| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D L Sparks, N S Buckholt. Combined inhibition of serotonin uptake and oxidative deamination attenuates audiogenic seizures in DBA/2J mice. Pharmacology, biochemistry, and behavior. vol 23. issue 5. 1986-02-13. PMID:4080761. |
in this study, the sensitivity of ags to 5-ht manipulation was evaluated by utilizing drug combinations which paralleled the actions of 6-meo-thbc and which also have been associated with the production of a serotonergic motor syndrome in rats. |
1986-02-13 |
2023-08-11 |
mouse |
| J M Olces. Enhancement of melatonin's antigonadal action by daily injections of the serotonin uptake inhibitor fluoxetine in male hamsters. Journal of neural transmission. vol 64. issue 2. 1986-02-07. PMID:3878389. |
as the serotonergic system of the brain has been shown to undergo daily variations, and to influence gonadotrophic activity, it was decided to investigate the relationship between melatonin effects and brain serotonergic function by employing the selective inhibitor of serotonin uptake fluoxetine (lilly 110140). |
1986-02-07 |
2023-08-11 |
Not clear |
| H A Ei-Fawal, P O Ogunbiyi, V Gordon, P Eyr. Reactivity of the bronchial artery to 5-hydroxytryptamine. Research communications in chemical pathology and pharmacology. vol 50. issue 3. 1986-02-05. PMID:2934778. |
the activity of 5-hydroxytryptamine and its antagonism by the selective 5-ht2 serotonergic receptor antagonist, ketanserin, was tested on the bronchial arteries of three domestic species; bovine, equine and ovine. |
1986-02-05 |
2023-08-11 |
cattle |
| A B Norman, G Battaglia, I Crees. [3H]WB4101 labels the 5-HT1A serotonin receptor subtype in rat brain. Guanine nucleotide and divalent cation sensitivity. Molecular pharmacology. vol 28. issue 6. 1986-01-29. PMID:2867462. |
furthermore, we have found a significant correlation (r = 0.96) between the affinities of a number of serotonergic and nonserotonergic compounds at [3h]wb4101-binding sites in the presence of 30 nm prazosin and [3h] lysergic acid diethylamide ([3h]lsd)-labeled 5-ht1 serotonin receptors in homogenates of rat cerebral cortex. |
1986-01-29 |
2023-08-11 |
rat |
| M T Pugh, K M O'Boyle, A G Molloy, J L Waddingto. Effects of the putative D-1 antagonist SCH 23390 on stereotyped behaviour induced by the D-2 agonist RU24213. Psychopharmacology. vol 87. issue 3. 1986-01-28. PMID:2934758. |
because sch 23390 has some affinity for 5-hydroxytryptamine receptors, any effect on the serotonergic behavioural syndrome induced by 10 mg/kg 5-methoxy-n,n-dimethyltryptamine was also studied. |
1986-01-28 |
2023-08-11 |
Not clear |
| M T Pugh, K M O'Boyle, A G Molloy, J L Waddingto. Effects of the putative D-1 antagonist SCH 23390 on stereotyped behaviour induced by the D-2 agonist RU24213. Psychopharmacology. vol 87. issue 3. 1986-01-28. PMID:2934758. |
the serotonergic responses of hind limb abduction, reciprocal forepaw treading and straub tail were unaltered after 40-200 micrograms/kg sch 23390, indicating no significant 5-ht blockade or non-specific depressant action at these doses which might influence the expression of stereotypy. |
1986-01-28 |
2023-08-11 |
Not clear |
| S O Ogren, O G Berge, C Johansso. Involvement of spinal serotonergic pathways in nociception but not in avoidance learning. Psychopharmacology. vol 87. issue 3. 1986-01-28. PMID:3001802. |
the effects of selective lesions of the descending serotonergic (5-ht) pathways on analgesia and avoidance deficit induced by the 5-ht releasing compound p-chloroamphetamine (pca, 2.5 mg/kg) were investigated in male rats. |
1986-01-28 |
2023-08-11 |
rat |
| S Ueda, N Ihara, Y San. The organization of serotonin fibers in the mammalian superior colliculus. An immunohistochemical study. Anatomy and embryology. vol 173. issue 1. 1986-01-23. PMID:2416244. |
to explore the degree of serotonergic innervation in each layer, a semi-quantitative assay of serotonin immunoreactive varicosities was conducted in the rat, chipmunk, cat, and monkey. |
1986-01-23 |
2023-08-11 |
rat |
| C Robaut, M P Fillion, S Dufois, C Fayolle-Bauguen, J C Rousselle, G Gillet, S Benkirane, G Fillio. Multiple high affinity binding sites for 5-hydroxytryptamine: a new class of sites distinct from 5-HT1 and S2. Brain research. vol 346. issue 2. 1985-12-20. PMID:4052778. |
two different classes of binding sites probably related to serotonergic receptors have already been reported: 5-ht1 binding sites recognize [3h]5-hydroxytryptamine with a high affinity (kd = 3 nm) and s2 binding sites recognize [3h]spiroperidol and [3h]ketanserine. |
1985-12-20 |
2023-08-11 |
rat |
| L Branchey, M Branchey, T M Worner, D Zucker, S Shaw, C S Liebe. Association between amino acid alterations and hallucinations in alcoholic patients. Biological psychiatry. vol 20. issue 11. 1985-12-18. PMID:2996640. |
because available evidence suggests that alterations in the serotonergic as well as dopaminergic tones underlie hallucinatory activity, we decided to investigate whether serotonin and dopamine pathways are modified in alcoholics with a history of hallucinosis. |
1985-12-18 |
2023-08-11 |
Not clear |
| A L Morrow, A B Norman, G Battaglia, R Loy, I Crees. Up-regulation of serotonergic binding sites labeled by [3H]WB4101 following fimbrial transection and 5,7-dihydroxytryptamine-induced lesions. Life sciences. vol 37. issue 20. 1985-12-18. PMID:4058260. |
the nanomolar site is serotonergic as the serotonergic agonists, serotonin and 8-hydroxydipropylaminotetraline (8-oh-dpat) have nanomolar affinity for [3h]wb4101 binding when studied in the presence of a prazosin mask (30 nm) of the alpha-1 component of [3h]wb4101 binding. |
1985-12-18 |
2023-08-11 |
Not clear |
| F S Kraly, K J Simansky, L A Coogan, M S Trattne. Histamine and serotonin independently elicit drinking in the rat. Physiology & behavior. vol 34. issue 6. 1985-12-18. PMID:4059386. |
serotonergic antagonism using ip 3 mg/kg m abolished drinking elicited by sc 0.63 mg/kg 5-ht, but it failed to inhibit drinking elicited by the ed50 or by the ed100 for sc histamine in the same rats. |
1985-12-18 |
2023-08-11 |
rat |
| G Gillet, S Ammor, G Fillio. Serotonin inhibits acetylcholine release from rat striatum slices: evidence for a presynaptic receptor-mediated effect. Journal of neurochemistry. vol 45. issue 6. 1985-12-16. PMID:4056789. |
this effect of 5-ht was mimicked by several agonists (5-methoxytryptamine, n,n-dimethyl-tryptamine, bufotenin) and blocked by serotonergic antagonists (methiothepin, methysergide, cinanserin) but not by haloperidol; methiothepin and methysergide alone slightly increased the k+-evoked overflow of tritium (3h). |
1985-12-16 |
2023-08-11 |
rat |
| R J Waldbillig, G E Weider, R M Clemmons, T J Bartnes. Rostral hypothalamic microinfusions of 5,7 dihydroxytryptamine produce anatomically and neurochemically selective depletions of hippocampal serotonin and increase the influence of estrogen and food deprivation on locomotor activity. Brain research. vol 347. issue 1. 1985-12-13. PMID:4052795. |
because estrogen is thought to decrease serotonergic transmission, the enhanced activity response to estrogen may be secondary to an estrogen-related exaggeration of the 5,7-dht-induced serotonin depletion. |
1985-12-13 |
2023-08-11 |
rat |
| E A Mueller, D L Murphy, T Sunderlan. Neuroendocrine effects of M-chlorophenylpiperazine, a serotonin agonist, in humans. The Journal of clinical endocrinology and metabolism. vol 61. issue 6. 1985-12-13. PMID:4055985. |
m-chlorophenylpiperazine (m-cpp) produces effects on the central serotonergic system in animals compatible with direct agonist activity on postsynaptic serotonin receptors. |
1985-12-13 |
2023-08-11 |
human |
| E A Mueller, D L Murphy, T Sunderlan. Neuroendocrine effects of M-chlorophenylpiperazine, a serotonin agonist, in humans. The Journal of clinical endocrinology and metabolism. vol 61. issue 6. 1985-12-13. PMID:4055985. |
these results are similar to those for other serotonin agonists and, thus, suggest that m-cpp merits further study as a pharmacological probe of serotonergic responsivity in humans. |
1985-12-13 |
2023-08-11 |
human |
| G F Oxenkrug, I M McIntyr. Stress-induced synthesis of melatonin: possible involvement of the endogenous monoamine oxidase inhibitor (tribulin). Life sciences. vol 37. issue 18. 1985-12-02. PMID:2414629. |
serotonergic turnover (ratio of 5-hydroxyindole acetic acid to serotonin) was significantly decreased in stressed but not in stressed rats pretreated with lorazepam, suggesting stress-induced inhibition of monoamine oxidase (mao). |
1985-12-02 |
2023-08-11 |
rat |
| M Schächter, P P Godfrey, M C Minchin, S J McClue, M M Youn. Serotonergic agonists stimulate inositol lipid metabolism in rabbit platelets. Life sciences. vol 37. issue 17. 1985-11-27. PMID:2997568. |
these results show that relatively small changes in phosphoinositide metabolism induced by serotonergic agonists can be investigated in the rabbit platelet, and this cell may therefore be a useful model for the study of some 5-ht receptors. |
1985-11-27 |
2023-08-11 |
rabbit |
| O Lingjaerd. Lactate-induced panic attacks: possible involvement of serotonin reuptake stimulation. Acta psychiatrica Scandinavica. vol 72. issue 2. 1985-11-20. PMID:4050513. |
the author draws attention to the fact that lactate as well as pyruvate stimulate serotonin uptake in human blood platelets, and suggests that lactate infusion may stimulate serotonin reuptake also in central serotonergic neurons, thereby decreasing serotonergic activity. |
1985-11-20 |
2023-08-11 |
human |
| C J Schmidt, W Lovenber. In vitro demonstration of dopamine uptake by neostriatal serotonergic neurons of the rat. Neuroscience letters. vol 59. issue 1. 1985-11-14. PMID:2413404. |
this serotonin (5-ht) release is inhibited by the same selective uptake blockers previously shown to protect serotonergic neurons from the neurotoxic effects of methamphetamine in vivo. |
1985-11-14 |
2023-08-11 |
rat |