| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lina Patterson, Steven P Rushton, Johannes Attems, Alan J Thomas, Christopher M Morri. Degeneration of dopaminergic circuitry influences depressive symptoms in Lewy body disorders. Brain pathology (Zurich, Switzerland). vol 29. issue 4. 2020-02-12. PMID:30582885. |
given the role of dopamine in the development of movement disorders, but also in motivation and reward, we investigated neurodegenerative pathology in dopaminergic circuitry in parkinson's disease (pd), pd with dementia (pdd) and dementia with lewy bodies (dlb) patients in relation to depressive symptoms. |
2020-02-12 |
2023-08-13 |
Not clear |
| Sergio Vegas-Suarez, Elena Paredes-Rodriguez, Asier Aristieta, Jose V Lafuente, Cristina Miguelez, Luisa Uged. Dysfunction of serotonergic neurons in Parkinson's disease and dyskinesia. International review of neurobiology. vol 146. 2020-02-03. PMID:31349930. |
parkinson's disease (pd) is characterized by the degeneration of dopaminergic neurons in the substantia nigra, the depletion of striatal dopamine and the presence of lewy aggregates containing alpha-synuclein. |
2020-02-03 |
2023-08-13 |
Not clear |
| Pierpaolo Turcano, John J Chen, Britta L Bureau, Rodolfo Savic. Early ophthalmologic features of Parkinson's disease: a review of preceding clinical and diagnostic markers. Journal of neurology. vol 266. issue 9. 2020-01-28. PMID:30209648. |
some of the visual symptoms of parkinson's disease can likely be explained by the presence of dopaminergic neurons within the retina, where the progressive loss of dopamine and the accumulation of α-synuclein within the retinal layers leads to visual dysfunction, while some are caused by abnormalities in cortical visual processing. |
2020-01-28 |
2023-08-13 |
Not clear |
| Jean-Paul Selten, Jan Booij, Bauke Buwalda, Andreas Meyer-Lindenber. Biological Mechanisms Whereby Social Exclusion May Contribute to the Etiology of Psychosis: A Narrative Review. Schizophrenia bulletin. vol 43. issue 2. 2020-01-27. PMID:28053019. |
the defeated animal shows evidence of an increased sensitivity to amphetamine, increased dopamine release in the nucleus accumbens and prefrontal cortex, and increased firing of dopaminergic neurons in the ventral tegmental area. |
2020-01-27 |
2023-08-13 |
Not clear |
| Kamin Kim, Nicolaas I Bohnen, Martijn L T M Müller, Cindy Lusti. Compensatory dopaminergic-cholinergic interactions in conflict processing: Evidence from patients with Parkinson's disease. NeuroImage. vol 190. 2020-01-27. PMID:29337277. |
supporting the compensatory hypothesis, regression models controlling for age and other covariates revealed an interaction between caudate dopamine and cortical cholinergic integrity: cortical cholinergic integrity was a stronger predictor of conflict processing in patients with relatively low caudate dopaminergic function. |
2020-01-27 |
2023-08-13 |
Not clear |
| David Meder, Damian Marc Herz, James Benedict Rowe, Stéphane Lehéricy, Hartwig Roman Siebne. The role of dopamine in the brain - lessons learned from Parkinson's disease. NeuroImage. vol 190. 2020-01-27. PMID:30465864. |
the core impairment of dopaminergic neurotransmission has motivated the use of functional magnetic resonance imaging (fmri) in patients with parkinson's disease to elucidate the role of dopamine in motor control and cognition in humans. |
2020-01-27 |
2023-08-13 |
Not clear |
| David Meder, Damian Marc Herz, James Benedict Rowe, Stéphane Lehéricy, Hartwig Roman Siebne. The role of dopamine in the brain - lessons learned from Parkinson's disease. NeuroImage. vol 190. 2020-01-27. PMID:30465864. |
the amount of neurodegeneration in the task-relevant dopaminergic nuclei and pharmacological dopamine replacement can therefore move performance either away or towards the task-specific optimum. |
2020-01-27 |
2023-08-13 |
Not clear |
| Jordan M Buck, Kelsey N Sanders, Charles R Wageman, Valerie S Knopik, Jerry A Stitzel, Heidi C O'Neil. Developmental nicotine exposure precipitates multigenerational maternal transmission of nicotine preference and ADHD-like behavioral, rhythmometric, neuropharmacological, and epigenetic anomalies in adolescent mice. Neuropharmacology. vol 149. 2020-01-27. PMID:30742847. |
pharmacological characterization of nicotinic and dopaminergic systems in striatum and frontal cortex reveals altered expression and dysfunction of nicotinic acetylcholine receptors (nachrs), hypersensitivity to nicotine-induced nachr-mediated dopamine release, and impaired dopamine transporter (dat) function in dne mice. |
2020-01-27 |
2023-08-13 |
mouse |
| Meng Zhao, Xiongfei Wang, Jiahui Deng, Yuguang Guan, Jian Zhou, Tianfu Li, Guoming Lua. Globus Pallidus Internus Electric High-Frequency Stimulation Modulates Dopaminergic Activity in the Striatum of a Rat Model of Tourette Syndrome. World neurosurgery. vol 127. 2020-01-23. PMID:30959252. |
the purpose of this study was to investigate the role of deep brain stimulation (dbs) of the globus pallidus internus (gpi) in dopamine and dopamine transporter metabolism and to explore the regulatory role of dbs on dopaminergic neurons in tourette syndrome by constructing an autoimmune model. |
2020-01-23 |
2023-08-13 |
rat |
| Hyeyoon Eo, Youngji Kwon, Eugene Huh, Yeomoon Sim, Jin Gyu Choi, Jin Seok Jeong, Xiao Fei Du, Hye Yeon Soh, Seon-Pyo Hong, Youngmi Kim Pak, Myung Sook O. Protective effects of DA-9805 on dopaminergic neurons against 6-hydroxydopamine-induced neurotoxicity in the models of Parkinson's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 117. 2020-01-17. PMID:31387167. |
furthermore, da-9805 prevented 6-ohda-induced movement impairment, as well as a decrease of dopaminergic neurons and dopamine transmission in rodents. |
2020-01-17 |
2023-08-13 |
Not clear |
| Sunil Bhurtel, Nikita Katila, Sunil Srivastav, Sabita Neupane, Dong-Young Cho. Mechanistic comparison between MPTP and rotenone neurotoxicity in mice. Neurotoxicology. vol 71. 2020-01-09. PMID:30605763. |
mptp clearly produced dopaminergic lesions in both the substantia nigra and the striatum as shown by loss of dopaminergic neurons, depletion of striatal dopamine, activation of glial cells in the nigrostriatal pathway and behavioral impairment. |
2020-01-09 |
2023-08-13 |
mouse |
| Veronica Francardo, Michal Geva, Francesco Bez, Quentin Denis, Lilach Steiner, Michael R Hayden, M Angela Cenc. Pridopidine Induces Functional Neurorestoration Via the Sigma-1 Receptor in a Mouse Model of Parkinson's Disease. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 16. issue 2. 2020-01-09. PMID:30756361. |
the behavioral recovery induced by pridopidine 0.3 mg/kg was accompanied by a significant protection of nigral dopamine cell bodies, an increased dopaminergic fiber density in the striatum, and striatal upregulation of gdnf, bdnf, and phosphorylated erk1/2. |
2020-01-09 |
2023-08-13 |
mouse |
| Yun Li, Yue Zhang, Xiao-Li Zhang, Xiao-Yan Feng, Chen-Zhe Liu, Xiu-Neng Zhang, Zhu-Sheng Quan, Jing-Ting Yan, Jin-Xia Zh. Dopamine promotes colonic mucus secretion through dopamine D American journal of physiology. Cell physiology. vol 316. issue 3. 2020-01-06. PMID:30624983. |
mice injected intraperitoneally with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) destroying enteric dopamine (da) neurons, rats microinjected with 6-hydroxydopamine (6-ohda) into the bilateral substantia nigra damaging central dopaminergic neurons, and dopamine d |
2020-01-06 |
2023-08-13 |
mouse |
| Jochen Hammes, Hendrik Theis, Kathrin Giehl, Merle C Hoenig, Andrea Greuel, Marc Tittgemeyer, Lars Timmermann, Gereon R Fink, Alexander Drzezga, Carsten Eggers, Thilo van Eimere. Dopamine metabolism of the nucleus accumbens and fronto-striatal connectivity modulate impulse control. Brain : a journal of neurology. vol 142. issue 3. 2020-01-06. PMID:30753324. |
here, we aimed to test the hypothesis of fewer mesolimbic projections as a risk factor by using dopamine synthesis capacity as a proxy of dopaminergic terminal density. |
2020-01-06 |
2023-08-13 |
human |
| Jochen Hammes, Hendrik Theis, Kathrin Giehl, Merle C Hoenig, Andrea Greuel, Marc Tittgemeyer, Lars Timmermann, Gereon R Fink, Alexander Drzezga, Carsten Eggers, Thilo van Eimere. Dopamine metabolism of the nucleus accumbens and fronto-striatal connectivity modulate impulse control. Brain : a journal of neurology. vol 142. issue 3. 2020-01-06. PMID:30753324. |
rather than a downregulation of dopamine transporters, a reduction of mesolimbic dopaminergic projections in conjunction with a dysfunctional rostral anterior cingulate cortex-a region known to play a key role in impulse control-could be the most crucial neurobiological risk factor for the development of impulsive-compulsive behaviours in patients with parkinson's disease under dopamine replacement therapy. |
2020-01-06 |
2023-08-13 |
human |
| Kristel Klaus, Kyla Penningto. Dopamine and Working Memory: Genetic Variation, Stress and Implications for Mental Health. Current topics in behavioral neurosciences. vol 41. 2020-01-06. PMID:31502081. |
at the molecular level, the neurotransmitter dopamine (da) is a key regulatory component of executive function in the prefrontal cortex (pfc) and dysfunction in dopaminergic (daergic) circuitry has been shown to result in impaired working memory (wm). |
2020-01-06 |
2023-08-13 |
Not clear |
| Hiroki Kurosaki, Kentaro Yamaguchi, Kohei Man-Yoshi, Shin-Ichi Muramatsu, Satoshi Hara, Hiroshi Ichinos. Administration of tetrahydrobiopterin restored the decline of dopamine in the striatum induced by an acute action of MPTP. Neurochemistry international. vol 125. 2020-01-03. PMID:30739038. |
mptp reduced the dopamine content and the in vivo activity of th in the striatum prior to degeneration of the dopaminergic neurons. |
2020-01-03 |
2023-08-13 |
mouse |
| Mei Zhou, Xiaokang Gong, Qin Ru, Qi Xiong, Lin Chen, Yuanren Si, Huaqiao Xiao, Chaoying L. The Neuroprotective Effect of L-Stepholidine on Methamphetamine-Induced Memory Deficits in Mice. Neurotoxicity research. vol 36. issue 2. 2020-01-02. PMID:31201732. |
meanwhile, the protein expression of dopaminergic d2 receptors in hippocampus area was significantly increased by repeated meth exposure, while the protein expression of dopamine transporter (dat) was significantly reduced. |
2020-01-02 |
2023-08-13 |
mouse |
| Sanford Pc Hsu, Dao-Yuan Wang, Ming-Yuan Min, Yu-Show F. Long-term challenge of methylphenidate changes the neuronal population and membrane property of dopaminergic neuron in rats. Neurochemistry international. vol 122. 2019-12-26. PMID:30423424. |
the firing behavior of dopaminergic neurons and dopamine concentration in the brain is affected by the long-term challenge of methylphenidate. |
2019-12-26 |
2023-08-13 |
rat |
| Fukie Yaoita, Masahiro Tsuchiya, Yuichiro Arai, Takeshi Tadano, Koichi Tan-N. Involvement of catecholaminergic and GABAAergic mediations in the anxiety-related behavior in long-term powdered diet-fed mice. Neurochemistry international. vol 124. 2019-12-24. PMID:30529642. |
moreover, that diet causes changes in the dopaminergic system, especially increased dopamine turnover and decreased dopamine d4 receptor signals in the frontal cortex. |
2019-12-24 |
2023-08-13 |
mouse |