| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D S Houston, P M Vanhoutt. Serotonin and the vascular system. Role in health and disease, and implications for therapy. Drugs. vol 31. issue 2. 1986-04-22. PMID:3512233. |
the antihypertensive efficacy of one serotonergic antagonist, ketanserin, raises questions about the possible involvement of serotonin in either the initiation or the maintenance of the elevated peripheral vascular resistance in several forms of hypertension, including essential hypertension. |
1986-04-22 |
2023-08-11 |
Not clear |
| S Romandini, E M Pich, E Esposito, A Z Kruszewska, R Samani. The effect of intracerebroventricular 5,7-dihydroxytryptamine on morphine analgesia is time-dependent. Life sciences. vol 38. issue 10. 1986-04-15. PMID:3951313. |
ten days after 5,7-dht, the inhibiting effect of metergoline, a serotonin antagonist, on morphine analgesia was still present, suggesting that functional recovery of the serotonergic system may partly explain the different results. |
1986-04-15 |
2023-08-11 |
rat |
| D L Commins, L S Seide. alpha-Methyltyrosine blocks methylamphetamine-induced degeneration in the rat somatosensory cortex. Brain research. vol 365. issue 1. 1986-04-11. PMID:3947981. |
since the ma-induced depletion of 5-ht and the ma-induced degeneration of cortical perikarya are correlated, we suggest that the serotonergic system may be involved in the toxic effects of ma on the cortical neurons. |
1986-04-11 |
2023-08-11 |
rat |
| K A Stauderman, D J Jone. Presynaptic serotonin receptors regulate [3H]serotonin release from rat spinal cord synaptosomes. European journal of pharmacology. vol 120. issue 1. 1986-04-10. PMID:3948909. |
superfused rat spinal cord synaptosomes were studied to determine if inhibitory serotonin (5-ht) receptors (autoreceptors) exist on spinal serotonergic nerve terminals. |
1986-04-10 |
2023-08-11 |
rat |
| S O Ogre. Evidence for a role of brain serotonergic neurotransmission in avoidance learning. Acta physiologica Scandinavica. Supplementum. vol 544. 1986-04-03. PMID:3006431. |
this thesis has analyzed the role of brain serotonergic (5-ht) neurotransmission in avoidance learning in the male rat using neurochemical, pharmacological and behavioural approaches. |
1986-04-03 |
2023-08-11 |
rat |
| P F Gately, D S Segal, M A Geye. The behavioral effects of depletions of brain serotonin induced by 5,7-dihydroxytryptamine vary with time after administration. Behavioral and neural biology. vol 45. issue 1. 1986-04-02. PMID:3954713. |
these results show that central serotonergic pathways play an important role in modulating both spontaneous and amphetamine-elicited activity in rats, and that compensatory mechanisms operate over time to alter the behavioral effects of 57dht-induced depletions of brain 5ht. |
1986-04-02 |
2023-08-11 |
rat |
| J P Yevich, J S New, D W Smith, W G Lobeck, J D Catt, J L Minielli, M S Eison, D P Taylor, L A Riblet, D L Templ. Synthesis and biological evaluation of 1-(1,2-benzisothiazol-3-yl)- and (1,2-benzisoxazol-3-yl)piperazine derivatives as potential antipsychotic agents. Journal of medicinal chemistry. vol 29. issue 3. 1986-03-31. PMID:2869146. |
although 24 has potent affinity for dopaminergic binding sites, its even greater affinity for serotonin receptors suggests that a serotonergic component may be relevant to its atypical profile. |
1986-03-31 |
2023-08-11 |
rat |
| P M Beart, D McDonald, M Cincotta, D J de Vries, A L Gundlac. Selectivity of some ergot derivatives for 5-HT1 and 5-HT2 receptors of rat cerebral cortex. General pharmacology. vol 17. issue 1. 1986-03-31. PMID:3949149. |
overall, the ergot derivatives displayed markedly different affinities and selectivities for central 5-ht receptors suggesting that their serotonergic actions should be considered when evaluating their pharmacological spectrum of activity. |
1986-03-31 |
2023-08-11 |
rat |
| R A Cohe. Adenine nucleotides and 5-hydroxytryptamine released by aggregating platelets inhibit adrenergic neurotransmission in canine coronary artery. The Journal of clinical investigation. vol 77. issue 2. 1986-03-26. PMID:3003158. |
the combination of the serotonergic antagonist, methiothepin, and the purinergic antagonist, theophylline, attenuated the inhibition of the responses of coronary rings; either antagonist alone failed to do so, but did significantly block the reductions caused by 5-hydroxytryptamine and adenosine diphosphate, respectively. |
1986-03-26 |
2023-08-11 |
Not clear |
| N N Osborne, D W Beato. Studies on serotonin-accumulating cells in rabbit retinal cultures. Brain research. vol 362. issue 2. 1986-03-11. PMID:3942878. |
the uptake process of serotonin is very specific; known serotonergic blockers, such as chlorimipramine, abolished transport, while benztropine, a dopamine uptake blocker, was ineffectual. |
1986-03-11 |
2023-08-11 |
rabbit |
| R W Fulle. Biochemical pharmacology of the serotonin system. Advances in neurology. vol 43. 1986-03-07. PMID:2936068. |
although relatively few drugs that specifically influence serotonin neurons have been used in humans, a wide variety of drugs has been used to modify serotonergic function in experimental animals. |
1986-03-07 |
2023-08-11 |
Not clear |
| R W Fulle. Biochemical pharmacology of the serotonin system. Advances in neurology. vol 43. 1986-03-07. PMID:2936068. |
in addition, several kinds of drugs decrease serotonergic function, including serotonin depletors and agents that destroy serotonin neurons, as well as direct serotonin-receptor antagonists. |
1986-03-07 |
2023-08-11 |
Not clear |
| L I Wolfson, L J Thal, L L Brow. Serotonin models of myoclonus in the guinea pig and rat. Advances in neurology. vol 43. 1986-03-07. PMID:3484858. |
following amine depletion or destruction of the serotonin neurons with 5,7-dht, myoclonus appeared as part of a complex serotonergic behavioral syndrome induced by serotonin agonists. |
1986-03-07 |
2023-08-11 |
rat |
| L I Wolfson, L J Thal, L L Brow. Serotonin models of myoclonus in the guinea pig and rat. Advances in neurology. vol 43. 1986-03-07. PMID:3484858. |
since serotonin is an inhibitory transmitter, we hypothesize that the decreases observed in cortex may be the result of direct serotonergic inhibition, whereas the increases observed in the thalamus probably represent indirect effects via polysynaptic pathways. |
1986-03-07 |
2023-08-11 |
rat |
| E Habert, D Graham, L Tahraoui, Y Claustre, S Z Lange. Characterization of [3H]paroxetine binding to rat cortical membranes. European journal of pharmacology. vol 118. issue 1-2. 1986-03-05. PMID:2935409. |
paroxetine is a selective and potent inhibitor of 5-hydroxytryptamine uptake into serotonergic neurons. |
1986-03-05 |
2023-08-11 |
rat |
| G F Martin, G DeLorenzo, R H Ho, A O Humbertson, R Waltze. Serotonergic innervation of the forebrain in the North American opossum. Brain, behavior and evolution. vol 26. issue 3-4. 1986-03-05. PMID:3910165. |
the retrograde transport of true blue combined with immunofluorescence for localization of serotonin revealed that serotonergic axons within the forebrain arise mainly within the dorsal raphe and superior central nuclei, but that some originate within the midbrain and pontine reticular formation and the locus coeruleus, pars alpha. |
1986-03-05 |
2023-08-11 |
Not clear |
| R Cash, R Raisman, A Ploska, Y Agi. High and low affinity [3H]imipramine binding sites in control and parkinsonian brains. European journal of pharmacology. vol 117. issue 1. 1986-02-28. PMID:3002804. |
saturation and inhibition curves showed both high affinity [3h]imipramine binding related to the serotonin uptake mechanism and low affinity binding which was sodium-independent and unrelated to serotonergic uptake. |
1986-02-28 |
2023-08-11 |
human |
| L Jansson, P E Leung, R C McEvo. Ablation of serotonergic nerves in the rat pancreas. Lack of effects on hormone secretion and intrinsic blood flow. Acta endocrinologica. vol 110. issue 4. 1986-02-26. PMID:2868599. |
since also high-affinity uptake of [3h]5-ht was absent it was concluded that intrapancreatic serotonergic nerves were destroyed. |
1986-02-26 |
2023-08-11 |
rat |
| B S Neal, S B Sparbe. Mianserin attenuates naloxone-precipitated withdrawal signs in rats acutely or chronically dependent upon morphine. The Journal of pharmacology and experimental therapeutics. vol 236. issue 1. 1986-02-20. PMID:3001281. |
thus, several signs of withdrawal (e.g., behavioral effects, weight loss and hypothermia) seem to involve serotonergic mediation and can be blocked by mianserin, while others (e.g., rise in plasma corticosterone), which may be unaffected by mianserin, may be a reflection of a compensatory response to withdrawal stress, rather than a mediator of maladaptive consequences of withdrawal that are not mediated by serotonin. |
1986-02-20 |
2023-08-11 |
rat |
| P D Hrdina, B A Pappas, D C Roberts, R J Bialik, C L Rya. Relationship between levels and uptake of serotonin and high affinity [3H]imipramine recognition sites in the rat brain. Canadian journal of physiology and pharmacology. vol 63. issue 10. 1986-02-17. PMID:3000552. |
high affinity [3h]imipramine binding, endogenous levels of serotonin and noradrenaline, and serotonin uptake were determined in brain regions of rats with selective destruction of serotonergic neurons by 5,7-dihydroxytryptamine (5,7-dht), of adrenergic neurons by 6-hydroxydopamine (6-ohda), and of rats treated with reserpine. |
1986-02-17 |
2023-08-11 |
rat |