| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yushan Jiang, Ying Liu, Mingqing Gao, Meilan Xue, Zilong Wang, Hui Lian. Nicotinamide riboside alleviates alcohol-induced depression-like behaviours in C57BL/6J mice by altering the intestinal microbiota associated with microglial activation and BDNF expression. Food & function. vol 11. issue 1. 2020-10-07. PMID:31820774. |
in addition, nr decreased the number of activated microglia in the hippocampus, and it reduced the levels of pro-inflammatory (il-1β, il-6, and tnf-α) and anti-inflammatory (il-10 and tgf-β) cytokines in the brain of mice with alcohol-induced depression. |
2020-10-07 |
2023-08-13 |
mouse |
| Jiayi Zhao, Wei Bi, Shu Xiao, Xin Lan, Xiaofeng Cheng, Jiawei Zhang, Daxiang Lu, Wei Wei, Yanping Wang, Hongmei Li, Yongmei Fu, Lihong Zh. Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice. Scientific reports. vol 9. issue 1. 2020-10-06. PMID:30962497. |
we found that lps treatment leads to sickness behavior and cognitive impairment in mice as shown in the morris water maze and passive avoidance test, and these effects were accompanied by microglia activation (labeled by ionized calcium binding adaptor molecule-1, iba-1) and neuronal cell loss (labeled by microtubule-associated protein 2, map-2) in the hippocampus. |
2020-10-06 |
2023-08-13 |
mouse |
| Lulu Zhang, Hongbo Zheng, Rengrong Wu, Thomas R Kosten, Xiang-Yang Zhang, Jingping Zha. The effect of minocycline on amelioration of cognitive deficits and pro-inflammatory cytokines levels in patients with schizophrenia. Schizophrenia research. vol 212. 2020-10-05. PMID:31416745. |
the microglia inhibitor minocycline might arrest this cytokine damage to the hippocampus and reverse the cognitive deficits of schizophrenia. |
2020-10-05 |
2023-08-13 |
Not clear |
| Alexandre Vallée, Yves Lecarpentie. Alzheimer Disease: Crosstalk between the Canonical Wnt/Beta-Catenin Pathway and PPARs Alpha and Gamma. Frontiers in neuroscience. vol 10. 2020-10-01. PMID:27807401. |
although ppar gamma is upregulated in ad patients, and despite the fact that it has been shown that the ppar gamma and wnt/beta catenin pathway systems work in an opposite manner, ppar gamma agonists diminish learning and memory deficits, decrease abeta activation of microglia, and prevent hippocampal and cortical neurons from dying. |
2020-10-01 |
2023-08-13 |
mouse |
| Yi-Lu Ye, Kai Zhong, Dan-Dan Liu, Jing Xu, Bei-Bei Pan, Xiang Li, Yue-Ping Yu, Qi Zhan. Huanglian-Jie-Du-Tang Extract Ameliorates Depression-Like Behaviors through BDNF-TrkB-CREB Pathway in Rats with Chronic Unpredictable Stress. Evidence-based complementary and alternative medicine : eCAM. vol 2017. 2020-10-01. PMID:28694833. |
also hjdt decreased the number of microglia and the proinflammatory cytokines in hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Dongliang Li, Lingling Liu, Liang Li, Xingang Li, Bin Huang, Changqing Zhou, Zhaohang Zhang, Chunling Wang, Ping Dong, Xiyan Zhang, Bo Yang, Li Zhan. Sevoflurane Induces Exaggerated and Persistent Cognitive Decline in a Type II Diabetic Rat Model by Aggregating Hippocampal Inflammation. Frontiers in pharmacology. vol 8. 2020-10-01. PMID:29238302. |
molecular studies revealed that the levels of pro-inflammatory cytokines and activated microglia in the hippocampus were higher in gk control rats than those in wistar control rats at both time points and were further increased in gk rats receiving sevoflurane. |
2020-10-01 |
2023-08-13 |
rat |
| Deepti Chugh, Christine T Ekdah. Interactions Between Microglia and Newly Formed Hippocampal Neurons in Physiological and Seizure-Induced Inflammatory Environment. Brain plasticity (Amsterdam, Netherlands). vol 1. issue 2. 2020-10-01. PMID:29765843. |
interactions between microglia and newly formed hippocampal neurons in physiological and seizure-induced inflammatory environment. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jennifer Stefani, Olga Tschesnokowa, Marta Parrilla, Bernard Robaye, Jean-Marie Boeynaems, Amparo Acker-Palmer, Herbert Zimmermann, Kristine Gamp. Disruption of the Microglial ADP Receptor P2Y Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:29867367. |
microglia is intimately associated with neural progenitor cells in the hippocampal dg and has been implicated, under varying experimental conditions, in the control of the proliferation, differentiation and survival of neural precursor cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Chuwen Li, Tongkai Chen, Hefeng Zhou, Yu Feng, Maggie P M Hoi, Dan Ma, Chao Zhao, Ying Zheng, Simon M Y Le. BHDPC Is a Novel Neuroprotectant That Provides Anti-neuroinflammatory and Neuroprotective Effects by Inactivating NF-κB and Activating PKA/CREB. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:29988625. |
furthermore, bhdpc provided protective actions against neuroinflammation-induced neurotoxicity in ht22 mouse hippocampal cells co-cultured with activated bv-2 microglia. |
2020-10-01 |
2023-08-13 |
mouse |
| Lijuan Zhang, Jinqiang Zhang, Zili Yo. Switching of the Microglial Activation Phenotype Is a Possible Treatment for Depression Disorder. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:30459555. |
however, postmortem and animal studies have shown that overactivated microglia can inhibit neurogenesis in the hippocampus and induce depressive-like behaviors. |
2020-10-01 |
2023-08-13 |
Not clear |
| Wei Wang, Rui Wang, Jingjing Xu, Xiaqing Qin, Hong Jiang, Arslan Khalid, Dexiang Liu, Fang Pan, Cyrus S H Ho, Roger C M H. Minocycline Attenuates Stress-Induced Behavioral Changes via Its Anti-inflammatory Effects in an Animal Model of Post-traumatic Stress Disorder. Frontiers in psychiatry. vol 9. 2020-10-01. PMID:30459654. |
the effects of minocycline on pro-inflammatory cytokines, activation of microglia, and nf-κb in the pfc and hippocampus were also examined. |
2020-10-01 |
2023-08-13 |
rat |
| Wei Wang, Rui Wang, Jingjing Xu, Xiaqing Qin, Hong Jiang, Arslan Khalid, Dexiang Liu, Fang Pan, Cyrus S H Ho, Roger C M H. Minocycline Attenuates Stress-Induced Behavioral Changes via Its Anti-inflammatory Effects in an Animal Model of Post-traumatic Stress Disorder. Frontiers in psychiatry. vol 9. 2020-10-01. PMID:30459654. |
taken together, our results suggest that the anxiolytic effect of minocycline is related to its ability to decrease the levels of pro-inflammatory cytokines and inhibit activation of microglia and nf-κb in the pfc and hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Juan Bu, Shen Shi, Hui-Qin Wang, Xiao-Shan Niu, Zong-Feng Zhao, Wei-Dong Wu, Xiao-Ling Zhang, Zhi Ma, Yan-Jun Zhang, Hui Zhang, Yi Zh. Acacetin protects against cerebral ischemia-reperfusion injury Neural regeneration research. vol 14. issue 4. 2020-10-01. PMID:30632500. |
to understand the effect of acacetin on microglia-mediated inflammatory response after cerebral ischemia-reperfusion injury, immunohistochemistry for the microglia marker calcium adapter protein ionized calcium-binding adaptor molecule 1 (iba1) was examined in the hippocampus of ischemic brain tissue. |
2020-10-01 |
2023-08-13 |
mouse |
| Michele Malaguarnera, Marta Llansola, Tiziano Balzano, Belén Gómez-Giménez, Carles Antúnez-Muñoz, Núria Martínez-Alarcón, Rahebeh Mahdinia, Vicente Felip. Bicuculline Reduces Neuroinflammation in Hippocampus and Improves Spatial Learning and Anxiety in Hyperammonemic Rats. Role of Glutamate Receptors. Frontiers in pharmacology. vol 10. 2020-10-01. PMID:30858801. |
the effects of bicuculline on microglia and astrocyte activation, il-1β content, on membrane expression of ampa and nmda glutamate receptors subunits in the hippocampus and on spatial learning and memory as well as anxiety were assessed. |
2020-10-01 |
2023-08-13 |
rat |
| Michele Malaguarnera, Marta Llansola, Tiziano Balzano, Belén Gómez-Giménez, Carles Antúnez-Muñoz, Núria Martínez-Alarcón, Rahebeh Mahdinia, Vicente Felip. Bicuculline Reduces Neuroinflammation in Hippocampus and Improves Spatial Learning and Anxiety in Hyperammonemic Rats. Role of Glutamate Receptors. Frontiers in pharmacology. vol 10. 2020-10-01. PMID:30858801. |
treatment with bicuculline reduces astrocyte activation and il-1β but not microglia activation in the hippocampus of hyperammonemic rats. |
2020-10-01 |
2023-08-13 |
rat |
| Noelia Rodríguez-Iglesias, Amanda Sierra, Jorge Valer. Rewiring of Memory Circuits: Connecting Adult Newborn Neurons With the Help of Microglia. Frontiers in cell and developmental biology. vol 7. 2020-10-01. PMID:30891446. |
herein we will focus on microglia, the resident immune cells of the cns, which modulate the production of new neurons in the adult hippocampus and are also well suited to participate in their circuit integration. |
2020-10-01 |
2023-08-13 |
Not clear |
| Noelia Rodríguez-Iglesias, Amanda Sierra, Jorge Valer. Rewiring of Memory Circuits: Connecting Adult Newborn Neurons With the Help of Microglia. Frontiers in cell and developmental biology. vol 7. 2020-10-01. PMID:30891446. |
importantly, microglia are able to sense subtle changes in their environment and may use this information to differently modulate hippocampal wiring, ultimately impacting on memory function. |
2020-10-01 |
2023-08-13 |
Not clear |
| Noelia Rodríguez-Iglesias, Amanda Sierra, Jorge Valer. Rewiring of Memory Circuits: Connecting Adult Newborn Neurons With the Help of Microglia. Frontiers in cell and developmental biology. vol 7. 2020-10-01. PMID:30891446. |
deciphering the role of microglia in hippocampal circuitry constant rewiring will help to better understand the influence of microglia on memory function. |
2020-10-01 |
2023-08-13 |
Not clear |
| Xianliang Zhang, Qiang He, Tao Huang, Na Zhao, Fei Liang, Bo Xu, Xianghe Chen, Tuojian Li, Jianzhong B. Treadmill Exercise Decreases Aβ Deposition and Counteracts Cognitive Decline in APP/PS1 Mice, Possibly Frontiers in aging neuroscience. vol 11. 2020-10-01. PMID:31024293. |
treadmill exercise significantly inhibited neuroinflammation, which was characterized by a remarkably reduced expression of pro-inflammatory factors and increased expression of anti-inflammatory mediators in the hippocampus, resulting from a shift in activated microglia from the m1 to m2 phenotype. |
2020-10-01 |
2023-08-13 |
mouse |
| Huaiqing Luo, Yang Xiang, Xiangping Qu, Huijun Liu, Chi Liu, Guangyi Li, Li Han, Xiaoqun Qi. Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer's Disease Through Activation of BDNF-TrkB Signaling Pathway. Frontiers in pharmacology. vol 10. 2020-10-01. PMID:31040784. |
moreover, apelin-13 inhibited microglia and astrocyte activation, reduced il-1β and tnf-α expression and hippocampal bdnf/trkb expression deficit in ad rats. |
2020-10-01 |
2023-08-13 |
rat |