| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Verge, G Daval, A Patey, H Gozlan, S el Mestikawy, M Hamo. Presynaptic 5-HT autoreceptors on serotonergic cell bodies and/or dendrites but not terminals are of the 5-HT1A subtype. European journal of pharmacology. vol 113. issue 3. 1985-11-08. PMID:2931289. |
presynaptic 5-ht autoreceptors on serotonergic cell bodies and/or dendrites but not terminals are of the 5-ht1a subtype. |
1985-11-08 |
2023-08-11 |
Not clear |
| R A Cohe. Serotonergic prejunctional inhibition of canine coronary adrenergic nerves. The Journal of pharmacology and experimental therapeutics. vol 235. issue 1. 1985-11-08. PMID:4045729. |
serotonergic antagonists were tested for their ability to block the prejunctional inhibition by 5-ht, as well as their effects on the response of the coronary artery to electrical stimulation and norepinephrine. |
1985-11-08 |
2023-08-11 |
Not clear |
| R A Cohe. Serotonergic prejunctional inhibition of canine coronary adrenergic nerves. The Journal of pharmacology and experimental therapeutics. vol 235. issue 1. 1985-11-08. PMID:4045729. |
the nonselective serotonergic antagonists, methiothepin and metergoline, but not the selective 5-ht2 antagonists, ketanserin and ly 53857, prevented the inhibition by 5-ht of the response to electrical stimulation and of the stimulated overflow of [3h]norepinephrine. |
1985-11-08 |
2023-08-11 |
Not clear |
| R A Cohe. Serotonergic prejunctional inhibition of canine coronary adrenergic nerves. The Journal of pharmacology and experimental therapeutics. vol 235. issue 1. 1985-11-08. PMID:4045729. |
however, the alpha adrenergic antagonist, phentolamine, had additional effects similar to the serotonergic antagonists, but did not antagonize prejunctional inhibition caused by 5-ht. |
1985-11-08 |
2023-08-11 |
Not clear |
| R A Cohe. Serotonergic prejunctional inhibition of canine coronary adrenergic nerves. The Journal of pharmacology and experimental therapeutics. vol 235. issue 1. 1985-11-08. PMID:4045729. |
because the prejunctional inhibition by 5-ht was unaffected by neuronal uptake blockade with cocaine, these results suggest specific, non-5-ht2 serotonergic receptors on coronary adrenergic nerves which, when activated, inhibit the stimulated release of norepinephrine. |
1985-11-08 |
2023-08-11 |
Not clear |
| S O Ogren, C Johansson, O Magnusso. Forebrain serotonergic involvement in avoidance learning. Neuroscience letters. vol 58. issue 3. 1985-11-06. PMID:2995878. |
the one-way active avoidance deficit caused by the serotonergic (5-ht) releasing compound p-chloroamphetamine (pca) was examined in rats after degeneration of 5-ht neurons in the forebrain. |
1985-11-06 |
2023-08-11 |
rat |
| B Scatton, A Serrano, T Nishikaw. GABA mimetics decrease extracellular concentrations of 5-HIAA (as measured by in vivo voltammetry) in the dorsal raphe of the rat. Brain research. vol 341. issue 2. 1985-11-04. PMID:2412636. |
it is concluded that gaba depresses serotonin metabolism not only in nerve endings, but also in dendrites (and/or cell bodies) of serotonergic neurons. |
1985-11-04 |
2023-08-11 |
rat |
| P M Vanhoutt. Can peripheral serotonergic blockade explain the hypotensive effect of ketanserin? Journal of cardiovascular pharmacology. vol 7 Suppl 7. 1985-10-17. PMID:2412025. |
such an involvement of serotonin is suggested by the following observations in humans and animals: the turnover rate of platelets is accelerated; the uptake of serotonin by platelets is reduced; the metabolism of serotonin by the endothelial cells is decreased; the vascular smooth muscles are hyperresponsive to the constrictor effects of serotonin and other serotonergic agonists; the s2-serotonergic antagonist ketanserin, which is devoid of agonistic properties, lowers arterial blood pressure in hypertensive humans. |
1985-10-17 |
2023-08-11 |
Not clear |
| M A Nelson, J P Coghlan, D A Denton, E H Mills, B A Scoggins, C D Spence, J A Whitwort. Serotonergic mechanisms and blood pressure in sheep. Journal of cardiovascular pharmacology. vol 7 Suppl 7. 1985-10-17. PMID:2412029. |
this study examined the effects of the serotonergic (5-ht2) antagonist ketanserin in sheep on haemodynamic responses to infused serotonin (5-ht), development of adrenocorticotrophin (acth)-induced hypertension, and the effect of acth on in vivo pressor responsiveness to 5-ht. |
1985-10-17 |
2023-08-11 |
Not clear |
| P A Jansse. Pharmacology of potent and selective S2-serotonergic antagonists. Journal of cardiovascular pharmacology. vol 7 Suppl 7. 1985-10-17. PMID:2412048. |
ketanserin is the prototype of a new series of serotonergic antagonists that competitively and selectively block 5-hydroxytryptamine (s2) serotonergic receptors. |
1985-10-17 |
2023-08-11 |
Not clear |
| M H Richard. Efflux of 3H-5-hydroxytryptamine from rat hypothalamic slices by continuous electrical stimulation: frequency-dependent responses to serotonergic antagonists and 5-hydroxytryptamine. Naunyn-Schmiedeberg's archives of pharmacology. vol 329. issue 4. 1985-10-15. PMID:4033805. |
efflux of 3h-5-hydroxytryptamine from rat hypothalamic slices by continuous electrical stimulation: frequency-dependent responses to serotonergic antagonists and 5-hydroxytryptamine. |
1985-10-15 |
2023-08-11 |
rat |
| R R Lorenz, P M Vanhoutt. Prejunctional adrenergic inhibition by aggregating platelets in canine blood vessels. The American journal of physiology. vol 249. issue 3 Pt 2. 1985-10-10. PMID:4037113. |
the reduction of transmitter overflow caused by 5-hydroxytryptamine was prevented by the serotonergic antagonist methiothepin in a concentration that did not significantly affect the release of 5-hydroxytryptamine or thromboxane b2 from the aggregating platelets. |
1985-10-10 |
2023-08-11 |
Not clear |
| J R Ieni, E Tobach, S R Zukin, G A Barr, H M Van Praa. Multiple [3H]imipramine binding sites in brains of male and female Fawn-Hooded and Long-Evans rats. European journal of pharmacology. vol 112. issue 2. 1985-10-09. PMID:2992999. |
most strikingly, no significant differences were observed between the two strains in any of the binding parameters, indicating that brain [3h]imipramine binding sites, which may be related to the serotonergic uptake process, appear normal in a strain of rats with serotonin platelet storage pool disease. |
1985-10-09 |
2023-08-11 |
rat |
| Y Nagai, S Narumi, Y Saji, Y Nagaw. [A TRH analog (DN-1417). Antagonistic effects on reserpine-induced decreases in local cerebral glucose utilization and cerebral monoamine levels]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 85. issue 5. 1985-10-09. PMID:3928465. |
the effects of dn-1417 were completely abolished by pretreatment with a dopaminergic (da) and a serotonergic (5-ht) receptor blocker, pimozide (1 mg/kg) and methysergide (5 mg/kg), respectively. |
1985-10-09 |
2023-08-11 |
mouse |
| F Amenta, M De Rossi, M C Mione, P Geppett. Characterization of [3H]5-hydroxytryptamine uptake within rat cerebrovascular tree. European journal of pharmacology. vol 112. issue 2. 1985-10-09. PMID:4029258. |
the serotonergic neurotoxin 5,7-dihydroxytryptamine and lesions to both the medial and the dorsal raphe nuclei caused a marked loss of [3h]5ht uptake but did not change the uptake of tritiated norepinephrine. |
1985-10-09 |
2023-08-11 |
rat |
| C T Dourish, P H Hutson, G Curzo. Low doses of the putative serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) elicit feeding in the rat. Psychopharmacology. vol 86. issue 1-2. 1985-09-25. PMID:3161115. |
the induction of feeding by a serotonin agonist appears paradoxical, since drugs which enhance brain serotonergic activity usually inhibit feeding. |
1985-09-25 |
2023-08-11 |
rat |
| S O Ogren, C Johansso. Separation of the associative and non-associative effects of brain serotonin released by p-chloroamphetamine: dissociable serotoninergic involvement in avoidance learning, pain and motor function. Psychopharmacology. vol 86. issue 1-2. 1985-09-25. PMID:3927348. |
it is concluded that behavioural processes related to serotonergic neurotransmission can be independently modified, suggesting differences in the underlying 5-ht mechanisms. |
1985-09-25 |
2023-08-11 |
Not clear |
| L A Barragan, N Delhaye-Bouchaud, P Lage. Drug-induced activation of the inferior olivary nucleus in young rabbits. Differential effects of harmaline and quipazine. Neuropharmacology. vol 24. issue 7. 1985-09-24. PMID:3160966. |
it is suggested that quipazine directly activates serotonin receptors which are already present at birth, whereas harmaline requires the presence of serotonergic fibres for such activation. |
1985-09-24 |
2023-08-11 |
rabbit |
| A Sharma, M Chandra, V R Gujrati, K Shanker, K P Bhargav. Involvement of catecholamines and serotonin in human hypertension. Pharmacological research communications. vol 17. issue 6. 1985-09-19. PMID:2410936. |
furthermore, alterations observed in platelet serotonin uptake and its basal content suggest the involvement of platelet serotonergic system in hypertension. |
1985-09-19 |
2023-08-11 |
human |
| S Consolo, J X Wang, G L Forloni, I Mocchetti, G Racagni, H Ladinsk. Studies on the up regulation of alpha-adrenoceptors on rat hippocampal perikarya by chemical lesion of the median raphe nucleus. Life sciences. vol 37. issue 5. 1985-09-04. PMID:2991683. |
neurotoxin-induced lesion of the serotonergic raphe-hippocampal pathway produced about a 50% increase in the density of a nm affinity alpha-adrenergic binding site for (3h)wb-4101 in rat hippocampus 18 days postlesion without altering the specific binding of (3h)5-ht to serotonergic receptors. |
1985-09-04 |
2023-08-11 |
rat |