| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniele Maria-Ferreira, Natalia Mulinari Turin de Oliveira, Liziane Cristine Malaquias da Silva, Elizabeth Soares Fernande. Evidence of a Role for the TRPC Subfamily in Mediating Oxidative Stress in Parkinson's Disease. Frontiers in physiology. vol 11. 2020-09-28. PMID:32457638. |
the generation of reactive oxygen species and reactive nitrogen intermediates, as well as the dysfunction of dopamine metabolism, play important roles in the degeneration of dopaminergic neurons. |
2020-09-28 |
2023-08-13 |
Not clear |
| Shahram Darabi, Ali Noori-Zadeh, Hojjat-Allah Abbaszadeh, Farzad Rajaei, Salar Bakhtiyar. Trehalose Neuroprotective Effects on the Substantia Nigra Dopaminergic Cells by Activating Autophagy and Non-canonical Nrf2 Pathways. Iranian journal of pharmaceutical research : IJPR. vol 18. issue 3. 2020-09-28. PMID:32641951. |
moreover, the levels of 3, 4-dihydroxyphenylacetic acid (dopac) and dopamine (da) were assessed.the behavioral test showed that trehalose in the treatment group reduced the damage to the substantial nigra dopaminergic neurons, which was characterized by improved motor and reduced rotations in the treatment group as compared with the lesion group. |
2020-09-28 |
2023-08-13 |
rat |
| Yanyan Kong, Haicong Zhou, Hu Feng, Junyi Zhuang, Tieqiao Wen, Chencheng Zhang, Bomin Sun, Jiao Wang, Yihui Gua. Elucidating the Relationship Between Diabetes Mellitus and Parkinson's Disease Using Frontiers in neuroscience. vol 14. 2020-09-28. PMID:32760240. |
intriguingly, polycystic monoamine transporter 2 (vmat2), which is co-expressed in dopaminergic neurons and β cells, is responsible for taking up dopamine into the presynaptic vesicles and can specifically bind to the β cells. |
2020-09-28 |
2023-08-13 |
Not clear |
| Georg A Petroianu, Dietrich E Lork. The Role of Serotonin in Singultus: A Review. Frontiers in neuroscience. vol 14. 2020-09-28. PMID:32765206. |
while an involvement of dopamine is certain, it is by no means clear that dopaminergic dysfunction is the hallmark of singultus. |
2020-09-28 |
2023-08-13 |
Not clear |
| Yue Yu, Richard P S de Campos, Seolim Hong, Dimitar L Krastev, Siddharth Sadanand, Yen Leung, Aaron R Wheele. Correction to: A microfluidic platform for continuous monitoring of dopamine homeostasis in dopaminergic cells. Microsystems & nanoengineering. vol 5. 2020-09-28. PMID:31063161. |
correction to: a microfluidic platform for continuous monitoring of dopamine homeostasis in dopaminergic cells. |
2020-09-28 |
2023-08-13 |
Not clear |
| Qing-Song Lin, Ping Chen, Wei-Xiong Wang, Chen-Chao Lin, Yao Zhou, Liang-Hong Yu, Yuan-Xiang Lin, Yan-Fang Xu, De-Zhi Kan. RIP1/RIP3/MLKL mediates dopaminergic neuron necroptosis in a mouse model of Parkinson disease. Laboratory investigation; a journal of technical methods and pathology. vol 100. issue 3. 2020-09-25. PMID:31506635. |
pretreatment with necrostatin-1 or the knockout of the rip3/mlkl gene to block necroptosis pathway dramatically ameliorated pd by increasing dopamine levels and rescuing the loss of dopaminergic neurons, independent of the apoptotic pathway. |
2020-09-25 |
2023-08-13 |
mouse |
| Angelina Rakovska, Daniel Javitt, Polina Petkova-Kirova, Andrea Balla, Rosalind Ang, Reni Kalfi. Neurochemical evidence that cysteamine modulates amphetamine-induced dopaminergic neuronal activity in striatum by decreasing dopamine release: an in vivo microdialysis study in freely moving rats. Brain research bulletin. vol 153. 2020-09-24. PMID:31401065. |
neurochemical evidence that cysteamine modulates amphetamine-induced dopaminergic neuronal activity in striatum by decreasing dopamine release: an in vivo microdialysis study in freely moving rats. |
2020-09-24 |
2023-08-13 |
rat |
| Wei-Lun Sun, Pamela M Quizon, Yaxia Yuan, Matthew J Strauss, Richard McCain, Chang-Guo Zhan, Jun Zh. Mutational effects of human dopamine transporter at tyrosine88, lysine92, and histidine547 on basal and HIV-1 Tat-inhibited dopamine transport. Scientific reports. vol 9. issue 1. 2020-09-24. PMID:30846720. |
dysregulation of dopaminergic system induced by hiv-1 tat protein-mediated direct inhibition of the dopamine transporter (dat) has been implicated as a mediating factor of hiv-1 associated neurocognitive disorders. |
2020-09-24 |
2023-08-13 |
human |
| Alagudurai Krishnamoorthy, Murugan Sevanan, Sugumar Mani, Mangayarkarasi Balu, Sravani Balaji, Ramajayan . Chrysin restores MPTP induced neuroinflammation, oxidative stress and neurotrophic factors in an acute Parkinson's disease mouse model. Neuroscience letters. vol 709. 2020-09-24. PMID:31325581. |
parkinson disease occurs due to the depletion of dopaminergic neurons in brain resulting in decreased dopamine level and abnormal protein aggregation. |
2020-09-24 |
2023-08-13 |
mouse |
| Shakshi Sharma, Anupam Awasthi, Shamsher Sing. Altered gut microbiota and intestinal permeability in Parkinson's disease: Pathological highlight to management. Neuroscience letters. vol 712. 2020-09-23. PMID:31560998. |
pd involves degeneration of dopaminergic neurons in the substantia nigra pars compacta (snpc) with deficiency of dopamine. |
2020-09-23 |
2023-08-13 |
Not clear |
| Abdullah Al Jaja, Jessica A Grahn, Björn Herrmann, Penny A MacDonal. The effect of aging, Parkinson's disease, and exogenous dopamine on the neural response associated with auditory regularity processing. Neurobiology of aging. vol 89. 2020-09-23. PMID:32057529. |
the finding that dopaminergic therapy attenuates rather than improves the sustained response coheres with the dopamine overdose response and is in line with previous findings that regularity processing implicates brain regions receiving dopamine from the ventral tegmental area that is relatively spared in pd and normal aging. |
2020-09-23 |
2023-08-13 |
Not clear |
| Zongbo Sun, Ye Ma, Lei Xie, Jinzhuang Huang, Shouxing Duan, Ruiwei Guo, Yao Xie, Junyao Lv, Zhirong Lin, Shuhua M. Behavioral Changes and Neuronal Damage in Rhesus Monkeys after 10 Weeks of Ketamine Administration Involve Prefrontal Cortex Dopamine D2 Receptor and Dopamine Transporter. Neuroscience. vol 415. 2020-09-23. PMID:31330230. |
the dopamine d2 receptor (drd2) and dopamine transporter (dat) play a regulatory role in dopaminergic neurotransmission and thus play an important role in drug addiction. |
2020-09-23 |
2023-08-13 |
monkey |
| Julie A Marusich, Elaine A Gay, Scott L Watson, Bruce E Bloug. Synthetic cathinone self-administration in female rats modulates neurotransmitter levels in addiction-related brain regions. Behavioural brain research. vol 376. 2020-09-22. PMID:31493431. |
notably, both α-pvp and 4mmc produced minimal changes in dopamine levels, suggesting that the dopaminergic effects of these synthetic cathinones are transient. |
2020-09-22 |
2023-08-13 |
rat |
| Markus Riessland, Benjamin Kolisnyk, Tae Wan Kim, Jia Cheng, Jason Ni, Jordan A Pearson, Emily J Park, Kevin Dam, Devrim Acehan, Lavoisier S Ramos-Espiritu, Wei Wang, Jack Zhang, Jae-Won Shim, Gabriele Ciceri, Lars Brichta, Lorenz Studer, Paul Greengar. Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons. Cell stem cell. vol 25. issue 4. 2020-09-21. PMID:31543366. |
loss of satb1 causes activation of a cellular senescence transcriptional program in dopamine neurons both in human stem cell-derived dopaminergic neurons and in mice. |
2020-09-21 |
2023-08-13 |
mouse |
| Myrtille C R Gumbs, Anna H Vuuregge, Leslie Eggels, Unga A Unmehopa, Khalid Lamuadni, Joram D Mul, Susanne E la Fleu. Afferent neuropeptide Y projections to the ventral tegmental area in normal-weight male Wistar rats. The Journal of comparative neurology. vol 527. issue 16. 2020-09-18. PMID:30950054. |
npy also acts in the mesolimbic dopaminergic circuitry, where it can increase motivational aspects of feeding behavior through effects on dopamine output in the nucleus accumbens (nac) and on neurotransmission in the ventral tegmental area (vta). |
2020-09-18 |
2023-08-13 |
rat |
| Shu Yao, Longjun Li, Xin Sun, Jun Hua, Keqi Zhang, Li Hao, Lixin Liu, Dongyan Shi, Hong Zho. FTY720 Inhibits MPP Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 14. issue 3. 2020-09-18. PMID:31069623. |
our findings indicated that fty720 significantly attenuated mptp-induced behavioral deficits, reduced the loss of dopaminergic neurons, and increased dopamine release. |
2020-09-18 |
2023-08-13 |
mouse |
| Benjamin G Trist, Dominic J Hare, Kay L Doubl. Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease. Aging cell. vol 18. issue 6. 2020-09-14. PMID:31432604. |
motor dysfunction results from the loss of dopaminergic neurons in the substantia nigra pars compacta and depletion of dopamine in the nigrostriatal pathway. |
2020-09-14 |
2023-08-13 |
Not clear |
| Bin Song, Young Cha, Sanghyeok Ko, Jeha Jeon, Nayeon Lee, Hyemyung Seo, Kyung-Joon Park, In-Hee Lee, Claudia Lopes, Melissa Feitosa, María José Luna, Jin Hyuk Jung, Jisun Kim, Dabin Hwang, Bruce M Cohen, Martin H Teicher, Pierre Leblanc, Bob S Carter, Jeffrey H Kordower, Vadim Y Bolshakov, Sek Won Kong, Jeffrey S Schweitzer, Kwang-Soo Ki. Human autologous iPSC-derived dopaminergic progenitors restore motor function in Parkinson's disease models. The Journal of clinical investigation. vol 130. issue 2. 2020-09-14. PMID:31714896. |
dopaminergic cells thus express high levels of characteristic mda markers, produce and secrete dopamine, and exhibit electrophysiological features typical of mda cells. |
2020-09-14 |
2023-08-13 |
human |
| R A Nolan, R Muir, K Runner, E K Haddad, P J Gaskil. Role of Macrophage Dopamine Receptors in Mediating Cytokine Production: Implications for Neuroinflammation in the Context of HIV-Associated Neurocognitive Disorders. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 14. issue 1. 2020-09-14. PMID:30519866. |
to determine the connection between dopaminergic alterations and hiv-associated neuroinflammation, we have examined the impact of dopamine exposure on macrophages from healthy and virally suppressed, chronically infected hiv patients. |
2020-09-14 |
2023-08-13 |
human |
| Yung Ming Chang, M Manoj Kumar, Cheng You Lu, Chuan Te Tsai, Chin Chuan Tsai, Po Hsiang Liao, Shu Luan Lin, Chia Cheng Chang, B Mahalakshmi, Wei Wen Kuo, Chih Yang Huan. Parkinson's disease a futile entangle of Mankind's credence on an herbal remedy: A review. Life sciences. vol 257. 2020-09-11. PMID:32629002. |
chiefly perceived as progressive degeneration of dopaminergic (da) neurons in the substantia nigra pars compacta (snpc) with the ensued loss of dopamine in the striatum and the presence of lewy bodies, consisting of α-synuclein agglomeration. |
2020-09-11 |
2023-08-13 |
human |