| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Suresh B Rangasamy, Sridevi Dasarathi, Priyanka Pahan, Malabendu Jana, Kalipada Paha. Low-Dose Aspirin Upregulates Tyrosine Hydroxylase and Increases Dopamine Production in Dopaminergic Neurons: Implications for Parkinson's Disease. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 14. issue 2. 2020-09-11. PMID:30187283. |
low-dose aspirin upregulates tyrosine hydroxylase and increases dopamine production in dopaminergic neurons: implications for parkinson's disease. |
2020-09-11 |
2023-08-13 |
mouse |
| Suresh B Rangasamy, Sridevi Dasarathi, Priyanka Pahan, Malabendu Jana, Kalipada Paha. Low-Dose Aspirin Upregulates Tyrosine Hydroxylase and Increases Dopamine Production in Dopaminergic Neurons: Implications for Parkinson's Disease. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 14. issue 2. 2020-09-11. PMID:30187283. |
although tyrosine hydroxylase (th) is the rate-limiting enzyme in the dopamine (da) biosynthesis pathway, there are no effective drugs/molecules to upregulate th and increase the production of da in nigral dopaminergic neurons. |
2020-09-11 |
2023-08-13 |
mouse |
| Yung Ming Chang, M Manoj Kumar, Cheng You Lu, Chuan Te Tsai, Chin Chuan Tsai, Po Hsiang Liao, Shu Luan Lin, Chia Cheng Chang, B Mahalakshmi, Wei Wen Kuo, Chih Yang Huan. Parkinson's disease a futile entangle of Mankind's credence on an herbal remedy: A review. Life sciences. vol 257. 2020-09-11. PMID:32629002. |
chiefly perceived as progressive degeneration of dopaminergic (da) neurons in the substantia nigra pars compacta (snpc) with the ensued loss of dopamine in the striatum and the presence of lewy bodies, consisting of α-synuclein agglomeration. |
2020-09-11 |
2023-08-13 |
human |
| Ana Paula Bertholo, Carina França, Wilma Silva Fiorini, Egberto Reis Barbosa, Rubens Gisbert Cur. Medical management after subthalamic stimulation in Parkinson's disease: a phenotype perspective. Arquivos de neuro-psiquiatria. vol 78. issue 4. 2020-09-09. PMID:32294747. |
in patients taking high doses of dopaminergic drugs or with high risk of impulse control disorders, an initial reduction in dopamine agonists after stn dbs is recommended to avoid the hyperdopaminergic syndrome, particularly hypomania. |
2020-09-09 |
2023-08-13 |
Not clear |
| Ruiwen Li, Wei Guo, Lei Lei, Ling Zhang, Yunhao Liu, Jian Han, Lianguo Chen, Bingsheng Zho. Early-life exposure to the organophosphorus flame-retardant tris (1,3-dichloro-2-propyl) phosphate induces delayed neurotoxicity associated with DNA methylation in adult zebrafish. Environment international. vol 134. 2020-09-08. PMID:31731001. |
decreased dopamine (da) concentration and down-regulation of dopaminergic signaling related genes were observed in the brains of adult females. |
2020-09-08 |
2023-08-13 |
zebrafish |
| Oleg V Ardashov, Alla V Pavlova, Arun Kumar Mahato, Yulia Sidorova, Ekaterina A Morozova, Dina V Korchagina, Georgi E Salnikov, Alexander M Genaev, Oksana S Patrusheva, Nikolay S Li-Zhulanov, Tat'yana G Tolstikova, Konstantin P Volcho, Nariman F Salakhutdino. A Novel Small Molecule Supports the Survival of Cultured Dopamine Neurons and May Restore the Dopaminergic Innervation of the Brain in the MPTP Mouse Model of Parkinson's Disease. ACS chemical neuroscience. vol 10. issue 10. 2020-09-04. PMID:31464415. |
a novel small molecule supports the survival of cultured dopamine neurons and may restore the dopaminergic innervation of the brain in the mptp mouse model of parkinson's disease. |
2020-09-04 |
2023-08-13 |
mouse |
| Hannes O Tiedt, Felicitas Ehlen, Fabian Klosterman. Increased conceptual switching by dopaminergic treatment in patients with Parkinson's disease. Brain and cognition. vol 144. 2020-09-03. PMID:32858496. |
here, we studied the impact of dopaminergic medication on specific cognitive components underlying vf task performance in 21 participants with pd on their regular medication and following dopamine withdrawal compared with healthy controls. |
2020-09-03 |
2023-08-13 |
human |
| b' Sacha Bohler, Xiaosong Liu, Julian Krauskopf, Florian Caiment, Jiri Aubrecht, Gerry A F Nicolaes, Jos C S Kleinjans, Jacco J Bried\\xc3\\xa. Acetaminophen Overdose as a Potential Risk Factor for Parkinson\'s Disease. Clinical and translational science. vol 12. issue 6. 2020-08-31. PMID:31305025.' |
similarities were found among molecular structures of dopamine (da), acetaminophen, and two known pd inducers indicating affinity for dopaminergic transport. |
2020-08-31 |
2023-08-13 |
human |
| Lars-Lennart Oettl, Max Scheller, Carla Filosa, Sebastian Wieland, Franziska Haag, Cathrin Loeb, Daniel Durstewitz, Roman Shusterman, Eleonora Russo, Wolfgang Kelsc. Phasic dopamine reinforces distinct striatal stimulus encoding in the olfactory tubercle driving dopaminergic reward prediction. Nature communications. vol 11. issue 1. 2020-08-31. PMID:32651365. |
phasic dopamine reinforces distinct striatal stimulus encoding in the olfactory tubercle driving dopaminergic reward prediction. |
2020-08-31 |
2023-08-13 |
Not clear |
| SeungJu Jackie Oh, Xiaoduo Fa. The Possible Role of the Angiotensin System in the Pathophysiology of Schizophrenia: Implications for Pharmacotherapy. CNS drugs. vol 33. issue 6. 2020-08-28. PMID:30993607. |
with a greater understanding of how ras inhibition directly modulates neurotransmitter balance in the brain, it is possible that compounds with ras-inhibiting properties could be used to optimize physiological levels of glutamate, dopamine, and gaba, and the balance among the three neurotransmitters, analogously to how antipsychotic medications mediate the dopaminergic pathways. |
2020-08-28 |
2023-08-13 |
Not clear |
| Antonio Pedro Vargas, Luiz Sérgio Vaz, Alex Reuter, Christian Marques Couto, Francisco Eduardo Costa Cardos. Impulse control symptoms in patients with Parkinson's disease: The influence of dopaminergic agonist. Parkinsonism & related disorders. vol 68. 2020-08-26. PMID:31621612. |
cross-sectional studies suggest an association between dopamine replacement therapy, especially dopaminergic agonists, and impulse control and related disorders in parkinson's disease. |
2020-08-26 |
2023-08-13 |
Not clear |
| Marloes van Hout, Jessica Klein, Philip K Ahring, David T Brown, Siganya Thaneshwaran, Altair B Dos Santos, Anders A Jensen, Kristi A Kohlmeier, Palle Christophersen, Tino Dyhrin. Characterization of AN6001, a positive allosteric modulator of α6β2-containing nicotinic acetylcholine receptors. Biochemical pharmacology. vol 174. 2020-08-24. PMID:31887290. |
α6β2-containing nicotinic acetylcholine receptors (α6β2* nachrs) are predominantly expressed in midbrain dopaminergic neurons, including substantia nigra pars compacta (snc) neurons and their projections to striatal regions, where they regulate dopamine release and nigrostriatal activity. |
2020-08-24 |
2023-08-13 |
human |
| Ju Hwan Kim, Choong-Hyun Lee, Hyung-Gun Kim, Hak Rim Ki. Decreased dopamine in striatum and difficult locomotor recovery from MPTP insult after exposure to radiofrequency electromagnetic fields. Scientific reports. vol 9. issue 1. 2020-08-19. PMID:30718744. |
these results suggest that the observed decrease in dopamine concentration in the striatum was caused by both a reduction in the number of dopaminergic neurons and a decline in the number of svs. |
2020-08-19 |
2023-08-13 |
mouse |
| Maxime Fouyssac, David Beli. Beyond drug-induced alteration of glutamate homeostasis, astrocytes may contribute to dopamine-dependent intrastriatal functional shifts that underlie the development of drug addiction: A working hypothesis. The European journal of neuroscience. vol 50. issue 6. 2020-08-12. PMID:30968489. |
capitalising on growing evidence that astrocytes play a fundamental regulatory role in glutamate and dopamine transmission in the striatum, we present an innovative model of a quadripartite synaptic microenvironment within which astrocytes channel functional interactions between the dopaminergic and glutamatergic systems that may represent the primary striatal functional unit that undergoes drug-induced adaptations eventually leading to addiction. |
2020-08-12 |
2023-08-13 |
Not clear |
| Gabriela A Perez-Barron, Sergio Montes, Moises Rubio-Osornio, Jose G Avila-Acevedo, Sara Garcia-Jimenez, Luis C Rios, Antonio Monroy-Noyol. Hydroxytyrosol inhibits MAO isoforms and prevents neurotoxicity inducible by MPP+ invivo. Frontiers in bioscience (Scholar edition). vol 12. 2020-08-05. PMID:31585863. |
parkinson's disease is considered to be due to an increase in the catabolism of dopamine by the action of monoamine oxidase (mao) enzymes which leads to an increase in reactive oxygen species (ros) and loss of dopaminergic neurons. |
2020-08-05 |
2023-08-13 |
rat |
| Michal Wegrzynowicz, Dana Bar-On, Laura Calo', Oleg Anichtchik, Mariangela Iovino, Jing Xia, Sergey Ryazanov, Andrei Leonov, Armin Giese, Jeffrey W Dalley, Christian Griesinger, Uri Ashery, Maria Grazia Spillantin. Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson's disease model. Acta neuropathologica. vol 138. issue 4. 2020-08-04. PMID:31165254. |
this is associated with a progressive reduction of striatal dopamine release, reduced striatal innervation and significant nigral dopaminergic nerve cell death starting from 6 and 12 months of age, respectively. |
2020-08-04 |
2023-08-13 |
mouse |
| Michal Wegrzynowicz, Dana Bar-On, Laura Calo', Oleg Anichtchik, Mariangela Iovino, Jing Xia, Sergey Ryazanov, Andrei Leonov, Armin Giese, Jeffrey W Dalley, Christian Griesinger, Uri Ashery, Maria Grazia Spillantin. Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson's disease model. Acta neuropathologica. vol 138. issue 4. 2020-08-04. PMID:31165254. |
treatment with the oligomer modulator anle138b, from 9 to 12 months of age, restored striatal dopamine release, prevented dopaminergic cell death and gait impairment. |
2020-08-04 |
2023-08-13 |
mouse |
| Giulia Castellani, Gabriella Contarini, Maddalena Mereu, Ennio Albanesi, Céline Devroye, Claudio D'Amore, Valentina Ferretti, Sara De Martin, Francesco Papale. Dopamine-mediated immunomodulation affects choroid plexus function. Brain, behavior, and immunity. vol 81. 2020-08-04. PMID:31175999. |
we performed a peripheral and cerebral immunophenotyping in mice bearing dopaminergic alteration produced by genetic liability (hypofunction of the dopamine transporter dat) and psychostimulant (amphetamine) administration. |
2020-08-04 |
2023-08-13 |
mouse |
| Mauro Pettorruso, Giovanni Martinotti, Fabrizio Cocciolillo, Luisa De Risio, Annarita Cinquino, Marco Di Nicola, Giovanni Camardese, Giuseppe Migliara, Lorenzo Moccia, Eliana Conte, Luigi Janiri, Daniela Di Giud. Striatal presynaptic dopaminergic dysfunction in gambling disorder: A Addiction biology. vol 24. issue 5. 2020-08-03. PMID:30226290. |
striatal presynaptic dopaminergic dysfunction in gambling disorder: a although the involvement of dopamine in gambling disorder (gd) has long been hypothesized, its precise role remains unclear. |
2020-08-03 |
2023-08-13 |
human |
| Catalina Valdés-Baizabal, Guillermo V Carbajal, David Pérez-González, Manuel S Malmierc. Dopamine modulates subcortical responses to surprising sounds. PLoS biology. vol 18. issue 6. 2020-07-29. PMID:32559190. |
this direct dopaminergic modulation of sensory pe signaling has profound implications for both the predictive coding framework and the understanding of dopamine function. |
2020-07-29 |
2023-08-13 |
rat |