| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Shiraga, M Hiramatsu, A Mor. Convulsive activity of alpha-guanidinoglutaric acid and the possible involvement of 5-hydroxytryptamine in the alpha-guanidinoglutaric acid-induced seizure mechanism. Journal of neurochemistry. vol 47. issue 6. 1986-12-17. PMID:3772379. |
the results also suggest that alpha-gga-induced seizures are associated with abnormal serotonergic function and that they are initiated by a decrease in the 5-ht level. |
1986-12-17 |
2023-08-11 |
rat |
| L Antkiewicz-Michalu. The influence of chronic treatment with antidepressant neuroleptics on the central serotonin system. Polish journal of pharmacology and pharmacy. vol 38. issue 4. 1986-12-10. PMID:3774629. |
chronic administration of antidepressant neuroleptics chlorprothixene (cpx) and levomepromazine (lmz) increases the sensitivity of one kind of serotonergic receptors in cns-5-ht2 receptors (which are involved in such behavioral responses as head-twitches and hyperthermia in heat adapted rats), but do not change 5-ht1 receptor population (responsible for the rate of serotonin synthesis). |
1986-12-10 |
2023-08-11 |
rat |
| H Agren, I N Mefford, M V Rudorfer, M Linnoila, W Z Potte. Interacting neurotransmitter systems. A non-experimental approach to the 5HIAA-HVA correlation in human CSF. Journal of psychiatric research. vol 20. issue 3. 1986-12-04. PMID:2430098. |
the concept of a serotonergic regulation of dopamine turnover was tested on brain punch analyses of serotonin and dopamine and their metabolites in two sets of dogs in a large number of brain areas. |
1986-12-04 |
2023-08-11 |
human |
| Y T Xuan, Y S Shi, Z F Zhou, J S Ha. Studies on the mesolimbic loop of antinociception--II. A serotonin-enkephalin interaction in the nucleus accumbens. Neuroscience. vol 19. issue 2. 1986-12-04. PMID:3022186. |
in a previous report we have shown that the antinociceptive effect elicited by microinjection of morphine into the periaqueductal gray is due, at least in part, to the activation of an ascending serotonergic pathway which releases 5-hydroxytryptamine in the nucleus accumbens. |
1986-12-04 |
2023-08-11 |
Not clear |
| Y T Xuan, Y S Shi, Z F Zhou, J S Ha. Studies on the mesolimbic loop of antinociception--II. A serotonin-enkephalin interaction in the nucleus accumbens. Neuroscience. vol 19. issue 2. 1986-12-04. PMID:3022186. |
it is concluded that morphine administered to the periaqueductal gray is capable of activating an ascending serotonergic pathway to release 5-hydroxytryptamine in the nucleus accumbens, which in turn activates an enkephalinergic mechanism within the same nucleus, resulting in an antinociceptive effect. |
1986-12-04 |
2023-08-11 |
Not clear |
| D Gadotti, L G Bauce, K Lukowiak, A G Bulloc. Transient depletion of serotonin in the nervous system of Helisoma. Journal of neurobiology. vol 17. issue 5. 1986-11-24. PMID:3021901. |
serotonergic depletion is not accompanied by development of receptor supersensitivity nor by the production of serotonin in extraneuronal sources. |
1986-11-24 |
2023-08-11 |
Not clear |
| I Fagervall, S B Ros. Failure to detect any transport of the irreversible monoamine oxidase inhibitor N-cyclopropyl-4-chloroamphetamine by the carrier of 5-hydroxytryptamine in the brain of the rat in vivo. Neuropharmacology. vol 25. issue 8. 1986-11-24. PMID:3490629. |
by using a small (0.1 microm) substrate concentration of [14c]5-ht and a synaptosomal preparation incubated in the absence and presence of a selective inhibitor of the uptake of 5-ht (citalopram) it is possible to measure the activity of mao in serotonergic nerve terminals. |
1986-11-24 |
2023-08-11 |
rat |
| D M Stone, D C Stahl, G R Hanson, J W Gib. The effects of 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) on monoaminergic systems in the rat brain. European journal of pharmacology. vol 128. issue 1-2. 1986-11-17. PMID:2875893. |
like meth, single or multiple 10 mg/kg doses of either drug caused marked reductions in both tryptophan hydroxylase (tph) activity and concentrations of 5-hydroxytryptamine (5-ht) and 5-hydroxyindoleacetic acid, in several serotonergic nerve terminal regions. |
1986-11-17 |
2023-08-11 |
rat |
| A Schoups, L Dillen, M Claeys, A Duchateau, T J Verbeuren, W P De Potte. Characterization of serotonin receptors and lack of effect of antidepressant therapy on monoamine functions in various regions of the rabbit brain. European journal of pharmacology. vol 126. issue 3. 1986-11-12. PMID:3758172. |
no significant correlation could be shown between the distribution of either of the receptors and the distribution of serotonergic nerve terminals (as measured by the 5-ht content and the [3h]5-ht accumulation). |
1986-11-12 |
2023-08-11 |
rat |
| A Schoups, L Dillen, M Claeys, A Duchateau, T J Verbeuren, W P De Potte. Characterization of serotonin receptors and lack of effect of antidepressant therapy on monoamine functions in various regions of the rabbit brain. European journal of pharmacology. vol 126. issue 3. 1986-11-12. PMID:3758172. |
the compounds only weakly inhibited the binding of [3h]5-ht and [3h]ketanserin as compared to the inhibition caused by serotonergic agonists and antagonists. |
1986-11-12 |
2023-08-11 |
rat |
| Chiang Chen-Yu, Gao B. The modification by systemic morphine of the responses of serotonergic and non-serotonergic neurons in nucleus raphe magnus to heating the tail. Pain. vol 26. issue 2. 1986-11-10. PMID:3020487. |
in anaesthetised rats, 63 raphe-spinal units in nucleus raphe magnus (nrm) have been identified by means of electrophysiological methods and further classified into serotonergic (5-ht) and non-5-ht units according to their conduction velocity and spontaneous discharge rate. |
1986-11-10 |
2023-08-11 |
rat |
| A C Rovescalli, N Brunello, C Franzetti, G Racagn. Interaction of putative endogenous tryptolines with the hypothalamic serotonergic system and prolactin secretion in adult male rats. Neuroendocrinology. vol 43. issue 5. 1986-10-23. PMID:2427964. |
although the three compounds increased the plasma titers of prl in a dose-dependent manner and enhanced the hypothalamic content of serotonin (5ht), they appear to affect the serotonergic system through different mechanisms. |
1986-10-23 |
2023-08-11 |
rat |
| A C Rovescalli, N Brunello, C Franzetti, G Racagn. Interaction of putative endogenous tryptolines with the hypothalamic serotonergic system and prolactin secretion in adult male rats. Neuroendocrinology. vol 43. issue 5. 1986-10-23. PMID:2427964. |
in particular, 5-oht might act at a presynaptic level, since its hyperprolactinemic effect was antagonized both by the depletion of central 5ht content after p-chlorophenylalanine and by the degeneration of serotonergic terminals after 5,7-dihydroxytryptamine. |
1986-10-23 |
2023-08-11 |
rat |
| B Levitt, S P Duckle. Evidence against serotonin as a vasoconstrictor neurotransmitter in the rabbit basilar artery. The Journal of pharmacology and experimental therapeutics. vol 238. issue 3. 1986-10-23. PMID:3091810. |
however, it was not possible to demonstrate specific accumulation of [3h]serotonin into distinct serotonergic nerves. |
1986-10-23 |
2023-08-11 |
rabbit |
| B Levitt, S P Duckle. Evidence against serotonin as a vasoconstrictor neurotransmitter in the rabbit basilar artery. The Journal of pharmacology and experimental therapeutics. vol 238. issue 3. 1986-10-23. PMID:3091810. |
both the basilar artery and ear artery (which has been shown not to be innervated with serotonergic nerves) accumulated [3h]serotonin when incubated with a low concentration (10(-8) m). |
1986-10-23 |
2023-08-11 |
rabbit |
| S D Mendelson, B B Gorzalk. Methysergide inhibits and facilitates lordosis behavior in the female rat in a time-dependent manner. Neuropharmacology. vol 25. issue 7. 1986-10-21. PMID:3748321. |
reports in the literature have indicated a facilitatory effect of the serotonin antagonist methysergide on lordosis behavior, suggesting an inhibitory role for serotonergic activity. |
1986-10-21 |
2023-08-11 |
rat |
| A M Stuart, I J Mitchell, P Slater, H L Unwin, A R Crossma. A semi-quantitative atlas of 5-hydroxytryptamine-1 receptors in the primate brain. Neuroscience. vol 18. issue 3. 1986-10-15. PMID:3748377. |
the distribution of 5-hydroxytryptamine-1 receptors is compared to the distribution of both 5-hydroxytryptamine receptors and terminal fields of serotonergic projections as previously described in subprimates. |
1986-10-15 |
2023-08-11 |
Not clear |
| F G Graeff, M L Brandão, E A Audi, M T Schüt. Modulation of the brain aversive system by GABAergic and serotonergic mechanisms. Behavioural brain research. vol 21. issue 1. 1986-10-02. PMID:3017372. |
similar experiments with drugs influencing serotonergic neurotransmission evidenced that intra-cg microinjection of serotonin (5-ht) or of the direct 5-ht receptor agonist 5-methoxy-n,n-dimethyltryptamine increased the aversive threshold. |
1986-10-02 |
2023-08-11 |
rat |
| E Nowakowska, A Chodera, K Szczawińska, D Cenaje. Effects of pethidine on central neurotransmitters: changes in the state of tolerance. Polish journal of pharmacology and pharmacy. vol 38. issue 2. 1986-10-01. PMID:2428018. |
in tolerant rats the gaba content in the cerebral tissue was increased, and the activity of serotonergic system (assessed from the changes in 5-hydroxyindoleacetic acid level and serotonin turnover rate) was augmented. |
1986-10-01 |
2023-08-11 |
rat |
| D H Park, D W Snyder, T H Jo. Postnatal developmental changes of tryptophan hydroxylase activity in serotonergic cell bodies and terminals of rat brain. Brain research. vol 378. issue 1. 1986-09-30. PMID:3742199. |
tryptophan hydroxylase (tph) is the rate limiting enzyme in serotonin biosynthesis, so its development is very important to the functional maturation of the serotonergic neurons. |
1986-09-30 |
2023-08-11 |
rat |