| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mathieu Verdurand, Luc Zimme. Hippocampal 5-HT Neuropharmacology. vol 123. 2018-04-17. PMID:28647411. |
hippocampal 5-ht there is increasing evidence that the serotonergic system is highly dysfunctional in alzheimer's disease (ad), and this could be related to cognitive impairments associated with dementia. |
2018-04-17 |
2023-08-13 |
Not clear |
| Ting Zhang, Lu Huang, Li Zhang, Minjie Tan, Mingliang Pu, Gary E Pickard, Kwok-Fai So, Chaoran Re. ON and OFF retinal ganglion cells differentially regulate serotonergic and GABAergic activity in the dorsal raphe nucleus. Scientific reports. vol 6. 2018-04-12. PMID:27181078. |
the dorsal raphe nucleus (drn), the major source of serotonergic input to the forebrain, receives excitatory input from the retina that can modulate serotonin levels and depressive-like behavior. |
2018-04-12 |
2023-08-13 |
Not clear |
| Kausar Jahan, Krishna K Pillai, Divya Vohor. Parachlorophenylalanine-induced 5-HT depletion alters behavioral and brain neurotransmitters levels in 6-Hz psychomotor seizure model in mice. Fundamental & clinical pharmacology. vol 31. issue 4. 2018-04-05. PMID:28295557. |
pre- and post-treatment with svp protected the mice from 6-hz seizures and attenuated pcpa-induced changes in the levels of 5-ht and da in the mice brain suggesting the protective effect of svp in the pharmacoresistant model of epilepsy involving mainly serotonergic mechanism. |
2018-04-05 |
2023-08-13 |
mouse |
| Zhong-Min Wu, Gui-Lian Ni, Ai-Min Shao, Rong Cu. Genistein alleviates anxiety-like behaviors in post-traumatic stress disorder model through enhancing serotonergic transmission in the amygdala. Psychiatry research. vol 255. 2018-04-05. PMID:28600997. |
furthermore, in these rats, genistein enhanced serotonergic transmission in the amygdala, including upregulation of tryptophan hydroxylase, serotonin, and phosphorylated (p)-camkii and p-creb, as well. |
2018-04-05 |
2023-08-13 |
human |
| Roberto Mandrioli, Michele Protti, Laura Mercolin. New-Generation, Non-SSRI Antidepressants: Therapeutic Drug Monitoring and Pharmacological Interactions. Part 1: SNRIs, SMSs, SARIs. Current medicinal chemistry. vol 25. issue 7. 2018-04-03. PMID:28707591. |
after the introduction of selective serotonin reuptake inhibitors (ssris), a plethora of other groups followed, identified by their main mechanisms of activity: serotonin and norepinephrine reuptake inhibitors (snri); serotonin modulators and stimulators (sms); serotonin antagonists and reuptake inhibitors (sari); noradrenergic and selective serotonergic antidepressants (nassa); norepinephrine reuptake inhibitors (neri); serotonin, norepinephrine and dopamine reuptake inhibitors (sndri) or triple reuptake inhibitors (tri); and melatonin and serotonin agonists (masa). |
2018-04-03 |
2023-08-13 |
Not clear |
| Oi Wan Wan, Eunju Shin, Bengt Mattsson, Dorian Caudal, Per Svenningsson, Anders Björklun. α-Synuclein induced toxicity in brain stem serotonin neurons mediated by an AAV vector driven by the tryptophan hydroxylase promoter. Scientific reports. vol 6. 2018-04-02. PMID:27211987. |
we studied the impact of α-synuclein overexpression in brainstem serotonin neurons using a novel vector construct where the expression of human wildtype α-synuclein is driven by the tryptophan hydroxylase promoter, allowing expression of α-synuclein at elevated levels, and with high selectivity, in serotonergic neurons. |
2018-04-02 |
2023-08-13 |
human |
| Jeanette Tour, Monika Löfgren, Kaisa Mannerkorpi, Björn Gerdle, Anette Larsson, Annie Palstam, Indre Bileviciute-Ljungar, Jan Bjersing, Ingvar Martin, Malin Ernberg, Martin Schalling, Eva Kose. Gene-to-gene interactions regulate endogenous pain modulation in fibromyalgia patients and healthy controls-antagonistic effects between opioid and serotonin-related genes. Pain. vol 158. issue 7. 2018-03-29. PMID:28282362. |
chronic pain is associated with dysfunctional endogenous pain modulation, involving both central opioid and serotonergic (5-ht) signaling. |
2018-03-29 |
2023-08-13 |
human |
| Jeanette Tour, Monika Löfgren, Kaisa Mannerkorpi, Björn Gerdle, Anette Larsson, Annie Palstam, Indre Bileviciute-Ljungar, Jan Bjersing, Ingvar Martin, Malin Ernberg, Martin Schalling, Eva Kose. Gene-to-gene interactions regulate endogenous pain modulation in fibromyalgia patients and healthy controls-antagonistic effects between opioid and serotonin-related genes. Pain. vol 158. issue 7. 2018-03-29. PMID:28282362. |
in summary, our results suggest that, by genetic association, the mu-opioid receptor interacts with 2 major serotonergic structures involved in 5-ht reuptake and release, to modulate eih. |
2018-03-29 |
2023-08-13 |
human |
| S D Schmidt, C R G Furini, C G Zinn, L E Cavalcante, F F Ferreira, J A K Behling, J C Myskiw, I Izquierd. Modulation of the consolidation and reconsolidation of fear memory by three different serotonin receptors in hippocampus. Neurobiology of learning and memory. vol 142. issue Pt A. 2018-03-26. PMID:28034785. |
with focus on serotonin (5-ht), a well characterized neurotransmitter that has been strongly implicated in learning and memory, we investigated, in the ca1 region of the dorsal hippocampus, whether the latest discovered serotonergic receptors, 5-ht |
2018-03-26 |
2023-08-13 |
Not clear |
| Zhen Tian, Manabu Yamanaka, Matteo Bernabucci, Ming-Gao Zhao, Min Zhu. Characterization of serotonin-induced inhibition of excitatory synaptic transmission in the anterior cingulate cortex. Molecular brain. vol 10. issue 1. 2018-03-26. PMID:28606116. |
acc neurons receive innervation of projecting serotonergic nerve terminals from raphe nuclei, but the possible effect of 5-ht on excitatory transmission in the acc has not been investigated. |
2018-03-26 |
2023-08-13 |
mouse |
| D S Danilo. [Multimodal serotonergic antidepressants]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 117. issue 9. 2018-03-26. PMID:29053130. |
based on the original literature, the author for the first time describes a history of selective serotonergic antidepressants simultaneously inhibiting the serotonin reuptake and directly interacting with serotonin receptors. |
2018-03-26 |
2023-08-13 |
Not clear |
| D S Danilo. [Multimodal serotonergic antidepressants]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 117. issue 9. 2018-03-26. PMID:29053130. |
the data presented suggest the rationale for unifying all selective serotonergic antidepressants, simultaneously inhibiting the serotonin reuptake and directly interacting with serotonin receptors (trazodone, etoperidone, nefazodone, vilazodone, vortioxetine), in one group of 'multimodal serotonergic antidepressants'. |
2018-03-26 |
2023-08-13 |
Not clear |
| Paula Sm Yamashita, Ailton Spiacci, James E Hassel, Christopher A Lowry, Helio Zangross. Disinhibition of the rat prelimbic cortex promotes serotonergic activation of the dorsal raphe nucleus and panicolytic-like behavioral effects. Journal of psychopharmacology (Oxford, England). vol 31. issue 6. 2018-03-22. PMID:28071216. |
our findings suggest that the pl-dr pathway, through dr serotonergic stimulation, is involved in the control of panic-related behaviors by control of serotonin release in structures that modulate panic responses, such as the dorsal periaqueductal gray. |
2018-03-22 |
2023-08-13 |
rat |
| Gabriella A Horvath, Lorelyn Meisner, Kathryn Selby, Robert Stowe, Bruce Carleto. Improved strength on 5-hydroxytryptophan and carbidopa in spinal cord atrophy. Journal of the neurological sciences. vol 378. 2018-03-14. PMID:28566180. |
we describe two sisters with hemiplegic migraine, low csf and platelet serotonin levels, and progressive spastic paraparesis associated with profound spinal cord atrophy whose lower extremity strength and ambulation responded to a precursor replacement strategy (5-hydroxytryptophan and carbidopa administration), an approach that may have broader applicability in myelopathies of diverse etiology where descending serotonergic projections are compromised. |
2018-03-14 |
2023-08-13 |
Not clear |
| Sarah Delcourte, Erika Abrial, Adeline Etiévant, Renaud Rovera, Jørn Arnt, Michael Didriksen, Nasser Haddjer. Asenapine modulates mood-related behaviors and 5-HT CNS neuroscience & therapeutics. vol 23. issue 6. 2018-03-12. PMID:28417559. |
asenapine modulates mood-related behaviors and 5-ht asenapine is a new atypical antipsychotic prescribed for the treatment of psychosis/bipolar disorders that presents higher affinity for serotonergic than dopaminergic receptors. |
2018-03-12 |
2023-08-13 |
Not clear |
| Luana C A Silva, Milena B Viana, José S Andrade, Melyssa A Souza, Isabel C Céspedes, Vânia D'Almeid. Tryptophan overloading activates brain regions involved with cognition, mood and anxiety. Anais da Academia Brasileira de Ciencias. vol 89. issue 1. 2018-03-08. PMID:28225852. |
tryptophan is the only precursor of serotonin and mediates serotonergic activity in the brain. |
2018-03-08 |
2023-08-13 |
rat |
| Yongzhi Xia, Dan Chen, Haijian Xia, Zhengbu Liao, Wenyuan Tang, Yi Ya. Serotonergic projections to lumbar levels and its plasticity following spinal cord injury. Neuroscience letters. vol 649. 2018-03-08. PMID:28396282. |
this 5-ht innervation pattern in the lumbar cord provides anatomical evidence that serotonergic fibers establish direct connections with lumbar motoneurons, which offers us a solid foundation that enhancing the plasticity of serotonergic pathway following sci may facilitate locomotor functional recovery. |
2018-03-08 |
2023-08-13 |
mouse |
| Patricia Gassó, Natalia Rodríguez, Daniel Boloc, Ana Blázquez, Teresa Torres, Ana Gortat, Maria Teresa Plana, Amalia Lafuente, Sergi Mas, Joan Albert Arnaiz, Luisa Lázar. Association of regulatory TPH2 polymorphisms with higher reduction in depressive symptoms in children and adolescents treated with fluoxetine. Progress in neuro-psychopharmacology & biological psychiatry. vol 77. 2018-03-05. PMID:28456685. |
tph2 is one of the most important serotonergic candidate genes in selective serotonin reuptake inhibitors (ssris) pharmacogenetic studies. |
2018-03-05 |
2023-08-13 |
human |
| James W Grau, Yung-Jen Huang, Joel D Turtle, Misty M Strain, Rajesh C Miranda, Sandra M Garraway, Michelle A Hoo. When Pain Hurts: Nociceptive Stimulation Induces a State of Maladaptive Plasticity and Impairs Recovery after Spinal Cord Injury. Journal of neurotrauma. vol 34. issue 10. 2018-03-02. PMID:27788626. |
sci sets the stage for nociceptive sensitization by disrupting serotonergic (5ht) fibers that quell overexcitation. |
2018-03-02 |
2023-08-13 |
Not clear |
| Zhenbo Huang, Nicolas Thiebaud, Debra Ann Fadoo. Differential serotonergic modulation across the main and accessory olfactory bulbs. The Journal of physiology. vol 595. issue 11. 2018-02-26. PMID:28229459. |
current-clamp experiments demonstrate that serotonergic afferents are largely excitatory for mitral cells (mcs) in the mob where 5-ht |
2018-02-26 |
2023-08-13 |
Not clear |