| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Estela Camara, Ulrike M Krämer, Toni Cunillera, Josep Marco-Pallarés, David Cucurell, Wido Nager, Anna Mestres-Missé, Peter Bauer, Rebecca Schüle, Ludger Schöls, Claus Tempelmann, Antoni Rodriguez-Fornells, Thomas F Münt. The effects of COMT (Val108/158Met) and DRD4 (SNP -521) dopamine genotypes on brain activations related to valence and magnitude of rewards. Cerebral cortex (New York, N.Y. : 1991). vol 20. issue 8. 2011-02-18. PMID:20038544. |
because of the established role of the dopaminergic system in the neural encoding of rewards and negative events, we investigated young healthy volunteers being homozygous for either the valine or methionine variant of the catechol-o-methyltransferase (comt) codon 158 polymorphism as well as homozygous for the c or t variant of the snp -521 polymorphism of the dopamine d4 receptor. |
2011-02-18 |
2023-08-12 |
human |
| Daniel C Javit. Glutamatergic theories of schizophrenia. The Israel journal of psychiatry and related sciences. vol 47. issue 1. 2011-02-18. PMID:20686195. |
further, nmda receptors are located on brain circuits that regulate dopamine release, suggesting that dopaminergic deficits in schizophrenia may also be secondary to underlying glutamatergic dysfunction. |
2011-02-18 |
2023-08-12 |
Not clear |
| G Brousse, F Vorspan, K Ksouda, V Bloch, K Peoc'h, J L Laplanche, S Mouly, J Schmidt, P M Llorca, J P Lepin. Could the inter-individual variability in cocaine-induced psychotic effects influence the development of cocaine addiction? Towards a new pharmacogenetic approach to addictions. Medical hypotheses. vol 75. issue 6. 2011-02-18. PMID:20801583. |
several studies have looked for a link between cocaine addiction and the genes of the dopaminergic system: the genes drd2, comt, slc6a3 (coding for the dopamine transporter dat) and dbh (coding for the dopamine beta hydroxylase) but unfortunately very few well established results. |
2011-02-18 |
2023-08-12 |
Not clear |
| Soojin Hwang, Darae Kim, Gahee Choi, Seon Woo An, Yoon Ki Hong, Yoon Seak Suh, Min Jung Lee, Kyoung Sang Ch. Parkin suppresses c-Jun N-terminal kinase-induced cell death via transcriptional regulation in Drosophila. Molecules and cells. vol 29. issue 6. 2011-02-14. PMID:20496123. |
parkin is the most prevalent genetic factor in the onset of autosomal recessive juvenile parkinsonism (ar-jp), and mutations in parkin has been reported to cause motor defects, which result from dopamine deficiency caused by dopaminergic neuronal cell death. |
2011-02-14 |
2023-08-12 |
drosophila_melanogaster |
| David K Miller, Abdalla Bowirrat, Matthew Manka, Merlene Miller, Stanley Stokes, Debra Manka, Cameron Allen, Charles Gant, B William Downs, Andrew Smolen, Emily Stevens, Swetha Yeldandi, Kenneth Blu. Acute intravenous synaptamine complex variant KB220™ "normalizes" neurological dysregulation in patients during protracted abstinence from alcohol and opiates as observed using quantitative electroencephalographic and genetic analysis for reward polymorphisms: part 1, pilot study with 2 case reports. Postgraduate medicine. vol 122. issue 6. 2011-02-14. PMID:21084795. |
based on previous research and our qeeg studies (parts 1 and 2 of this study), we cautiously suggest that long-term activation of dopaminergic receptors (ie, drd2 receptors) will result in their proliferation and lead to enhanced "dopamine sensitivity" and an increased sense of happiness, particularly in carriers of the drd2 a1 allele. |
2011-02-14 |
2023-08-12 |
Not clear |
| Gabriela Rodríguez-Manzo, Francisco Pellice. Electrical stimulation of dorsal and ventral striatum differentially alters the copulatory behavior of male rats. Behavioral neuroscience. vol 124. issue 5. 2011-02-09. PMID:20939668. |
sexual behavior is a natural reward that activates striatal dopaminergic (da) circuits, and dopamine exerts a facilitative influence on copulation. |
2011-02-09 |
2023-08-12 |
rat |
| Kurt A Jellinge. Interaction between α-synuclein and tau in Parkinson's disease comment on Wills et al.: elevated tauopathy and α-synuclein pathology in postmortem Parkinson's disease brains with and without dementia. Exp Neurol 2010; 225: 210-218. Experimental neurology. vol 227. issue 1. 2011-02-04. PMID:20965169. |
recent neurochemical studies in postmortem brains of patients with parkinson's disease (pd), pd with dementia (pdd) and age-matched controls revealed significant decrease of tyrosine hydroxylase (th) and dopamine transporter (dat) in striatum, confirming previous studies indicating substantial loss of dopaminergic neurons and terminals. |
2011-02-04 |
2023-08-12 |
mouse |
| Dengke Zhang, Xuyi Wang, Xiaojun Xiang, Hongxian Chen, Jian Zhang, Qiaorong Su, Wei Ha. The dopamine D(2) partial agonist and antagonist terguride decreases heroin self-administration on fixed- and progressive-ratio schedules. Pharmacology, biochemistry, and behavior. vol 97. issue 2. 2011-02-03. PMID:20705086. |
these drugs bind to dopamine receptors with high affinity and low intrinsic activity and are hypothesized to behave as functional antagonists in conditions of high dopaminergic tone. |
2011-02-03 |
2023-08-12 |
Not clear |
| Yasunori Okabe, Akira Kusaga, Tomoyuki Takahashi, Chiaki Mitsumasu, Yoshinaka Murai, Eiichiro Tanaka, Hideho Higashi, Toyojiro Matsuishi, Ken-ichiro Kosa. Neural development of methyl-CpG-binding protein 2 null embryonic stem cells: a system for studying Rett syndrome. Brain research. vol 1360. 2011-02-03. PMID:20816763. |
dopamine production and release in response to a depolarizing stimulus in mecp2-null es-derived dopaminergic neurons was intact. |
2011-02-03 |
2023-08-12 |
Not clear |
| Nicola Simola, Annalisa Pinna, Sandro Fen. Pharmacological therapy of Parkinson's disease: current options and new avenues. Recent patents on CNS drug discovery. vol 5. issue 3. 2011-01-31. PMID:20726838. |
drugs acting on dopamine transmission, as l-dopa, direct dopaminergic agonists, inhibitors for either the mao or comt enzymes and drugs acting on neurotransmitters other than dopamine (e.g. |
2011-01-31 |
2023-08-12 |
Not clear |
| Tiziana Alberio, Monica Colapinto, Massimo Natale, Raffaella Ravizza, Marzia B Gariboldi, Enrico M Bucci, Leonardo Lopiano, Mauro Fasan. Changes in the two-dimensional electrophoresis pattern of the Parkinson's disease related protein DJ-1 in human SH-SY5Y neuroblastoma cells after dopamine treatment. IUBMB life. vol 62. issue 9. 2011-01-27. PMID:20836127. |
there is accumulating evidence supporting a specific role of dj-1 in protecting dopaminergic neurons from dopamine itself. |
2011-01-27 |
2023-08-12 |
human |
| Neil M Richtand, Yanhong Liu, Rebecca Ahlbrand, Juliana R Sullivan, Amy Hauck Newman, Robert K McNamar. Dopaminergic regulation of dopamine D3 and D3nf receptor mRNA expression. Synapse (New York, N.Y.). vol 64. issue 8. 2011-01-26. PMID:20340170. |
dopaminergic regulation of dopamine d3 and d3nf receptor mrna expression. |
2011-01-26 |
2023-08-12 |
Not clear |
| C M Leite, A B Ribeiro, R E Szawka, J A Anselmo-Franc. Activity of hypothalamic dopaminergic neurones during the day of oestrus: involvement in prolactin secretion. Journal of neuroendocrinology. vol 22. issue 10. 2011-01-26. PMID:20722974. |
the transitory decrease in the activity of neuroendocrine dopaminergic neurones temporally associated with the prolactin surge on the afternoon of oestrus suggests a role for dopamine in the generation of the oestrous prolactin surge. |
2011-01-26 |
2023-08-12 |
rat |
| Santiago Perez-Lloret, Olivier Rasco. Dopamine receptor agonists for the treatment of early or advanced Parkinson's disease. CNS drugs. vol 24. issue 11. 2011-01-26. PMID:20932066. |
as with any other drug, dopamine agonists can also cause adverse drug reactions, which can be related or unrelated to dopaminergic hyperactivation. |
2011-01-26 |
2023-08-12 |
Not clear |
| H L Melrose, J C Dächsel, B Behrouz, S J Lincoln, M Yue, K M Hinkle, C B Kent, E Korvatska, J P Taylor, L Witten, Y-Q Liang, J E Beevers, M Boules, B N Dugger, V A Serna, A Gaukhman, X Yu, M Castanedes-Casey, A T Braithwaite, S Ogholikhan, N Yu, D Bass, G Tyndall, G D Schellenberg, D W Dickson, C Janus, M J Farre. Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice. Neurobiology of disease. vol 40. issue 3. 2011-01-25. PMID:20659558. |
in vivo analysis of the dopaminergic system revealed abnormal dopamine neurotransmission in both hwt and g2019s transgenic mice evidenced by a decrease in extra-cellular dopamine levels, which was detected without pharmacological manipulation. |
2011-01-25 |
2023-08-12 |
mouse |
| Domingo Afonso-Oramas, Ignacio Cruz-Muros, Pedro Barroso-Chinea, Diego Álvarez de la Rosa, Javier Castro-Hernández, Josmar Salas-Hernández, Teresa Giráldez, Tomás González-Hernánde. The dopamine transporter is differentially regulated after dopaminergic lesion. Neurobiology of disease. vol 40. issue 3. 2011-01-25. PMID:20688165. |
the dopamine transporter is differentially regulated after dopaminergic lesion. |
2011-01-25 |
2023-08-12 |
rat |
| Stephanie M J Fliedner, Hendrik Lehnert, Karel Paca. Metastatic paraganglioma. Seminars in oncology. vol 37. issue 6. 2011-01-25. PMID:21167381. |
recently, a dopaminergic phenotype (excess dopamine or methoxytyramine) was recognized as a good indicator of metastatic disease. |
2011-01-25 |
2023-08-12 |
Not clear |
| Dong-Feng Chen, Ling-Jie Meng, Shao-Hui Du, Hai-Ling Zhang, Hui Li, Jian-Hong Zhou, Yi-Wei Li, He-Ping Zeng, Zi-Chun Hu. (+)-Cholesten-3-one induces differentiation of neural stem cells into dopaminergic neurons through BMP signaling. Neuroscience research. vol 68. issue 3. 2011-01-21. PMID:20708045. |
phenotypic cellular analysis indicated that (+)-cholesten-3-one induces differentiation of nscs to dopaminergic neurons with increased expression of specific dopaminergic markers including th, dopamine transporter, dopa decarboxylase and higher level of dopamine secretion. |
2011-01-21 |
2023-08-12 |
Not clear |
| C M Jin, Y J Yang, H S Huang, M Kai, M K Le. Mechanisms of L-DOPA-induced cytotoxicity in rat adrenal pheochromocytoma cells: implication of oxidative stress-related kinases and cyclic AMP. Neuroscience. vol 170. issue 2. 2011-01-20. PMID:20670675. |
l-dopa therapy for parkinson's disease has a double-edge effect on nigrostriatal dopaminergic neurons: l-dopa increases the intracellular level of dopamine, but it induces neuron cytotoxicity in a concentration-dependent manner. |
2011-01-20 |
2023-08-12 |
rat |
| Kelly P Cosgrov. Imaging receptor changes in human drug abusers. Current topics in behavioral neurosciences. vol 3. 2011-01-20. PMID:21161754. |
one recurrent finding is that dopaminergic dysfunction is prevalent in both alcohol and drug dependent populations, and specifically there is a lower availability of dopamine type 2/3 receptors in cocaine-, alcohol-, nicotine-, and heroin-dependent individuals compared to healthy controls. |
2011-01-20 |
2023-08-12 |
human |