| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Markus Koesters, Giovanni Ostuzzi, Giuseppe Guaiana, Johanna Breilmann, Corrado Barbu. Vortioxetine for depression in adults. The Cochrane database of systematic reviews. vol 7. 2017-09-08. PMID:28677828. |
it is assumed that vortioxetine's antidepressant action is related to a direct modulation of serotonergic receptor activity and inhibition of the serotonin transporter. |
2017-09-08 |
2023-08-13 |
Not clear |
| Antonio Flores-Burgess, Carmelo Millón, Belén Gago, Manuel Narváez, Dasiel O Borroto-Escuela, Guadalupe Mengod, José Angel Narváez, Kjell Fuxe, Luis Santín, Zaida Díaz-Cabial. Galanin (1-15) enhancement of the behavioral effects of Fluoxetine in the forced swimming test gives a new therapeutic strategy against depression. Neuropharmacology. vol 118. 2017-09-05. PMID:28288814. |
the pharmacological treatment of major depression is mainly based on drugs elevating serotonergic (5-ht) activity. |
2017-09-05 |
2023-08-13 |
rat |
| Carl L Faingold, Marcus Randall, Chang Zeng, Shifang Peng, Xiaoyan Long, Hua-Jun Fen. Serotonergic agents act on 5-HT Epilepsy & behavior : E&B. vol 64. issue Pt A. 2017-09-04. PMID:27743549. |
serotonergic agents act on 5-ht drugs that enhance the action of serotonin (5-hydroxytrypamine, 5-ht), including several selective serotonin reuptake inhibitors (ssris), reduce susceptibility to seizure-induced respiratory arrest (s-ira) that leads to death in the dba/1 mouse model of sudden unexpected death in epilepsy (sudep). |
2017-09-04 |
2023-08-13 |
mouse |
| Barnali Chakraborti, Deepak Verma, Arijit Karmakar, Preeti Jaiswal, Aritrika Sanyal, Debarshi Paul, Swagata Sinha, Asem Surindro Singh, Subhrangshu Guhathakurta, Anirban Roychowdhury, Chinmoy Kumar Panda, Saurabh Ghosh, Kochupurackal P Mohanakumar, Kanchan Mukhophadhyay, Usha Rajamm. Genetic variants of MAOB affect serotonin level and specific behavioral attributes to increase autism spectrum disorder (ASD) susceptibility in males. Progress in neuro-psychopharmacology & biological psychiatry. vol 71. 2017-08-30. PMID:27381555. |
abnormal 5-ht synthesis and signalling, platelet hyperserotonemia and amelioration of repetitive behaviours by ssri are some of the key findings, which reinforced the hypothesis that serotonergic genes might act as asd susceptible genes. |
2017-08-30 |
2023-08-13 |
Not clear |
| Masaru Ishibashi, Iryna Gumenchuk, Kenichi Miyazaki, Takafumi Inoue, William N Ross, Christopher S Leonar. Hypocretin/Orexin Peptides Alter Spike Encoding by Serotonergic Dorsal Raphe Neurons through Two Distinct Mechanisms That Increase the Late Afterhyperpolarization. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 39. 2017-08-22. PMID:27683906. |
orexins (hypocretins) are neuropeptides that regulate multiple homeostatic processes, including reward and arousal, in part by exciting serotonergic dorsal raphe neurons, the major source of forebrain serotonin. |
2017-08-22 |
2023-08-13 |
mouse |
| Stefano Paolucc. Advances in antidepressants for treating post-stroke depression. Expert opinion on pharmacotherapy. vol 18. issue 10. 2017-08-22. PMID:28535081. |
serotonergic drugs are preferable because of their better safety profile, but in the recent years there has been an important debate on possible association between selective serotonin reuptake inhibitor use and increased mortality. |
2017-08-22 |
2023-08-13 |
Not clear |
| Hao-Qiang Zhang, Yong Zhang, Lin Liu, Jin-Lian Li, Ya-Cheng Lu, Ying-Ying Yu, Hui Li, Ting Zhang, Ying-Shing Chan, Fu-Xing Zhang, Yun-Qing L. Neural connection supporting endogenous 5-hydroxytryptamine influence on autonomic activity in medial prefrontal cortex. Autonomic neuroscience : basic & clinical. vol 203. 2017-08-21. PMID:27932203. |
the abundant and heterogeneous densities of 5-ht fibers across laminae in mpfc suggest serotonergic innervation of mpfc-dvc projection neurons whereby endogenous 5-ht acts to regulate autonomic activities. |
2017-08-21 |
2023-08-13 |
Not clear |
| Maria Moltesen, Danielle Caroline Laursen, Per-Ove Thörnqvist, Madelene Åberg Andersson, Svante Winberg, Erik Höglun. Effects of acute and chronic stress on telencephalic neurochemistry and gene expression in rainbow trout (Oncorhynchus mykiss). The Journal of experimental biology. vol 219. issue Pt 24. 2017-08-18. PMID:27802140. |
plasma cortisol, forebrain serotonergic (5-htergic) neurochemistry, and mrna levels of corticotropin-releasing factor (crf), crf-binding protein (crf-bp), crf receptors (crfr1 and crfr2), mineralocorticoid receptor (mr), glucocorticoid receptors (gr1 and gr2) and serotonin type 1a (5-ht |
2017-08-18 |
2023-08-13 |
Not clear |
| Jose Henrique Ledo, Estefania P Azevedo, Danielle Beckman, Felipe C Ribeiro, Luis E Santos, Daniela S Razolli, Grasielle C Kincheski, Helen M Melo, Maria Bellio, Antonio L Teixeira, Licio A Velloso, Debora Foguel, Fernanda G De Felice, Sergio T Ferreir. Cross Talk Between Brain Innate Immunity and Serotonin Signaling Underlies Depressive-Like Behavior Induced by Alzheimer's Amyloid-β Oligomers in Mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 48. 2017-08-18. PMID:27903721. |
results establish that aβos trigger depressive-like behavior via a double impact on brain serotonin levels and microglial activation, unveiling a cross talk between brain innate immunity and serotonergic signaling as a key player in mood alterations in ad. |
2017-08-18 |
2023-08-13 |
mouse |
| N N Kudryavtseva, D A Smagin, I L Kovalenko, A G Galyamina, G B Vishnivetskaya, V N Babenko, Yu L Orlo. [Serotonergic genes in the development of anxiety/depression-like state and pathology of aggressive behavior in male mice: RNA-seq data]. Molekuliarnaia biologiia. vol 51. issue 2. 2017-08-14. PMID:28537235. |
using the data of whole transcriptome analysis (rna-seq), the changes in the expression of serotonergic genes involved in the synthesis, inactivation, and reception of serotonin, as well as of the creb1 (transcription factor) gene and the bdnf (brain-derived neurotrophic factor) gene were detected in the striatum (str), ventral tegmental area (vta), midbrain raphe nuclei (mrn), hypothalamus (hyp), and hippocampus (hip) of defeated and aggressive male mice. |
2017-08-14 |
2023-08-13 |
mouse |
| Luc Maroteaux, Estelle Ayme-Dietrich, Gaëlle Aubertin-Kirch, Sophie Banas, Emily Quentin, Roland Lawson, Laurent Monassie. New therapeutic opportunities for 5-HT Pharmacology & therapeutics. vol 170. 2017-08-09. PMID:27771435. |
new therapeutic opportunities for 5-ht serotonergic dysfunction is mainly associated with neuropsychiatric and cardiovascular disorders but has also been linked with many other pathological conditions. |
2017-08-09 |
2023-08-13 |
Not clear |
| Weipang Chang, Hirosato Kanda, Ryo Ikeda, Jennifer Ling, Jianguo G G. Serotonergic transmission at Merkel discs: modulation by exogenously applied chemical messengers and involvement of I Journal of neurochemistry. vol 141. issue 4. 2017-08-07. PMID:28267198. |
our recent study has shown that merkel discs in whisker hair follicles are serotonergic synapses using endogenous serotonin to transmit tactile signals from merkel cells to aβ-afferent endings. |
2017-08-07 |
2023-08-13 |
mouse |
| Kwang Woo Ko, Matthew N Rasband, Victor Meseguer, Richard H Kramer, Nace L Goldin. Serotonin modulates spike probability in the axon initial segment through HCN channels. Nature neuroscience. vol 19. issue 6. 2017-08-02. PMID:27110919. |
furthermore, the control of spike threshold by hcn channels in the ais can be altered through serotonergic modulation of 5-hydroxytryptamine 1a (5-ht1a) receptors, which hyperpolarizes the activation range of hcn channels. |
2017-08-02 |
2023-08-13 |
Not clear |
| Urs Kalbitzer, Christian Roos, Gisela H Kopp, Thomas M Butynski, Sascha Knauf, Dietmar Zinner, Julia Fische. Insights into the genetic foundation of aggression in Papio and the evolution of two length-polymorphisms in the promoter regions of serotonin-related genes (5-HTTLPR and MAOALPR) in Papionini. BMC evolutionary biology. vol 16. issue 1. 2017-08-01. PMID:27287312. |
), variation in aggressiveness among individuals is associated with polymorphisms in the serotonergic (5-ht) neurotransmitter system. |
2017-08-01 |
2023-08-13 |
monkey |
| Makoto Takahashi, Masahiko Nomura, Junichi Tanak. GABAergic modulation of serotonin release in the rat subfornical organ area. Neuroscience letters. vol 630. 2017-07-26. PMID:27453060. |
these results show the involvement of both gabaa and gabab receptors in the modulation of the 5-ht release in the sfo area, and imply that the gabaa receptor mechanism may be importance for the serotonergic regulatory system of body fluid balance. |
2017-07-26 |
2023-08-13 |
rat |
| Li Xu, Jianzheng He, Andrea Kaiser, Nikolas Gräber, Laura Schläger, Yvonne Ritze, Henrike Schol. A Single Pair of Serotonergic Neurons Counteracts Serotonergic Inhibition of Ethanol Attraction in Drosophila. PloS one. vol 11. issue 12. 2017-07-26. PMID:27936023. |
we generated a mutated version of the serotonin transporter that prolongs serotonin signaling in the synaptic cleft and is targeted via the gal4 system to different sets of serotonergic neurons. |
2017-07-26 |
2023-08-13 |
drosophila_melanogaster |
| Li Xu, Jianzheng He, Andrea Kaiser, Nikolas Gräber, Laura Schläger, Yvonne Ritze, Henrike Schol. A Single Pair of Serotonergic Neurons Counteracts Serotonergic Inhibition of Ethanol Attraction in Drosophila. PloS one. vol 11. issue 12. 2017-07-26. PMID:27936023. |
given the evolutionarily conserved nature of the serotonin transporter and serotonin, the bidirectional serotonergic mechanisms delineate a basic principle for how random behavior is switched into targeted approach behavior. |
2017-07-26 |
2023-08-13 |
drosophila_melanogaster |
| Alexander Wirth, Katrin Holst, Evgeni Ponimaski. How serotonin receptors regulate morphogenic signalling in neurons. Progress in neurobiology. vol 151. 2017-07-11. PMID:27013076. |
serotonin (5-hydroxytrympamine or 5-ht) is one of the phylogenetically oldest neurotransmitters, and the serotonergic system is among the earliest developed neuronal systems. |
2017-07-11 |
2023-08-13 |
Not clear |
| Carlos Pantoja, Adam Hoagland, Elizabeth C Carroll, Vasiliki Karalis, Alden Conner, Ehud Y Isacof. Neuromodulatory Regulation of Behavioral Individuality in Zebrafish. Neuron. vol 91. issue 3. 2017-07-03. PMID:27397519. |
drn neuron activity decreases during habituation in proportion to habituation and a genetic manipulation that reduces serotonin content in drn neurons increases habituation, whereas serotonergic agonism or drn activation with chr2 reduces habituation. |
2017-07-03 |
2023-08-13 |
zebrafish |
| Mariarosaria Ferraro, Matteo Masetti, Maurizio Recanatini, Andrea Cavalli, Giovanni Bottegon. Mapping Cholesterol Interaction Sites on Serotonin Transporter through Coarse-Grained Molecular Dynamics. PloS one. vol 11. issue 12. 2017-07-03. PMID:27907003. |
serotonin transporter (sert) modulates serotonergic signaling via re-uptake of serotonin in pre-synaptic cells. |
2017-07-03 |
2023-08-13 |
Not clear |