| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jixiang Wang, Baijuan Yue, Xuhua Zhang, Xin Guo, Zilong Sun, Ruiyan Ni. Effect of exercise on microglial activation and transcriptome of hippocampus in fluorosis mice. The Science of the total environment. vol 760. 2021-01-19. PMID:33172640. |
in conclusion, these results indicate that treadmill running inhibits the excessive activation of microglia in hippocampus of the fluoride-toxic mice, accompanied with the alteration of neuroactive ligand-receptor interaction pathway. |
2021-01-19 |
2023-08-13 |
mouse |
| Rui Guo, Wei-Shuai Qin, Shuang-Yong Zhang, Shu-Ling Zhan. [Effects of modified Xiaoyao San on TLR4/NF-κB pathway in hippocampal microglia of LPS-induced depression model rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 36. issue 4. 2021-01-18. PMID:33167098. |
[effects of modified xiaoyao san on tlr4/nf-κb pathway in hippocampal microglia of lps-induced depression model rats]. |
2021-01-18 |
2023-08-13 |
rat |
| Rui Guo, Wei-Shuai Qin, Shuang-Yong Zhang, Shu-Ling Zhan. [Effects of modified Xiaoyao San on TLR4/NF-κB pathway in hippocampal microglia of LPS-induced depression model rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 36. issue 4. 2021-01-18. PMID:33167098. |
to investigate the effects of modified xiaoyao san on tlr4/nf-κb pathway in hippocampal microglia of lps-induced depression model rats, and to explore its antidepressant mechanism. |
2021-01-18 |
2023-08-13 |
rat |
| YunLei Wang, YuGe Zhang, WenZhu Wang, Xu Liu, YaFei Chi, JianFeng Lei, BaoGui Zhang, Tong Zhan. Effects of circadian rhythm disorder on the hippocampus of SHR and WKY rats. Neurobiology of learning and memory. vol 168. 2021-01-13. PMID:31857218. |
crd and hypertension decreased fractional anisotropy values, the number of neurons and astrocytes in the hippocampus, and the expression of brain-derived neurotrophic factor and synapsin 1; it also enhanced the degeneration of neurons and microglia and reduced blood flow in the hippocampus, and increased nuclear factor κb, caspase, neuron-specific enolase, and interleukin-6 levels. |
2021-01-13 |
2023-08-13 |
rat |
| Alexander Levit, Sonny Cheng, Olivia Hough, Qingfan Liu, Yuksel Agca, Cansu Agca, Vladimir Hachinski, Shawn N Whitehea. Hypertension and Pathogenic hAPP Independently Induce White Matter Astrocytosis and Cognitive Impairment in the Rat. Frontiers in aging neuroscience. vol 12. 2021-01-10. PMID:32351378. |
angiotensin ii infusion did not affect activation of microglia, which were elevated in the white matter and hippocampus of transgenic rats. |
2021-01-10 |
2023-08-13 |
human |
| Kanako Nozaki, Hikaru Ito, Masahiro Ohgidani, Yosuke Yamawaki, Ezgi Hatice Sahin, Takashi Kitajima, Seishi Katsumata, Shigeto Yamawaki, Takahiro A Kato, Hidenori Aizaw. Antidepressant effect of the translocator protein antagonist ONO-2952 on mouse behaviors under chronic social defeat stress. Neuropharmacology. vol 162. 2021-01-06. PMID:31682855. |
in mice submitted to chronic social defeat stress, microglia predominantly expressed tspo in limbic areas implicated in depressive-like behaviors, including the amygdala, ventral hippocampus and nucleus accumbens, in which an increase in the production of pro-inflammatory cytokines in vivo were associated. |
2021-01-06 |
2023-08-13 |
mouse |
| Sarah M Smith, Erich Giedzinski, Maria C Angulo, Tiffany Lui, Celine Lu, Audrey L Park, Sharon Tang, Vahan Martirosian, Ning Ru, Nicole N Chmielewski, Yaxuan Liang, Janet E Baulch, Munjal M Acharya, Charles L Limol. Functional equivalence of stem cell and stem cell-derived extracellular vesicle transplantation to repair the irradiated brain. Stem cells translational medicine. vol 9. issue 1. 2021-01-04. PMID:31568685. |
these morphometric improvements were accompanied by increased levels of glial cell-derived growth factor and significant attenuation of radiation-induced increases in postsynaptic density protein 95 and activated microglia were found ipsi- and contra-lateral to the transplantation sites of the irradiated hippocampus treated with hnscs or hnsc-derived evs. |
2021-01-04 |
2023-08-13 |
human |
| Jing Su, Yi-Wei Pan, Si-Qi Wang, Xue-Zhen Li, Fang Huang, Shi-Ping M. Saikosaponin-d attenuated lipopolysaccharide-induced depressive-like behaviors via inhibiting microglia activation and neuroinflammation. International immunopharmacology. vol 80. 2021-01-04. PMID:31926446. |
furthermore, immunostaining results showed that ssd pretreatment inhibited lps-induced microglia activation in the hippocampus of mice and primary microglia cells. |
2021-01-04 |
2023-08-13 |
mouse |
| Weixu Luo, Yuanshan Han, Pan Meng, Qin Yang, Hongqing Zhao, Jia Ling, Yuhong Wan. Resatorvid Relieves Breast Cancer Complicated with Depression by Inactivating Hippocampal Microglia Through TLR4/NF-κB/NLRP3 Signaling Pathway. Cancer management and research. vol 12. 2020-12-31. PMID:33376394. |
resatorvid relieves breast cancer complicated with depression by inactivating hippocampal microglia through tlr4/nf-κb/nlrp3 signaling pathway. |
2020-12-31 |
2023-08-13 |
Not clear |
| Weixu Luo, Yuanshan Han, Pan Meng, Qin Yang, Hongqing Zhao, Jia Ling, Yuhong Wan. Resatorvid Relieves Breast Cancer Complicated with Depression by Inactivating Hippocampal Microglia Through TLR4/NF-κB/NLRP3 Signaling Pathway. Cancer management and research. vol 12. 2020-12-31. PMID:33376394. |
we aim to identify a new drug and identify its functional mechanism in the regulation of hippocampal microglia (mg) in breast cancer complicated with depression (bccd). |
2020-12-31 |
2023-08-13 |
Not clear |
| De-Huang Guo, Masaki Yamamoto, Caterina M Hernandez, Hesam Khodadadi, Babak Baban, Alexis M Stranaha. Visceral adipose NLRP3 impairs cognition in obesity via IL-1R1 on CX3CR1+ cells. The Journal of clinical investigation. vol 130. issue 4. 2020-12-30. PMID:31935195. |
flow cytometric and gene expression analyses revealed that vat transplantation recapitulated the effects of obesity on microglial activation and il-1β gene expression, and visualization of hippocampal microglia revealed similar effects in vivo. |
2020-12-30 |
2023-08-13 |
mouse |
| De-Huang Guo, Masaki Yamamoto, Caterina M Hernandez, Hesam Khodadadi, Babak Baban, Alexis M Stranaha. Visceral adipose NLRP3 impairs cognition in obesity via IL-1R1 on CX3CR1+ cells. The Journal of clinical investigation. vol 130. issue 4. 2020-12-30. PMID:31935195. |
inducible ablation of il-1r1 in cx3cr1-expressing cells eliminated cognitive impairment in mice with dietary obesity and in transplant recipients and restored immunoquiescence in hippocampal microglia. |
2020-12-30 |
2023-08-13 |
mouse |
| Yang Hao-Ran, Liu Li-Na, G E Fei, Yan Jing, Chen Qin-Lei, L U Wei-Ting, Qiao Fe. [Effect of Xiaoyao San on OVX combined with CUS anxiety and depression model rats based on hippocampal microglia M1 polarization]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 20. 2020-12-23. PMID:33350270. |
[effect of xiaoyao san on ovx combined with cus anxiety and depression model rats based on hippocampal microglia m1 polarization]. |
2020-12-23 |
2023-08-13 |
rat |
| Yang Hao-Ran, Liu Li-Na, G E Fei, Yan Jing, Chen Qin-Lei, L U Wei-Ting, Qiao Fe. [Effect of Xiaoyao San on OVX combined with CUS anxiety and depression model rats based on hippocampal microglia M1 polarization]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 20. 2020-12-23. PMID:33350270. |
the model of perimenopausal depression was established by ovx and cus; the level of anxiety and depression was evaluated by open field test; the levels of interleukin-1β(il-1β) and interleukin-6(il-6) mrna in rat hippocampus were detected by real-time qpcr; double staining immunofluorescence was used to detect the expression of ionized calcium binding adaptor molecule-1(iba-1) and inducible nitric oxide synthase(inos) in microglia of rat dentate gyrus(dg); western blot was used to detect the protein expression of iba-1 and inos of microglia in dg region of rat hippocampus. |
2020-12-23 |
2023-08-13 |
rat |
| Yang Hao-Ran, Liu Li-Na, G E Fei, Yan Jing, Chen Qin-Lei, L U Wei-Ting, Qiao Fe. [Effect of Xiaoyao San on OVX combined with CUS anxiety and depression model rats based on hippocampal microglia M1 polarization]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 20. 2020-12-23. PMID:33350270. |
the results showed that in the model group, the number of horizontal movement, the number of vertical movement and central residence time were significantly reduced, and the grooming time was significantly prolonged(p<0.05 or p<0.01); the levels of il-1β and il-6 in hippocampus increased significantly(p<0.05); the number of positive cells with co-expression of iba-1/inos of microglia cells in dg region of hippocampus increased; the expression levels of iba-1 and inos protein in hippocampus were significantly increased(p<0.01), suggesting that microglia in dg region of hippocampus was activated and polarized toward m1 type in rats with stress. |
2020-12-23 |
2023-08-13 |
rat |
| Yang Hao-Ran, Liu Li-Na, G E Fei, Yan Jing, Chen Qin-Lei, L U Wei-Ting, Qiao Fe. [Effect of Xiaoyao San on OVX combined with CUS anxiety and depression model rats based on hippocampal microglia M1 polarization]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 20. 2020-12-23. PMID:33350270. |
meanwhile, it reversed the activation and quantity change of microglia in hippocampus. |
2020-12-23 |
2023-08-13 |
rat |
| Yang Hao-Ran, Liu Li-Na, G E Fei, Yan Jing, Chen Qin-Lei, L U Wei-Ting, Qiao Fe. [Effect of Xiaoyao San on OVX combined with CUS anxiety and depression model rats based on hippocampal microglia M1 polarization]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 20. 2020-12-23. PMID:33350270. |
low dose xiaoyao san significantly decreased inos protein level(p<0.05), and high dose xiaoyao san significantly down-regulated the protein expression of iba-1 and inos in hippocampus microglia(p<0.05 or p<0.01). |
2020-12-23 |
2023-08-13 |
rat |
| Yang Hao-Ran, Liu Li-Na, G E Fei, Yan Jing, Chen Qin-Lei, L U Wei-Ting, Qiao Fe. [Effect of Xiaoyao San on OVX combined with CUS anxiety and depression model rats based on hippocampal microglia M1 polarization]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 20. 2020-12-23. PMID:33350270. |
in conclusion, xiaoyao san can improve anxiety and depression-like behavior in ovx combined with cus model rats, and its mechanism is related to its anti-inflammatory effect by inhibiting m1 polarization of hippocampal microglia. |
2020-12-23 |
2023-08-13 |
rat |
| Suman K Guha, Ishita Sarkar, Mandar Patgaonkar, Souvik Banerjee, Siuli Mukhopadhyay, Shobhona Sharma, Sulabha Pathak, Vidita A Vaidy. A history of juvenile mild malaria exacerbates chronic stress-evoked anxiety-like behavior, neuroinflammation, and decline of adult hippocampal neurogenesis in mice. Journal of neuroimmunology. vol 348. 2020-12-14. PMID:32919145. |
at baseline, a-h/jmal mice showed increased activated microglia within the hippocampal dentate gyrus subfield. |
2020-12-14 |
2023-08-13 |
mouse |
| Megan K Lowther, Jarrod P Tunnell, Jayme M Palka, Darlene R King, Damilola C Salako, Dimitri G Macris, Jay B Italiya, Justin L Grodin, Carol S North, E Sherwood Brow. Relationship between inflammatory biomarker galectin-3 and hippocampal volume in a community study. Journal of neuroimmunology. vol 348. 2020-12-14. PMID:32927397. |
galectin-3 (gal3) is expressed by microglia and performs functions including adhesion; activation of macrophages and fibroblasts, and mediates inflammatory responses in the hippocampus. |
2020-12-14 |
2023-08-13 |
human |