| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Asberg, A Wägne. Biochemical effects of antidepressant treatment--studies of monoamine metabolites in cerebrospinal fluid and platelet [3H]imipramine binding. Ciba Foundation symposium. vol 123. 1987-04-08. PMID:2434288. |
two putative markers of serotonergic function, the concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-hiaa) and the binding parameters of [3h]imipramine to blood platelets, are discussed. |
1987-04-08 |
2023-08-11 |
Not clear |
| S Benkirane, S Arbilla, S Z Lange. Newly synthesized noradrenaline mediates the alpha 2-adrenoceptor inhibition of [3H]5-hydroxytryptamine release induced by beta-phenylethylamine in rat hippocampal slices. European journal of pharmacology. vol 131. issue 2-3. 1987-04-07. PMID:3028829. |
in slices of the rat hippocampus, alpha 2-adrenoceptors located presynaptically on serotonergic nerve terminals modulate the electrically evoked calcium-dependent release of [3h]serotonin [( 3h]5ht). |
1987-04-07 |
2023-08-11 |
rat |
| P J Conn, A Janowsky, E Sanders-Bus. Denervation supersensitivity of 5-HT-1c receptors in rat choroid plexus. Brain research. vol 400. issue 2. 1987-04-02. PMID:3815085. |
the current study demonstrates that treatment of rats with the serotonergic neurotoxin, 5,7-dihydroxytryptamine, caused a marked depletion of 5-ht and a supersensitive 5-ht-1c mediated phosphoinositide hydrolysis response. |
1987-04-02 |
2023-08-11 |
rat |
| S K Salzman, E Hirofuji, C Llados-Eckman, G D MacEwen, A L Beckma. Monoaminergic responses to spinal trauma. Participation of serotonin in posttraumatic progression of neural damage. Journal of neurosurgery. vol 66. issue 3. 1987-04-01. PMID:2434632. |
the data are discussed in terms of a serotonergic hypothesis of the progression of neural damage after trauma, with the interaction of 5-ht with raphe-spinal nerve terminals as a principal event. |
1987-04-01 |
2023-08-11 |
Not clear |
| R E Purdy, D L Murray, G L Stupeck. Receptors for 5-hydroxytryptamine in rabbit blood vessels: activation of alpha adrenoceptors in rabbit thoracic aorta. The Journal of pharmacology and experimental therapeutics. vol 240. issue 2. 1987-03-26. PMID:2879909. |
it is concluded that the contractile response to concentrations of 5-ht below 1 x 10(-5) m is mediated exclusively by serotonergic receptors. |
1987-03-26 |
2023-08-11 |
rabbit |
| A Henschen, M R Palmer, L Olso. Raphe dorsalis-spinal cord cografts in oculo: electrophysiological evidence for an excitatory serotonergic innervation of transplanted spinal neurons. Brain research bulletin. vol 17. issue 6. 1987-03-19. PMID:3026581. |
the results further support an excitatory or modulatory role of the descending spinal serotonergic pathways and demonstrate that functional contacts can be established between isolated cns grafts when 5-ht fibers invade immature or mature spinal cord tissue. |
1987-03-19 |
2023-08-11 |
Not clear |
| G F Weiss, P Papadakos, K Knudson, S F Leibowit. Medial hypothalamic serotonin: effects on deprivation and norepinephrine-induced eating. Pharmacology, biochemistry, and behavior. vol 25. issue 6. 1987-03-17. PMID:3027720. |
tests with receptor antagonists, injected into the pvn immediately prior to 5-ht, revealed a dose-dependent blockade of 5-ht's action by the serotonergic blockers, metergoline, methysergide and cinanserin. |
1987-03-17 |
2023-08-11 |
rat |
| H Hayashi, T Kushiro, N Kajiwar. [The effects of ketanserin on the hemodynamic response after intracerebroventricular administration of 5-hydroxytryptamine]. Nihon Naibunpi Gakkai zasshi. vol 62. issue 10. 1987-03-05. PMID:3803631. |
the purpose of this experiment is to investigate the role of the central and peripheral serotonergic receptor in the hemodynamic responses induced by intracerebroventricular (i.c.v) administration of 5-hydroxytryptamine (5-ht). |
1987-03-05 |
2023-08-11 |
rat |
| K Bec. Exogenous serotonin and histamine-stimulated gastric acid and pepsin secretion in dogs. Scandinavian journal of gastroenterology. vol 21. issue 10. 1987-03-04. PMID:2880389. |
in conclusion, serotonin inhibits histamine-stimulated gastric acid secretion via serotonergic receptors and beta-adrenoceptors, whereas pepsin secretion is unaffected. |
1987-03-04 |
2023-08-11 |
Not clear |
| M H Joseph, G A Kennet. Serotonin release in rat hippocampus examined by in vivo voltammetry: serotonergic function and tryptophan availability. Annals of the New York Academy of Sciences. vol 473. 1987-02-19. PMID:2432820. |
serotonin release in rat hippocampus examined by in vivo voltammetry: serotonergic function and tryptophan availability. |
1987-02-19 |
2023-08-11 |
rat |
| N J Penington, R J Reiffenstei. Lack of effect of antagonists on serotonin-induced inhibition in rat hippocampus. Canadian journal of physiology and pharmacology. vol 64. issue 11. 1987-02-18. PMID:3791042. |
the results of this study suggest that ca1 hippocampus is another structure, innervated by serotonergic neurones, where all (peripherally active) serotonin antagonists tested to date are ineffective against 5-hydroxytryptamine induced inhibition. |
1987-02-18 |
2023-08-11 |
rat |
| S K Bhattacharya, P J Rao, S J Brumleve, S S Parma. Effects of intracerebroventricular administration of bradykinin on rat brain serotonin and prostaglandins. Research communications in chemical pathology and pharmacology. vol 54. issue 3. 1987-02-12. PMID:3797812. |
these results have provided support for the contention that pgs may presumably mediate some of the central actions of bradykinin and that bradykinin-induced augmentation of central serotonergic activity could possibly account for pge2-induced modulation of rat brain serotonin. |
1987-02-12 |
2023-08-11 |
rat |
| M A Blackshear, L L Martin, E Sanders-Bus. Adaptive changes in the 5-HT2 binding site after chronic administration of agonists and antagonists. Neuropharmacology. vol 25. issue 11. 1987-02-11. PMID:3796800. |
similar adaptive changes in 5-ht2 sites after administration of mianserin, a presumed 5-ht antagonist, and after tfpp, a presumed 5-ht agonist, suggests that adaptive mechanisms in the serotonergic system are different from those in other aminergic systems or that the drugs used to characterize 5-ht receptor systems need to be re-evaluated. |
1987-02-11 |
2023-08-11 |
rat |
| F G Graeff, M L Brandão, E A Audi, M T Schüt. Modulation of the brain aversive system by GABAergic and serotonergic mechanisms. Behavioural brain research. vol 22. issue 2. 1987-02-10. PMID:3024664. |
similar experiments with drugs influencing serotonergic neurotransmission evidenced that intra-cg microinjection of serotonin (5-ht) or of the direct 5-ht receptor agonist 5-methoxy-n,n-dimethyltryptamine increased the aversive threshold. |
1987-02-10 |
2023-08-11 |
rat |
| P J Conn, E Sanders-Bus. Regulation of serotonin-stimulated phosphoinositide hydrolysis: relation to the serotonin 5-HT-2 binding site. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 6. issue 12. 1987-02-10. PMID:3025382. |
depletion of 5-ht levels with para-chlorophenylalanine or chemical denervation of serotonergic neurons with 5,7-dihydroxytryptamine had no significant effect upon 5-ht-2 receptor density or upon the phosphoinositide response to 5-ht. |
1987-02-10 |
2023-08-11 |
Not clear |
| J S Sprouse, G K Aghajania. (-)-Propranolol blocks the inhibition of serotonergic dorsal raphe cell firing by 5-HT1A selective agonists. European journal of pharmacology. vol 128. issue 3. 1987-01-27. PMID:2878817. |
the ability of the beta-adrenoceptor antagonist propranolol to block the effects of serotonin (5-ht) and 5-ht1a-selective agonists on the spontaneous firing of serotonergic dorsal raphe neurons was assessed. |
1987-01-27 |
2023-08-11 |
Not clear |
| D L DeHaven, M R Krigman, R B Mailma. Temporal changes in dopaminergic and serotonergic function caused by administration of trimethyltin to adult rats. Neurobehavioral toxicology and teratology. vol 8. issue 5. 1987-01-21. PMID:2431332. |
following a dose of 7 mg/kg, changes in serotonergic function, as evidenced by increased turnover and decreased concentrations of 5-ht, were present in striatum, olfactory tubercle, septum and frontal cortex. |
1987-01-21 |
2023-08-11 |
rat |
| S E Lenahan, H R Seibel, J H Johnso. Evidence for multiple serotonergic influences on LH release in ovariectomized rats and for modulation of their relative effectiveness by estrogen. Neuroendocrinology. vol 44. issue 1. 1987-01-07. PMID:3024057. |
both opiates and serotonin (5ht) are known to inhibit lh release in ovariectomized rats, and estrogen has been shown to reverse certain serotonergic effects. |
1987-01-07 |
2023-08-11 |
rat |
| S E Lenahan, H R Seibel, J H Johnso. Evidence for multiple serotonergic influences on LH release in ovariectomized rats and for modulation of their relative effectiveness by estrogen. Neuroendocrinology. vol 44. issue 1. 1987-01-07. PMID:3024057. |
these results suggest the existence of a multiplicity of serotonergic influences on the release of lh in the rat, not only in terms of particular species of 5ht receptors, but also in neuronal connectivity. |
1987-01-07 |
2023-08-11 |
rat |
| P C Waldmeier, L Maître, P A Baumann, K Hauser, S Bischoff, H Bittiger, R Paion. Ifoxetine, a compound with atypical effects on serotonin uptake. European journal of pharmacology. vol 130. issue 1-2. 1987-01-06. PMID:2877890. |
this suggests that it also interferes with 5-ht metabolism in the absence of depleting agents, which means that it interacts in some way with serotonergic transmission. |
1987-01-06 |
2023-08-11 |
human |