| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ping Zhong, Qing Cao, Zhen Ya. Selective impairment of circuits between prefrontal cortex glutamatergic neurons and basal forebrain cholinergic neurons in a tauopathy mouse model. Cerebral cortex (New York, N.Y. : 1991). 2022-03-02. PMID:35235649. |
the attenuated long-range pfc to bf pathway in the ad model significantly increased the failure rate of action potential firing of bf cholinergic neurons triggered by optogenetic stimulations of glutamatergic terminals from pfc. |
2022-03-02 |
2023-08-13 |
mouse |
| Jenya Kolpakova, Vincent van der Vinne, Pablo Giménez-Gómez, Timmy Le, In-Jee You, Rubing Zhao-Shea, Cristina Velazquez-Marrero, Andrew R Tapper, Gilles E Marti. Binge Alcohol Drinking Alters Synaptic Processing of Executive and Emotional Information in Core Nucleus Accumbens Medium Spiny Neurons. Frontiers in cellular neuroscience. vol 15. 2021-12-07. PMID:34867199. |
it receives glutamatergic projections from multiple forebrain and limbic regions such as the prefrontal cortex (pfcx) and basolateral amygdala (bla), respectively. |
2021-12-07 |
2023-08-13 |
mouse |
| Glenn Dallérac, Xia Li, Pierre Lecouflet, Nadège Morisot, Silvia Sacchi, Rachel Asselot, Thu Ha Pham, Brigitte Potier, David J G Watson, Staffan Schmidt, Grégoire Levasseur, Pascal Fossat, Andrey Besedin, Jean-Michel Rivet, Joseph T Coyle, Ginetta Collo, Loredano Pollegioni, Jan Kehr, Micaela Galante, Kevin C Fone, Alain M Gardier, Thomas Freret, Angelo Contarino, Mark J Millan, Jean-Pierre Mothe. Dopaminergic neuromodulation of prefrontal cortex activity requires the NMDA receptor coagonist d-serine. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 23. 2021-12-04. PMID:34083436. |
here, using electrophysiological recordings, we show that d-serine is required for the fine-tuning of glutamatergic neurotransmission, neuronal excitability, and synaptic plasticity in the pfc through the actions of dopamine at d |
2021-12-04 |
2023-08-13 |
Not clear |
| Adriana Caballero, Amanda Orozco, Kuei Y Tsen. Developmental regulation of excitatory-inhibitory synaptic balance in the prefrontal cortex during adolescence. Seminars in cell & developmental biology. vol 118. 2021-12-01. PMID:33714681. |
the intrinsic function of the pfc is defined by the interaction of local glutamatergic and gabaergic neurons and their modulation by long-range inputs. |
2021-12-01 |
2023-08-13 |
Not clear |
| Luye Qin, Jamal B Williams, Tao Tan, Tiaotiao Liu, Qing Cao, Kaijie Ma, Zhen Ya. Deficiency of autism risk factor ASH1L in prefrontal cortex induces epigenetic aberrations and seizures. Nature communications. vol 12. issue 1. 2021-11-30. PMID:34782621. |
furthermore, ash1l deficiency in pfc causes the diminished gabaergic inhibition, enhanced glutamatergic transmission, and elevated pfc pyramidal neuronal excitability, which is associated with severe seizures and early mortality. |
2021-11-30 |
2023-08-13 |
mouse |
| Jing Wei, Jia Cheng, Nicholas J Waddell, Zi-Jun Wang, Xiaodong Pang, Qing Cao, Aiyi Liu, Javed M Chitaman, Kristen Abreu, Rahul Singh Jasrotia, Lara J Duffney, Jinfeng Zhang, David M Dietz, Jian Feng, Zhen Ya. DNA Methyltransferase 3A Is Involved in the Sustained Effects of Chronic Stress on Synaptic Functions and Behaviors. Cerebral cortex (New York, N.Y. : 1991). vol 31. issue 4. 2021-11-25. PMID:33230530. |
in contrast, overexpression of dnmt3a in pfc of stressed animals prevented the loss of glutamatergic responses. |
2021-11-25 |
2023-08-13 |
rat |
| Jing Wei, Jia Cheng, Nicholas J Waddell, Zi-Jun Wang, Xiaodong Pang, Qing Cao, Aiyi Liu, Javed M Chitaman, Kristen Abreu, Rahul Singh Jasrotia, Lara J Duffney, Jinfeng Zhang, David M Dietz, Jian Feng, Zhen Ya. DNA Methyltransferase 3A Is Involved in the Sustained Effects of Chronic Stress on Synaptic Functions and Behaviors. Cerebral cortex (New York, N.Y. : 1991). vol 31. issue 4. 2021-11-25. PMID:33230530. |
finally, we found that there were genome-wide dna methylation changes and transcriptome alterations in pfc of stressed rats, both of which were enriched at several neural pathways, including glutamatergic synapse and microtubule-associated protein kinase signaling. |
2021-11-25 |
2023-08-13 |
rat |
| Xing Wang, Xuan Sun, Hou-Cheng Zhou, Fei Lu. Activation of β3-adrenoceptor increases the number of readily releasable glutamatergic vesicle via activating Ca Scientific reports. vol 11. issue 1. 2021-11-25. PMID:34526598. |
activation of β3-adrenoceptor increases the number of readily releasable glutamatergic vesicle via activating ca it is well known that β3-adrenoceptor (β3-ar) in many brain structures including prefrontal cortex (pfc) is involved in stress-related behavioral changes. |
2021-11-25 |
2023-08-13 |
rat |
| Xing Wang, Xuan Sun, Hou-Cheng Zhou, Fei Lu. Activation of β3-adrenoceptor increases the number of readily releasable glutamatergic vesicle via activating Ca Scientific reports. vol 11. issue 1. 2021-11-25. PMID:34526598. |
in this study, whole cell patch-clamp recordings were employed to investigate the glutamatergic transmission of layer v/vi pyramidal cells in slices of the rat pfc. |
2021-11-25 |
2023-08-13 |
rat |
| Carlos A Sánchez-León, Álvaro Sánchez-López, María A Gómez-Climent, Isabel Cordones, Roi Cohen Kadosh, Javier Márquez-Rui. Impact of chronic transcranial random noise stimulation (tRNS) on GABAergic and glutamatergic activity markers in the prefrontal cortex of juvenile mice. Progress in brain research. vol 264. 2021-11-24. PMID:34167661. |
impact of chronic transcranial random noise stimulation (trns) on gabaergic and glutamatergic activity markers in the prefrontal cortex of juvenile mice. |
2021-11-24 |
2023-08-13 |
mouse |
| Colette A Steinegger, Niklaus Zoelch, Andreas Hock, Anke Henning, Etna J E Engeli, Erich Seifritz, Lea M Hulka, Marcus Herdene. Neurometabolic alterations in the nucleus accumbens of smokers assessed with Addiction biology. vol 26. issue 6. 2021-11-10. PMID:33825270. |
recent findings in animal models highlight the role of alterations in glutamatergic projections from the prefrontal cortex onto the nucleus accumbens (nac) in relapse vulnerability. |
2021-11-10 |
2023-08-13 |
Not clear |
| A R Deane, N Potemkin, R D War. Mitogen-activated protein kinase (MAPK) signalling corresponds with distinct behavioural profiles in a rat model of maternal immune activation. Behavioural brain research. vol 396. 2021-11-09. PMID:32846206. |
findings are considered with respect to the glutamatergic nmda hypofunction theory of schizophrenia, as well as the critical role of pfc in contingency learning. |
2021-11-09 |
2023-08-13 |
rat |
| Olena Bukalo, Mio Nonaka, Chase A Weinholtz, Adriana Mendez, William W Taylor, Andrew Holme. Effects of optogenetic photoexcitation of infralimbic cortex inputs to the basolateral amygdala on conditioned fear and extinction. Behavioural brain research. vol 396. 2021-11-09. PMID:32950607. |
previous studies in rodents have shown that glutamatergic projections from the infralimbic prefrontal cortex (il) to basolateral amygdala (bla) play a crucial instructional role in the formation of extinction memories, and also indicate that variation in the strength of this input correlates with extinction efficacy. |
2021-11-09 |
2023-08-13 |
Not clear |
| Wei Wang, Qing Cao, Tao Tan, Fengwei Yang, Jamal B Williams, Zhen Ya. Epigenetic treatment of behavioral and physiological deficits in a tauopathy mouse model. Aging cell. vol 20. issue 10. 2021-11-09. PMID:34547169. |
concomitantly, the diminished pfc neuronal excitability and glutamatergic synaptic transmission in p301s tau mice are also normalized by unc0642 treatment. |
2021-11-09 |
2023-08-13 |
mouse |
| Cora E Smiley, Heyam K Saleh, Katherine E Nimchuk, Constanza Garcia-Keller, Justin T Gas. Adolescent exposure to delta-9-tetrahydrocannabinol and ethanol heightens sensitivity to fear stimuli. Behavioural brain research. vol 415. 2021-11-04. PMID:34389427. |
in summary, these studies support the hypothesis that adolescent exposure to thc and ethanol leads to alterations in fear stimuli processing through glutamatergic reliant modifications in pfc signaling. |
2021-11-04 |
2023-08-13 |
Not clear |
| Max E Joffe, Danny G Winder, P Jeffrey Con. Increased Synaptic Strength and mGlu Alcoholism, clinical and experimental research. vol 45. issue 3. 2021-11-02. PMID:33434325. |
at least 80% of the neurons in pfc are glutamatergic pyramidal cells. |
2021-11-02 |
2023-08-13 |
Not clear |
| Maryam Mahmoodkhani, Maedeh Ghasemi, Leila Derafshpour, Mohammad Amini, Nasrin Mehranfar. Long-Term Decreases in the Expression of Calcineurin and GABAA Receptors Induced by Early Maternal Separation Are Associated with Increased Anxiety-Like Behavior in Adult Male Rats. Developmental neuroscience. vol 42. issue 2-4. 2021-10-26. PMID:33341802. |
here, we investigated the effect of early life stress, such as repeated maternal separation (ms; 3 h per day from postnatal day [p] 2 to 11), on changes in the expression of calcineurin as well as the ionotropic glutamatergic and gabaergic receptors including α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa), n-methyl-d-aspartate (nmda) and gabaa receptors in the hippocampus and prefrontal cortex (pfc) of adolescent (p35) and adult (p62) male wistar rats and their correlations with anxiety-like behavior in adulthood. |
2021-10-26 |
2023-08-13 |
rat |
| Julio César Morales-Medina, Patricia Aguilar-Alonso, Alessandro Di Cerbo, Tommaso Iannitti, Gonzalo Flore. New insights on nitric oxide: Focus on animal models of schizophrenia. Behavioural brain research. vol 409. 2021-10-18. PMID:33865887. |
in regards to glutamatergic models of schizophrenia, phencyclidine (pcp) administration increases no levels in the prefrontal cortex (pfc) and ventral hippocampus. |
2021-10-18 |
2023-08-13 |
mouse |
| Yan-Yan Guo, Ying Zhou, Yu-Jiao Li, An Liu, Jiao Yue, Qing-Qing Liu, Le Yang, Yu-Mei Wu, Shui-Bing Liu, Kun Zhang, Ming-Gao Zha. Scutellarin ameliorates the stress-induced anxiety-like behaviors in mice by regulating neurotransmitters. Phytotherapy research : PTR. vol 35. issue 7. 2021-09-27. PMID:33856723. |
scu treatment suppressed action potential firing frequency, restored excessive presynaptic quantal release, and down-regulated glutamatergic receptor expression levels in the prefrontal cortex (pfc) of stressed mice. |
2021-09-27 |
2023-08-13 |
mouse |
| Dong-Dong Shi, Ying-Dan Zhang, Yan-Yan Ren, Shi-Yu Peng, Ti-Fei Yuan, Zhen Wan. Predictable maternal separation confers adult stress resilience via the medial prefrontal cortex oxytocin signaling pathway in rats. Molecular psychiatry. 2021-09-25. PMID:34561611. |
we demonstrate that structural and functional impairments occur in glutamatergic synapses in pyramidal neurons of the medial prefrontal cortex (mpfc) in rats with unpredictable ms but not in rats with predictable ms. then, we used differentially expressed gene (deg) analysis of rna sequencing data from the adult male pfc to identify a hub gene that is responsible for stress resilience. |
2021-09-25 |
2023-08-13 |
rat |