| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthieu Béreau, Paul Krack, Norbert Brüggemann, Thomas F Münt. Neurobiology and clinical features of impulse control failure in Parkinson's disease. Neurological research and practice. vol 1. 2020-12-17. PMID:33324875. |
they result from sensitization of the mesocorticolimbic pathway that arose in predisposed pd patients concomitantly with spreading of pd pathology, non-physiological dopaminergic and pulsatile administration of dopamine replacement therapy (drt). |
2020-12-17 |
2023-08-13 |
Not clear |
| Serda Kecel-Gunduz, Yasemin Budama-Kilinc, Rabia Cakir-Koc, Tolga Zorlu, Bilge Bicak, Yagmur Kokcu, Zeynep Kaya, Aysen E Ozel, Sevim Akyu. In silico Analysis of Sulpiride, Synthesis, Characterization and In vitro Studies of its Nanoparticle for the Treatment of Schizophrenia. Current computer-aided drug design. vol 16. issue 2. 2020-12-17. PMID:31244443. |
sulpiride, which has selective dopaminergic blocking activity, is a substituted benzamide antipsychotic drug playing a prominent role in the treatment of schizophrenia, which more selective and primarily blocks dopamine d2 and d3 receptor. |
2020-12-17 |
2023-08-13 |
Not clear |
| Chao-Qun Lin, Lu-Kui Che. Cerebral dopamine neurotrophic factor promotes the proliferation and differentiation of neural stem cells in hypoxic environments. Neural regeneration research. vol 15. issue 11. 2020-12-11. PMID:32394962. |
previous research found that cerebral dopamine neurotrophic factor (cdnf) has a protective effect on brain dopaminergic neurons, and cdnf is regarded as a promising therapeutic agent for neurodegenerative diseases. |
2020-12-11 |
2023-08-13 |
rat |
| Christine Bus, Laimdota Zizmare, Marita Feldkaemper, Sven Geisler, Maria Zarani, Anna Schaedler, Franziska Klose, Jakob Admard, Craig J Mageean, Giuseppe Arena, Petra Fallier-Becker, Aslihan Ugun-Klusek, Klaudia K Maruszczak, Konstantina Kapolou, Benjamin Schmid, Doron Rapaport, Marius Ueffing, Nicolas Casadei, Rejko Krüger, Thomas Gasser, Daniela M Vogt Weisenhorn, Philipp J Kahle, Christoph Trautwein, Christian J Gloeckner, Julia C Fitzgeral. Human Dopaminergic Neurons Lacking PINK1 Exhibit Disrupted Dopamine Metabolism Related to Vitamin B6 Co-Factors. iScience. vol 23. issue 12. 2020-12-11. PMID:33299968. |
human dopaminergic neurons lacking pink1 exhibit disrupted dopamine metabolism related to vitamin b6 co-factors. |
2020-12-11 |
2023-08-13 |
human |
| Seunghyi Kook, Xuanzhi Zhan, Kimberly Thibeault, Mohamed R Ahmed, Vsevolod V Gurevich, Eugenia V Gurevic. Mdm2 enhances ligase activity of parkin and facilitates mitophagy. Scientific reports. vol 10. issue 1. 2020-12-10. PMID:32193420. |
loss-of-function mutations in the e3 ubiquitin ligase parkin have been implicated in the death of dopaminergic neurons in the substantia nigra, which is the root cause of dopamine deficit in the striatum in parkinson's disease. |
2020-12-10 |
2023-08-13 |
Not clear |
| Tina Kazemi, Shuyan Huang, Naze G Avci, Charlotte Mae K Waits, Yasemin M Akay, Metin Aka. Investigating the influence of perinatal nicotine and alcohol exposure on the genetic profiles of dopaminergic neurons in the VTA using miRNA-mRNA analysis. Scientific reports. vol 10. issue 1. 2020-12-08. PMID:32929144. |
dopaminergic (da) neurons of the dopamine reward pathway originate from the vta, which is believed to be central to the mechanism of addiction and drug reinforcement. |
2020-12-08 |
2023-08-13 |
rat |
| Kyle Farmer, Khaled S Abd-Elrahman, Alexa Derksen, Elyn M Rowe, Ashley M Thompson, Christopher A Rudyk, Natalie A Prowse, Zachary Dwyer, Samantha C Bureau, Teresa Fortin, Stephen S G Ferguson, Shawn Hayle. mGluR5 Allosteric Modulation Promotes Neurorecovery in a 6-OHDA-Toxicant Model of Parkinson's Disease. Molecular neurobiology. vol 57. issue 3. 2020-12-04. PMID:31754998. |
parkinson's disease is a neurodegenerative disease characterized by a loss of dopaminergic substantia nigra neurons and depletion of dopamine. |
2020-12-04 |
2023-08-13 |
mouse |
| Timo Fischer, Paula Scheffler, Christian Loh. Dopamine-induced calcium signaling in olfactory bulb astrocytes. Scientific reports. vol 10. issue 1. 2020-11-30. PMID:31959788. |
in the present study, we used confocal calcium imaging in mouse brain slices of the olfactory bulb, a brain region with a large population of dopaminergic neurons, to investigate calcium signaling evoked by dopamine in astrocytes. |
2020-11-30 |
2023-08-13 |
mouse |
| Raza Mushtaq, Matthew D Kay, Laura Steinmeyer, Devdutta Warhadpande, Phillip H Ku. Pearls and Pitfalls of Quantitative Software Analysis of Dopamine Transporter SPECT. Clinical nuclear medicine. vol 45. issue 11. 2020-11-25. PMID:32701796. |
dopamine transporter spect with i-n-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) nortropane (i-ioflupane) aids in the diagnosis of parkinsonian syndrome by demonstrating loss of striatal dopamine transporters, proportional to nigrostriatal dopaminergic neuronal loss. |
2020-11-25 |
2023-08-13 |
Not clear |
| Yuhei Hasuike, Takuyuki Endo, Michiyo Koroyasu, Misa Matsui, Chiaki Mori, Misaki Yamadera, Harutoshi Fujimura, Saburo Sakod. Bile acid abnormality induced by intestinal dysbiosis might explain lipid metabolism in Parkinson's disease. Medical hypotheses. vol 134. 2020-11-23. PMID:31678900. |
sibo-positive patients had a significantly smaller dopaminergic drug load (dopamine replacement of parkinson's disease drug potency) (p = 0.009) and significantly lower serum triglyceride (tg) (p = 0.024) and total bilirubin (p = 0.019) levels. |
2020-11-23 |
2023-08-13 |
Not clear |
| Z Syambani Ulha. Dopamine D2 receptor influences eye development and function in Zebrafish. Archivos de la Sociedad Espanola de Oftalmologia. vol 95. issue 2. 2020-11-23. PMID:31955999. |
considering the role of dopaminergic neurons in retinal development and function, dysfunction of dopaminergic neuron signaling pathways in the retina may cause visual abnormalities, particularly in the involvement of dopamine in regulating light response. |
2020-11-23 |
2023-08-13 |
zebrafish |
| Eri Hayano, Mikito Shimizu, Kousuke Baba, Munehisa Shimamura, Tomokatsu Yoshida, Hideki Mochizuk. [A case of Alexander disease presented with dystonia of lower limb and decreased dopaminergic uptake in dopamine transporter scintigraphy]. Rinsho shinkeigaku = Clinical neurology. vol 60. issue 10. 2020-11-23. PMID:32893243. |
[a case of alexander disease presented with dystonia of lower limb and decreased dopaminergic uptake in dopamine transporter scintigraphy]. |
2020-11-23 |
2023-08-13 |
Not clear |
| Domen Pregeljc, Diana Teodorescu-Perijoc, Robert Vianello, Nejc Umek, Janez Mavr. How Important Is the Use of Cocaine and Amphetamines in the Development of Parkinson Disease? A Computational Study. Neurotoxicity research. vol 37. issue 3. 2020-11-20. PMID:31828739. |
we studied dopamine levels in three compartments of the dopaminergic synapse, including the presynaptic neuron cytosol, dopamine storage vesicles, and the synaptic gap. |
2020-11-20 |
2023-08-13 |
human |
| D R Belov, E V Efimova, Z S Fesenko, K A Antonova, S F Kolodyazhny, A M Lakstygal, R R Gainetdino. Putative Trace-Amine Associated Receptor 5 (TAAR5) Agonist α-NETA Increases Electrocorticogram Gamma-Rhythm in Freely Moving Rats. Cellular and molecular neurobiology. vol 40. issue 2. 2020-11-18. PMID:31385135. |
administration of α-neta caused significant modulation of dopaminergic system as evidenced by an altered dopamine turnover rate in the striatum. |
2020-11-18 |
2023-08-13 |
mouse |
| Se Eun Jang, Lifeng Qiu, Ling Ling Chan, Eng-King Tan, Li Zen. Current Status of Stem Cell-Derived Therapies for Parkinson's Disease: From Cell Assessment and Imaging Modalities to Clinical Trials. Frontiers in neuroscience. vol 14. 2020-11-13. PMID:33177975. |
pd is characterized by the gradual loss of dopaminergic (da) neurons and decreased striatal dopamine levels. |
2020-11-13 |
2023-08-13 |
Not clear |
| Jeremiah Ramos, Ethan J Hardin, Alice H Grant, Grace Flores-Robles, Adrian T Gonzalez, Bryan Cruz, Arantxa K Martinez, Nina M Beltran, Katherine M Serafin. The Effects of Eating a High Fat Diet on Sensitivity of Male and Female Rats to Methamphetamine and Dopamine D The Journal of pharmacology and experimental therapeutics. vol 374. issue 1. 2020-11-12. PMID:32265322. |
the effects of eating a high fat diet on sensitivity of male and female rats to methamphetamine and dopamine d rats eating high fat chow are more sensitive to the behavioral effects of dopaminergic drugs, including methamphetamine and the dopamine d |
2020-11-12 |
2023-08-13 |
rat |
| Susanna Waters, Clas Sonesson, Peder Svensson, Joakim Tedroff, Manolo Carta, Elisabeth Ljung, Jenny Gunnergren, Malin Edling, Boel Svanberg, Anne Fagerberg, Johan Kullingsjö, Stephan Hjorth, Nicholas Water. Preclinical Pharmacology of [2-(3-Fluoro-5-Methanesulfonyl-phenoxy)Ethyl](Propyl)amine (IRL790), a Novel Dopamine Transmission Modulator for the Treatment of Motor and Psychiatric Complications in Parkinson Disease. The Journal of pharmacology and experimental therapeutics. vol 374. issue 1. 2020-11-12. PMID:32358046. |
we hypothesized that such a dopamine antagonist with physicochemical properties similar to agonists would exert antidyskinetic and antipsychotic effects in states of dysregulated dopaminergic signaling while having little negative impact on physiologic dopamine transmission and, hence, minimal liability for side effects related to dopamine-dependent functions. |
2020-11-12 |
2023-08-13 |
Not clear |
| Francesco Napolitano, Arianna De Rosa, Rosita Russo, Anna Di Maio, Martina Garofalo, Mauro Federici, Sara Migliarini, Ada Ledonne, Francesca Romana Rizzo, Luigi Avallone, Tommaso Nuzzo, Tommaso Biagini, Massimo Pasqualetti, Nicola Biagio Mercuri, Tommaso Mazza, Angela Chambery, Alessandro Usiell. The striatal-enriched protein Rhes is a critical modulator of cocaine-induced molecular and behavioral responses. Scientific reports. vol 9. issue 1. 2020-11-05. PMID:31653935. |
despite dramatic striatal alterations associated to cocaine exposure, our data did not reveal any significant changes in midbrain dopaminergic neurons as a lack of rhes did not affect: (i) dat activity; (ii) d2r-dependent regulation of girk; and (iii) d2r-dependent regulation of dopamine release. |
2020-11-05 |
2023-08-13 |
mouse |
| Alfonso Rubino, Claudio D'Addario, Martina Di Bartolomeo, Enrico Michele Salamone, Nicoletta Locuratolo, Francesco Fattapposta, Nicola Vanacore, Esterina Pascal. DNA methylation of the 5'-UTR DAT 1 gene in Parkinson's disease patients. Acta neurologica Scandinavica. vol 142. issue 3. 2020-11-05. PMID:32415851. |
among others, we, here, focused the attention on the dopamine transporter (dat) gene playing a critical role in maintaining the integrity of dopaminergic neurons. |
2020-11-05 |
2023-08-13 |
Not clear |
| Anum Maqsood, Salman Akram, Faisal Akra. Chlorpromazine-Induced Relapse of Tourette Syndrome in a Patient With Intellectual Disability, Attention Deficit Hyperactivity Disorder, and Schizophrenia. Cureus. vol 12. issue 9. 2020-11-05. PMID:33145137. |
a fundamental step in the pathophysiology of ts is the hyperactivity of dopaminergic system leading to increased dopamine release in the cortical-basal ganglia-thalamo-cortical (cbgtc) circuits, thereby providing the rationale for treatment with dopamine receptor, in particular d2, antagonists. |
2020-11-05 |
2023-08-13 |
Not clear |