| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Esther Fujimoto, Tamara J Stevenson, Chi-Bin Chien, Joshua L Bonkowsk. Identification of a dopaminergic enhancer indicates complexity in vertebrate dopamine neuron phenotype specification. Developmental biology. vol 352. issue 2. 2011-05-26. PMID:21276790. |
the dopaminergic neurons of the basal ganglia play critical roles in cns function and human disease, but specification of dopamine neuron phenotype is poorly understood in vertebrates. |
2011-05-26 |
2023-08-12 |
mouse |
| Kazuhisa Nakano, Kunihiro Yamaoka, Kentaro Hanami, Kazuyoshi Saito, Yasuyuki Sasaguri, Nobuyuki Yanagihara, Shinya Tanaka, Ichiro Katsuki, Sho Matsushita, Yoshiya Tanak. Dopamine induces IL-6-dependent IL-17 production via D1-like receptor on CD4 naive T cells and D1-like receptor antagonist SCH-23390 inhibits cartilage destruction in a human rheumatoid arthritis/SCID mouse chimera model. Journal of immunology (Baltimore, Md. : 1950). vol 186. issue 6. 2011-05-26. PMID:21307293. |
taken together, these findings indicate that dopamine released by dcs induces il-6-th17 axis and causes aggravation of synovial inflammation of ra, which is the first time, to our knowledge, that actual evidence has shown the pathological relevance of dopaminergic signaling with ra. |
2011-05-26 |
2023-08-12 |
mouse |
| Dustin R Wakeman, Hemraj B Dodiya, Jeffrey H Kordowe. Cell transplantation and gene therapy in Parkinson's disease. The Mount Sinai journal of medicine, New York. vol 78. issue 1. 2011-05-24. PMID:21259269. |
cellular transplantation of dopamine-secreting cells was hypothesized as a substitute for pharmacotherapy to directly provide dopamine, whereas gene therapy has primarily focused on restoration of dopamine synthesis or neuroprotection and restoration of spared host dopaminergic circuitry through trophic factors as a means to enhance sustained controlled dopamine transmission. |
2011-05-24 |
2023-08-12 |
Not clear |
| Bruno R Souza, Karen C L Torres, Débora M Miranda, Bernardo S Motta, Fernando S Caetano, Daniela V F Rosa, Renan P Souza, Antônio Giovani, Daniel S Carneiro, Melissa M Guimarães, Cristina Martins-Silva, Helton J Reis, Marcus V Gomez, Andreas Jeromin, Marco A Romano-Silv. Downregulation of the cAMP/PKA pathway in PC12 cells overexpressing NCS-1. Cellular and molecular neurobiology. vol 31. issue 1. 2011-05-19. PMID:20838877. |
it is well known that dopamine imbalances are associated with many psychiatric disorders and that the dopaminergic receptor d₂ is the main target of antipsychotics. |
2011-05-19 |
2023-08-12 |
Not clear |
| Alejandro Reynoso Palomar, Berenice Navarrete Larios, Victoria Chagoya De Sánchez, Lidia Martínez Pérez, Fidel De La Cruz López, Gonzalo Flores, Maria de Jesús Gómez-Villalobo. Expression and distribution of dopamine transporter in cardiac tissues of the guinea pig. Neurochemical research. vol 36. issue 3. 2011-05-19. PMID:21170736. |
dopamine transporter (dat) is a membrane protein that it is a marker for dopaminergic neurons. |
2011-05-19 |
2023-08-12 |
Not clear |
| Beth Levant, Troy J Zarcone, Paul F Davis, Marlies K Ozias, Stephen C Fowle. Differences in methylphenidate dose response between periadolescent and adult rats in the familiar arena-novel alcove task. The Journal of pharmacology and experimental therapeutics. vol 337. issue 1. 2011-05-19. PMID:21205916. |
developmental differences in dopaminergic neurochemistry were also observed, including increased dopamine content in the caudate-putamen, nucleus accumbens, and frontal cortex and decreased densities of d(1)-like receptors in the frontal cortex in p70 than in p42 rats. |
2011-05-19 |
2023-08-12 |
rat |
| Marina Ezcurra, Yoshinori Tanizawa, Peter Swoboda, William R Schafe. Food sensitizes C. elegans avoidance behaviours through acute dopamine signalling. The EMBO journal. vol 30. issue 6. 2011-05-19. PMID:21304491. |
food modulation is dependent on the mechanosensory cilia of the dopaminergic neurons, indicating that dopamine is released in response to sensation of bacteria. |
2011-05-19 |
2023-08-12 |
caenorhabditis_elegans |
| Thomas Mülle. Rivastigmine in the treatment of patients with Alzheimer's disease. Neuropsychiatric disease and treatment. vol 3. issue 2. 2011-05-17. PMID:19300554. |
recent studies show that this altered balance between dopamine and acetylcholine due to cholinesterase inhibition, with its possible negative impact on motion behaviour, does not present a major problem in clinical practice in ad patients and may be compensated for by modification of dopaminergic substitution in pd patients with dementia. |
2011-05-17 |
2023-08-12 |
Not clear |
| Gulcin Benbir, Christian Guilleminaul. Pramipexole: new use for an old drug - the potential use of pramipexole in the treatment of restless legs syndrome. Neuropsychiatric disease and treatment. vol 2. issue 4. 2011-05-17. PMID:19412489. |
it is well known, however, that dopamine plays a crucial role in the pathophysiology of rls, as dopaminergic agonists achieve marked improvement. |
2011-05-17 |
2023-08-12 |
Not clear |
| Florian Bayersdorfer, Aaron Voigt, Stephan Schneuwly, José A Botell. Dopamine-dependent neurodegeneration in Drosophila models of familial and sporadic Parkinson's disease. Neurobiology of disease. vol 40. issue 1. 2011-05-16. PMID:20211259. |
in recent years, a number of reports have proposed dopamine as a common player responsible in the loss of dopaminergic neurons independent of its etiology. |
2011-05-16 |
2023-08-12 |
drosophila_melanogaster |
| Florian Bayersdorfer, Aaron Voigt, Stephan Schneuwly, José A Botell. Dopamine-dependent neurodegeneration in Drosophila models of familial and sporadic Parkinson's disease. Neurobiology of disease. vol 40. issue 1. 2011-05-16. PMID:20211259. |
using rnai lines we were able to generate flies with drastically reduced dopamine levels in the dopaminergic neurons. |
2011-05-16 |
2023-08-12 |
drosophila_melanogaster |
| Florian Bayersdorfer, Aaron Voigt, Stephan Schneuwly, José A Botell. Dopamine-dependent neurodegeneration in Drosophila models of familial and sporadic Parkinson's disease. Neurobiology of disease. vol 40. issue 1. 2011-05-16. PMID:20211259. |
combining these flies with a chemically induced parkinson model (rotenone) and a familial form of parkinson (mutant alpha-synuclein) we were able to show a strong reduction of neurotoxicity and a protection of the dopaminergic neurons when cellular dopamine levels were reduced. |
2011-05-16 |
2023-08-12 |
drosophila_melanogaster |
| Florian Bayersdorfer, Aaron Voigt, Stephan Schneuwly, José A Botell. Dopamine-dependent neurodegeneration in Drosophila models of familial and sporadic Parkinson's disease. Neurobiology of disease. vol 40. issue 1. 2011-05-16. PMID:20211259. |
these results show that dopamine homeostasis plays a central role for the susceptibility of dopaminergic neurons to environmental and genetic factors in in vivo models of parkinson disease. |
2011-05-16 |
2023-08-12 |
drosophila_melanogaster |
| Dominic Thibault, Paul R Albert, Graciela Pineyro, Louis-Éric Trudea. Neurotensin triggers dopamine D2 receptor desensitization through a protein kinase C and beta-arrestin1-dependent mechanism. The Journal of biological chemistry. vol 286. issue 11. 2011-05-16. PMID:21233215. |
the peptide neurotensin (nt) is known to exert a potent excitatory effect on the dopaminergic system by inhibiting d2 dopamine (da) receptor (d2r) function. |
2011-05-16 |
2023-08-12 |
Not clear |
| Zong-Peng Sun, Lei Gong, Shu-Hong Huang, Zhao Geng, Lei Cheng, Zhe-Yu Che. Intracellular trafficking and secretion of cerebral dopamine neurotrophic factor in neurosecretory cells. Journal of neurochemistry. vol 117. issue 1. 2011-05-16. PMID:21235575. |
cerebral dopamine neurotrophic factor (cdnf) is a novel evolutionary conserved protein which can protect and restore the function of dopaminergic neurons in the rat model of parkinson's disease, suggesting that cdnf might be beneficial for the treatment of parkinson's disease. |
2011-05-16 |
2023-08-12 |
human |
| Keith F Moquin, Adrian C Michae. An inverse correlation between the apparent rate of dopamine clearance and tonic autoinhibition in subdomains of the rat striatum: a possible role of transporter-mediated dopamine efflux. Journal of neurochemistry. vol 117. issue 1. 2011-05-16. PMID:21244425. |
the dopaminergic terminal field in the rat striatum is compartmentalized into sub-domains that exhibit distinct dynamics of electrically evoked dopamine release. |
2011-05-16 |
2023-08-12 |
rat |
| Keith F Moquin, Adrian C Michae. An inverse correlation between the apparent rate of dopamine clearance and tonic autoinhibition in subdomains of the rat striatum: a possible role of transporter-mediated dopamine efflux. Journal of neurochemistry. vol 117. issue 1. 2011-05-16. PMID:21244425. |
the fast striatal domains, where dopamine release is predominantly vesicular, exhibit conventional dopaminergic activity. |
2011-05-16 |
2023-08-12 |
rat |
| Kathryn C Dickerson, Jian Li, Mauricio R Delgad. Parallel contributions of distinct human memory systems during probabilistic learning. NeuroImage. vol 55. issue 1. 2011-05-13. PMID:21056678. |
given the connectivity of both structures with dopaminergic midbrain centers, we further applied a reinforcement learning algorithm often used to highlight the role of dopamine in human reward related learning paradigms. |
2011-05-13 |
2023-08-12 |
human |
| Adarsh M Kumar, Raymond L Ownby, Drenna Waldrop-Valverde, Benny Fernandez, Mahendra Kuma. Human immunodeficiency virus infection in the CNS and decreased dopamine availability: relationship with neuropsychological performance. Journal of neurovirology. vol 17. issue 1. 2011-05-12. PMID:21165787. |
hiv-1 enters the brain soon after the initial infection and is distributed in varying concentrations in different regions with specific affinity to the subcortical regions, particularly the basal ganglia, causing neurodegeneration of dopaminergic regions and resulting in the decreased availability of dopamine (da) in the cns. |
2011-05-12 |
2023-08-12 |
human |
| Tomás Gescheidt, Martin Bare. Impulse control disorders in patients with Parkinson's disease. Acta neurologica Belgica. vol 111. issue 1. 2011-05-12. PMID:21510226. |
pathological preoccupation with repeated mechanical activities (so-called punding) and excessive compulsive intake of dopaminergic medication (so-called dopamine dysregulation syndrome or also syndrome of hedonistic homeostatic dysregulation) are of similar nature. |
2011-05-12 |
2023-08-12 |
Not clear |