| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hui Dong, Juan Wang, Yan-Fei Yang, Yan Shen, Wei-Min Qu, Zhi-Li Huan. Dorsal Striatum Dopamine Levels Fluctuate Across the Sleep-Wake Cycle and Respond to Salient Stimuli in Mice. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:30949023. |
here, we employed an intensity-based genetically encoded dopamine indicator, dlight1.1, to track striatal dopamine levels across the spontaneous sleep-wake cycle and the dopaminergic response to external stimuli. |
2020-10-01 |
2023-08-13 |
mouse |
| Nicholas G Norwitz, Michele T Hu, Kieran Clark. The Mechanisms by Which the Ketone Body D-β-Hydroxybutyrate May Improve the Multiple Cellular Pathologies of Parkinson's Disease. Frontiers in nutrition. vol 6. 2020-10-01. PMID:31139630. |
although dopamine replacement therapy temporarily helps patients manage their motor symptoms, this current standard of care fails to address the underlying network of pathologies that contribute to the persistent death of dopaminergic neurons. |
2020-10-01 |
2023-08-13 |
Not clear |
| Erika Coletto, John S Dolan, Sara Pritchard, Alex Gant, Atsuko Hikima, Michael J Jackson, Christopher D Benham, K Ray Chaudhuri, Sarah Rose, Peter Jenner, Mahmoud M Iravan. Contractile dysfunction and nitrergic dysregulation in small intestine of a primate model of Parkinson's disease. NPJ Parkinson's disease. vol 5. 2020-10-01. PMID:31231674. |
the absence of the relaxation and the inefficacy of l-name in the mptp tissues suggests that central dopaminergic loss dopamine may eventually lead to the impairment of no signal coupling that affects bowel function, and this may be the result of a complex dysregulation at the level of the neuroeffector junction. |
2020-10-01 |
2023-08-13 |
marmoset |
| Ashley L Green, Aseel Eid, Le Zhan, Helmut Zarbl, Grace L Guo, Jason R Richardso. Epigenetic Regulation of the Ontogenic Expression of the Dopamine Transporter. Frontiers in genetics. vol 10. 2020-10-01. PMID:31749842. |
the dopamine transporter (dat) is a plasma membrane transport protein responsible for regulating the duration and intensity of dopaminergic signaling. |
2020-10-01 |
2023-08-13 |
rat |
| Miguel A Pieron. Investigation of apomorphine during sleep in Parkinson's: Improvement in UPDRS Scores. Neurology international. vol 11. issue 4. 2020-10-01. PMID:31871600. |
this study proposes that dopaminergic deficit may be responsible for the circadian dysregulation that occur with neurodegeneration and therefore a restitution of rem sleep and an improvement in parkinson disease's symptoms can be achieved with the controlled use of dopamine agonists during the night. |
2020-10-01 |
2023-08-13 |
Not clear |
| Shashank Vasudevan, Janko Kajtez, Ada-Ioana Bunea, Ana Gonzalez-Ramos, Tania Ramos-Moreno, Arto Heiskanen, Merab Kokaia, Niels B Larsen, Alberto Martínez-Serrano, Stephan S Keller, Jenny Emnéu. Leaky Optoelectrical Fiber for Optogenetic Stimulation and Electrochemical Detection of Dopamine Exocytosis from Human Dopaminergic Neurons. Advanced science (Weinheim, Baden-Wurttemberg, Germany). vol 6. issue 24. 2020-10-01. PMID:31871869. |
leaky optoelectrical fiber for optogenetic stimulation and electrochemical detection of dopamine exocytosis from human dopaminergic neurons. |
2020-10-01 |
2023-08-13 |
human |
| Shashank Vasudevan, Janko Kajtez, Ada-Ioana Bunea, Ana Gonzalez-Ramos, Tania Ramos-Moreno, Arto Heiskanen, Merab Kokaia, Niels B Larsen, Alberto Martínez-Serrano, Stephan S Keller, Jenny Emnéu. Leaky Optoelectrical Fiber for Optogenetic Stimulation and Electrochemical Detection of Dopamine Exocytosis from Human Dopaminergic Neurons. Advanced science (Weinheim, Baden-Wurttemberg, Germany). vol 6. issue 24. 2020-10-01. PMID:31871869. |
in parkinson's disease, the degeneration of dopaminergic neurons in substantia nigra leads to a decrease in the physiological levels of dopamine in striatum. |
2020-10-01 |
2023-08-13 |
human |
| Shashank Vasudevan, Janko Kajtez, Ada-Ioana Bunea, Ana Gonzalez-Ramos, Tania Ramos-Moreno, Arto Heiskanen, Merab Kokaia, Niels B Larsen, Alberto Martínez-Serrano, Stephan S Keller, Jenny Emnéu. Leaky Optoelectrical Fiber for Optogenetic Stimulation and Electrochemical Detection of Dopamine Exocytosis from Human Dopaminergic Neurons. Advanced science (Weinheim, Baden-Wurttemberg, Germany). vol 6. issue 24. 2020-10-01. PMID:31871869. |
transplanting dopaminergic neurons derived from stem cells could restore dopamine levels without additional motor complications. |
2020-10-01 |
2023-08-13 |
human |
| Shashank Vasudevan, Janko Kajtez, Ada-Ioana Bunea, Ana Gonzalez-Ramos, Tania Ramos-Moreno, Arto Heiskanen, Merab Kokaia, Niels B Larsen, Alberto Martínez-Serrano, Stephan S Keller, Jenny Emnéu. Leaky Optoelectrical Fiber for Optogenetic Stimulation and Electrochemical Detection of Dopamine Exocytosis from Human Dopaminergic Neurons. Advanced science (Weinheim, Baden-Wurttemberg, Germany). vol 6. issue 24. 2020-10-01. PMID:31871869. |
finally, light leaking from the micro-optical windows is used to stimulate the dopaminergic neurons resulting in the release of dopamine that is detected in real-time using chronoamperometry. |
2020-10-01 |
2023-08-13 |
human |
| Mehmet Atilla Uysal, Ülgen Sever, Ayşe Feyda Nursal, Sacide Pehlİva. Dopamine D4 Receptor Gene Exon III VNTR Variant Influences Smoking Status in Turkish Population. Noro psikiyatri arsivi. vol 56. issue 4. 2020-10-01. PMID:31903031. |
dopaminergic gene variants may affect nicotine dependence through their possible impact on the dopamine reward pathway. |
2020-10-01 |
2023-08-13 |
Not clear |
| Henin. Restless Legs Syndrome. Current treatment options in neurology. vol 1. issue 4. 2020-09-30. PMID:11096718. |
the optimal initial approach to rls in the general patient is usually the use of a dopaminergic agent: low-dose levodopa in milder cases, a dopamine agonist in more severe ones. |
2020-09-30 |
2023-08-12 |
Not clear |
| David M White, Nina V Kraguljac, Meredith A Reid, Adrienne C Laht. Contribution of substantia nigra glutamate to prediction error signals in schizophrenia: a combined magnetic resonance spectroscopy/functional imaging study. NPJ schizophrenia. vol 1. 2020-09-30. PMID:26878032. |
because dopamine neurons signal a mismatch between expected and actual reward called prediction error (pe), aberrant pe signals in schizophrenia have been attributed to known dopaminergic abnormalities. |
2020-09-30 |
2023-08-13 |
Not clear |
| Katsuhiro Nagatomo, Sechiko Suga, Masato Saitoh, Masahito Kogawa, Kazuto Kobayashi, Yoshio Yamamoto, Katsuya Yamad. Dopamine D1 Receptor Immunoreactivity on Fine Processes of GFAP-Positive Astrocytes in the Substantia Nigra Pars Reticulata of Adult Mouse. Frontiers in neuroanatomy. vol 11. 2020-09-30. PMID:28203148. |
substantia nigra pars reticulata (snr), the major output nucleus of the basal ganglia, receives dopamine from dendrites extending from dopaminergic neurons of the adjacent nucleus pars compacta (snc), which is known for its selective degeneration in parkinson's disease. |
2020-09-30 |
2023-08-13 |
mouse |
| Lachlan Ferguson, Alice Petty, Chelsie Rohrscheib, Michael Troup, Leonie Kirszenblat, Darryl W Eyles, Bruno van Swindere. Transient Dysregulation of Dopamine Signaling in a Developing Frontiers in psychiatry. vol 8. 2020-09-30. PMID:28243212. |
transient dysregulation of dopamine signaling in a developing the dopamine ontogeny hypothesis for schizophrenia proposes that transient dysregulation of the dopaminergic system during brain development increases the likelihood of this disorder in adulthood. |
2020-09-30 |
2023-08-13 |
drosophila_melanogaster |
| Anni Richter, Adriana Barman, Torsten Wüstenberg, Joram Soch, Denny Schanze, Anna Deibele, Gusalija Behnisch, Anne Assmann, Marieke Klein, Martin Zenker, Constanze Seidenbecher, Björn H Schot. Behavioral and Neural Manifestations of Reward Memory in Carriers of Low-Expressing versus High-Expressing Genetic Variants of the Dopamine D2 Receptor. Frontiers in psychology. vol 8. 2020-09-30. PMID:28507526. |
dopamine is critically important in the neural manifestation of motivated behavior, and alterations in the human dopaminergic system have been implicated in the etiology of motivation-related psychiatric disorders, most prominently addiction. |
2020-09-30 |
2023-08-13 |
human |
| Kenneth Blum, Edward J Modestino, Marcelo Febo, Bruce Steinberg, Thomas McLaughlin, Lyle Fried, David Baron, David Siwicki, Rajendra D Badgaiya. Lyme and Dopaminergic Function: Hypothesizing Reduced Reward Deficiency Symptomatology by Regulating Dopamine Transmission. Journal of systems and integrative neuroscience. vol 3. issue 3. 2020-09-30. PMID:28736624. |
lyme and dopaminergic function: hypothesizing reduced reward deficiency symptomatology by regulating dopamine transmission. |
2020-09-30 |
2023-08-13 |
Not clear |
| Rahul Patel, Joshua M Bradner, Kristen A Stout, William Michael Caudl. Alteration to Dopaminergic Synapses Following Exposure to Perfluorooctane Sulfonate (PFOS), in Vitro and in Vivo. Medical sciences (Basel, Switzerland). vol 4. issue 3. 2020-09-30. PMID:29083377. |
however, subsequent exposure to the selective dopaminergic neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) significantly reduced the expression of dopamine transporter (dat) and tyrosine hydroxylase (th), and resulted in an even greater reduction in dat expression in animals previously exposed to pfos. |
2020-09-30 |
2023-08-13 |
mouse |
| Janna Niens, Fabienne Reh, Büşra Çoban, Karol Cichewicz, Julia Eckardt, Yi-Ting Liu, Jay Hirsh, Thomas D Riemensperge. Dopamine Modulates Serotonin Innervation in the Frontiers in systems neuroscience. vol 11. 2020-09-30. PMID:29085286. |
dopamine modulates serotonin innervation in the parkinson's disease (pd) results from a progressive degeneration of the dopaminergic nigrostriatal system leading to a decline in movement control, with resting tremor, rigidity and postural instability. |
2020-09-30 |
2023-08-13 |
drosophila_melanogaster |
| Yuhan Wang, Fu-Ming Zho. Striatal But Not Extrastriatal Dopamine Receptors Are Critical to Dopaminergic Motor Stimulation. Frontiers in pharmacology. vol 8. 2020-09-30. PMID:29311936. |
striatal but not extrastriatal dopamine receptors are critical to dopaminergic motor stimulation. |
2020-09-30 |
2023-08-13 |
mouse |
| Guo-Qing Wang, Dai-Di Li, Chun Huang, Di-Sheng Lu, Chao Zhang, Shao-Yu Zhou, Jie Liu, Feng Zhan. Icariin Reduces Dopaminergic Neuronal Loss and Microglia-Mediated Inflammation Frontiers in molecular neuroscience. vol 10. 2020-09-30. PMID:29375304. |
icariin reduces dopaminergic neuronal loss and microglia-mediated inflammation parkinson's disease (pd) is one of the most common neurodegenerative diseases characterized with a gradual loss of midbrain substantia nigra (sn) dopamine (da) neurons. |
2020-09-30 |
2023-08-13 |
rat |