| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Ghosh, D Burkhardt, R Read, C Bellenge. Recent advances in animal models for evaluating chondroprotective drugs. The Journal of rheumatology. Supplement. vol 27. 1991-06-12. PMID:2027116. |
morphological and biochemical studies of joint cartilage after 6 months revealed slowly progressive changes similar to those seen in early oa, characterized by cartilage fibrillation, chondrocyte hypertrophy, matrix proliferation and marginal osteophyte formation. |
1991-06-12 |
2023-08-11 |
human |
| S Ekman, H Rodriguez-Martine. Ultrastructural localization of alkaline phosphatase activity in the normal and osteochondrotic joint cartilage of growing pigs. Acta anatomica. vol 140. issue 1. 1991-06-10. PMID:2028727. |
intense ap activity was primarily present in the cytoplasm, the plasmalemmae, the long cellular processes and the matrix vesicles budding off from proliferative and hypertrophic chondrocytes in those areas of cartilage where normal calcification appeared. |
1991-06-10 |
2023-08-11 |
Not clear |
| S M Factor, J Butany, M J Sole, E D Wigle, W C Williams, M Rojkin. Pathologic fibrosis and matrix connective tissue in the subaortic myocardium of patients with hypertrophic cardiomyopathy. Journal of the American College of Cardiology. vol 17. issue 6. 1991-05-23. PMID:2016452. |
pathologic fibrosis and matrix connective tissue in the subaortic myocardium of patients with hypertrophic cardiomyopathy. |
1991-05-23 |
2023-08-11 |
Not clear |
| S M Factor, J Butany, M J Sole, E D Wigle, W C Williams, M Rojkin. Pathologic fibrosis and matrix connective tissue in the subaortic myocardium of patients with hypertrophic cardiomyopathy. Journal of the American College of Cardiology. vol 17. issue 6. 1991-05-23. PMID:2016452. |
to evaluate scar-type and matrix connective tissue and to assess their role in the diastolic dysfunction of hypertrophic cardiomyopathy, surgically resected subaortic myectomy specimens and several autopsy hearts from patients with hypertrophic cardiomyopathy were studied. |
1991-05-23 |
2023-08-11 |
Not clear |
| S M Factor, J Butany, M J Sole, E D Wigle, W C Williams, M Rojkin. Pathologic fibrosis and matrix connective tissue in the subaortic myocardium of patients with hypertrophic cardiomyopathy. Journal of the American College of Cardiology. vol 17. issue 6. 1991-05-23. PMID:2016452. |
thus, these studies revealed a striking increase of both scar-type and matrix connective tissue in hypertrophic cardiomyopathy. |
1991-05-23 |
2023-08-11 |
Not clear |
| T F Linsenmayer, Q A Chen, E Gibney, M K Gordon, J K Marchant, R Mayne, T M Schmi. Collagen types IX and X in the developing chick tibiotarsus: analyses of mRNAs and proteins. Development (Cambridge, England). vol 111. issue 1. 1991-05-17. PMID:2015794. |
type x collagen protein in the hypertrophic matrix also extends to the marrow cavity. |
1991-05-17 |
2023-08-11 |
chicken |
| T F Linsenmayer, Q A Chen, E Gibney, M K Gordon, J K Marchant, R Mayne, T M Schmi. Collagen types IX and X in the developing chick tibiotarsus: analyses of mRNAs and proteins. Development (Cambridge, England). vol 111. issue 1. 1991-05-17. PMID:2015794. |
type ix collagen is found throughout the hypertrophic matrix, as well as throughout the younger cartilaginous matrices. |
1991-05-17 |
2023-08-11 |
chicken |
| S Ekman, D Heinegård, O Johnell, H Rodriguez-Martine. Immunohistochemical localization of proteoglycans and non-collagenous matrix proteins in normal and osteochondrotic porcine articular-epiphyseal cartilage complex. Matrix (Stuttgart, Germany). vol 10. issue 6. 1991-05-10. PMID:2084518. |
some of the non-collagenous macromolecules (fibromodulin, large aggregating proteoglycans, fibronectin, 100-kda subunit protein and 148-kda protein) were conspicuously prominent within the osteochondrotic cartilage, compared to the matrix of the "normal" resting, proliferative and hypertrophic regions. |
1991-05-10 |
2023-08-11 |
Not clear |
| D M Visco, M A Hill, D C Van Sickle, S A Kincai. The development of centres of ossification of bones forming elbow joints in young swine. Journal of anatomy. vol 171. 1991-05-09. PMID:2081708. |
centres of ossification are initiated when foci of chondrocytes adjacent to one side of a cartilage canal undergo hypertrophy and the inter-territorial matrix becomes calcified. |
1991-05-09 |
2023-08-11 |
Not clear |
| T Ohira, K Ishikaw. Histochemical localization of calcium with potassium pyroantimonate in the articular tissues in calcium pyrophosphate dihydrate crystal deposition disease. Clinical orthopaedics and related research. issue 264. 1991-04-04. PMID:1705190. |
focal areas with deposition of cppd crystals in each tissue showed electron-dense precipitates of the antimony-calcium complex: (1) in the cytoplasm of hypertrophic chondrocytes around cppd crystals, especially on the margins of intracellular lipid droplets or within electron-dense amorphous material or both; and (2) on the margins of lipid droplets and within electron-dense amorphous material in the degenerated matrix surrounding the hypertrophic chondrocytes. |
1991-04-04 |
2023-08-11 |
Not clear |
| T Ohira, K Ishikaw. Histochemical localization of calcium with potassium pyroantimonate in the articular tissues in calcium pyrophosphate dihydrate crystal deposition disease. Clinical orthopaedics and related research. issue 264. 1991-04-04. PMID:1705190. |
these findings suggest that the hypertrophic chondrocytes may contribute to the formation of cppd crystals by intracellular accumulation of calcium and subsequent release of high concentration of calcium into their surrounding matrix. |
1991-04-04 |
2023-08-11 |
Not clear |
| M A Karim, A G Ferguson, B T Wakim, A M Samare. In vivo collagen turnover during development of thyroxine-induced left ventricular hypertrophy. The American journal of physiology. vol 260. issue 2 Pt 1. 1991-03-27. PMID:1825450. |
increased procollagen synthesis, enhanced flux of newly synthesized procollagens through intracellular degradative pathways, and extensive extracellular matrix remodeling without disproportionate collagen accumulation are characteristics of this form of "physiological" left ventricular hypertrophy. |
1991-03-27 |
2023-08-11 |
rat |
| I Masuda, K Ishikawa, G Usuk. A histologic and immunohistochemical study of calcium pyrophosphate dihydrate crystal deposition disease. Clinical orthopaedics and related research. issue 263. 1991-03-19. PMID:1993383. |
the articular cartilage, synovial membrane, and meniscus from ten patients who had calcium pyrophosphate dihydrate (cppd) crystal deposition disease showed strong immunoreactivity for dermatan sulfate proteoglycan, type i collagen, and s-100 protein in hypertrophic chondrocytes around the crystals, their pericellular matrix, and deposits of the crystals. |
1991-03-19 |
2023-08-11 |
Not clear |
| I Masuda, K Ishikawa, G Usuk. A histologic and immunohistochemical study of calcium pyrophosphate dihydrate crystal deposition disease. Clinical orthopaedics and related research. issue 263. 1991-03-19. PMID:1993383. |
electron microscopy revealed that small crystals were formed around the hypertrophic chondrocytes, especially in the degenerated matrix containing electron-dense granular materials and cellular debris. |
1991-03-19 |
2023-08-11 |
Not clear |
| L C Gerstenfeld, W J Landi. Gene expression and extracellular matrix ultrastructure of a mineralizing chondrocyte cell culture system. The Journal of cell biology. vol 112. issue 3. 1991-03-08. PMID:1991793. |
conditions were defined for promoting cell growth, hypertrophy, and extracellular matrix mineralization of a culture system derived from embryonic chick vertebral chondrocytes. |
1991-03-08 |
2023-08-11 |
chicken |
| F Contard, V Koteliansky, F Marotte, I Dubus, L Rappaport, J L Samue. Specific alterations in the distribution of extracellular matrix components within rat myocardium during the development of pressure overload. Laboratory investigation; a journal of technical methods and pathology. vol 64. issue 1. 1991-03-05. PMID:1824954. |
cardiac hypertrophy secondary to a sudden aortic pressure overload results in the remodeling of myocytes and extracellular matrix components. |
1991-03-05 |
2023-08-11 |
rat |
| F Contard, V Koteliansky, F Marotte, I Dubus, L Rappaport, J L Samue. Specific alterations in the distribution of extracellular matrix components within rat myocardium during the development of pressure overload. Laboratory investigation; a journal of technical methods and pathology. vol 64. issue 1. 1991-03-05. PMID:1824954. |
in conclusion, the three components of the extracellular matrix studied here develop a specific pattern of accumulation in response to a sudden pressure overload that induces cardiac hypertrophy. |
1991-03-05 |
2023-08-11 |
rat |
| M Iwamoto, A Shimazu, K Nakashima, F Suzuki, Y Kat. Reduction of basic fibroblasts growth factor receptor is coupled with terminal differentiation of chondrocytes. The Journal of biological chemistry. vol 266. issue 1. 1991-02-14. PMID:1845975. |
basic fibroblast growth factor (bfgf) stimulates proliferation of chondrocytes and their extracellular matrix synthesis but inhibits terminal differentiation to hypertrophic cells (kato, y., and iwamoto, m., (1990) j. biol. |
1991-02-14 |
2023-08-11 |
Not clear |
| R Stanescu, V Stanescu, P Maroteau. Homozygous achondroplasia: morphologic and biochemical study of cartilage. American journal of medical genetics. vol 37. issue 3. 1991-01-31. PMID:2260574. |
the matrix did not stain with safranin o and lacked metachromasia, except for pericellular rims around the hypertrophic cell clusters. |
1991-01-31 |
2023-08-11 |
Not clear |
| K Shimizu, T Hamamoto, T Hamakubo, W J Lee, K Suzuki, Y Nakagawa, T Murachi, T Yamamur. Immunohistochemical and biochemical demonstration of calcium-dependent cysteine proteinase (calpain) in calcifying cartilage of rats. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 9. issue 1. 1991-01-23. PMID:1984047. |
immunoperoxidase (peroxidase-antiperoxidase) staining of the frozen sections of the knee joint from 3-day-old and 6-day-old wistar rats, using polyclonal antibodies against the respective heavy subunits of calpains i and ii, showed positive staining only with the anti-calpain ii antibody in the hypertrophic chondrocytes and surrounding cartilaginous matrix of the growth cartilage. |
1991-01-23 |
2023-08-11 |
rat |