, Bernadeta Szewczy. Concentration-Dependent Dual Mode of Zn Action at Serotonin 5-HT1A Receptors: In Vitro and In Vivo Studies. Molecular neurobiology. vol 53. issue 10. 2017-12-22. PMID:26660328. |
recent data has indicated that zn can modulate serotonergic function through the 5-ht |
2017-12-22 |
2023-08-13 |
Not clear |
| Victor M Lopez-Alvarez, Maria Puigdomenech, Xavier Navarro, Stefano Cobianch. Monoaminergic descending pathways contribute to modulation of neuropathic pain by increasing-intensity treadmill exercise after peripheral nerve injury. Experimental neurology. vol 299. issue Pt A. 2017-12-20. PMID:28993250. |
this study characterizes the impact of increasing-intensity treadmill exercise (itr) on noradrenergic (ne) and serotonergic (5ht) modulation of neuropathic pain. |
2017-12-20 |
2023-08-13 |
rat |
| Weisheng V Chen, Chiamaka L Nwakeze, Christine A Denny, Sean O'Keeffe, Michael A Rieger, George Mountoufaris, Amy Kirner, Joseph D Dougherty, René Hen, Qiang Wu, Tom Maniati. Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice. Science (New York, N.Y.). vol 356. issue 6336. 2017-12-19. PMID:28450636. |
serotonergic neurons project their axons pervasively throughout the brain and innervate various target fields in a space-filling manner, leading to tiled arrangements of their axon terminals to allow optimal allocation of serotonin among target neurons. |
2017-12-19 |
2023-08-13 |
mouse |
| Aarthi Manoharan, Ravi Philip Rajkumar, Deepak Gopal Shewade, Rajan Sundaram, Avin Muthuramalingam, Abialbon Pau. Evaluation of interleukin-6 and serotonin as biomarkers to predict response to fluoxetine. Human psychopharmacology. vol 31. issue 3. 2017-12-15. PMID:27018372. |
only 30% of major depressive disorder (mdd) patients achieve complete remission with a serotonergic antidepressant (selective serotonin reuptake inhibitor). |
2017-12-15 |
2023-08-13 |
Not clear |
| Scott A Givan, Kevin J Cumming. Intermittent severe hypoxia induces plasticity within serotonergic and catecholaminergic neurons in the neonatal rat ventrolateral medulla. Journal of applied physiology (Bethesda, Md. : 1985). vol 120. issue 11. 2017-12-14. PMID:26968026. |
we hypothesized that 1) catecholaminergic neurons in the neonatal vlm are activated following ish, 2) this activation is compromised following an acute loss of brain stem 5-ht, and 3) ish induces cellular and/or transcriptomic plasticity within catecholaminergic and serotonergic neurons that are within or project to the vlm, respectively. |
2017-12-14 |
2023-08-13 |
rat |
| Scott A Givan, Kevin J Cumming. Intermittent severe hypoxia induces plasticity within serotonergic and catecholaminergic neurons in the neonatal rat ventrolateral medulla. Journal of applied physiology (Bethesda, Md. : 1985). vol 120. issue 11. 2017-12-14. PMID:26968026. |
along with immunohistochemistry to detect tyrosine hydroxylase (th)- or fos-positive neurons, we used rna sequencing to resolve the effects of ish and 5-ht deficiency on the expression of serotonergic and catecholaminergic system genes in the vlm. |
2017-12-14 |
2023-08-13 |
rat |
| Adam K Klein, Michael A Brito, Sayeh Akhavan, Dylan R Flanagan, Nikki Le, Tatum Ohana, Anand S Patil, Erin M Purvis, Carl Provenzano, Alex Wei, Lucy Zhou, Aaron Ettenber. Attenuation of the anxiogenic effects of cocaine by 5-HT Psychopharmacology. vol 234. issue 3. 2017-12-13. PMID:27888284. |
a possible substrate contributing to these actions is the serotonergic (5-ht) pathway projecting from the dorsal raphé (drn) to regions of the extended amygdala, including the bed nucleus of the stria terminalis (bnst) which have been implicated in the production of anxiogenic states. |
2017-12-13 |
2023-08-13 |
Not clear |
| C Duparc, C André, J Ménard, B Godouet-Getti, J Wils, A F Cailleux, L Moreau-Grangé, E Louiset, H Lefebvr. l-Lysine Acts as a Serotonin Type 4 Receptor Antagonist to Counteract In Vitro and In Vivo the Stimulatory Effect of Serotonergic Agents on Aldosterone Secretion in Man. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 49. issue 4. 2017-12-11. PMID:28103616. |
l-lysine acts as a serotonin type 4 receptor antagonist to counteract in vitro and in vivo the stimulatory effect of serotonergic agents on aldosterone secretion in man. |
2017-12-11 |
2023-08-13 |
human |
| Catherine A Marcinkiewcz, Emily G Lowery-Gionta, Thomas L Kas. Serotonin's Complex Role in Alcoholism: Implications for Treatment and Future Research. Alcoholism, clinical and experimental research. vol 40. issue 6. 2017-12-08. PMID:27161942. |
given the heterogeneity in responsiveness to serotonergic drugs across the spectrum of alcoholic subtypes, we assess the contribution of specific 5-ht circuits to discrete endophenotypes of alcohol dependence. |
2017-12-08 |
2023-08-13 |
Not clear |
| Catherine A Marcinkiewcz, Emily G Lowery-Gionta, Thomas L Kas. Serotonin's Complex Role in Alcoholism: Implications for Treatment and Future Research. Alcoholism, clinical and experimental research. vol 40. issue 6. 2017-12-08. PMID:27161942. |
5-ht circuits play a distinctive role in reward, stress, and executive function which may account for the variation in response to serotonergic drugs. |
2017-12-08 |
2023-08-13 |
Not clear |
| Jon Stefansson, Andreas Chatzittofis, Peter Nordström, Stefan Arver, Marie Åsberg, Jussi Jokine. CSF and plasma testosterone in attempted suicide. Psychoneuroendocrinology. vol 74. 2017-12-08. PMID:27567115. |
dual-hormone serotonergic theory on human impulsive aggression implies high testosterone/cortisol ratio acting on the amygdala and low serotonin in the prefrontal cortex. |
2017-12-08 |
2023-08-13 |
human |
| José Ángel García-Pedraza, Mónica García, María Luisa Martín, Nélida Eleno, Asunción Morá. Chronic Sarpogrelate Treatment Reveals 5-HT7 Receptor in the Serotonergic Inhibition of the Rat Vagal Bradycardia. Journal of cardiovascular pharmacology. vol 69. issue 1. 2017-11-27. PMID:27676327. |
our outcomes suggest that blocking chronically 5-ht2 receptors modifies the serotonergic influence on cardiac vagal neurotransmission exhibiting 5-ht as an exclusively inhibitory agent via prejunctional 5-ht7 receptor. |
2017-11-27 |
2023-08-13 |
rat |
| Yosta Vegting, Liesbeth Reneman, Jan Booi. The effects of ecstasy on neurotransmitter systems: a review on the findings of molecular imaging studies. Psychopharmacology. vol 233. issue 19-20. 2017-11-24. PMID:27568200. |
importantly, it has been suggested that use of mdma may be neurotoxic particularly for serotonergic (5-hydroxytryptamine (5-ht)) neurons. |
2017-11-24 |
2023-08-13 |
Not clear |
| Felix-Martin Werner, Rafael Covena. Serotonergic Drugs: Agonists/Antagonists at Specific Serotonergic Subreceptors for the Treatment of Cognitive, Depressant and Psychotic Symptoms in Alzheimer's Disease. Current pharmaceutical design. vol 22. issue 14. 2017-11-16. PMID:26818863. |
in post-mortem studies, serotonin levels and the number of specific serotonergic subreceptors, for example 5-ht1b receptors, decreased. |
2017-11-16 |
2023-08-13 |
Not clear |
| C A Roberts, A Jones, C Montgomer. Meta-analysis of executive functioning in ecstasy/polydrug users. Psychological medicine. vol 46. issue 8. 2017-11-16. PMID:26966023. |
ecstasy/3,4-methylenedioxymethamphetamine (mdma) use is proposed to cause damage to serotonergic (5-ht) axons in humans. |
2017-11-16 |
2023-08-13 |
Not clear |
| b' J Gasull-Cam\\xc3\\xb3s, M Tarr\\xc3\\xa9s-Gatius, F Artigas, A Casta\\xc3\\xb1\\xc3\\xa. Glial GLT-1 blockade in infralimbic cortex as a new strategy to evoke rapid antidepressant-like effects in rats. Translational psychiatry. vol 7. issue 2. 2017-11-16. PMID:28221365.' |
the dhk-evoked antidepressant-like responses appear to be mediated by an ampa-r-driven enhancement of serotonergic activity, as (i) they were prevented by nbqx 2,3-dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide disodium salt) and mimicked by s-ampa; (ii) dhk and s-ampa elevated similarly extracellular glutamate in il and prl, although extracellular 5-ht and c-fos expression in the midbrain dorsal raphe increased only when these agents were applied in il; and (iii) dhk antidepressant-like responses were prevented by 5-ht synthesis inhibition and mimicked by citalopram microinfusion in il. |
2017-11-16 |
2023-08-13 |
rat |