| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ville Sallinen, Maria Sundvik, Ilkka Reenilä, Nina Peitsaro, Denis Khrustalyov, Oleg Anichtchik, Gabija Toleikyte, Jan Kaslin, Pertti Panul. Hyperserotonergic phenotype after monoamine oxidase inhibition in larval zebrafish. Journal of neurochemistry. vol 109. issue 2. 2009-04-24. PMID:19222706. |
deprenyl decreased 5-ht-immunoreactivity in serotonergic neurons and induced novel ectopic 5-ht-immunoreactivity neurons in the diencephalon in a manner dependent on 5-ht uptake. |
2009-04-24 |
2023-08-12 |
zebrafish |
| Anna Haduch, Jacek Wójcikowski, Władysława A Danie. Effect of selected antidepressant drugs on cytochrome P450 2B (CYP2B) in rat liver. An in vitro and in vivo study. Pharmacological reports : PR. vol 60. issue 6. 2009-04-23. PMID:19211989. |
the aim of the present study was to investigate the influence of antidepressants with different chemical structures and mechanisms of action affecting serotonergic and/or noradrenergic systems - tricyclic antidepressant drugs (tad), selective serotonin reuptake inhibitors (ssris) and novel antidepressants (mirtazapine, nefazodone) - on the activity of rat cyp2b measured as the rate of 16beta-hydroxylation of testosterone. |
2009-04-23 |
2023-08-12 |
rat |
| Mustapha Moussaif, Ji Ying Sz. Intraflagellar transport/Hedgehog-related signaling components couple sensory cilium morphology and serotonin biosynthesis in Caenorhabditis elegans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 13. 2009-04-23. PMID:19339602. |
here, we show that the hh receptor patched-related factor daf-6 and intraflagellar transport modulate serotonin production in caenorhabditis elegans animals, by remodeling the architecture of dendritic cilia of a pair of adf serotonergic chemosensory neurons. |
2009-04-23 |
2023-08-12 |
caenorhabditis_elegans |
| Mustapha Moussaif, Ji Ying Sz. Intraflagellar transport/Hedgehog-related signaling components couple sensory cilium morphology and serotonin biosynthesis in Caenorhabditis elegans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 13. 2009-04-23. PMID:19339602. |
our study revealed the cilium structure of serotonergic neurons as a trigger of regulated serotonin production, and demonstrated that a hedgehog-related signaling component is dynamically regulated by environment and underscores neuroplasticity of serotonergic neurons in c. elegans under stress and stress recovery. |
2009-04-23 |
2023-08-12 |
caenorhabditis_elegans |
| Christophe Mallet, Laurence Daulhac, Jérôme Bonnefont, Catherine Ledent, Monique Etienne, Eric Chapuy, Frédéric Libert, Alain Eschalie. Endocannabinoid and serotonergic systems are needed for acetaminophen-induced analgesia. Pain. vol 139. issue 1. 2009-04-21. PMID:18485596. |
in addition, similarly to the interaction of acetaminophen with bulbospinal serotonergic pathways and spinal serotonin receptors, we observed that the antinociceptive activity of acea, a cb(1) receptor agonist, was inhibited by lesion of bulbospinal serotonergic pathways and antagonists of spinal 5-ht receptors. |
2009-04-21 |
2023-08-12 |
mouse |
| Tyler Fortune, Diana I Luri. Chronic low-level lead exposure affects the monoaminergic system in the mouse superior olivary complex. The Journal of comparative neurology. vol 513. issue 5. 2009-04-17. PMID:19226511. |
the soc receives a serotonergic innervation from the dorsal raphe, and serotonin has been implicated in auditory temporal processing within the brainstem and inferior colliculus. |
2009-04-17 |
2023-08-12 |
mouse |
| Masahide Yoshida, Yuki Takayanagi, Kiyoshi Inoue, Tadashi Kimura, Larry J Young, Tatsushi Onaka, Katsuhiko Nishimor. Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 7. 2009-04-16. PMID:19228979. |
infusion of a 5-ht(2a/2c) receptor antagonist blocked the anxiolytic effect of oxytocin, suggesting that oxytocin receptor activation in serotonergic neurons mediates the anxiolytic effects of oxytocin. |
2009-04-16 |
2023-08-12 |
mouse |
| Masahide Yoshida, Yuki Takayanagi, Kiyoshi Inoue, Tadashi Kimura, Larry J Young, Tatsushi Onaka, Katsuhiko Nishimor. Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 7. 2009-04-16. PMID:19228979. |
this is the first demonstration that oxytocin may regulate serotonin release and exert anxiolytic effects via direct activation of oxytocin receptor expressed in serotonergic neurons of the raphe nuclei. |
2009-04-16 |
2023-08-12 |
mouse |
| J L Lukkes, C H Summers, J L Scholl, K J Renner, G L Forste. Early life social isolation alters corticotropin-releasing factor responses in adult rats. Neuroscience. vol 158. issue 2. 2009-04-15. PMID:19010398. |
in contrast, infusion of 500 ng crf into the drn transiently increased 5-ht release in the nac of both group-reared and isolated animals with isolated animals showing a more prolonged serotonergic response. |
2009-04-15 |
2023-08-12 |
rat |
| M S Rahman, P Thoma. Molecular cloning, characterization and expression of two tryptophan hydroxylase (TPH-1 and TPH-2) genes in the hypothalamus of Atlantic croaker: down-regulation after chronic exposure to hypoxia. Neuroscience. vol 158. issue 2. 2009-04-15. PMID:19015006. |
as a first step in understanding the molecular responses of the hypothalamic serotonergic system to hypoxia, we cloned and characterized the genes for the enzymes regulating the rate-limiting step in serotonin biosynthesis, tryptophan hydroxylase (tph-1 and tph-2) in the croaker brain. |
2009-04-15 |
2023-08-12 |
Not clear |
| Caitlin A Jones, Andrew C McCrear. Serotonergic approaches in the development of novel antipsychotics. Neuropharmacology. vol 55. issue 6. 2009-04-14. PMID:18621404. |
the main scope of this review will evaluate the major preclinical and clinical pharmacological findings concerning the aforementioned strategies and pharmacological agents, and compare their therapeutic potential with currently available antipsychotics; however, recent developments at other emerging serotonergic targets such as 5-ht(2c), 5-ht(6) and 5-ht(7) receptors will also be considered. |
2009-04-14 |
2023-08-12 |
Not clear |
| Dennis L Murphy, Meredith A Fox, Kiara R Timpano, Pablo R Moya, Renee Ren-Patterson, Anne M Andrews, Andrew Holmes, Klaus-Peter Lesch, Jens R Wendlan. How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems. Neuropharmacology. vol 55. issue 6. 2009-04-14. PMID:18824000. |
these include examples of the consequences that result from direct serotonergic gene manipulation (gene deletion or overexpression) in mice and other species; an evaluation of some phenotypes related to functional human serotonergic gene variants, particularly in slc6a4, the serotonin transporter gene; and finally, a consideration of the pharmacogenomics of serotonergic drugs with respect to both their therapeutic actions and side effects. |
2009-04-14 |
2023-08-12 |
mouse |
| Lars Wöckel, Florian Daniel Zepf, Sabrina Koch, Anikó-Eva Meyer-Keitel, Martin H Schmid. Serotonin-induced decrease of intracellular Ca(2+) release in platelets of bulimic patients normalizes during treatment. Journal of neural transmission (Vienna, Austria : 1996). vol 116. issue 1. 2009-04-13. PMID:19082524. |
numerous symptoms related to eating disorders have been shown to be influenced by serotonergic (5-ht) functioning, with the 5-ht(2a) receptor subtype being one of the most relevant involved in the pathophysiology of bulimia nervosa (bn). |
2009-04-13 |
2023-08-12 |
Not clear |
| Jesper T Andreasen, John P Redrob. Nicotine, but not mecamylamine, enhances antidepressant-like effects of citalopram and reboxetine in the mouse forced swim and tail suspension tests. Behavioural brain research. vol 197. issue 1. 2009-04-10. PMID:18786574. |
nicotine increases serotonergic and noradrenergic neuronal activity and facilitates serotonin and noradrenaline release. |
2009-04-10 |
2023-08-12 |
mouse |
| Masami Nishikawa, Mirko Diksic, Yojiro Sakai, Hiroaki Kumano, Dara Charney, Jorge Palacios-Boix, Juan Negrete, Kathryn Gil. Alterations in brain serotonin synthesis in male alcoholics measured using positron emission tomography. Alcoholism, clinical and experimental research. vol 33. issue 2. 2009-04-10. PMID:18976348. |
a consistent association between low endogenous 5ht function and high alcohol preference has been observed, and a number of serotonergic manipulations (uptake blockers, agonists) alter alcohol consumption in animals and humans. |
2009-04-10 |
2023-08-12 |
Not clear |
| S Dracheva, N Patel, D A Woo, S M Marcus, L J Siever, V Haroutunia. Increased serotonin 2C receptor mRNA editing: a possible risk factor for suicide. Molecular psychiatry. vol 13. issue 11. 2009-04-08. PMID:17848916. |
because the vsv isoform of 5-ht 2c r exhibits low functional activity, an increase in its expression frequency may significantly influence the serotonergic regulation of the brain. |
2009-04-08 |
2023-08-12 |
human |
| Pan-Yue Deng, Saobo Le. Serotonin increases GABA release in rat entorhinal cortex by inhibiting interneuron TASK-3 K+ channels. Molecular and cellular neurosciences. vol 39. issue 2. 2009-04-08. PMID:18687403. |
whereas the entorhinal cortex (ec) receives profuse serotonergic innervations from the raphe nuclei in the brain stem and is critically involved in the generation of temporal lobe epilepsy, the function of serotonin (5-hydroxytryptamine, 5-ht) in the ec and particularly its roles in temporal lobe epilepsy are still elusive. |
2009-04-08 |
2023-08-12 |
rat |
| Shannon Pearce, Nasiva Ahned, Grace M Vara. A case study of delayed serotonin syndrome: lessons learned. The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists. vol 24. issue 1. 2009-04-07. PMID:19275460. |
though serotonin syndrome is most often associated with ingestion of more than one serotonergic drug, many other mechanisms have been associated with serotonergic excess. |
2009-04-07 |
2023-08-12 |
Not clear |
| Kristina Annerbrink, Marie Olsson, Lydia K Melchior, Jan Hedner, Elias Eriksso. Serotonin depletion increases respiratory variability in freely moving rats: implications for panic disorder. The international journal of neuropsychopharmacology. vol 6. issue 1. 2009-04-06. PMID:12899736. |
to elucidate if serotonergic transmission affects respiratory variability, a parameter consistently found increased in patients with panic disorder, we studied the effect of a serotonin synthesis inhibitor, para-chlorophenylalanine (pcpa), on respiratory variability at baseline and during co2-induced hyperventilation in awake and unrestrained rats. |
2009-04-06 |
2023-08-12 |
rat |
| L Clark, J P Roiser, T W Robbins, B J Sahakia. Disrupted 'reflection' impulsivity in cannabis users but not current or former ecstasy users. Journal of psychopharmacology (Oxford, England). vol 23. issue 1. 2009-04-03. PMID:18515464. |
evidence for serotonin involvement in impulsivity has generated interest in the measurement of impulsivity in regular ecstasy users, who are thought to display serotonergic dysfunction. |
2009-04-03 |
2023-08-12 |
human |