| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elisa Caggiu, Giannina Arru, Sepideh Hosseini, Magdalena Niegowska, GianPietro Sechi, Ignazio Roberto Zarbo, Leonardo A Sech. Inflammation, Infectious Triggers, and Parkinson's Disease. Frontiers in neurology. vol 10. 2020-10-01. PMID:30837941. |
parkinson's disease is a neurodegenerative disorder characterized by progressive loss of dopaminergic neurons of the substantia nigra pars compacta with a reduction of dopamine concentration in the striatum. |
2020-10-01 |
2023-08-13 |
Not clear |
| Robert S Eisinger, Adolfo Ramirez-Zamora, Samuel Carbunaru, Brandon Ptak, Zhongxing Peng-Chen, Michael S Okun, Aysegul Gundu. Medications, Deep Brain Stimulation, and Other Factors Influencing Impulse Control Disorders in Parkinson's Disease. Frontiers in neurology. vol 10. 2020-10-01. PMID:30863353. |
although it is now well-recognized that dopaminergic treatments and especially dopamine agonists underpin many icds, medications alone are not the sole cause. |
2020-10-01 |
2023-08-13 |
Not clear |
| Robert S Eisinger, Adolfo Ramirez-Zamora, Samuel Carbunaru, Brandon Ptak, Zhongxing Peng-Chen, Michael S Okun, Aysegul Gundu. Medications, Deep Brain Stimulation, and Other Factors Influencing Impulse Control Disorders in Parkinson's Disease. Frontiers in neurology. vol 10. 2020-10-01. PMID:30863353. |
beyond dopamine, other icd associations have been described but remain difficult to explain, including deep brain stimulation surgery, especially in the setting of a reduction in dopaminergic medication use. |
2020-10-01 |
2023-08-13 |
Not clear |
| Krista Farrell, Roger A Barke. Stem cells and regenerative therapies for Parkinson's disease. Degenerative neurological and neuromuscular disease. vol 2. 2020-10-01. PMID:30890881. |
currently the mainstay of parkinson's disease (pd) therapy is the pharmacological replacement of the loss of the dopaminergic nigrostriatal pathway using drugs such as dopamine agonists and levodopa. |
2020-10-01 |
2023-08-13 |
Not clear |
| Krista Farrell, Roger A Barke. Stem cells and regenerative therapies for Parkinson's disease. Degenerative neurological and neuromuscular disease. vol 2. 2020-10-01. PMID:30890881. |
indeed all these studies have provided evidence that following the transplantation of fetal vm tissue, dopaminergic cells can survive long term, produce dopamine, and bring about clinical improvements in younger patients over many years. |
2020-10-01 |
2023-08-13 |
Not clear |
| Hui Dong, Juan Wang, Yan-Fei Yang, Yan Shen, Wei-Min Qu, Zhi-Li Huan. Dorsal Striatum Dopamine Levels Fluctuate Across the Sleep-Wake Cycle and Respond to Salient Stimuli in Mice. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:30949023. |
here, we employed an intensity-based genetically encoded dopamine indicator, dlight1.1, to track striatal dopamine levels across the spontaneous sleep-wake cycle and the dopaminergic response to external stimuli. |
2020-10-01 |
2023-08-13 |
mouse |
| Nicholas G Norwitz, Michele T Hu, Kieran Clark. The Mechanisms by Which the Ketone Body D-β-Hydroxybutyrate May Improve the Multiple Cellular Pathologies of Parkinson's Disease. Frontiers in nutrition. vol 6. 2020-10-01. PMID:31139630. |
although dopamine replacement therapy temporarily helps patients manage their motor symptoms, this current standard of care fails to address the underlying network of pathologies that contribute to the persistent death of dopaminergic neurons. |
2020-10-01 |
2023-08-13 |
Not clear |
| Erika Coletto, John S Dolan, Sara Pritchard, Alex Gant, Atsuko Hikima, Michael J Jackson, Christopher D Benham, K Ray Chaudhuri, Sarah Rose, Peter Jenner, Mahmoud M Iravan. Contractile dysfunction and nitrergic dysregulation in small intestine of a primate model of Parkinson's disease. NPJ Parkinson's disease. vol 5. 2020-10-01. PMID:31231674. |
the absence of the relaxation and the inefficacy of l-name in the mptp tissues suggests that central dopaminergic loss dopamine may eventually lead to the impairment of no signal coupling that affects bowel function, and this may be the result of a complex dysregulation at the level of the neuroeffector junction. |
2020-10-01 |
2023-08-13 |
marmoset |
| E E M Knowles, S R Mathias, D R McKay, E Sprooten, John Blangero, Laura Almasy, D C Glah. Genome-Wide Analyses of Working-Memory Ability: A Review. Current behavioral neuroscience reports. vol 1. issue 4. 2020-10-01. PMID:25729637. |
interestingly, the results of those searches converge on the mediating role of neuronal excitability in working-memory performance, such that the role of each gene highlighted by genome-wide methods plays a part in ion channel formation and/or dopaminergic signaling in the brain, with either direct or indirect influence on dopamine levels in the prefrontal cortex. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ashish Kumar Gupta, Ruchika Pokhriyal, Uddipan Das, Mohd Imran Khan, Domada Ratna Kumar, Rishab Gupta, Rakesh Kumar Chadda, Rashmi Ramachandran, Vinay Goyal, Manjari Tripathi, Gururao Hariprasa. Evaluation of α-synuclein and apolipoprotein E as potential biomarkers in cerebrospinal fluid to monitor pharmacotherapeutic efficacy in dopamine dictated disease states of Parkinson's disease and schizophrenia. Neuropsychiatric disease and treatment. vol 15. 2020-09-30. PMID:31410011. |
these two neuropsychiatric disorders represent disease end points of the dopaminergic spectrum where parkinson's disease represents dopamine deficit and schizophrenia represents dopamine hyperactivity in the mid-brain. |
2020-09-30 |
2023-08-13 |
Not clear |
| Ali Farzam, Karan Chohan, Miroslava Strmiskova, Sarah J Hewitt, David S Park, John P Pezacki, Dennis Özceli. A functionalized hydroxydopamine quinone links thiol modification to neuronal cell death. Redox biology. vol 28. 2020-09-30. PMID:31760358. |
here, we compare 6-hydroxydopamine (6-ohda), a product of dopamine oxidation that commonly induces dopaminergic neurodegeneration in laboratory animals, with a synthetic alkyne-functionalized 6-ohda variant. |
2020-09-30 |
2023-08-13 |
Not clear |
| Ali Farzam, Karan Chohan, Miroslava Strmiskova, Sarah J Hewitt, David S Park, John P Pezacki, Dennis Özceli. A functionalized hydroxydopamine quinone links thiol modification to neuronal cell death. Redox biology. vol 28. 2020-09-30. PMID:31760358. |
our study links dopamine oxidation to protein modification and protein folding in dopaminergic neurons and the pd model. |
2020-09-30 |
2023-08-13 |
Not clear |
| Kohei Ueno, Johannes Morstein, Kyoko Ofusa, Shintaro Naganos, Ema Suzuki-Sawano, Saika Minegishi, Samir P Rezgui, Hiroaki Kitagishi, Brian W Michel, Christopher J Chang, Junjiro Horiuchi, Minoru Saito. Carbon Monoxide, a Retrograde Messenger Generated in Postsynaptic Mushroom Body Neurons, Evokes Noncanonical Dopamine Release. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 18. 2020-09-30. PMID:32253360. |
dopaminergic neurons innervate extensive areas of the brain and release dopamine (da) onto a wide range of target neurons. |
2020-09-30 |
2023-08-13 |
Not clear |
| David M White, Nina V Kraguljac, Meredith A Reid, Adrienne C Laht. Contribution of substantia nigra glutamate to prediction error signals in schizophrenia: a combined magnetic resonance spectroscopy/functional imaging study. NPJ schizophrenia. vol 1. 2020-09-30. PMID:26878032. |
because dopamine neurons signal a mismatch between expected and actual reward called prediction error (pe), aberrant pe signals in schizophrenia have been attributed to known dopaminergic abnormalities. |
2020-09-30 |
2023-08-13 |
Not clear |
| Katsuhiro Nagatomo, Sechiko Suga, Masato Saitoh, Masahito Kogawa, Kazuto Kobayashi, Yoshio Yamamoto, Katsuya Yamad. Dopamine D1 Receptor Immunoreactivity on Fine Processes of GFAP-Positive Astrocytes in the Substantia Nigra Pars Reticulata of Adult Mouse. Frontiers in neuroanatomy. vol 11. 2020-09-30. PMID:28203148. |
substantia nigra pars reticulata (snr), the major output nucleus of the basal ganglia, receives dopamine from dendrites extending from dopaminergic neurons of the adjacent nucleus pars compacta (snc), which is known for its selective degeneration in parkinson's disease. |
2020-09-30 |
2023-08-13 |
mouse |
| Lachlan Ferguson, Alice Petty, Chelsie Rohrscheib, Michael Troup, Leonie Kirszenblat, Darryl W Eyles, Bruno van Swindere. Transient Dysregulation of Dopamine Signaling in a Developing Frontiers in psychiatry. vol 8. 2020-09-30. PMID:28243212. |
transient dysregulation of dopamine signaling in a developing the dopamine ontogeny hypothesis for schizophrenia proposes that transient dysregulation of the dopaminergic system during brain development increases the likelihood of this disorder in adulthood. |
2020-09-30 |
2023-08-13 |
drosophila_melanogaster |
| Anni Richter, Adriana Barman, Torsten Wüstenberg, Joram Soch, Denny Schanze, Anna Deibele, Gusalija Behnisch, Anne Assmann, Marieke Klein, Martin Zenker, Constanze Seidenbecher, Björn H Schot. Behavioral and Neural Manifestations of Reward Memory in Carriers of Low-Expressing versus High-Expressing Genetic Variants of the Dopamine D2 Receptor. Frontiers in psychology. vol 8. 2020-09-30. PMID:28507526. |
dopamine is critically important in the neural manifestation of motivated behavior, and alterations in the human dopaminergic system have been implicated in the etiology of motivation-related psychiatric disorders, most prominently addiction. |
2020-09-30 |
2023-08-13 |
human |
| Kenneth Blum, Edward J Modestino, Marcelo Febo, Bruce Steinberg, Thomas McLaughlin, Lyle Fried, David Baron, David Siwicki, Rajendra D Badgaiya. Lyme and Dopaminergic Function: Hypothesizing Reduced Reward Deficiency Symptomatology by Regulating Dopamine Transmission. Journal of systems and integrative neuroscience. vol 3. issue 3. 2020-09-30. PMID:28736624. |
lyme and dopaminergic function: hypothesizing reduced reward deficiency symptomatology by regulating dopamine transmission. |
2020-09-30 |
2023-08-13 |
Not clear |
| Rahul Patel, Joshua M Bradner, Kristen A Stout, William Michael Caudl. Alteration to Dopaminergic Synapses Following Exposure to Perfluorooctane Sulfonate (PFOS), in Vitro and in Vivo. Medical sciences (Basel, Switzerland). vol 4. issue 3. 2020-09-30. PMID:29083377. |
however, subsequent exposure to the selective dopaminergic neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) significantly reduced the expression of dopamine transporter (dat) and tyrosine hydroxylase (th), and resulted in an even greater reduction in dat expression in animals previously exposed to pfos. |
2020-09-30 |
2023-08-13 |
mouse |
| Janna Niens, Fabienne Reh, Büşra Çoban, Karol Cichewicz, Julia Eckardt, Yi-Ting Liu, Jay Hirsh, Thomas D Riemensperge. Dopamine Modulates Serotonin Innervation in the Frontiers in systems neuroscience. vol 11. 2020-09-30. PMID:29085286. |
dopamine modulates serotonin innervation in the parkinson's disease (pd) results from a progressive degeneration of the dopaminergic nigrostriatal system leading to a decline in movement control, with resting tremor, rigidity and postural instability. |
2020-09-30 |
2023-08-13 |
drosophila_melanogaster |