| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Alini, Y Matsui, G R Dodge, A R Pool. The extracellular matrix of cartilage in the growth plate before and during calcification: changes in composition and degradation of type II collagen. Calcified tissue international. vol 50. issue 4. 1992-06-03. PMID:1571844. |
calcification occurs in the extracellular matrix of the hypertrophic zone of the growth plate when the extracellular matrix volume is reduced to a minimum and alkaline phosphatase content is maximal. |
1992-06-03 |
2023-08-11 |
cattle |
| M Alini, Y Matsui, G R Dodge, A R Pool. The extracellular matrix of cartilage in the growth plate before and during calcification: changes in composition and degradation of type II collagen. Calcified tissue international. vol 50. issue 4. 1992-06-03. PMID:1571844. |
the concentrations within the extracellular matrix of the c-propeptide of type ii collagen, aggregating proteoglycan (aggrecan), and hyaluronic acid all progressively increased in the maturing and hypertrophic zones, being maximal (or near maximal) at the time of initiation of mineralization. |
1992-06-03 |
2023-08-11 |
cattle |
| M Alini, Y Matsui, G R Dodge, A R Pool. The extracellular matrix of cartilage in the growth plate before and during calcification: changes in composition and degradation of type II collagen. Calcified tissue international. vol 50. issue 4. 1992-06-03. PMID:1571844. |
total collagen concentration (measured as hydroxyproline) in the extracellular matrix initially increased through the proliferating and maturing zones but then rapidly decreased in the hypertrophic zone. |
1992-06-03 |
2023-08-11 |
cattle |
| Q Chen, C Linsenmayer, H Gu, T M Schmid, T F Linsenmaye. Domains of type X collagen: alteration of cartilage matrix by fibril association and proteoglycan accumulation. The Journal of cell biology. vol 117. issue 3. 1992-06-02. PMID:1572897. |
the matrix of hypertrophic cartilage contains at least one tissue-specific component, type x collagen. |
1992-06-02 |
2023-08-11 |
Not clear |
| K Ishizeki, N Kuroda, T Naw. Morphological characteristics of the life cycle of resting cartilage cells in mouse rib investigated in intrasplenic isografts. Anatomy and embryology. vol 185. issue 5. 1992-05-21. PMID:1567018. |
in spite of the hypertrophic chondrocytes in the central zone being surrounded by an extensively calcified matrix during days 14-21 after transplantation, these cells had well-preserved organized organelles, except that golgi-associated elements and endoplasmic reticulum revealed a tendency toward degenerative changes. |
1992-05-21 |
2023-08-11 |
mouse |
| K Ishizeki, N Kuroda, T Naw. Morphological characteristics of the life cycle of resting cartilage cells in mouse rib investigated in intrasplenic isografts. Anatomy and embryology. vol 185. issue 5. 1992-05-21. PMID:1567018. |
with increased duration of the grafting period, from 30-60 days, the calcification zone progressed gradually, and the number of hypertrophic chondrocytes embedded in the calcified matrix decreased considerably. |
1992-05-21 |
2023-08-11 |
mouse |
| K Ishizeki, N Kuroda, T Naw. Morphological characteristics of the life cycle of resting cartilage cells in mouse rib investigated in intrasplenic isografts. Anatomy and embryology. vol 185. issue 5. 1992-05-21. PMID:1567018. |
during the present study, we observed no vascular invasion into the calcified matrix, or appearance of bone-related cells, and the morphological changes from the resting chondrocytes to cellular hypertrophy accompanied by the formation of a calcified matrix were observed at day 60. |
1992-05-21 |
2023-08-11 |
mouse |
| B D Boyan, L D Swain, Z Schwartz, V Ramirez, D L Carne. Epithelial cell lines that induce bone formation in vivo produce alkaline phosphatase-enriched matrix vesicles in culture. Clinical orthopaedics and related research. issue 277. 1992-05-07. PMID:1555351. |
hypertrophic chondrocytes and osteoblasts produce alkaline phosphatase (alpase)-enriched matrix vesicles in vivo and in vitro and, along with certain epithelial cell lines and osteoblast precursors, induce bone when implanted in mesenchymal tissues. |
1992-05-07 |
2023-08-11 |
mouse |
| S Byers, B Caterson, J J Hopwood, B K Foste. Immunolocation analysis of glycosaminoglycans in the human growth plate. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 40. issue 2. 1992-04-27. PMID:1372629. |
also present in the extracellular matrix was an oversulfated chondroitin/dermatan sulfate glycosaminoglycan which appeared to be specific to the proliferative and hypertrophic zones of the growth plate. |
1992-04-27 |
2023-08-11 |
human |
| S Byers, B Caterson, J J Hopwood, B K Foste. Immunolocation analysis of glycosaminoglycans in the human growth plate. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 40. issue 2. 1992-04-27. PMID:1372629. |
these changes in matrix glycosaminoglycan content, both in the different zones and within zones, indicate constant subtle alterations in chondrocyte metabolic products as they proceed through their life cycle of proliferation, maturation, and hypertrophy. |
1992-04-27 |
2023-08-11 |
human |
| K D Brand. Transection of the anterior cruciate ligament in the dog: a model of osteoarthritis. Seminars in arthritis and rheumatism. vol 21. issue 3 Suppl 2. 1992-04-08. PMID:1796303. |
this report validates the cruciate-deficient dog as a model of progressive oa and emphasizes that, before full-thickness loss of articular cartilage, oa is marked by a phase of cartilage hypertrophy associated with a striking increase in synthesis of matrix macromolecules by the chondrocyte (compensatory repair). |
1992-04-08 |
2023-08-11 |
dog |
| R M Leach, G E Rosselo. The use of avian epiphyseal chondrocytes for in vitro studies of skeletal metabolism. The Journal of nutrition. vol 122. issue 3 Suppl. 1992-04-06. PMID:1542051. |
under the proper culture conditions, the chondrocytes will become confluent and achieve a hypertrophic morphology followed by mineralization of the extracellular matrix. |
1992-04-06 |
2023-08-11 |
Not clear |
| R Loeser, C S Carlson, H Tulli, W G Jerome, L Miller, R Walli. Articular-cartilage matrix gamma-carboxyglutamic acid-containing protein. Characterization and immunolocalization. The Biochemical journal. vol 282 ( Pt 1). 1992-03-31. PMID:1540125. |
in newborn articular cartilage mgp was present diffusely throughout the matrix, whereas in growth-plate cartilage it was seen mainly in late hypertrophic and calcifying-zone chondrocytes. |
1992-03-31 |
2023-08-11 |
human |
| F Matsumoto, Y Miyamoto, M Nagayam. Light- and electron-microscopic observations on the mandibular condylar cartilages in growing rats on a low-calcium diet. Acta anatomica. vol 142. issue 1. 1992-03-06. PMID:1781238. |
histological changes occurring in the mandibular condylar cartilages of the rats fed on a low-calcium diet were as follows: (1) narrow proliferative and mature cell zones and a wide hypertrophic cell zone, (2) inhibition of development of cell organelles in the mature chondrocytes, (3) decrease in dead cells in the proliferative zone, (4) decrease in glycogen accumulation in the chondrocytes and (5) inhibition of calcification in the extracellular matrix of the hypertrophic cell zone. |
1992-03-06 |
2023-08-11 |
rat |
| T M Schmid, D K Bonen, L Luchene, T F Linsenmaye. Late events in chondrocyte differentiation: hypertrophy, type X collagen synthesis and matrix calcification. In vivo (Athens, Greece). vol 5. issue 5. 1992-02-25. PMID:1768805. |
late events in chondrocyte differentiation: hypertrophy, type x collagen synthesis and matrix calcification. |
1992-02-25 |
2023-08-11 |
Not clear |
| T M Schmid, D K Bonen, L Luchene, T F Linsenmaye. Late events in chondrocyte differentiation: hypertrophy, type X collagen synthesis and matrix calcification. In vivo (Athens, Greece). vol 5. issue 5. 1992-02-25. PMID:1768805. |
during endochondral bone formation chondrocytes pass through several stages of differentiation which are characterized by cell proliferation, matrix synthesis and cell hypertrophy. |
1992-02-25 |
2023-08-11 |
Not clear |
| T M Schmid, D K Bonen, L Luchene, T F Linsenmaye. Late events in chondrocyte differentiation: hypertrophy, type X collagen synthesis and matrix calcification. In vivo (Athens, Greece). vol 5. issue 5. 1992-02-25. PMID:1768805. |
type x collagen is synthesized in vivo after chondrocytes have become hypertrophic, but before abundant mineral accumulates in the cartilage extracellular matrix. |
1992-02-25 |
2023-08-11 |
Not clear |
| A G Durmowicz, D B Badesch, W C Parks, R P Mecham, K R Stenmar. Hypoxia-induced inhibition of tropoelastin synthesis by neonatal calf pulmonary artery smooth muscle cells. American journal of respiratory cell and molecular biology. vol 5. issue 5. 1991-12-17. PMID:1718337. |
animals chronically exposed to hypoxia develop characteristic structural changes in the pulmonary arterial vasculature including cell hypertrophy, hyperplasia, and increased deposition of extracellular matrix proteins. |
1991-12-17 |
2023-08-11 |
cattle |
| J Chen, Q Zhang, C A McCulloch, J Sode. Immunohistochemical localization of bone sialoprotein in foetal porcine bone tissues: comparisons with secreted phosphoprotein 1 (SPP-1, osteopontin) and SPARC (osteonectin). The Histochemical journal. vol 23. issue 6. 1991-12-11. PMID:1938474. |
staining for bsp was observed in the matrix of mineralized bone and also in the mineralized cartilage and associated cells of the epiphysis, but was not observed in the hypertrophic zone nor in any of the soft tissues including the periosteum. |
1991-12-11 |
2023-08-11 |
Not clear |
| J S Haynes, J Gof. Distribution of type X collagen in tibiotarsi of broiler chickens with vitamin D deficiency. Calcified tissue international. vol 49. issue 3. 1991-12-03. PMID:1933585. |
type x collagen is a significant component of the extracellular matrix of the hypertrophic zone of physeal cartilage, but its precise role in endochondral ossification has not been determined. |
1991-12-03 |
2023-08-11 |
chicken |