| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kazuhiko Nakamura, Ayyappan Anitha, Kazuo Yamada, Masatsugu Tsujii, Yoshimi Iwayama, Eiji Hattori, Tomoko Toyota, Shiro Suda, Noriyoshi Takei, Yasuhide Iwata, Katsuaki Suzuki, Hideo Matsuzaki, Masayoshi Kawai, Yoshimoto Sekine, Kenji J Tsuchiya, Gen-Ichi Sugihara, Yasuomi Ouchi, Toshiro Sugiyama, Takeo Yoshikawa, Norio Mor. Genetic and expression analyses reveal elevated expression of syntaxin 1A ( STX1A) in high functioning autism. The international journal of neuropsychopharmacology. vol 11. issue 8. 2009-01-26. PMID:18593506. |
during early childhood, there is a period of high brain serotonin synthesis that is disrupted in autistic children; stx1a might influence the serotonergic system during this stage of neurodevelopment, as implied by the association with adi-r_d. |
2009-01-26 |
2023-08-12 |
Not clear |
| Sharla L Powell, Tanja Gödecke, Dejan Nikolic, Shao-Nong Chen, Soyoun Ahn, Birgit Dietz, Norman R Farnsworth, Richard B van Breemen, David C Lankin, Guido F Pauli, Judy L Bolto. In vitro serotonergic activity of black cohosh and identification of N(omega)-methylserotonin as a potential active constituent. Journal of agricultural and food chemistry. vol 56. issue 24. 2009-01-26. PMID:19049296. |
because serotonergic receptors and transporters are involved with thermoregulation, black cohosh and its phytoconstituents were evaluated for serotonergic activity using 5-ht7 receptor binding, camp induction, and serotonin selective re-uptake inhibitor (ssri) assays. |
2009-01-26 |
2023-08-12 |
Not clear |
| S G Hasselbalch, K Madsen, C Svarer, L H Pinborg, S Holm, O B Paulson, G Waldemar, G M Knudse. Reduced 5-HT2A receptor binding in patients with mild cognitive impairment. Neurobiology of aging. vol 29. issue 12. 2009-01-23. PMID:17544547. |
we conclude that widespread reductions in 5-ht(2a) receptor binding were found in amnestic mci, pointing at the presence of serotonergic dysfunction in prodromal ad. |
2009-01-23 |
2023-08-12 |
human |
| Christopher A Lowry, Matthew W Hale, Andrew K Evans, Jasper Heerkens, Daniel R Staub, Paul J Gasser, Anantha Shekha. Serotonergic systems, anxiety, and affective disorder: focus on the dorsomedial part of the dorsal raphe nucleus. Annals of the New York Academy of Sciences. vol 1148. 2009-01-23. PMID:19120094. |
depressed suicide patients have elevated expression of neuronal tryptophan hydroxylase 2 (tph2) mrna and protein in midbrain serotonergic neurons, as well as increases in brain serotonin turnover. |
2009-01-23 |
2023-08-12 |
Not clear |
| Christopher A Lowry, Matthew W Hale, Andrew K Evans, Jasper Heerkens, Daniel R Staub, Paul J Gasser, Anantha Shekha. Serotonergic systems, anxiety, and affective disorder: focus on the dorsomedial part of the dorsal raphe nucleus. Annals of the New York Academy of Sciences. vol 1148. 2009-01-23. PMID:19120094. |
the mechanisms underlying these changes are uncertain, but increased tph2 expression and serotonin turnover could result from genetic influences, adverse early life experiences, or acute stressful life events, all of which can alter serotonergic neurotransmission and have been implicated in determining vulnerability to major depression. |
2009-01-23 |
2023-08-12 |
Not clear |
| S K Kaushalya, R Desai, S Arumugam, H Ghosh, J Balaji, S Mait. Three-photon microscopy shows that somatic release can be a quantitatively significant component of serotonergic neurotransmission in the mammalian brain. Journal of neuroscience research. vol 86. issue 15. 2009-01-22. PMID:18709651. |
using three-photon microscopy, we directly imaged serotonin autofluorescence and investigated the total serotonin content, release competence, and release kinetics of somatic serotonergic vesicles in the dorsal raphe neurons of the rat. |
2009-01-22 |
2023-08-12 |
rat |
| S K Kaushalya, R Desai, S Arumugam, H Ghosh, J Balaji, S Mait. Three-photon microscopy shows that somatic release can be a quantitatively significant component of serotonergic neurotransmission in the mammalian brain. Journal of neuroscience research. vol 86. issue 15. 2009-01-22. PMID:18709651. |
the amount of releasable serotonin stored in the somatic vesicles is comparable to the total serotonin content of all the synaptic vesicles in a raphe neuron, indicating that somatic release can potentially play a major role in serotonergic neurotransmission in the mammalian brain. |
2009-01-22 |
2023-08-12 |
rat |
| Eric Fakra, Luke W Hyde, Adam Gorka, Patrick M Fisher, Karen E Muñoz, Mark Kimak, Indrani Halder, Robert E Ferrell, Stephen B Manuck, Ahmad R Harir. Effects of HTR1A C(-1019)G on amygdala reactivity and trait anxiety. Archives of general psychiatry. vol 66. issue 1. 2009-01-16. PMID:19124686. |
serotonin 1a (5-hydroxytryptamine 1a [5-ht(1a)]) autoreceptors mediate negative feedback inhibition of serotonergic neurons and play a critical role in regulating serotonin signaling involved in shaping the functional response of major forebrain targets, such as the amygdala, supporting complex behavioral processes. |
2009-01-16 |
2023-08-12 |
human |
| Robert J Carey, Joseph P Huston, Christian P Mülle. Pharmacological inhibition of dopamine and serotonin activity blocks spontaneous and cocaine-activated behaviour. Progress in brain research. vol 172. 2009-01-15. PMID:18772041. |
the dopaminergic (da) and serotonergic (5-ht) systems are modulatory transmitter systems that can influence a wide range of behavioural functions. |
2009-01-15 |
2023-08-12 |
Not clear |
| G I Papakostas, C H Homberger, M Fav. A meta-analysis of clinical trials comparing mirtazapine with selective serotonin reuptake inhibitors for the treatment of major depressive disorder. Journal of psychopharmacology (Oxford, England). vol 22. issue 8. 2009-01-13. PMID:18308801. |
the objective of this paper was to compare response rates among patients with mdd treated with either mirtazapine, an anti-depressant thought to simultaneously enhance both noradrenergic and serotonergic neurotransmission, or selective serotonin reuptake inhibitors (ssris). |
2009-01-13 |
2023-08-12 |
Not clear |
| Antonella Gasbarri, Agata Cifariello, Assunta Pompili, Alfredo Menese. Effect of 5-HT(7) antagonist SB-269970 in the modulation of working and reference memory in the rat. Behavioural brain research. vol 195. issue 1. 2009-01-12. PMID:18308404. |
it has been established that serotonergic pathways project to cerebral areas involved in learning and memory and that serotonin (5-ht) receptor agonists and antagonists modify these processes. |
2009-01-12 |
2023-08-12 |
rat |
| Sara Eugenia Cruz-Morales, Norma Laura García-Saldívar, María Reyes González-López, Georgina Castillo-Roberto, Juana Monroy, Roberto Domíngue. Acute restriction impairs memory in the elevated T-maze (ETM) and modifies serotonergic activity in the dorsolateral striatum. Behavioural brain research. vol 195. issue 1. 2009-01-12. PMID:18378013. |
the memory impairment seems to be associated with changes in striatal serotonergic system, given that 5-ht concentration increased, while serotonergic activity decreased. |
2009-01-12 |
2023-08-12 |
Not clear |
| Sara Eugenia Cruz-Morales, Norma Laura García-Saldívar, María Reyes González-López, Georgina Castillo-Roberto, Juana Monroy, Roberto Domíngue. Acute restriction impairs memory in the elevated T-maze (ETM) and modifies serotonergic activity in the dorsolateral striatum. Behavioural brain research. vol 195. issue 1. 2009-01-12. PMID:18378013. |
the differences in the activity of 5-ht detected in each experiment could be explained by the effects of different stressors on the serotonergic neurons ability to synthesize the neurotransmitter. |
2009-01-12 |
2023-08-12 |
Not clear |
| B Bert, H Fink, J Rothe, J Walstab, H Bönisc. Learning and memory in 5-HT(1A)-receptor mutant mice. Behavioural brain research. vol 195. issue 1. 2009-01-12. PMID:18396339. |
although the 5-ht(1a)-receptor is one of the best described receptor subtypes of the serotonergic system, its complex distribution pattern, pre- and postsynaptic localisation, and its impact on various neurotransmitters aggravate the attribution of 5-ht(1a)-agonistic effects to behavioural outcomes. |
2009-01-12 |
2023-08-12 |
mouse |
| Hélène Jeltsch-David, Julie Koenig, Jean-Christophe Casse. Modulation of cholinergic functions by serotonin and possible implications in memory: general data and focus on 5-HT(1A) receptors of the medial septum. Behavioural brain research. vol 195. issue 1. 2009-01-12. PMID:18400315. |
it will then focus on a brain region and a neuropharmacological substrate that have been poorly studied as regards serotonergic modulation of memory functions, namely the medial septum and its 5-ht(1a) receptors. |
2009-01-12 |
2023-08-12 |
Not clear |
| Bríd A Nic Dhonnchadha, Kathryn A Cunningha. Serotonergic mechanisms in addiction-related memories. Behavioural brain research. vol 195. issue 1. 2009-01-12. PMID:18639587. |
this review briefly traces the history of 5-ht involvement in retrieval of drug-cue associations and future targets of serotonergic manipulation that may reduce the impact that drug cues have on addictive behavior and relapse. |
2009-01-12 |
2023-08-12 |
Not clear |
| Norbert Gyongyosi, Brigitta Balogh, Eszter Kirilly, Tamas Kitka, Sandor Kantor, Gyorgy Bagd. MDMA treatment 6 months earlier attenuates the effects of CP-94,253, a 5-HT1B receptor agonist, on motor control but not sleep inhibition. Brain research. vol 1231. 2009-01-07. PMID:18638459. |
these data suggest that long-term changes in 5-ht(1b) receptor function occur after serotonergic damage caused by a single dose of mdma. |
2009-01-07 |
2023-08-12 |
rat |
| N P Dimopoulos, C I Mitsonis, V V Psarr. Delusional disorder, somatic type treated with aripiprazole--mirtazapine combination. Journal of psychopharmacology (Oxford, England). vol 22. issue 7. 2009-01-06. PMID:18308798. |
initially, antipsychotics and especially pimozide were considered to be the pharmacological approach of choice but, subsequently, tryciclic anti-depressants and selective serotonin re-uptake inhibitors (ssris) were also suggested to be effective, implicating the serotonergic system in the pathophysiology of the disorder. |
2009-01-06 |
2023-08-12 |
Not clear |
| George M Bosse, Henry A Spiller, Aaron M Collin. A fatal case of venlafaxine overdose. Journal of medical toxicology : official journal of the American College of Medical Toxicology. vol 4. issue 1. 2009-01-06. PMID:18338306. |
based on its primary action of serotonin reuptake inhibition, venlafaxine overdose would be expected to result in serotonergic effects. |
2009-01-06 |
2023-08-12 |
Not clear |
| Pl Johnson, Ca Lowry, W Truitt, A Shekha. Disruption of GABAergic tone in the dorsomedial hypothalamus attenuates responses in a subset of serotonergic neurons in the dorsal raphe nucleus following lactate-induced panic. Journal of psychopharmacology (Oxford, England). vol 22. issue 6. 2008-12-30. PMID:18308791. |
facilitation of serotonergic signaling with selective serotonin reuptake inhibitors can suppress anxiety and panic-like responses, but the mechanisms involved are not clearly defined. |
2008-12-30 |
2023-08-12 |
rat |