| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniel P Eisenberg, Philip D Kohn, Erica B Baller, Joel A Bronstein, Joseph C Masdeu, Karen F Berma. Seasonal effects on human striatal presynaptic dopamine synthesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 44. 2010-12-08. PMID:21048126. |
in humans, seasonal effects have been described for dopaminergic markers in csf and postmortem brain, and there exists a range of affective, psychotic, and substance abuse disorders that have been associated with both seasonal symptomatic fluctuations and dopamine neurotransmission abnormalities. |
2010-12-08 |
2023-08-12 |
human |
| Shilpa Aggarwal, Seetald Dodd, Michael Ber. Restless leg syndrome associated with olanzapine: a case series. Current drug safety. vol 5. issue 2. 2010-12-07. PMID:20406161. |
dopamine agonists and l-dopa reduce the symptoms of rls, and some agents that block the dopaminergic system aggravate rls. |
2010-12-07 |
2023-08-12 |
Not clear |
| Henrik Ponten, Johan Kullingsjö, Sören Lagerkvist, Peter Martin, Fredrik Pettersson, Clas Sonesson, Susanna Waters, Nicholas Water. In vivo pharmacology of the dopaminergic stabilizer pridopidine. European journal of pharmacology. vol 644. issue 1-3. 2010-12-07. PMID:20667452. |
dopaminergic stabilizers act primarily at dopamine type 2 (d(2)) receptors and display state-dependent behavioural effects. |
2010-12-07 |
2023-08-12 |
mouse |
| Xiomara A Perez, Tanuja Bordia, J Michael McIntosh, Maryka Qui. α6ß2* and α4ß2* nicotinic receptors both regulate dopamine signaling with increased nigrostriatal damage: relevance to Parkinson's disease. Molecular pharmacology. vol 78. issue 5. 2010-12-07. PMID:20732972. |
single-pulse-stimulated α6β2* and α4β2* receptor dopamine release decreased to a similar extent with increasing nigrostriatal damage, indicating that both subtypes contribute to the control of dopaminergic transmission with lesioning. |
2010-12-07 |
2023-08-12 |
Not clear |
| Robert T Egel, George E Hoganson, M Ammar Katerji, Martin J Borenstei. Zonisamide ameliorates symptoms of secondary paroxysmal dystonia. Pediatric neurology. vol 43. issue 3. 2010-12-06. PMID:20691944. |
a number of medications have been used with varying success to treat the symptoms of generalized, focal, and paroxysmal dyskinesias; these agents include anticonvulsant, benzodiazepine, neuroleptic, dopaminergic, dopamine antagonist, and carbonic anhydrase inhibitor types. |
2010-12-06 |
2023-08-12 |
Not clear |
| Andrzej Mysiak, Małgorzata Kobusiak-Prokopowicz, Tomasz Kucharski, Rafał Kleczy. [Neurohormonal effects following treatment with dopamine. More advantages or disadvantages?]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. vol 29. issue 171. 2010-12-03. PMID:20931821. |
due to a big amount of dopaminergic receptors set in the vertebrate central nervous system (cns), endogenously freed dopamine determines motor and cognitive activities of an organism. |
2010-12-03 |
2023-08-12 |
Not clear |
| Hong Liu, Feng Dong, Zhaowei Meng, Benshu Zhang, Jian Tan, Yu Wan. Evaluation of Tourette's syndrome by (99m)Tc-TRODAT-1 SPECT/CT imaging. Annals of nuclear medicine. vol 24. issue 7. 2010-12-01. PMID:20544324. |
clinical evidence indicates that the tourette's syndrome (ts) is associated with hyperactivity of the dopaminergic system; however, imaging studies of dopamine transporter (dat) in ts patients remain controversial. |
2010-12-01 |
2023-08-12 |
human |
| Li Qian, Patrick M Flood, Jau-Shyong Hon. Neuroinflammation is a key player in Parkinson's disease and a prime target for therapy. Journal of neural transmission (Vienna, Austria : 1996). vol 117. issue 8. 2010-11-30. PMID:20571837. |
parkinson's disease (pd) is a neurodegenerative movement disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra and depletion of dopamine in the striatum, which lead to pathological and clinical abnormalities. |
2010-11-30 |
2023-08-12 |
Not clear |
| Werner Poewe, Angelo Antonini, Jan Cm Zijlmans, Pierre R Burkhard, François Vingerhoet. Levodopa in the treatment of Parkinson's disease: an old drug still going strong. Clinical interventions in aging. vol 5. 2010-11-30. PMID:20852670. |
compared with other available dopaminergic therapies, dopamine replacement with ld is associated with the greatest improvement in motor function. |
2010-11-30 |
2023-08-12 |
Not clear |
| Nicola Pavese, Vinod Metta, Subrata K Bose, Kallol Ray Chaudhuri, David J Brook. Fatigue in Parkinson's disease is linked to striatal and limbic serotonergic dysfunction. Brain : a journal of neurology. vol 133. issue 11. 2010-11-30. PMID:20884645. |
we used ¹⁸f-dopa and ¹¹c-dasb [n,n-dimethyl-2-(2-amino-4-cyanophenylthio) benzylamine] positron emission tomography, markers of dopamine storage capacity and serotonin transporter availability, to investigate whether fatigue in parkinson's disease is associated with dopaminergic and serotonergic dysfunction in basal ganglia and limbic circuits. |
2010-11-30 |
2023-08-12 |
Not clear |
| Mohammad Moshahid Khan, Md Nasrul Hoda, Tauheed Ishrat, Ajmal Ahmad, Mohammad Badruzzaman Khan, Gulrana Khuwaja, Syed Shadab Raza, Mohammed M Safhi, Fakhrul Isla. Amelioration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced behavioural dysfunction and oxidative stress by Pycnogenol in mouse model of Parkinson's disease. Behavioural pharmacology. vol 21. issue 5-6. 2010-11-24. PMID:20657266. |
an increase in the number of dopaminergic d2 receptors and decrease in the level of dopamine and its metabolite 3,4-dihydroxyphenyl acetic acid in the striatum were observed after mptp injection, and restored significantly after pyc pretreatment. |
2010-11-24 |
2023-08-12 |
mouse |
| Takaaki Matsuo, Yasuhiko Izumi, Toshiaki Kume, Yuki Takada-Takatori, Hideyuki Sawada, Akinori Akaik. Protective effect of aripiprazole against glutamate cytotoxicity in dopaminergic neurons of rat mesencephalic cultures. Neuroscience letters. vol 481. issue 2. 2010-11-22. PMID:20600606. |
these results suggest that aripiprazole protects dopaminergic neurons against glutamate cytotoxicity partly by reducing intracellular dopamine content. |
2010-11-22 |
2023-08-12 |
rat |
| Gemma Navarro, Estefanía Moreno, Marisol Aymerich, Daniel Marcellino, Peter J McCormick, Josefa Mallol, Antoni Cortés, Vicent Casadó, Enric I Canela, Jordi Ortiz, Kjell Fuxe, Carmen Lluís, Sergi Ferré, Rafael Franc. Direct involvement of sigma-1 receptors in the dopamine D1 receptor-mediated effects of cocaine. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 43. 2010-11-22. PMID:20956312. |
this mechanism should lead to a general increase in dopaminergic neurotransmission, and yet dopamine d(1) receptors (d(1)rs) play a more significant role in the behavioral effects of cocaine than the other dopamine receptor subtypes. |
2010-11-22 |
2023-08-12 |
mouse |
| K Ishibashi, K Kanemaru, Y Saito, S Murayama, K Oda, K Ishiwata, H Mizusawa, K Ishi. Cerebrospinal fluid metabolite and nigrostriatal dopaminergic function in Parkinson's disease. Acta neurologica Scandinavica. vol 122. issue 1. 2010-11-16. PMID:20002007. |
to evaluate the association between cerebrospinal fluid (csf) homovanillic acid (hva) concentrations and nigrostriatal dopaminergic function assessed by positron emission tomography (pet) imaging with carbon-11-labeled 2beta-carbomethoxy-3beta-(4-fluorophenyl)-tropane ((11)c-cft), which can measure the dopamine transporter (dat) density, in parkinson's disease (pd). |
2010-11-16 |
2023-08-12 |
Not clear |
| Marco Bisaglia, Maria Eugenia Soriano, Irene Arduini, Stefano Mammi, Luigi Bubacc. Molecular characterization of dopamine-derived quinones reactivity toward NADH and glutathione: implications for mitochondrial dysfunction in Parkinson disease. Biochimica et biophysica acta. vol 1802. issue 9. 2010-11-16. PMID:20600874. |
a plausible source of oxidative stress in nigral dopaminergic neurons is the redox reactions that specifically involve dopamine (da) and produce various toxic molecules, i.e., free radicals and quinone species (daq). |
2010-11-16 |
2023-08-12 |
Not clear |
| Jakob K Dreyer, Kjartan F Herrik, Rune W Berg, Jørn D Hounsgaar. Influence of phasic and tonic dopamine release on receptor activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 42. 2010-11-16. PMID:20962248. |
however, the relationship between spike patterns in dopaminergic neurons, the extracellular concentration of dopamine, and activation of dopamine receptors remains unresolved. |
2010-11-16 |
2023-08-12 |
Not clear |
| Gunasingh Masilamoni, John Votaw, Leonard Howell, Rosa M Villalba, Mark Goodman, Ronald J Voll, Jeffrey Stehouwer, Thomas Wichmann, Yoland Smit. (18)F-FECNT: validation as PET dopamine transporter ligand in parkinsonism. Experimental neurology. vol 226. issue 2. 2010-11-12. PMID:20832405. |
the goal of this study is to validate the use of (18)f-fecnt as a pet radiotracer to assess the degree of striatal dopamine terminals denervation and midbrain dopaminergic cell loss in mptp-treated parkinsonian monkeys. |
2010-11-12 |
2023-08-12 |
monkey |
| Gunasingh Masilamoni, John Votaw, Leonard Howell, Rosa M Villalba, Mark Goodman, Ronald J Voll, Jeffrey Stehouwer, Thomas Wichmann, Yoland Smit. (18)F-FECNT: validation as PET dopamine transporter ligand in parkinsonism. Experimental neurology. vol 226. issue 2. 2010-11-12. PMID:20832405. |
these findings demonstrate that (18)f-fecnt is a highly sensitive pet imaging ligand to quantify both striatal dopamine denervation and midbrain dopaminergic cell loss associated with parkinsonism. |
2010-11-12 |
2023-08-12 |
monkey |
| Emma Thornton, Tuyet T B Tran, Robert Vin. A substance P mediated pathway contributes to 6-hydroxydopamine induced cell death. Neuroscience letters. vol 481. issue 1. 2010-11-08. PMID:20599590. |
the neurotoxin 6-hydroxydopamine (6-ohda) is used to induce dopaminergic cell death, resulting in insufficient striatal dopamine content in the basal ganglia and motor dysfunction typical of parkinson's disease. |
2010-11-08 |
2023-08-12 |
Not clear |
| Carine Chassain, Guy Bielicki, Cécile Keller, Jean-Pierre Renou, Franck Duri. Metabolic changes detected in vivo by 1H MRS in the MPTP-intoxicated mouse. NMR in biomedicine. vol 23. issue 6. 2010-11-04. PMID:20661872. |
we used in vivo proton ((1)h) magnetic resonance spectroscopy (mrs) to measure the levels of the main excitatory amino acid, glutamate (glu) and also glutamine (gln) and gaba in the striatum and cerebral cortex in the mptp-intoxicated mouse, a model of dopaminergic denervation, before and after dopamine (da) replacement. |
2010-11-04 |
2023-08-12 |
mouse |