| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Boris Mlinar, Alberto Montalbano, Jonas Waider, Klaus-Peter Lesch, Renato Corradett. Increased functional coupling of 5-HT European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 27. issue 12. 2018-07-09. PMID:29126768. |
increased functional coupling of 5-ht firing activity of serotonergic neurons is under regulatory control by somatodendritic 5-ht |
2018-07-09 |
2023-08-13 |
Not clear |
| Nerea Llamosas, Luisa Ugedo, Maria Torrecill. Inactivation of GIRK channels weakens the pre- and postsynaptic inhibitory activity in dorsal raphe neurons. Physiological reports. vol 5. issue 3. 2018-06-22. PMID:28196855. |
the serotonergic tone of the dorsal raphe (dr) is regulated by 5-ht |
2018-06-22 |
2023-08-13 |
Not clear |
| Alexandra Jean, Laetitia Laurent, Sabira Delaunay, Stéphane Doly, Nicole Dusticier, David Linden, Rachael Neve, Luc Maroteaux, André Nieoullon, Valérie Compa. Adaptive Control of Dorsal Raphe by 5-HT4 in the Prefrontal Cortex Prevents Persistent Hypophagia following Stress. Cell reports. vol 21. issue 4. 2018-06-13. PMID:29069597. |
this network consists of the ascending serotonergic inputs from the dorsal raphe nucleus (dr) to the medial prefrontal cortex (mpfc). specifically, adult restoration of serotonin 4 receptor (5-ht |
2018-06-13 |
2023-08-13 |
Not clear |
| b' Karolina Pytka, Katarzyna Soca\\xc5\\x82a, Anna Rapacz, Dorota Nieoczym, Mateusz Pier\\xc3\\xb3g, Anna Grybo\\xc5\\x9b, Agata Siwek, Anna Waszkielewicz, Piotr Wla\\xc5\\xb. HBK-14 and HBK-15, triple 5-HT Progress in neuro-psychopharmacology & biological psychiatry. vol 79. issue Pt B. 2018-06-12. PMID:28729118.' |
hbk-14 and hbk-15, triple 5-ht most antidepressants lower seizure threshold, which might be due to the modulation of serotonergic neurotransmission. |
2018-06-12 |
2023-08-13 |
Not clear |
| Clarissa M D Mota, Caroline Rodrigues-Santos, Rodrigo A R Fernández, Ruither O G Carolino, José Antunes-Rodrigues, Janete A Anselmo-Franci, Luiz G S Branc. Central serotonin attenuates LPS-induced systemic inflammation. Brain, behavior, and immunity. vol 66. 2018-06-06. PMID:28723348. |
dysfunction of the serotonergic system is mainly linked to psychiatric disorders, but emerging evidence suggests that immune system activation may also alter brain 5-ht signaling. |
2018-06-06 |
2023-08-13 |
rat |
| Yefei Sun, Xiaoyu Sun, Huiling Qu, Shanshan Zhao, Ting Xiao, Chuansheng Zha. Neuroplasticity and behavioral effects of fluoxetine after experimental stroke. Restorative neurology and neuroscience. vol 35. issue 5. 2018-06-04. PMID:28854520. |
fluoxetine is an antidepressant which enhances serotonergic neurotransmission through selective inhibition of neuronal reuptake of serotonin. |
2018-06-04 |
2023-08-13 |
rat |
| Wandilson Dos Santos Rodrigues Junior, Priscilla Oliveira-Silva, Adriana da Cunha Faria-Melibeu, Paula Campello-Costa, Claudio Alberto Serfat. Serotonin transporter immunoreactivity is modulated during development and after fluoxetine treatment in the rodent visual system. Neuroscience letters. vol 657. 2018-05-28. PMID:28756191. |
although the serotonergic system has received a lot of attention, little is known about the effects of these drugs over serotonin transporters. |
2018-05-28 |
2023-08-13 |
Not clear |
| Xiaoxue Gao, Jinting Liu, Pingyuan Gong, Junhui Wang, Wan Fang, Hongming Yan, Lusha Zhu, Xiaolin Zho. Identifying new susceptibility genes on dopaminergic and serotonergic pathways for the framing effect in decision-making. Social cognitive and affective neuroscience. vol 12. issue 9. 2018-05-24. PMID:28431168. |
this effect has been found to be modulated by the serotonin transporter gene (slc6a4) and the catechol-o-methyltransferase gene (comt) polymorphisms, which are on the dopaminergic and serotonergic pathways and which are associated with affective processing. |
2018-05-24 |
2023-08-13 |
human |
| Wendy K Adams, Chris Barkus, Jacqueline-Marie N Ferland, Trevor Sharp, Catharine A Winstanle. Pharmacological evidence that 5-HT Psychopharmacology. vol 234. issue 20. 2018-05-22. PMID:28733811. |
serotonergic drugs that target 5-ht |
2018-05-22 |
2023-08-13 |
human |
| Rubem Carlos Araújo Guedes, Maria das Graças Rodrigues de Araújo, Taciana Cristovam Verçosa, Francisca Martins Bion, Andrea Lima de Sá, Antônio Pereira, Ricardo Abadie-Guede. Evidence of an inverse correlation between serotonergic activity and spreading depression propagation in the rat cortex. Brain research. vol 1672. 2018-05-18. PMID:28751192. |
csd parameters (propagation velocity, and amplitude and duration of the dc-shift) was evaluated in rats that received two treatments that increased cortical serotonergic activity, electrical stimulation of the raphe nuclei and subcutaneous injection of a selective serotonin reuptake inhibitor, sumatriptan. |
2018-05-18 |
2023-08-13 |
rat |
| Paula Kopschina Feltes, Janine Doorduin, Hans C Klein, Luis Eduardo Juárez-Orozco, Rudi Ajo Dierckx, Cristina M Moriguchi-Jeckel, Erik Fj de Vrie. Anti-inflammatory treatment for major depressive disorder: implications for patients with an elevated immune profile and non-responders to standard antidepressant therapy. Journal of psychopharmacology (Oxford, England). vol 31. issue 9. 2018-05-17. PMID:28653857. |
stimuli like inflammation and infection can trigger the activation of microglia to release pro-inflammatory cytokines, acting on two main pathways: (1) activation of the hypothalamic-pituitary adrenal axis, generating an imbalance in the serotonergic and noradrenergic circuits; (2) increased activity of the enzyme indoleamine-2,3-dioxygenase, resulting in depletion of serotonin levels and the production of quinolinic acid. |
2018-05-17 |
2023-08-13 |
Not clear |
| Christopher L Petersen, Laura M Hurle. Putting it in Context: Linking Auditory Processing with Social Behavior Circuits in the Vertebrate Brain. Integrative and comparative biology. vol 57. issue 4. 2018-05-04. PMID:28985384. |
we propose a model in which the brain's social behavior network serves as an afferent effector of the serotonergic dorsal raphe nucleus in order to gate contextual release of serotonin in the ic. |
2018-05-04 |
2023-08-13 |
mouse |
| Yasmina Martí, Friederike Matthaeus, Thorsten Lau, Patrick Schlos. Methyl-4-phenylpyridinium (MPP+) differentially affects monoamine release and re-uptake in murine embryonic stem cell-derived dopaminergic and serotonergic neurons. Molecular and cellular neurosciences. vol 83. 2018-05-03. PMID:28673772. |
mpp+ is also a high affinity substrate for the serotonin transporter (sert), however little is known about possible toxic effects of mpp+ on serotonergic (5-ht) neurons. |
2018-05-03 |
2023-08-13 |
mouse |
| Ewelina Dziwota, Marcin Olajoss. VORTIOXETINE - THE NEW ANTIDEPRESSANT AGENT WITH PROCOGNITIVE PROPERTIES. Acta poloniae pharmaceutica. vol 73. issue 6. 2018-05-03. PMID:29634095. |
with its unique properties and strong affinity towards serotonin transporter (5-htt), vortioxetine is a modulator and stimulator of serotonergic transmission. |
2018-05-03 |
2023-08-13 |
mouse |
| Wai Kin D Ko, Qin Li, Long Yun Cheng, Micaela Morelli, Manolo Carta, Erwan Bezar. A preclinical study on the combined effects of repeated eltoprazine and preladenant treatment for alleviating L-DOPA-induced dyskinesia in Parkinson's disease. European journal of pharmacology. vol 813. 2018-05-02. PMID:28739086. |
eltoprazine, a serotonergic (5-ht) |
2018-05-02 |
2023-08-13 |
Not clear |
| Srikanta Chowdhury, Akihiro Yamanak. Optogenetic activation of serotonergic terminals facilitates GABAergic inhibitory input to orexin/hypocretin neurons. Scientific reports. vol 6. 2018-04-30. PMID:27824065. |
these neurons innervate wide areas of the brain and receive diverse synaptic inputs including those from serotonergic (5-ht) neurons in the raphe nucleus. |
2018-04-30 |
2023-08-13 |
mouse |
| Gwenn S Smith, Frederick S Barrett, Jin Hui Joo, Najlla Nassery, Alena Savonenko, Devin J Sodums, Christopher M Marano, Cynthia A Munro, Jason Brandt, Michael A Kraut, Yun Zhou, Dean F Wong, Clifford I Workma. Molecular imaging of serotonin degeneration in mild cognitive impairment. Neurobiology of disease. vol 105. 2018-04-18. PMID:28511918. |
the serotonin transporter is a selective marker of serotonin terminals and of the integrity of serotonin projections to cortical, subcortical and limbic regions and is found in high concentrations in the serotonergic cell bodies of origin of these projections (raphe nuclei). |
2018-04-18 |
2023-08-13 |
human |
| Roland Ricken, Sven Ulrich, Peter Schlattmann, Mazda Adl. Tranylcypromine in mind (Part II): Review of clinical pharmacology and meta-analysis of controlled studies in depression. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 27. issue 8. 2018-04-18. PMID:28579071. |
interaction with serotonergic drugs bears the risk of severe serotonin toxicity (sst) and combination with indirect sympathomimetic drugs may result in hypertensive crisis which both adds to the risks of tcp. |
2018-04-18 |
2023-08-13 |
Not clear |
| Alain D Dekker, Yannick Vermeiren, Christelle Albac, Eva Lana-Elola, Sheona Watson-Scales, Dorota Gibbins, Tony Aerts, Debby Van Dam, Elizabeth M C Fisher, Victor L J Tybulewicz, Marie-Claude Potier, Peter P De Dey. Aging rather than aneuploidy affects monoamine neurotransmitters in brain regions of Down syndrome mouse models. Neurobiology of disease. vol 105. 2018-04-18. PMID:28624415. |
here, we used rp-hplc with electrochemical detection to quantify (nor)adrenergic (na, adrenaline and mhpg), dopaminergic (da, hva and dopac), and serotonergic compounds (tryptophan, 5-ht and 5-hiaa) in ten regionally dissected brain regions of ts65dn mice, as well as in dp1tyb mice - a novel ds mouse model. |
2018-04-18 |
2023-08-13 |
mouse |
| Sofi da Cunha-Bang, Liv Vadskjaer Hjordt, Erik Perfalk, Vincent Beliveau, Camilla Bock, Szabolcs Lehel, Carsten Thomsen, Dorte Sestoft, Claus Svarer, Gitte Moos Knudse. Serotonin 1B Receptor Binding Is Associated With Trait Anger and Level of Psychopathy in Violent Offenders. Biological psychiatry. vol 82. issue 4. 2018-04-17. PMID:27108021. |
the involvement of serotonin in aggression has traditionally been attributed to impaired prefrontal serotonergic inhibitory control of emotional reactions to provocations in antisocial individuals. |
2018-04-17 |
2023-08-13 |
Not clear |