| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Beryl Koener, Stéphanie Goursaud, Morgane Van De Stadt, André-Guilhem Calas, Anne P Jeanjean, Jean-Marie Maloteaux, Emmanuel Herman. Pharmacological blockade of dopamine D2 receptors by aripiprazole is not associated with striatal sensitization. Naunyn-Schmiedeberg's archives of pharmacology. vol 383. issue 1. 2011-07-15. PMID:21061116. |
as it is established that responses induced by dopamine d₂ receptor agonists are increased in models of dopaminergic sensitization, this paradigm was used in order to facilitate the detection of the partial agonist properties of aripiprazole. |
2011-07-15 |
2023-08-12 |
rat |
| Sofia T Duarte, Carlos Ortez, Ana Pérez, Rafael Artuch, Angels García-Cazorl. Analysis of synaptic proteins in the cerebrospinal fluid as a new tool in the study of inborn errors of neurotransmission. Journal of inherited metabolic disease. vol 34. issue 2. 2011-07-15. PMID:21229320. |
these kinds of studies could help elucidate new causes of disturbed dopaminergic and gabaergic transmission as well as understanding different responses to l-dopa in inherited disorders affecting dopamine metabolism. |
2011-07-15 |
2023-08-12 |
human |
| Marek Cieślak, Michał Komoszyński, Andrzej Wojtcza. Adenosine A(2A) receptors in Parkinson's disease treatment. Purinergic signalling. vol 4. issue 4. 2011-07-14. PMID:18438720. |
co-localization of adenosine a(2a) and dopaminergic d2 receptors in striatum creates a milieu for antagonistic interaction between adenosine and dopamine. |
2011-07-14 |
2023-08-12 |
Not clear |
| Julia Reinholz, Oliver Skopp, Caterina Breitenstein, Iwo Bohr, Hilke Winterhoff, Stefan Knech. Compensatory weight gain due to dopaminergic hypofunction: new evidence and own incidental observations. Nutrition & metabolism. vol 5. 2011-07-14. PMID:19046419. |
overeating and resulting weight gain may be induced by genetic predisposition for lower dopaminergic activity, but might also be a behavioral mechanism of compensating for decreased dopamine signaling after dopaminergic overstimulation, for example after smoking cessation or overconsumption of high palatable food. |
2011-07-14 |
2023-08-12 |
rat |
| Yann L Strat, Nicolas Ramoz, Gunter Schumann, Philip Gorwoo. Molecular genetics of alcohol dependence and related endophenotypes. Current genomics. vol 9. issue 7. 2011-07-14. PMID:19506733. |
since dopamine is the main neurotransmitter in the reward circuit, genes involved in the dopaminergic pathway represent candidates of interest. |
2011-07-14 |
2023-08-12 |
Not clear |
| Jörg Neddens, Detlef Vullhorst, Daniel Paredes, Andres Buonann. Neuregulin links dopaminergic and glutamatergic neurotransmission to control hippocampal synaptic plasticity. Communicative & integrative biology. vol 2. issue 3. 2011-07-14. PMID:19641746. |
we have recently demonstrated that nrg-1 regulates glutamatergic plasticity by rapidly increasing extracellular hippocampal dopamine levels and activation of d4 dopamine receptors.7 these new findings position the nrg-1/erbb4 signaling pathway at the crossroads between dopaminergic and glutamatergic neurotransmission and offer novel ways to consolidate genetic, functional and pharmacological data toward a better understanding of the etiological processes underlying schizophrenia, and the role of nrg-1 for normal synaptic function and plasticity. |
2011-07-14 |
2023-08-12 |
Not clear |
| Torsten Falk, Shiling Zhang, Scott J Sherma. Vascular endothelial growth factor B (VEGF-B) is up-regulated and exogenous VEGF-B is neuroprotective in a culture model of Parkinson's disease. Molecular neurodegeneration. vol 4. 2011-07-14. PMID:20003314. |
parkinson's disease (pd) results from the degeneration of dopaminergic neurons in the substantia nigra and the consequent deficit of dopamine released in the striatum. |
2011-07-14 |
2023-08-12 |
rat |
| Ashish Aggarwal, R C Jiloh. Olanzapine induced tardive dystonia. Indian journal of pharmacology. vol 40. issue 5. 2011-07-14. PMID:20040965. |
compared to typical antipsychotics, it has a greater affinity for serotonin 5-ht2a than dopamine d2 receptors, with preferential action at mesolimbic than nigrostriatal dopaminergic pathways. |
2011-07-14 |
2023-08-12 |
Not clear |
| Vanessa Nieratschker, Markus M Nöthen, Marcella Rietsche. New Genetic Findings in Schizophrenia: Is there Still Room for the Dopamine Hypothesis of Schizophrenia? Frontiers in behavioral neuroscience. vol 4. 2011-07-14. PMID:20485477. |
genes involved in the dopaminergic system are considered to be major candidates since the "dopamine hypothesis" of impairment in dopaminergic neurotransmission is one of the most widely accepted hypotheses of the etiology of schizophrenia. |
2011-07-14 |
2023-08-12 |
Not clear |
| Lorenza S Colzato, Jay Pratt, Bernhard Homme. Dopaminergic Control of Attentional Flexibility: Inhibition of Return is Associated with the Dopamine Transporter Gene (DAT1). Frontiers in human neuroscience. vol 4. 2011-07-14. PMID:20661460. |
dopaminergic control of attentional flexibility: inhibition of return is associated with the dopamine transporter gene (dat1). |
2011-07-14 |
2023-08-12 |
human |
| Susanne Graef, Guido Biele, Lea K Krugel, Frank Marzinzik, Michael Wahl, Johann Wotka, Fabian Klostermann, Hauke R Heekere. Differential influence of levodopa on reward-based learning in Parkinson's disease. Frontiers in human neuroscience. vol 4. 2011-07-14. PMID:21048900. |
the mesocorticolimbic dopamine (da) system linking the dopaminergic midbrain to the prefrontal cortex and subcortical striatum has been shown to be sensitive to reinforcement in animals and humans. |
2011-07-14 |
2023-08-12 |
Not clear |
| Karen S Rommelfanger, Thomas Wichman. Extrastriatal dopaminergic circuits of the Basal Ganglia. Frontiers in neuroanatomy. vol 4. 2011-07-14. PMID:21103009. |
dopamine has long been identified as an important modulator of basal ganglia function in the striatum, and disturbances of striatal dopaminergic transmission have been implicated in diseases such as parkinson's disease (pd), addiction and attention deficit hyperactivity disorder. |
2011-07-14 |
2023-08-12 |
Not clear |
| Karen S Rommelfanger, Thomas Wichman. Extrastriatal dopaminergic circuits of the Basal Ganglia. Frontiers in neuroanatomy. vol 4. 2011-07-14. PMID:21103009. |
however, recent evidence suggests that dopamine may also modulate basal ganglia function at sites outside of the striatum, and that changes in dopaminergic transmission at these sites may contribute to the symptoms of pd and other neuropsychiatric disorders. |
2011-07-14 |
2023-08-12 |
Not clear |
| Jean-Luc Dreye. New insights into the roles of microRNAs in drug addiction and neuroplasticity. Genome medicine. vol 2. issue 12. 2011-07-14. PMID:21205279. |
recent studies have identified changes of several specific mirna expression profiles and polymorphisms affecting the interactions between mirnas and their targets in various brain disorders, including addiction: mir-16 causes adaptive changes in production of the serotonin transporter; mir-133b is specifically expressed in midbrain dopaminergic neurons, and regulates the production of tyrosine hydroxylase and the dopamine transporter; mir-212 affects production of striatal brain-derived neurotrophic factor and synaptic plasticity upon cocaine. |
2011-07-14 |
2023-08-12 |
Not clear |
| Tahira Farooqui, Akhlaq A Farooqu. Lipid-mediated oxidative stress and inflammation in the pathogenesis of Parkinson's disease. Parkinson's disease. vol 2011. 2011-07-14. PMID:21403820. |
pd is characterized by the progressive loss of dopaminergic neurons in the substantia nigra, depletion of dopamine in the striatum, abnormal mitochondrial and proteasomal functions, and accumulation of α-synuclein that may be closely associated with pathological and clinical abnormalities. |
2011-07-14 |
2023-08-12 |
Not clear |
| Maria Letizia Trincavelli, Serena Cuboni, Mario Catena Dell'osso, Roberto Maggio, Karl-Norbert Klotz, Francesca Novi, Anna Panighini, Simona Daniele, Claudia Martin. Receptor crosstalk: haloperidol treatment enhances A(2A) adenosine receptor functioning in a transfected cell model. Purinergic signalling. vol 6. issue 4. 2011-07-14. PMID:21437008. |
in this context, possible changes in a(2a) adenosine receptor functional responses caused by the chronic blockade/activation of d(2) dopamine receptors should be considered to optimise the therapeutic effectiveness of dopaminergic agents and to reduce any possible side effects. |
2011-07-14 |
2023-08-12 |
Not clear |
| Penny A Macdonald, Oury Monch. Differential effects of dopaminergic therapies on dorsal and ventral striatum in Parkinson's disease: implications for cognitive function. Parkinson's disease. vol 2011. 2011-07-14. PMID:21437185. |
unlike motor symptoms that are clearly improved by dopaminergic therapy, the effect of dopamine replacement on cognition seems paradoxical. |
2011-07-14 |
2023-08-12 |
Not clear |
| Penny A Macdonald, Oury Monch. Differential effects of dopaminergic therapies on dorsal and ventral striatum in Parkinson's disease: implications for cognitive function. Parkinson's disease. vol 2011. 2011-07-14. PMID:21437185. |
increased awareness of contrasting effects of dopamine replacement on dorsal versus ventral striatum functions will lead clinicians to survey a broader range of symptoms in determining optimal therapy, taking into account both those aspects of cognition that will be helped versus those that will be hindered by dopaminergic treatment. |
2011-07-14 |
2023-08-12 |
Not clear |
| Young-Min Park, Seung-Gul Kang, Jung-Eun Choi, Yong-Ku Kim, Seung-Hyun Kim, Ji-Young Park, Leen Kim, Heon-Jeong Le. No Evidence for an Association between Dopamine D2 Receptor Polymorphisms and Tardive Dyskinesia in Korean Schizophrenia Patients. Psychiatry investigation. vol 8. issue 1. 2011-07-14. PMID:21519536. |
dopaminergic activity in the nigrostriatal system have been proposed to be involved in development of td and dopamine d2 receptors (drd2) has been regarded as a candidate gene for td because the antipsychotics have potent antagonism drd2. |
2011-07-14 |
2023-08-12 |
Not clear |
| Melissa L Perreault, Ahmed Hasbi, Brian F O'Dowd, Susan R Georg. The dopamine d1-d2 receptor heteromer in striatal medium spiny neurons: evidence for a third distinct neuronal pathway in Basal Ganglia. Frontiers in neuroanatomy. vol 5. 2011-07-14. PMID:21747759. |
dopaminergic signaling within the basal ganglia has classically been thought to occur within two distinct neuronal pathways; the direct striatonigral pathway which contains the dopamine d1 receptor and the neuropeptides dynorphin (dyn) and substance p, and the indirect striatopallidal pathway which expresses the dopamine d2 receptor and enkephalin (enk). |
2011-07-14 |
2023-08-12 |
Not clear |