| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seong Su Kang, Eun Hee Ahn, Xia Liu, Matthew Bryson, Gary W Miller, David Weinshenker, Keqiang Y. ApoE4 inhibition of VMAT2 in the locus coeruleus exacerbates Tau pathology in Alzheimer's disease. Acta neuropathologica. vol 142. issue 1. 2021-10-19. PMID:33895869. |
pretangle tau in the noradrenergic locus coeruleus (lc) is the earliest detectable ad-like pathology in the human brain. |
2021-10-19 |
2023-08-13 |
human |
| Jan Willem de Gee, Camile M C Correa, Matthew Weaver, Tobias H Donner, Simon van Gaa. Pupil Dilation and the Slow Wave ERP Reflect Surprise about Choice Outcome Resulting from Intrinsic Variability in Decision Confidence. Cerebral cortex (New York, N.Y. : 1991). vol 31. issue 7. 2021-10-15. PMID:33822917. |
such a learning signal might be encoded and broadcasted by the brain's arousal systems, including the noradrenergic locus coeruleus. |
2021-10-15 |
2023-08-13 |
human |
| Benjamin Huynh, Yuhong Fu, Deniz Kirik, James M Shine, Glenda M Hallida. Comparison of Locus Coeruleus Pathology with Nigral and Forebrain Pathology in Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. vol 36. issue 9. 2021-10-13. PMID:33899954. |
pathology in the noradrenergic a6 locus coeruleus has not been compared with more rostral dopaminergic a9 substantia nigra and a10 ventral tegmental area, and cholinergic ch4 basal nucleus and ch1/2 septal regions in the same cases of parkinson's disease (pd). |
2021-10-13 |
2023-08-13 |
Not clear |
| Shankar Tumati, Martin P Paulus, Georg Northof. Out-of-step: brain-heart desynchronization in anxiety disorders. Molecular psychiatry. vol 26. issue 6. 2021-10-11. PMID:33504952. |
biochemically, cardiac afferents reach subcortical serotonergic raphe nuclei and noradrenergic locus coeruleus (among others) which, in turn, are known to reciprocally modulate the dmn and smn/sn on the cortical level. |
2021-10-11 |
2023-08-13 |
Not clear |
| Mehmet Bülbül, Osman Sinen, Onur Bayramoğl. Central neuropeptide-S administration alleviates stress-induced impairment of gastric motor functions through orexin-A. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology. vol 31. issue 1. 2021-10-07. PMID:32009616. |
the novel brain peptide neuropeptide-s (nps) is produced exclusively by a small group of cells adjacent to the noradrenergic locus coeruleus. |
2021-10-07 |
2023-08-13 |
Not clear |
| Nathan W Burnham, Corryn N Chaimowitz, Cortland C Vis, Ana Paula Segantine Dornellas, Montserrat Navarro, Todd E Thiel. Lateral hypothalamus-projecting noradrenergic locus coeruleus pathway modulates binge-like ethanol drinking in male and female TH-ires-cre mice. Neuropharmacology. vol 196. 2021-10-01. PMID:34246685. |
lateral hypothalamus-projecting noradrenergic locus coeruleus pathway modulates binge-like ethanol drinking in male and female th-ires-cre mice. |
2021-10-01 |
2023-08-13 |
mouse |
| William M Vanderheyden, Michaela Kehoe, Giancarlo Vanini, Steven L Britton, Lauren Gerard Koc. Rat models for low and high adaptive response to exercise differ for stress-related memory and anxiety. Physiological reports. vol 9. issue 4. 2021-09-29. PMID:33619911. |
exercise sensitivity plays a significant role in the activation of the plasticity-associated molecule extracellular signal-regulated kinase, changes in stress hormone activity, and anatomical modifications to the noradrenergic locus coeruleus. |
2021-09-29 |
2023-08-13 |
human |
| Samuel Deurveilher, Michael Antonchuk, Brock St C Saumure, Andrew Baldin, Kazue Semb. No loss of orexin/hypocretin, melanin-concentrating hormone or locus coeruleus noradrenergic neurons in a rat model of chronic sleep restriction. The European journal of neuroscience. vol 54. issue 6. 2021-09-24. PMID:34355453. |
several studies using mice reported substantial losses of wake-active orexin/hypocretin and locus coeruleus (lc) noradrenergic neurons, but not rapid eye movement sleep-active melanin-concentrating hormone (mch) neurons, following csr. |
2021-09-24 |
2023-08-13 |
mouse |
| Sawa Horie, Emi Kiyokage, Shuichi Hayashi, Kanako Inoue, Jaerin Sohn, Hiroyuki Hioki, Takahiro Furuta, Kazunori Toid. Structural basis for noradrenergic regulation of neural circuits in the mouse olfactory bulb. The Journal of comparative neurology. vol 529. issue 9. 2021-09-23. PMID:33616936. |
in this study, we analyzed the centrifugal noradrenergic (na) fibers derived from the locus coeruleus (lc), because their projection pathways and synaptic connections in the ob have not been clarified in detail. |
2021-09-23 |
2023-08-13 |
mouse |
| Dmitrii E Korzhevskii, Olga V Kirik, Valeriia V Guselnikova, Darya L Tsyba, Elena A Fedorova, Igor P Grigore. Changes in cytoplasmic and extracellular neuromelanin in human substantia nigra with normal aging. European journal of histochemistry : EJH. vol 65. issue s1. 2021-09-23. PMID:34468106. |
it is present in various areas of the human brain, most often in the substantia nigra (sn) pars compacta and the locus coeruleus, the main centers of dopaminergic and noradrenergic innervation, respectively. |
2021-09-23 |
2023-08-13 |
human |
| Mauro Congiu, Laura Micheli, Michele Santoni, Claudia Sagheddu, Anna Lisa Muntoni, Alexandros Makriyannis, Michael S Malamas, Carla Ghelardini, Lorenzo Di Cesare Mannelli, Marco Pisti. N-Acylethanolamine Acid Amidase Inhibition Potentiates Morphine Analgesia and Delays the Development of Tolerance. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2021-09-23. PMID:34553321. |
we tested this hypothesis by measuring the pain threshold to noxious mechanical stimuli and, as a neural correlate, we conducted in vivo electrophysiological recordings from pain-sensitive locus coeruleus (lc) noradrenergic neurons in anesthetized rats. |
2021-09-23 |
2023-08-13 |
rat |
| Filippo Sean Giorgi, Alessandro Galgani, Stefano Puglisi-Allegra, Fiona Limanaqi, Carla Letizia Busceti, Francesco Forna. Locus Coeruleus and neurovascular unit: From its role in physiology to its potential role in Alzheimer's disease pathogenesis. Journal of neuroscience research. vol 98. issue 12. 2021-09-17. PMID:32875628. |
locus coeruleus (lc) is the main noradrenergic (na) nucleus of the central nervous system. |
2021-09-17 |
2023-08-13 |
Not clear |
| Seiichiro Amemiya, Maina Ishida, Natsuko Kubota, Takeshi Nishijima, Ichiro Kit. Stress drives deliberative tendencies by influencing vicarious trial and error in decision making. Neurobiology of learning and memory. vol 174. 2021-09-15. PMID:32693161. |
in addition, stress activated serotonergic and noradrenergic neurons in the dorsal raphe nucleus and locus coeruleus, which are modulators of impulsivity and attentional control in decision making. |
2021-09-15 |
2023-08-13 |
rat |
| Andrew K Evans, Heui Hye Park, Nay Lui Saw, Kratika Singhal, Gaku Ogawa, Ryan D Leib, Mehrdad Shamlo. Age-related neuroinflammation and pathology in the locus coeruleus and hippocampus: beta-adrenergic antagonists exacerbate impairment of learning and memory in aged mice. Neurobiology of aging. vol 106. 2021-09-14. PMID:34320462. |
the locus coeruleus (lc) provides the primary noradrenergic input to the forebrain and hippocampus, and may be vulnerable to degeneration and contribute to age-related cognitive decline and neuroinflammation. |
2021-09-14 |
2023-08-13 |
mouse |
| Xin Wang, Joan B Escobar, David Mendelowit. Sex Differences in the Hypothalamic Oxytocin Pathway to Locus Coeruleus and Augmented Attention with Chemogenetic Activation of Hypothalamic Oxytocin Neurons. International journal of molecular sciences. vol 22. issue 16. 2021-09-14. PMID:34445224. |
the tightly localized noradrenergic neurons (na) in the locus coeruleus (lc) are well recognized as essential for focused arousal and novelty-oriented responses, while many children with autism spectrum disorder (asd) exhibit diminished attention, engagement and orienting to exogenous stimuli. |
2021-09-14 |
2023-08-13 |
human |
| Joost M Riphagen, Maxime van Egroo, Heidi I L Jacob. Elevated Norepinephrine Metabolism Gauges Alzheimer's Disease-Related Pathology and Memory Decline. Journal of Alzheimer's disease : JAD. vol 80. issue 2. 2021-09-13. PMID:33554915. |
the noradrenergic (ne) locus coeruleus (lc) is vulnerable to hyperphosphorylated tau, and dysregulated ne-metabolism is linked to greater tau and disease progression. |
2021-09-13 |
2023-08-13 |
human |
| Stephanie L Foster, Ewa Galaj, Saumya L Karne, Sergi Ferré, David Weinshenke. Cell-type specific expression and behavioral impact of galanin and GalR1 in the locus coeruleus during opioid withdrawal. Addiction biology. vol 26. issue 5. 2021-09-10. PMID:33768673. |
the neuropeptide galanin is reported to attenuate opioid withdrawal symptoms, potentially by reducing neuronal hyperactivity in the noradrenergic locus coeruleus (lc) via galanin receptor 1 (galr1). |
2021-09-10 |
2023-08-13 |
mouse |
| Rola A Bekdas. The Cholinergic System, the Adrenergic System and the Neuropathology of Alzheimer's Disease. International journal of molecular sciences. vol 22. issue 3. 2021-09-08. PMID:33525357. |
the locus coeruleus norepinephrine (lc-ne) is the main noradrenergic nucleus that projects and supplies norepinephrine to different brain regions. |
2021-09-08 |
2023-08-13 |
Not clear |
| Filippo Sean Giorgi, Luigi Francesco Saccaro, Carla Letizia Busceti, Francesca Biagioni, Francesco Forna. Epilepsy and Alzheimer's Disease: Potential mechanisms for an association. Brain research bulletin. vol 160. 2021-08-31. PMID:32380189. |
these include, for instance, gabaergic and glutamatergic alterations, aβ and tau protein, the role of the noradrenergic nucleus locus coeruleus, and neuroinflammation. |
2021-08-31 |
2023-08-13 |
human |
| Robert P Ganley, Kira Werder, Hendrik Wildner, Hanns Ulrich Zeilhofe. Spinally projecting noradrenergic neurons of the locus coeruleus display resistance to AAV2retro-mediated transduction. Molecular pain. vol 17. 2021-08-14. PMID:34344259. |
spinally projecting noradrenergic neurons of the locus coeruleus display resistance to aav2retro-mediated transduction. |
2021-08-14 |
2023-08-13 |
Not clear |