All Relations between glutamatergic and prefrontal cortex

Publication Sentence Publish Date Extraction Date Species
Mahum T Siddiqi, Dhruba Podder, Amanda R Pahng, Alexandria C Athanason, Tali Nadav, Chelsea Cates-Gatto, Max Kreifeldt, Candice Contet, Amanda J Roberts, Scott Edwards, Marisa Roberto, Florence P Varodaya. Prefrontal cortex glutamatergic adaptations in a mouse model of alcohol use disorder. Addiction neuroscience. vol 9. 2023-12-28. PMID:38152067. prefrontal cortex glutamatergic adaptations in a mouse model of alcohol use disorder. 2023-12-28 2023-12-30 mouse
Eugenia Vivi, Lea R Seeholzer, Anastasiia Nagumanova, Barbara Di Benedett. Early Age- and Sex-Dependent Regulation of Astrocyte-Mediated Glutamatergic Synapse Elimination in the Rat Prefrontal Cortex: Establishing an Organotypic Brain Slice Culture Investigating Tool. Cells. vol 12. issue 23. 2023-12-09. PMID:38067189. early age- and sex-dependent regulation of astrocyte-mediated glutamatergic synapse elimination in the rat prefrontal cortex: establishing an organotypic brain slice culture investigating tool. 2023-12-09 2023-12-17 rat
Roxana E Mesías, Yosif Zaki, Christopher A Guevara, Lauren G Friedman, Ayan Hussein, Karen Therrien, Alexandra R Magee, Nikolaos Tzavaras, Pamela Del Valle, Mark G Baxter, George W Huntley, Deanna L Benso. Development and cadherin-mediated control of prefrontal corticostriatal projections in mice. iScience. vol 26. issue 10. 2023-10-20. PMID:37854688. mutant mice showed diminished pfc axon targeting and reduced spontaneous glutamatergic synaptic activity in the dorsal striatum. 2023-10-20 2023-11-08 mouse
Aurore Thomazeau, Olivier Lassalle, Olivier J Manzon. Glutamatergic synaptic deficits in the prefrontal cortex of the Ts65Dn mouse model for Down syndrome. Frontiers in neuroscience. vol 17. 2023-10-16. PMID:37841687. glutamatergic synaptic deficits in the prefrontal cortex of the ts65dn mouse model for down syndrome. 2023-10-16 2023-11-08 mouse
Seyedeh Leila Mousavi, Ameneh Rezayof, Sakineh Alijanpour, Ladan Delphi, Oveis Hosseinzadeh Sahaf. Activation of mediodorsal thalamic dopamine receptors inhibited nicotine-induced anxiety in rats: A possible role of corticolimbic NMDA neurotransmission and BDNF expression. Pharmacology, biochemistry, and behavior. 2023-10-01. PMID:37778541. the present study aimed to evaluate the functional interaction between the dopaminergic and glutamatergic systems of the mediodorsal thalamus (md), the ventral hippocampus (vh), and the prefrontal cortex (pfc) in nicotine-induced anxiogenic-like behaviors. 2023-10-01 2023-10-07 rat
Seyedeh Leila Mousavi, Ameneh Rezayof, Sakineh Alijanpour, Ladan Delphi, Oveis Hosseinzadeh Sahaf. Activation of mediodorsal thalamic dopamine receptors inhibited nicotine-induced anxiety in rats: A possible role of corticolimbic NMDA neurotransmission and BDNF expression. Pharmacology, biochemistry, and behavior. 2023-10-01. PMID:37778541. these findings suggest that the functional interaction between the md dopaminergic d1/d2-like and the vh/pfc glutamatergic nmda receptors may be partially involved in the anxiogenic-like effects of nicotine, likely via the alteration of bdnf levels in the hippocampus and the pfc. 2023-10-01 2023-10-07 rat
Kouji Fukuyama, Eishi Motomura, Motohiro Okad. A Novel Gliotransmitter, L-β-Aminoisobutyric Acid, Contributes to Pathophysiology of Clinical Efficacies and Adverse Reactions of Clozapine. Biomolecules. vol 13. issue 9. 2023-09-28. PMID:37759688. considering the expressions of gaba-b and iii-mglu receptors (localised in the presynaptic regions), the activation of gaba-b and iii-mglu receptors can explain the distinct therapeutic advantages of clozapine in schizophrenia or trs associated with n-methyl-d-aspartate (nmda) receptor disturbance compared with other atypical antipsychotics via the inhibition of the persistent tonic hyperactivation of thalamocortical glutamatergic transmission in the prefrontal cortex. 2023-09-28 2023-10-07 Not clear
Zohreh Farsi, Ally Nicolella, Sean K Simmons, Sameer Aryal, Nate Shepard, Kira Brenner, Sherry Lin, Linnea Herzog, Sean P Moran, Katherine J Stalnaker, Wangyong Shin, Vahid Gazestani, Bryan J Song, Kevin Bonanno, Hasmik Keshishian, Steven A Carr, Jen Q Pan, Evan Z Macosko, Sandeep Robert Datta, Borislav Dejanovic, Eunjoon Kim, Joshua Z Levin, Morgan Shen. Brain-region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice. Neuron. 2023-09-01. PMID:37657442. by transcriptomic, proteomic, and behavioral analyses, we report that heterozygous grin2a mutant mice show (1) large-scale gene expression changes across multiple brain regions and in neuronal (excitatory and inhibitory) and non-neuronal cells (astrocytes and oligodendrocytes), (2) evidence of hypoactivity in the prefrontal cortex (pfc) and hyperactivity in the hippocampus and striatum, (3) an elevated dopamine signaling in the striatum and hypersensitivity to amphetamine-induced hyperlocomotion (aih), (4) altered cholesterol biosynthesis in astrocytes, (5) a reduction in glutamatergic receptor signaling proteins in the synapse, and (6) an aberrant locomotor pattern opposite of that induced by antipsychotic drugs. 2023-09-01 2023-09-07 mouse
Xinjuan Wang, Xueyu Hou, Yu Huo, Di Wang, Xiang Fan, Xiaorui Lin, Weidong Yu, Cailian Cui, Jingzhu Guo, Yijing L. Phosphorylated Ser187-SNAP25-modulated hyperfunction of glutamatergic system in the vmPFC mediates depressive-like behaviors in male mice. Neuropharmacology. 2023-08-25. PMID:37625690. here, we employed chronic unpredictable mild stress (cums) to induce depression-like behavior in male mice and to assess the alterations of glutamatergic system within the ventromedial prefrontal cortex (vmpfc). 2023-08-25 2023-09-07 mouse
Jing Sun, Qijie Cong, Tingkai Sun, Siyu Xi, Yunxi Liu, Rongsen Zeng, Jia Wang, Weining Zhang, Jing Gao, Jinjun Qian, Shengying Qi. Prefrontal cortex-specific Dcc deletion induces schizophrenia-related behavioral phenotypes and fail to be rescued by olanzapine treatment. European journal of pharmacology. 2023-08-04. PMID:37541362. knockdown of dcc in prefrontal cortex results in glutamatergic dysfunction, including defects in glutamine synthetase and postsynaptic maturation. 2023-08-04 2023-08-14 mouse
Yu-Ting Hu, Zhong-Lin Tan, Dusan Hirjak, Georg Northof. Brain-wide changes in excitation-inhibition balance of major depressive disorder: a systematic review of topographic patterns of GABA- and glutamatergic alterations. Molecular psychiatry. 2023-07-26. PMID:37495889. we found: i) brain-wide gaba- and glutamatergic alterations; ii) attenuated gabaergic with enhanced glutamatergic signaling in the cortical-subcortical limbic system; iii) that gabaergic signaling is decreased in regions comprising the default mode network (dmn) while it is increased in lateral prefrontal cortex (lpfc). 2023-07-26 2023-08-14 human
Henk Karst, Marian Joël. Corticosterone rapidly reduces glutamatergic but not GABAergic transmission in the infralimbic prefrontal cortex of male mice. Steroids. 2023-07-24. PMID:37487816. corticosterone rapidly reduces glutamatergic but not gabaergic transmission in the infralimbic prefrontal cortex of male mice. 2023-07-24 2023-08-14 mouse
Benedetta Demartini, Veronica Nisticò, Caroline Benayoun, Anna Chiara Cigognini, Roberta Ferrucci, Alessandra Vezzoli, Cinzia Dellanoce, Orsola Gambini, Alberto Priori, Simona Mrakic-Spost. Glutamatergic dysfunction, neuroplasticity, and redox status in the peripheral blood of patients with motor conversion disorders (functional movement disorders): a first step towards potential biomarkers discovery. Translational psychiatry. vol 13. issue 1. 2023-06-17. PMID:37330537. first evidence showed that, compared to healthy controls (ctr), fmd patients presented increased levels of glutamate+glutamine in the anterior cingulate cortex/medial prefrontal cortex, and decreased levels of glutamate in the cerebrospinal fluid, suggesting that a glutamatergic dysfunction might play a role in fmd pathophysiology. 2023-06-17 2023-08-14 human
Lia Forti, Elona Ndoj, Jessica Mingardi, Emanuele Secchi, Tiziana Bonifacino, Emanuele Schiavon, Giulia Carini, Luca La Via, Isabella Russo, Marco Milanese, Massimo Gennarelli, Giambattista Bonanno, Maurizio Popoli, Alessandro Barbon, Laura Musazz. Dopamine-Dependent Ketamine Modulation of Glutamatergic Synaptic Plasticity in the Prelimbic Cortex of Adult Rats Exposed to Acute Stress. International journal of molecular sciences. vol 24. issue 10. 2023-05-27. PMID:37240064. here, we asked if acute fs may also induce any changes in glutamatergic synaptic plasticity in the pfc 24 h after stress exposure and whether ketamine administration 6 h after stress may have any effect. 2023-05-27 2023-08-14 rat
Lia Forti, Elona Ndoj, Jessica Mingardi, Emanuele Secchi, Tiziana Bonifacino, Emanuele Schiavon, Giulia Carini, Luca La Via, Isabella Russo, Marco Milanese, Massimo Gennarelli, Giambattista Bonanno, Maurizio Popoli, Alessandro Barbon, Laura Musazz. Dopamine-Dependent Ketamine Modulation of Glutamatergic Synaptic Plasticity in the Prelimbic Cortex of Adult Rats Exposed to Acute Stress. International journal of molecular sciences. vol 24. issue 10. 2023-05-27. PMID:37240064. although more studies are needed to understand the effects of acute stress and ketamine on pfc glutamatergic plasticity, this first report suggests a restoring effect of acute ketamine, supporting the potential benefit of ketamine in limiting the impact of acute traumatic stress. 2023-05-27 2023-08-14 rat
Daniela Lescano Uliana, Cassiano Ricardo Alves Faria Diniz, Leandro Antero da Silva, Anna Bárbara Borges-Assis, Sabrina Francesca Lisboa, Leonardo Barbosa Moraes Resste. Contextual fear expression engages a complex set of interactions between ventromedial prefrontal cortex cholinergic, glutamatergic, nitrergic and cannabinergic signaling. Neuropharmacology. 2023-04-06. PMID:37024011. contextual fear expression engages a complex set of interactions between ventromedial prefrontal cortex cholinergic, glutamatergic, nitrergic and cannabinergic signaling. 2023-04-06 2023-08-14 rat
Yiting Hu, Fang Dong, Ting Xue, Mi Zhou, Ruoyan Huang, Feng Sui, Qiang Guo, Wenbao Hou, Wenlong Cai, Kai Yuan, Hongde Wang, Dahua Y. Glutamate levels in the ventromedial prefrontal cortex and resting-state functional connectivity within reward circuits in alcohol-dependent patients. Addiction biology. vol 28. issue 4. 2023-04-05. PMID:37016753. glutamatergic projections from the prefrontal cortex to some brain regions are present in the reward circuit. 2023-04-05 2023-08-14 Not clear
Yiting Hu, Fang Dong, Ting Xue, Mi Zhou, Ruoyan Huang, Feng Sui, Qiang Guo, Wenbao Hou, Wenlong Cai, Kai Yuan, Hongde Wang, Dahua Y. Glutamate levels in the ventromedial prefrontal cortex and resting-state functional connectivity within reward circuits in alcohol-dependent patients. Addiction biology. vol 28. issue 4. 2023-04-05. PMID:37016753. the ventromedial prefrontal cortex (vmpfc) is believed to play a critical role in addiction disorders, and glutamatergic projections from the prefrontal cortex to several regions of the brain are present in reward circuits. 2023-04-05 2023-08-14 Not clear
Sam Ej Paton, Caroline Menar. Glutamate shall not pass: a mechanistic role for astrocytic O-GlcNAc transferase in stress and depression. The Journal of clinical investigation. vol 133. issue 7. 2023-04-03. PMID:37009895. major depressive disorder, characterized by aberrant glutamatergic signaling in the prefrontal cortex (pfc), is a leading cause of disability worldwide. 2023-04-03 2023-08-14 mouse
Roxana E Mesías, Yosif Zaki, Christopher A Guevara, Lauren G Friedman, Ayan Hussein, Karen Therrien, Alexandra R Magee, Nikolaos Tzavaras, Pamela Del Valle, Mark G Baxter, George W Huntley, Deanna L Benso. Development of prefrontal corticostriatal connectivity in mice. bioRxiv : the preprint server for biology. 2023-03-30. PMID:36993639. as corticostriatal synapse density increased over late postnatal ages, the strength of evoked pfc input onto dorsomedial striatal projection neurons also increased, but spontaneous glutamatergic synaptic activity was stable. 2023-03-30 2023-08-14 mouse