| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Junlong Li, Suixin Deng, Quansheng He, Wei Ke, Yousheng Sh. Asynchronous Glutamate Release at Autapses Regulates Spike Reliability and Precision in Mouse Neocortical Pyramidal Cells. Cerebral cortex (New York, N.Y. : 1991). vol 31. issue 4. 2021-09-16. PMID:33279969. |
thus, glutamatergic autapses should be essential elements in pfc and contribute to cortical information processing. |
2021-09-16 |
2023-08-13 |
mouse |
| Samuel Kohtala, Tomi Rantamäk. Rapid-acting antidepressants and the regulation of TrkB neurotrophic signalling-Insights from ketamine, nitrous oxide, seizures and anaesthesia. Basic & clinical pharmacology & toxicology. vol 129. issue 2. 2021-08-12. PMID:33973360. |
increased glutamatergic neurotransmission and synaptic plasticity in the prefrontal cortex have been associated with the rapid antidepressant effects of ketamine. |
2021-08-12 |
2023-08-13 |
Not clear |
| Lilla Ravasz, Katalin Adrienna Kékesi, Dániel Mittli, Mihail Ivilinov Todorov, Zsolt Borhegyi, Mária Ercsey-Ravasz, Botond Tyukodi, Jinhui Wang, Tamás Bártfai, James Eberwine, Gábor Juhás. Cell Surface Protein mRNAs Show Differential Transcription in Pyramidal and Fast-Spiking Cells as Revealed by Single-Cell Sequencing. Cerebral cortex (New York, N.Y. : 1991). vol 31. issue 2. 2021-08-11. PMID:32710103. |
in the pfc, the two major classes of neurons are the glutamatergic pyramidal (pyr) cells and the gabaergic interneurons such as fast-spiking (fs) cells. |
2021-08-11 |
2023-08-13 |
mouse |
| Lilla Ravasz, Katalin Adrienna Kékesi, Dániel Mittli, Mihail Ivilinov Todorov, Zsolt Borhegyi, Mária Ercsey-Ravasz, Botond Tyukodi, Jinhui Wang, Tamás Bártfai, James Eberwine, Gábor Juhás. Cell Surface Protein mRNAs Show Differential Transcription in Pyramidal and Fast-Spiking Cells as Revealed by Single-Cell Sequencing. Cerebral cortex (New York, N.Y. : 1991). vol 31. issue 2. 2021-08-11. PMID:32710103. |
despite extensive electrophysiological, morphological, and pharmacological studies of the pfc, the therapeutically utilized drug targets are restricted to dopaminergic, glutamatergic, and gabaergic receptors. |
2021-08-11 |
2023-08-13 |
mouse |
| Zi-Jun Wang, Ben Rein, Ping Zhong, Jamal Williams, Qing Cao, Fengwei Yang, Freddy Zhang, Kaijie Ma, Zhen Ya. Autism risk gene KMT5B deficiency in prefrontal cortex induces synaptic dysfunction and social deficits via alterations of DNA repair and gene transcription. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 9. 2021-08-04. PMID:34007043. |
kmt5b deficiency also produces deficits in pfc glutamatergic synaptic transmission, which is accompanied by the reduced synaptic expression of glutamate receptor subunits and associated proteins. |
2021-08-04 |
2023-08-13 |
mouse |
| Benjamin L Thompson, Marlene Oscar-Berman, Gary B Kapla. Opioid-induced structural and functional plasticity of medium-spiny neurons in the nucleus accumbens. Neuroscience and biobehavioral reviews. vol 120. 2021-06-21. PMID:33152423. |
additionally, glutamatergic neurons from the prefrontal cortex, the basolateral amygdala, the hippocampus, and the thalamus project to these same msns, providing an enriched target for synaptic plasticity. |
2021-06-21 |
2023-08-13 |
Not clear |
| Sara M Green, Sanya Nathani, Joseph Zimmerman, David Fireman, Nikhil M Ur. Retrograde Labeling Illuminates Distinct Topographical Organization of D1 and D2 Receptor-Positive Pyramidal Neurons in the Prefrontal Cortex of Mice. eNeuro. vol 7. issue 5. 2021-06-18. PMID:33037031. |
glutamatergic pyramidal neurons in the prefrontal cortex (pfc) are topographically organized in different subregions such as the prelimbic, infralimbic (il), and orbitofrontal and project to topographically-organized subcortical target regions. |
2021-06-18 |
2023-08-13 |
mouse |
| Sara M Green, Sanya Nathani, Joseph Zimmerman, David Fireman, Nikhil M Ur. Retrograde Labeling Illuminates Distinct Topographical Organization of D1 and D2 Receptor-Positive Pyramidal Neurons in the Prefrontal Cortex of Mice. eNeuro. vol 7. issue 5. 2021-06-18. PMID:33037031. |
dopamine d1 and d2 receptors are expressed on glutamatergic pyramidal neurons in the pfc. |
2021-06-18 |
2023-08-13 |
mouse |
| Eman M Khedr, Yasser Elserogy, Mohamed Fawzy, Mostafa Elnoaman, Amr M Gala. Global cortical hypoexcitability of the dominant hemisphere in major depressive disorder: A transcranial magnetic stimulation study. Neurophysiologie clinique = Clinical neurophysiology. vol 50. issue 3. 2021-05-26. PMID:32169427. |
accumulating evidence suggests that major depressive disorders (mdd) are associated with an imbalance of excitation-inhibition within the prefrontal cortex (pfc), generated by a deficit of inhibitory synaptic transmission onto glutamatergic principal neurons. |
2021-05-26 |
2023-08-13 |
Not clear |
| Judith Tirado-Muñoz, Ana Belen Lopez-Rodriguez, Francina Fonseca, Magi Farré, Marta Torrens, Maria-Paz Vivero. Effects of cannabis exposure in the prenatal and adolescent periods: Preclinical and clinical studies in both sexes. Frontiers in neuroendocrinology. vol 57. 2021-05-24. PMID:32339546. |
in general, animal studies support behavioural alterations reported in humans and have revealed diverse sex differences and potential underlying mechanisms (altered mesolimbic dopaminergic and hippocampal glutamatergic systems and interference with prefrontal cortex maturation). |
2021-05-24 |
2023-08-13 |
human |
| Charalampos Brakatselos, Foteini Delis, Michail-Zois Asprogerakas, Panagiotis Lekkas, Ioulia Tseti, Petros S Tzimas, Eleftherios A Petrakis, Maria Halabalaki, Leandros A Skaltsounis, Katerina Antonio. Cannabidiol Modulates the Motor Profile and NMDA Receptor-related Alterations Induced by Ketamine. Neuroscience. vol 454. 2021-05-14. PMID:32950556. |
therefore, the aim of the present study is to evaluate the role of cbd on ket-induced motor response and relevant glutamatergic signaling in the prefrontal cortex, the nucleus accumbens, the dorsal and ventral hippocampus. |
2021-05-14 |
2023-08-13 |
Not clear |
| Mingyue Zhang, Hannah Weiland, Michael Schöfbänker, Weiqi Zhan. Estrogen Receptors Alpha and Beta Mediate Synaptic Transmission in the PFC and Hippocampus of Mice. International journal of molecular sciences. vol 22. issue 3. 2021-04-09. PMID:33540803. |
whole-cell recordings of spontaneous excitatory postsynaptic currents (sepsc) in the pfc showed that e2 acts as a neuromodulator in glutamatergic transmission in the pfc in both sexes, but often in a cell-specific manner. |
2021-04-09 |
2023-08-13 |
mouse |
| Gilli Moshitzky, Shai Shoham, Nimrod Madrer, Amir Mouhammed Husain, David S Greenberg, Raz Yirmiya, Yoram Ben-Shaul, Hermona Sore. Cholinergic Stress Signals Accompany MicroRNA-Associated Stereotypic Behavior and Glutamatergic Neuromodulation in the Prefrontal Cortex. Biomolecules. vol 10. issue 6. 2021-04-08. PMID:32503154. |
cholinergic stress signals accompany microrna-associated stereotypic behavior and glutamatergic neuromodulation in the prefrontal cortex. |
2021-04-08 |
2023-08-13 |
mouse |
| Lucia Caffino, Francesca Mottarlini, Boyd Van Reijmersdal, Francesca Telese, Michel M M Verheij, Fabio Fumagalli, Judith R Homber. The role of the serotonin transporter in prefrontal cortex glutamatergic signaling following short- and long-access cocaine self-administration. Addiction biology. vol 26. issue 2. 2021-03-26. PMID:32187792. |
the role of the serotonin transporter in prefrontal cortex glutamatergic signaling following short- and long-access cocaine self-administration. |
2021-03-26 |
2023-08-13 |
Not clear |
| Placido Illiano, Damiana Leo, Raul R Gainetdinov, Marta Pard. Early Adolescence Prefrontal Cortex Alterations in Female Rats Lacking Dopamine Transporter. Biomedicines. vol 9. issue 2. 2021-03-16. PMID:33562738. |
in brief, we observed a concurrent hyperactive phenotype, accompanied by pfc alterations in glutamatergic neurotransmission, signs of neurodegeneration and glial activation in dat-ablated rats. |
2021-03-16 |
2023-08-13 |
human |
| G Siano, M Varisco, A Scarlatti, M C Caiazza, K Dunville, F Cremisi, M Costa, L Pancrazi, C Di Primio, A Cattane. Gene Expression of Disease-related Genes in Alzheimer's Disease is Impaired by Tau Aggregation. Journal of molecular biology. vol 432. issue 24. 2021-03-04. PMID:33058882. |
together, this evidence links the altered glutamatergic function in the pfc during ad progression to the newly discovered function of nuclear tau. |
2021-03-04 |
2023-08-13 |
Not clear |
| Patricia Rivera, Rubén Tovar, María Teresa Ramírez-López, Juan Antonio Navarro, Antonio Vargas, Juan Suárez, Fernando Rodríguez de Fonsec. Sex-Specific Anxiety and Prefrontal Cortex Glutamatergic Dysregulation Are Long-Term Consequences of Pre-and Postnatal Exposure to Hypercaloric Diet in a Rat Model. Nutrients. vol 12. issue 6. 2021-03-01. PMID:32575416. |
sex-specific anxiety and prefrontal cortex glutamatergic dysregulation are long-term consequences of pre-and postnatal exposure to hypercaloric diet in a rat model. |
2021-03-01 |
2023-08-13 |
rat |
| Patricia Rivera, Rubén Tovar, María Teresa Ramírez-López, Juan Antonio Navarro, Antonio Vargas, Juan Suárez, Fernando Rodríguez de Fonsec. Sex-Specific Anxiety and Prefrontal Cortex Glutamatergic Dysregulation Are Long-Term Consequences of Pre-and Postnatal Exposure to Hypercaloric Diet in a Rat Model. Nutrients. vol 12. issue 6. 2021-03-01. PMID:32575416. |
to this end, we examined both anxiety responses and the mrna/protein expression of glutamatergic, gabaergic and endocannabinoid signaling pathways in the prefrontal cortex of adult offspring. |
2021-03-01 |
2023-08-13 |
rat |
| Xiuping Sun, Yu Zhang, Xianglei Li, Xinmin Liu, Chuan Qi. Early-Life Neglect Alters Emotional and Cognitive Behavior in a Sex-Dependent Manner and Reduces Glutamatergic Neuronal Excitability in the Prefrontal Cortex. Frontiers in psychiatry. vol 11. 2021-02-13. PMID:33574771. |
early-life neglect alters emotional and cognitive behavior in a sex-dependent manner and reduces glutamatergic neuronal excitability in the prefrontal cortex. |
2021-02-13 |
2023-08-13 |
mouse |
| Xiuping Sun, Yu Zhang, Xianglei Li, Xinmin Liu, Chuan Qi. Early-Life Neglect Alters Emotional and Cognitive Behavior in a Sex-Dependent Manner and Reduces Glutamatergic Neuronal Excitability in the Prefrontal Cortex. Frontiers in psychiatry. vol 11. 2021-02-13. PMID:33574771. |
no studies to date have examined the impact of early-life stress on glutamatergic neuronal excitability in the pfc. |
2021-02-13 |
2023-08-13 |
mouse |