| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lulin Ma, Juan Li, Junli Zhou, Dexin Zhang, Zhi Xiao, Tian Yu, Ying Li, Song Ca. Intravenous lidocaine alleviates postherpetic neuralgia in rats via regulation of neuroinflammation of microglia and astrocytes. iScience. vol 24. issue 2. 2021-02-20. PMID:33604528. |
in addition, it reduced the activation of astrocyte but not microglia in pfc, acc, and hippocampus. |
2021-02-20 |
2023-08-13 |
rat |
| Lulin Ma, Juan Li, Junli Zhou, Dexin Zhang, Zhi Xiao, Tian Yu, Ying Li, Song Ca. Intravenous lidocaine alleviates postherpetic neuralgia in rats via regulation of neuroinflammation of microglia and astrocytes. iScience. vol 24. issue 2. 2021-02-20. PMID:33604528. |
intravenous lidocaine may relieve phn by inhibiting the activation of microglia and astrocyte in sdh or by reducing the neuroinflammation and astrocyte activation in pfc, acc, and hippocampus. |
2021-02-20 |
2023-08-13 |
rat |
| Shouhong Zhou, Shanshan Chen, Wenxia Xie, Xiaoxiao Guo, Jianfeng Zha. Microglia polarization of hippocampus is involved in the mechanism of Apelin-13 ameliorating chronic water immersion restraint stress-induced depression-like behavior in rats. Neuropeptides. vol 81. 2021-02-12. PMID:31932110. |
microglia polarization of hippocampus is involved in the mechanism of apelin-13 ameliorating chronic water immersion restraint stress-induced depression-like behavior in rats. |
2021-02-12 |
2023-08-13 |
rat |
| Shouhong Zhou, Shanshan Chen, Wenxia Xie, Xiaoxiao Guo, Jianfeng Zha. Microglia polarization of hippocampus is involved in the mechanism of Apelin-13 ameliorating chronic water immersion restraint stress-induced depression-like behavior in rats. Neuropeptides. vol 81. 2021-02-12. PMID:31932110. |
chronic stress induces the activation of hippocampal microglia, which produces many inflammatory mediators and mediates the occurrence of depression. |
2021-02-12 |
2023-08-13 |
rat |
| Shouhong Zhou, Shanshan Chen, Wenxia Xie, Xiaoxiao Guo, Jianfeng Zha. Microglia polarization of hippocampus is involved in the mechanism of Apelin-13 ameliorating chronic water immersion restraint stress-induced depression-like behavior in rats. Neuropeptides. vol 81. 2021-02-12. PMID:31932110. |
double-labelling immunofluorescence co-localization showed that, compared with the cwirs + saline group, cwirs + apelin-13 group significantly inhibited the co-localization expression of iba-1 and inos, and promoted the co-localization expression of iba-1 and arg1 in hippocampus microglia. |
2021-02-12 |
2023-08-13 |
rat |
| Yue Qu, Jun-Yan Wu, Qing Yua. [Effect of acupuncture on hippocampal inflammation in rats with intrauterine distress induced hypoxic-ischemic brain injury]. Zhen ci yan jiu = Acupuncture research. vol 46. issue 1. 2021-02-10. PMID:33559420. |
to observe the effects of acupuncture on the behavior, serum inflammatory cytokines, hippocampal nod-like receptor protein 3(nlrp3) inflammasome-related proteins and microglia activation in rats with intrauterine distress induced ischemia-hypoxic brain injury (hibd), so as to explore the mechanism of acupuncture underlying treatment of hibd by regulating hippocampal inflammation. |
2021-02-10 |
2023-08-13 |
rat |
| Tian Lin, Juan Du, Li Liu, Zheng Wu, Xiangkai Kong, Yu Liu, Yiling Ca. Treatment with Minocycline Suppresses Microglia Activation and Reverses Neural Stem Cells Loss after Simulated Microgravity. BioMed research international. vol 2020. 2021-02-09. PMID:32382569. |
the present study aimed to investigate the effect of microglia on simulated microgravity-induced hippocampal neurogenesis reduction and the possible mechanism underlying. |
2021-02-09 |
2023-08-13 |
rat |
| Tian Lin, Juan Du, Li Liu, Zheng Wu, Xiangkai Kong, Yu Liu, Yiling Ca. Treatment with Minocycline Suppresses Microglia Activation and Reverses Neural Stem Cells Loss after Simulated Microgravity. BioMed research international. vol 2020. 2021-02-09. PMID:32382569. |
additionally, liquid protein chip analysis was applied to detect proinflammatory factors in hippocampus in order to find out the cytokines responsible for microglia activation after microgravity. |
2021-02-09 |
2023-08-13 |
rat |
| Jing-Jing Du, Zhi-Qin Liu, Yue Yan, Jing Xiong, Xiao-Tao Jia, Zheng-Li Di, Jing-Jing Re. The Cannabinoid WIN 55,212-2 Reduces Delayed Neurologic Sequelae After Carbon Monoxide Poisoning by Promoting Microglial M2 Polarization Through ST2 Signaling. Journal of molecular neuroscience : MN. vol 70. issue 3. 2021-02-08. PMID:31732924. |
this behavioral improvement was accompanied by reduced neuron loss, decreased production of pro-inflammatory cytokines, and a limited number of microglia in the hippocampus. |
2021-02-08 |
2023-08-13 |
rat |
| Jing-Jing Du, Zhi-Qin Liu, Yue Yan, Jing Xiong, Xiao-Tao Jia, Zheng-Li Di, Jing-Jing Re. The Cannabinoid WIN 55,212-2 Reduces Delayed Neurologic Sequelae After Carbon Monoxide Poisoning by Promoting Microglial M2 Polarization Through ST2 Signaling. Journal of molecular neuroscience : MN. vol 70. issue 3. 2021-02-08. PMID:31732924. |
moreover, win 55,212-2 elevated the protein expression of il-33 (the ligand of st2) and st2, increased the ratio of cd206-positive (m2 phenotype) and st2-positive microglia, and augmented production of m2 microglia-associated cytokines in the hippocampus of co-exposed rats. |
2021-02-08 |
2023-08-13 |
rat |
| Yuchen Song, Haixia Yuan, Tianyi Chen, Manqi Lu, Shuang Lei, Xinmin Ha. An Shen Ding Zhi Ling Alleviates Symptoms of Attention Deficit Hyperactivity Disorder via Anti-Inflammatory Effects in Spontaneous Hypertensive Rats. Frontiers in pharmacology. vol 11. 2021-02-06. PMID:33536923. |
asdzl reduced the pro-inflammatory factors interleukin (il)-1β, il-4, il-6, tumor necrosis factor (tnf)-α and monocyte chemoattractant protein (mcp)-1 and increased anti-inflammatory factor il-10 in shrs, and decreased the activation of microglia, astrocytes and mast cells in the prefrontal cortex (pfc) and hippocampus. |
2021-02-06 |
2023-08-13 |
rat |
| Yu Takahashi, Hideaki Wakita, Kenmei Mizutani, Atsushi Watanabe, Shigeru Sonoda, Hidekazu Tomimot. Selective accumulation of adiponectin in the cerebral cortex under chronic cerebral hypoperfusion in the rat. Neuroreport. vol 31. issue 2. 2021-02-03. PMID:31855901. |
microglia are activated shortly after ischemia and correlate with the severity of white matter and hippocampal tissue damage. |
2021-02-03 |
2023-08-13 |
rat |
| Chuan He, Zhong-Sheng Huang, Hong-Ru Chen, Chao-Chao Yu, Xue-Song Wang, Tao Jiang, Li-Hong Kon. [Effect of pretreatment of acupuncture on learning-memory ability and related protein of NLRP3 inflammasome in hippocampus in Alzheimer's disease like rats]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 40. issue 12. 2021-02-01. PMID:33415876. |
to observe the effect of pretreatment of acupuncture on the expression of nucleotide-binding oligomerization domain-like receptor 3(nlrp3), caspase-1, interleukin1β(il-1β) and the number of activated microglia (mg) in the hippocampus in alzheimer's disease (ad) like rats, so as to explore the mechanism of pretreatment of acupuncture in preventing and treating ad. |
2021-02-01 |
2023-08-13 |
rat |
| Katherine R Giordano, Charlotte R Denman, Phoebe S Dubisch, Murtaza Akhter, Jonathan Lifshit. An update on the rod microglia variant in experimental and clinical brain injury and disease. Brain communications. vol 3. issue 1. 2021-01-30. PMID:33501429. |
rod microglia are most commonly observed in the cortex, aligned perpendicular to the dural surface and adjacent to neuronal processes; in the hippocampus, they are aligned perpendicular to hippocampal layers. |
2021-01-30 |
2023-08-13 |
Not clear |
| Yiying Zhou, Xiang Wu, Luying Ye, Yujing Bai, Hui Zhang, Zhenquan Xuan, Yi Feng, Panpan Zhang, Yi Chen, Yushan Yan, Binbin Zhu, Wei Cu. Edaravone at high concentrations attenuates cognitive dysfunctions induced by abdominal surgery under general anesthesia in aged mice. Metabolic brain disease. vol 35. issue 2. 2021-01-29. PMID:31916204. |
edaravone could also decrease glial fibrillary acidic protein (gfap) and ionized calcium binding adaptor molecule-1 (iba-1) positive areas in the hippocampal regions of surgery mice, suggesting that edaravone might inhibit surgery-induced over-activation of microglia and astrocytes. |
2021-01-29 |
2023-08-13 |
mouse |
| Yangmin Zhao, Yunxiao Gan, Gewei Xu, Guoli Yin, Dandan Li. MSCs-Derived Exosomes Attenuate Acute Brain Injury and Inhibit Microglial Inflammation by Reversing CysLT2R-ERK1/2 Mediated Microglia M1 Polarization. Neurochemical research. vol 45. issue 5. 2021-01-29. PMID:32112178. |
the production of pro-inflammatory factors decreased, while the anti-inflammatory cytokines and neurotrophic factors increased both in the cortex and hippocampus of ischemic hemisphere as well as in the culture supernatant of microglia treated with ogd and nmltc4. |
2021-01-29 |
2023-08-13 |
rat |
| Bruno Pinto, Giovanni Morelli, Mohit Rastogi, Annalisa Savardi, Amos Fumagalli, Andrea Petretto, Martina Bartolucci, Emilio Varea, Tiziano Catelani, Andrea Contestabile, Laura E Perlini, Laura Cancedd. Rescuing Over-activated Microglia Restores Cognitive Performance in Juvenile Animals of the Dp(16) Mouse Model of Down Syndrome. Neuron. vol 108. issue 5. 2021-01-27. PMID:33027640. |
in the hippocampus of the dp(16) mouse model of ds and ds individuals, we found activated microglia, as assessed by their morphology; activation markers; and, for ds mice, electrophysiological profile. |
2021-01-27 |
2023-08-13 |
mouse |
| Giorgi Lobzhanidze, Nadezhda Japaridze, Tamar Lordkipanidze, Fuad Rzayev, Derrick MacFabe, Mzia Zhvani. Behavioural and brain ultrastructural changes following the systemic administration of propionic acid in adolescent male rats. Further development of a rodent model of autism. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 80. issue 2. 2021-01-25. PMID:31997401. |
both transient and enduring ultrastructural alterations in synapses, astro- and microglia were detected in the ca1 hippocampal area. |
2021-01-25 |
2023-08-13 |
rat |
| John F Bowyer, Sumit Sarkar, Susan M Burks, Jade N Hess, Serena Tolani, James P O'Callaghan, Joseph P Hani. Microglial activation and responses to vasculature that result from an acute LPS exposure. Neurotoxicology. vol 77. 2021-01-22. PMID:32014511. |
at 24 h, almost all the microglia soma and proximal processes in the hippocampus, parietal cortex, and thalamus were closely associated with the vasculature and had increased almost 2.0-fold in size. |
2021-01-22 |
2023-08-13 |
mouse |
| Jixiang Wang, Baijuan Yue, Xuhua Zhang, Xin Guo, Zilong Sun, Ruiyan Ni. Effect of exercise on microglial activation and transcriptome of hippocampus in fluorosis mice. The Science of the total environment. vol 760. 2021-01-19. PMID:33172640. |
we discovered that the number of m1-type microglia in fluorosis-mice hippocampus was significantly increased when compared to group c; group f + e showed a decrease in the number of m1-type microglia with the comparison to group f. in addition, the hippocampal transcriptome analysis showed that 576 differential expression genes (deg) were confirmed in group f, compared to group c, and 670 deg were differently expressed in group f + e when compared to group f. gene ontology (go) analysis showed that changed genes were implicated in regulation of transcription, dna-templated, integral component of membrane and adenosine triphosphate (atp) binding. |
2021-01-19 |
2023-08-13 |
mouse |