| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michal Wegrzynowicz, Dana Bar-On, Laura Calo', Oleg Anichtchik, Mariangela Iovino, Jing Xia, Sergey Ryazanov, Andrei Leonov, Armin Giese, Jeffrey W Dalley, Christian Griesinger, Uri Ashery, Maria Grazia Spillantin. Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson's disease model. Acta neuropathologica. vol 138. issue 4. 2020-08-04. PMID:31165254. |
this is associated with a progressive reduction of striatal dopamine release, reduced striatal innervation and significant nigral dopaminergic nerve cell death starting from 6 and 12 months of age, respectively. |
2020-08-04 |
2023-08-13 |
mouse |
| Michal Wegrzynowicz, Dana Bar-On, Laura Calo', Oleg Anichtchik, Mariangela Iovino, Jing Xia, Sergey Ryazanov, Andrei Leonov, Armin Giese, Jeffrey W Dalley, Christian Griesinger, Uri Ashery, Maria Grazia Spillantin. Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson's disease model. Acta neuropathologica. vol 138. issue 4. 2020-08-04. PMID:31165254. |
treatment with the oligomer modulator anle138b, from 9 to 12 months of age, restored striatal dopamine release, prevented dopaminergic cell death and gait impairment. |
2020-08-04 |
2023-08-13 |
mouse |
| Giulia Castellani, Gabriella Contarini, Maddalena Mereu, Ennio Albanesi, Céline Devroye, Claudio D'Amore, Valentina Ferretti, Sara De Martin, Francesco Papale. Dopamine-mediated immunomodulation affects choroid plexus function. Brain, behavior, and immunity. vol 81. 2020-08-04. PMID:31175999. |
we performed a peripheral and cerebral immunophenotyping in mice bearing dopaminergic alteration produced by genetic liability (hypofunction of the dopamine transporter dat) and psychostimulant (amphetamine) administration. |
2020-08-04 |
2023-08-13 |
mouse |
| Mauro Pettorruso, Giovanni Martinotti, Fabrizio Cocciolillo, Luisa De Risio, Annarita Cinquino, Marco Di Nicola, Giovanni Camardese, Giuseppe Migliara, Lorenzo Moccia, Eliana Conte, Luigi Janiri, Daniela Di Giud. Striatal presynaptic dopaminergic dysfunction in gambling disorder: A Addiction biology. vol 24. issue 5. 2020-08-03. PMID:30226290. |
striatal presynaptic dopaminergic dysfunction in gambling disorder: a although the involvement of dopamine in gambling disorder (gd) has long been hypothesized, its precise role remains unclear. |
2020-08-03 |
2023-08-13 |
human |
| Catalina Valdés-Baizabal, Guillermo V Carbajal, David Pérez-González, Manuel S Malmierc. Dopamine modulates subcortical responses to surprising sounds. PLoS biology. vol 18. issue 6. 2020-07-29. PMID:32559190. |
this direct dopaminergic modulation of sensory pe signaling has profound implications for both the predictive coding framework and the understanding of dopamine function. |
2020-07-29 |
2023-08-13 |
rat |
| Renee F Keller, Tina Kazemi, Andrei Dragomir, Yasemin M Akay, Metin Aka. Comparison between dopaminergic and non-dopaminergic neurons in the VTA following chronic nicotine exposure during pregnancy. Scientific reports. vol 9. issue 1. 2020-07-27. PMID:30679632. |
several studies have shown that nicotine produces long-lasting effects on gene expression within many brain regions, including the ventral tegmental area (vta), which is the origin of dopaminergic neurons and the dopamine reward pathway. |
2020-07-27 |
2023-08-13 |
rat |
| Jin Zhang, Yong Wang, Yi Na Sun, Li Bo Li, Li Zhang, Yuan Guo, Tao Wang, Lu Yao, Li Chen, Jian Li. Blockade of calcium-permeable AMPA receptors in the lateral habenula produces increased antidepressant-like effects in unilateral 6-hydroxydopamine-lesioned rats compared to sham-lesioned rats. Neuropharmacology. vol 157. 2020-07-21. PMID:31251995. |
our findings indicate that blockade of lhb cp-ampars produces antidepressant-like effects, which attribute to decreased firing activity of lhb neurons and increased levels of dopamine and serotonin in the mpfc, and provide further evidence that lhb cp-ampars regulate the firing activity of pvta dopaminergic neurons and mrn serotonergic neurons indirectly via the rmtg. |
2020-07-21 |
2023-08-13 |
rat |
| Benjamin N Greenwoo. The role of dopamine in overcoming aversion with exercise. Brain research. vol 1713. 2020-07-20. PMID:30171838. |
the current review summarizes exercise adaptations in dopaminergic circuits that lead to a hyperdopaminergic state; during which dopamine release in the striatum is sensitized during exposure to non-exercise stimuli, even aversive stressors that do not typically activate reward-related dopamine circuits. |
2020-07-20 |
2023-08-13 |
Not clear |
| I Csoti, H Herbst, P Urban, D Woitalla, U Wüllne. Polypharmacy in Parkinson's disease: risks and benefits with little evidence. Journal of neural transmission (Vienna, Austria : 1996). vol 126. issue 7. 2020-07-20. PMID:31222606. |
medical treatment targeting the dopaminergic system alone may include up to five different compounds: l-dopa (in combination with a dopa decarboxylase inhibitor), a catechol-o-methyltransferase (comt) and a monoamine oxidase (mao-b) inhibitor and a dopamine agonist. |
2020-07-20 |
2023-08-13 |
Not clear |
| Mary Hongying Cheng, Luca Ponzoni, Tatiana Sorkina, Ji Young Lee, She Zhang, Alexander Sorkin, Ivet Baha. Trimerization of dopamine transporter triggered by AIM-100 binding: Molecular mechanism and effect of mutations. Neuropharmacology. vol 161. 2020-07-14. PMID:31228486. |
the study suggests the possibility of controlling the effective transport of dopamine by altering the oligomerization state of dat upon small molecule binding, as a possible intervention strategy to modulate dopaminergic signaling. |
2020-07-14 |
2023-08-13 |
Not clear |
| Danielle E Bolland, Amy E Moritz, Daniel J Stanislowski, Roxanne A Vaughan, James D Foste. Palmitoylation by Multiple DHHC Enzymes Enhances Dopamine Transporter Function and Stability. ACS chemical neuroscience. vol 10. issue 6. 2020-07-07. PMID:30965003. |
the dopamine transporter (dat) is a plasma membrane protein that mediates the reuptake of extracellular dopamine (da) and controls the spatiotemporal dynamics of dopaminergic neurotransmission. |
2020-07-07 |
2023-08-13 |
human |
| Sacnité Albarrán-Bravo, José Arturo Ávalos-Fuentes, Hernán Cortés, Marina Rodriguez-Sánchez, Norberto Leyva-García, Claudia Rangel-Barajas, David Erlij, Benjamín Florá. Severity of Dyskinesia and D3R Signaling Changes Induced by L-DOPA Treatment of Hemiparkinsonian Rats Are Features Inherent to the Treated Subjects. Biomolecules. vol 9. issue 9. 2020-07-06. PMID:31480516. |
we examined whether the severity of lid correlated with changes in dopamine 3 receptor (d3r) signaling because of the following: (a) d3r expression and the induction of lid are strongly correlated; and (b) dopaminergic denervation induces a qualitative change in d3r signaling in the snr. |
2020-07-06 |
2023-08-13 |
human |
| Alexis E Whitton, Jenna M Reinen, Mark Slifstein, Yuen-Siang Ang, Patrick J McGrath, Dan V Iosifescu, Anissa Abi-Dargham, Diego A Pizzagalli, Franklin R Schneie. Baseline reward processing and ventrostriatal dopamine function are associated with pramipexole response in depression. Brain : a journal of neurology. vol 143. issue 2. 2020-07-06. PMID:32040562. |
although these findings await replication, they suggest that measures of reward-related mesolimbic dopamine function may hold promise for identifying depressed individuals likely to respond favourably to dopaminergic pharmacotherapy. |
2020-07-06 |
2023-08-13 |
Not clear |
| Omar Collazo-Navarrete, David Hernández-García, Gilda Guerrero-Flores, René Drucker-Colín, Magdalena Guerra-Crespo, Luis Covarrubia. The Substantia Nigra Is Permissive and Gains Inductive Signals When Lesioned for Dopaminergic Differentiation of Embryonic Stem Cells. Stem cells and development. vol 28. issue 16. 2020-07-02. PMID:31140356. |
transplantation of dopaminergic (da) cells into the striatum can rescue from dopamine deficiency in a parkinson's disease condition, but this is not a suitable procedure for regaining the full control of motor activity. |
2020-07-02 |
2023-08-13 |
Not clear |
| Annika H Runegaard, Kathrine Louise Jensen, Gitta Wörtwein, Ulrik Gethe. Initial rewarding effects of cocaine and amphetamine assessed in a day using the single-exposure place preference protocol. The European journal of neuroscience. vol 50. issue 3. 2020-06-30. PMID:30044020. |
in rodents, only a single dose of cocaine or amphetamine is required to cause a marked increase in extracellular dopamine, induce hyperlocomotion and cause persistent plasticity changes within dopaminergic neurons of the ventral tegmental area (vta). |
2020-06-30 |
2023-08-13 |
mouse |
| Jacqueline D Keighron, JoLynn B Giancola, Rachel J Shaffer, Emily M DeMarco, Mark A Coggiano, Rachel D Slack, Amy Hauck Newman, Gianluigi Tand. Distinct effects of (R)-modafinil and its (R)- and (S)-fluoro-analogs on mesolimbic extracellular dopamine assessed by voltammetry and microdialysis in rats. The European journal of neuroscience. vol 50. issue 3. 2020-06-30. PMID:30402972. |
here, we have tested the effects of the clinically available (r)-enantiomer of mod on extracellular dopamine levels in the nucleus accumbens shell, a mesolimbic dopaminergic projection field that plays significant roles in various aspects of psychostimulant use disorders, measured in vivo by fast-scan cyclic voltammetry and by microdialysis in sprague-dawley rats. |
2020-06-30 |
2023-08-13 |
rat |
| Huiying Liu, Hao Wu, Ning Zhu, Zijie Xu, Yue Wang, Yan Qu, Jun Wan. Lactoferrin protects against iron dysregulation, oxidative stress, and apoptosis in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease in mice. Journal of neurochemistry. vol 152. issue 3. 2020-06-30. PMID:31442326. |
its pathological features are dopaminergic neuronal death in the substantia nigra (sn), and significant reduction in dopamine (da) content in the striatum. |
2020-06-30 |
2023-08-13 |
mouse |
| Christian P Mülle. Everything you always wanted to know about sex and dopamine, but were afraid to ask: An Editorial for 'No basal or drug-induced sex differences in striatal dopaminergic levels: a cluster and metaanalysis of rat microdialysis studies' on page 482. Journal of neurochemistry. vol 152. issue 4. 2020-06-30. PMID:31792978. |
everything you always wanted to know about sex and dopamine, but were afraid to ask: an editorial for 'no basal or drug-induced sex differences in striatal dopaminergic levels: a cluster and metaanalysis of rat microdialysis studies' on page 482. |
2020-06-30 |
2023-08-13 |
rat |
| Fanni F Geibl, Martin T Henrich, Wolfgang H Oerte. Mesencephalic and extramesencephalic dopaminergic systems in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 126. issue 4. 2020-06-26. PMID:30643975. |
neurodegeneration of the nigrostriatal dopaminergic system and concurrent dopamine (da) deficiency in the basal ganglia represent core features of parkinson's disease (pd). |
2020-06-26 |
2023-08-13 |
Not clear |
| R Horowski, P-A Löschman. Classical dopamine agonists. Journal of neural transmission (Vienna, Austria : 1996). vol 126. issue 4. 2020-06-26. PMID:30805732. |
he was awarded the nobel price for the discovery of the crucial role of dopamine (da) as a neurotransmitter in the cns, thereby forming the basis for the symptomatic therapy of parkinson's disease (pd) with l-dopa and subsequently dopaminergic drugs. |
2020-06-26 |
2023-08-13 |
Not clear |