| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jesse A May, Najam A Sharif, Hwang-Hsing Chen, John C Liao, Curtis R Kelly, Richard A Glennon, Richard Young, Jun-Xu Li, Kenner C Rice, Charles P Franc. Pharmacological properties and discriminative stimulus effects of a novel and selective 5-HT2 receptor agonist AL-38022A [(S)-2-(8,9-dihydro-7H-pyrano[2,3-g]indazol-1-yl)-1-methylethylamine]. Pharmacology, biochemistry, and behavior. vol 91. issue 3. 2009-04-02. PMID:18718483. |
al-38022a is a novel synthetic serotonergic (5-ht) ligand that exhibited high affinity for each of the 5-ht2 receptor subtypes (ki100-fold less) affinity for other 5-ht receptors. |
2009-04-02 |
2023-08-12 |
human |
| Casey M Rand, Elizabeth M Berry-Kravis, Wenqing Fan, Debra E Weese-Maye. HTR2A variation and sudden infant death syndrome: a case-control analysis. Acta paediatrica (Oslo, Norway : 1992). vol 98. issue 1. 2009-04-02. PMID:18771483. |
the serotonergic (5-ht) system functions in central autonomic regulation with homeostatic roles in cardiorespiratory control, thermoregulation, arousal and sleep-wake cycling. |
2009-04-02 |
2023-08-12 |
Not clear |
| Yuji Odagak. Atypical neuroleptic malignant syndrome or serotonin toxicity associated with atypical antipsychotics? Current drug safety. vol 4. issue 1. 2009-03-31. PMID:19149529. |
the reciprocal interaction between the dopaminergic and serotonergic systems disturbed by either dopaminergic blockers or serotonergic enhancers leads to the disruption of homeostasis, with typical forms of nms and serotonin syndrome representing the ends of the common pathophysiological background. |
2009-03-31 |
2023-08-12 |
Not clear |
| Diana Martinez, Mark Slifstein, Roberto Gil, Dah-Ren Hwang, Yiyun Huang, Audrey Perez, W Gordon Frankle, Marc Laruelle, John Krystal, Anissa Abi-Dargha. Positron emission tomography imaging of the serotonin transporter and 5-HT(1A) receptor in alcohol dependence. Biological psychiatry. vol 65. issue 2. 2009-03-20. PMID:18962444. |
this study examines two indices of serotonergic transmission, 5-ht transporter levels and 5-ht(1a) availability, in vivo, in type ii alcoholism. |
2009-03-20 |
2023-08-12 |
human |
| Diana Martinez, Mark Slifstein, Roberto Gil, Dah-Ren Hwang, Yiyun Huang, Audrey Perez, W Gordon Frankle, Marc Laruelle, John Krystal, Anissa Abi-Dargha. Positron emission tomography imaging of the serotonin transporter and 5-HT(1A) receptor in alcohol dependence. Biological psychiatry. vol 65. issue 2. 2009-03-20. PMID:18962444. |
this is the first report of combined tracers for pre- and postsynaptic serotonergic transmission in the same alcoholic subjects and the first study of 5-ht(1a) receptors in alcoholism. |
2009-03-20 |
2023-08-12 |
human |
| Martha L Ita, Ma del Carmen Cortés, Jaime Valencia, Jose R Eguiba. Activation of serotonin 5-HT1-receptors decreased gripping-induced immobility episodes in taiep rats. Neuroscience letters. vol 449. issue 2. 2009-03-20. PMID:18996171. |
these results show that serotonergic 5-ht(1)-receptors are involved in the susceptibility of gripping-induced ies in taiep rats. |
2009-03-20 |
2023-08-12 |
rat |
| Alastair S Garfield, Lora K Heisle. Pharmacological targeting of the serotonergic system for the treatment of obesity. The Journal of physiology. vol 587. issue 1. 2009-03-18. PMID:19029184. |
the attenuation of food intake as induced by an increase in serotonergic (5-hydroxytryptamine, 5-ht) efficacy has been a target of antiobesity pharmacotherapies. |
2009-03-18 |
2023-08-12 |
human |
| George S Zubenko, Michelle L Jones, Annette O Estevez, Hugh B Hughes, Miguel Esteve. Identification of a CREB-dependent serotonergic pathway and neuronal circuit regulating foraging behavior in Caenorhabditis elegans: a useful model for mental disorders and their treatments? American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 150B. issue 1. 2009-03-10. PMID:19035344. |
in the anterior afferent arm of the circuit, crh-1 controls fr by regulating the expression of tph-1, the sole structural gene for tryptophan hydroxylase, in serotonergic sensory (adf) neurons whose post-synaptic effects are mediated through 5ht(2)-like ser-1 receptors. |
2009-03-10 |
2023-08-12 |
caenorhabditis_elegans |
| Patrycja Stein, Markus Savli, Wolfgang Wadsak, Markus Mitterhauser, Martin Fink, Christoph Spindelegger, Leonhard-Key Mien, Ulrike Moser, Robert Dudczak, Kurt Kletter, Siegfried Kasper, Rupert Lanzenberge. The serotonin-1A receptor distribution in healthy men and women measured by PET and [carbonyl-11C]WAY-100635. European journal of nuclear medicine and molecular imaging. vol 35. issue 12. 2009-03-09. PMID:18542956. |
the present positron emission tomography (pet) study investigated the influence of sex on the major inhibitory serotonergic receptor subtype, the serotonin-1a (5-ht(1a)) receptor. |
2009-03-09 |
2023-08-12 |
Not clear |
| Polina Petkova-Kirova, Angelina Rakovska, Galina Zaekova, Chiara Ballini, Laura Della Corte, Radomir Radomirov, Anikó Vágvölgy. Stimulation by neurotensin of dopamine and 5-hydroxytryptamine (5-HT) release from rat prefrontal cortex: possible role of NTR1 receptors in neuropsychiatric disorders. Neurochemistry international. vol 53. issue 6-8. 2009-03-09. PMID:18835308. |
the modulation of cortical dopaminergic and serotonergic neurotransmissions by neurotensin (nt) was studied by measuring the release of dopamine (da) and 5-hydroxytryptamine (5-ht) from the prefrontal cortex (pfc) of freely moving rats. |
2009-03-09 |
2023-08-12 |
rat |
| Polina Petkova-Kirova, Angelina Rakovska, Galina Zaekova, Chiara Ballini, Laura Della Corte, Radomir Radomirov, Anikó Vágvölgy. Stimulation by neurotensin of dopamine and 5-hydroxytryptamine (5-HT) release from rat prefrontal cortex: possible role of NTR1 receptors in neuropsychiatric disorders. Neurochemistry international. vol 53. issue 6-8. 2009-03-09. PMID:18835308. |
the potentiating effects of neurotensin on da and 5-ht release in the pfc are regulated by ntr1 receptors, probably located on dopaminergic and serotonergic nerve terminals or axons. |
2009-03-09 |
2023-08-12 |
rat |
| David J Mokler, Jason R Dugal, Jill M Hoffman, Peter J Morgan. Functional interrelations between nucleus raphé dorsalis and nucleus raphé medianus: a dual probe microdialysis study of glutamate-stimulated serotonin release. Brain research bulletin. vol 78. issue 4-5. 2009-03-06. PMID:18955118. |
a reciprocal innervation from the median raphé to the dorsal raphé is not mediated by glutamate, does not appear to be serotonergic, and does not regulate extracellular serotonin in the dorsal raphé. |
2009-03-06 |
2023-08-12 |
Not clear |
| Sefi Kronenberg, Amos Frisch, Beni Rotberg, Miri Carmel, Alan Apter, Abraham Weizma. Pharmacogenetics of selective serotonin reuptake inhibitors in pediatric depression and anxiety. Pharmacogenomics. vol 9. issue 11. 2009-03-06. PMID:19018726. |
an emphasis is put on serotonergic genes such as the serotonin transporter (5-htt) and additional genes known to be active in the cns. |
2009-03-06 |
2023-08-12 |
Not clear |
| Maruschka Weber, Angelika Schmitt, Erhard Wischmeyer, Frank Dörin. Excitability of pontine startle processing neurones is regulated by the two-pore-domain K+ channel TASK-3 coupled to 5-HT2C receptors. The European journal of neuroscience. vol 28. issue 5. 2009-03-05. PMID:18691333. |
consistently, we measured afferent synaptic inputs from serotonergic raphe neurones and detected 5-ht(2c) receptors in pnc giant neurones by immunohistochemistry. |
2009-03-05 |
2023-08-12 |
Not clear |
| Paul Gacek, Tamlin S Conner, Howard Tennen, Henry R Kranzler, Jonathan Covaul. Tryptophan hydroxylase 2 gene and alcohol use among college students. Addiction biology. vol 13. issue 3-4. 2009-03-05. PMID:18782386. |
tryptophan hydroxylase (tph2) plays an important role in serotonergic neurotransmission by serving as the rate-limiting enzyme for serotonin biosynthesis in the midbrain and serotonergic neurons. |
2009-03-05 |
2023-08-12 |
human |
| J Pratuangdejkul, B Schneider, J-M Launay, O Kellermann, P Manive. Computational approaches for the study of serotonin and its membrane transporter SERT: implications for drug design in neurological sciences. Current medicinal chemistry. vol 15. issue 30. 2009-03-05. PMID:19075665. |
in the serotonergic system, deregulation of the tightly controlled extracellular concentration of 5-ht appears to be at the origin of a host of metabolic and psychiatric disorders. |
2009-03-05 |
2023-08-12 |
Not clear |
| J Pratuangdejkul, B Schneider, J-M Launay, O Kellermann, P Manive. Computational approaches for the study of serotonin and its membrane transporter SERT: implications for drug design in neurological sciences. Current medicinal chemistry. vol 15. issue 30. 2009-03-05. PMID:19075665. |
a key step that regulates 5-ht external level is the re-uptake of 5-ht into cells by the 5-ht transporter (sert), which is besides the target of numerous drugs interacting with the serotonergic system. |
2009-03-05 |
2023-08-12 |
Not clear |
| E A Engleman, Z A Rodd, R L Bell, J M Murph. The role of 5-HT3 receptors in drug abuse and as a target for pharmacotherapy. CNS & neurological disorders drug targets. vol 7. issue 5. 2009-03-05. PMID:19128203. |
the serotonergic (5-ht) system, in concert with others neurotransmitter systems, plays a key role in modulating neuronal systems within the mesolimbic pathway. |
2009-03-05 |
2023-08-12 |
human |
| Marcelle Moulin-Sallanon, Yves Charnay, Nathalie Ginovart, Pascale Perret, Laurence Lanfumey, Michel Hamon, René Hen, Daniel Fagret, Vicente Ibáñez, Philippe Mille. Acute and chronic effects of citalopram on 5-HT1A receptor-labeling by [18F]MPPF and -coupling to receptors-G proteins. Synapse (New York, N.Y.). vol 63. issue 2. 2009-03-03. PMID:19016488. |
the delayed therapeutic efficacy of citalopram did not appear to be linked to either a downregulation of 5-ht(1a) receptors or to a 5-ht(1a) receptor-g protein decoupling process in serotonergic neurons, but to increased functional sensitivity of postsynaptic 5-ht(1a) receptors. |
2009-03-03 |
2023-08-12 |
mouse |
| Shiuchi Ueda, Shin-Ichi Sakakibara, Taro Kadowaki, Takuya Naitoh, Koichi Hirata, Kanji Yoshimot. Chronic treatment with melatonin attenuates serotonergic degeneration in the striatum and olfactory tubercle of zitter mutant rats. Neuroscience letters. vol 448. issue 2. 2009-02-27. PMID:18955113. |
immunohistochemical staining for serotonin was consistent with the neurochemical data and further demonstrated substantially increased numbers of serotonergic nerve terminals in these areas. |
2009-02-27 |
2023-08-12 |
rat |