| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Massimiliano Caiazzo, Maria Teresa Dell'Anno, Elena Dvoretskova, Dejan Lazarevic, Stefano Taverna, Damiana Leo, Tatyana D Sotnikova, Andrea Menegon, Paola Roncaglia, Giorgia Colciago, Giovanni Russo, Piero Carninci, Gianni Pezzoli, Raul R Gainetdinov, Stefano Gustincich, Alexander Dityatev, Vania Broccol. Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. Nature. vol 476. issue 7359. 2011-09-16. PMID:21725324. |
induced dopaminergic (ida) cells release dopamine and show spontaneous electrical activity organized in regular spikes consistent with the pacemaker activity featured by brain dopaminergic neurons. |
2011-09-16 |
2023-08-12 |
mouse |
| Tiziana Alberio, Claudia Anchieri, Luca Piacentini, Giovanna Gentile, Maurizio Simmaco, Mara Biasin, Mauro Fasan. Proteomic characterization of Jurkat T leukemic cells after dopamine stimulation: A model of circulating dopamine-sensitive cells. Biochimie. vol 93. issue 5. 2011-09-15. PMID:21300132. |
a saturating, non-toxic, non-oxidant 50 μm dopamine challenge induces the upregulation of an interacting chaperone network known to protect specifically dopaminergic neurons, thus validating t-cells as a biomarker discovery source in parkinson's disease. |
2011-09-15 |
2023-08-12 |
human |
| M Flint Bea. Neuroprotective effects of creatine. Amino acids. vol 40. issue 5. 2011-09-15. PMID:21448659. |
creatine produced dose-dependent neuroprotective effects against mptp toxicity reducing the loss of dopamine within the striatum and the loss of dopaminergic neurons in the substantia nigra. |
2011-09-15 |
2023-08-12 |
mouse |
| Candan Depboylu, Kathrin Schorlemmer, Martin Klietz, Wolfgang H Oertel, Eberhard Weihe, Günter U Höglinger, Martin K-H Schäfe. Upregulation of microglial C1q expression has no effects on nigrostriatal dopaminergic injury in the MPTP mouse model of Parkinson disease. Journal of neuroimmunology. vol 236. issue 1-2. 2011-09-13. PMID:21640391. |
however, mice deficient in functional c1q protein were not significantly different in mptp-induced loss of nigral dopaminergic neurons, striatal dopaminergic fibers and dopamine levels than their control littermates. |
2011-09-13 |
2023-08-12 |
mouse |
| Ian C Ballard, Vishnu P Murty, R McKell Carter, Jeffrey J MacInnes, Scott A Huettel, R Alison Adcoc. Dorsolateral prefrontal cortex drives mesolimbic dopaminergic regions to initiate motivated behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 28. 2011-09-12. PMID:21753011. |
our findings of a directional prefrontal influence on dopaminergic regions during reward anticipation suggest a model in which the dlpfc integrates and transmits representations of reward to the mesolimbic and mesocortical dopamine systems, thereby initiating motivated behavior. |
2011-09-12 |
2023-08-12 |
human |
| Wiebke Potjans, Markus Diesmann, Abigail Morriso. An imperfect dopaminergic error signal can drive temporal-difference learning. PLoS computational biology. vol 7. issue 5. 2011-09-09. PMID:21589888. |
experimental evidence that supports the hypothesis that the mammalian brain performs temporal-difference learning includes the resemblance of the phasic activity of the midbrain dopaminergic neurons to the td error and the discovery that cortico-striatal synaptic plasticity is modulated by dopamine. |
2011-09-09 |
2023-08-12 |
Not clear |
| Danhui Zhang, Arthi Kanthasamy, Vellareddy Anantharam, Anumantha Kanthasam. Effects of manganese on tyrosine hydroxylase (TH) activity and TH-phosphorylation in a dopaminergic neural cell line. Toxicology and applied pharmacology. vol 254. issue 2. 2011-09-06. PMID:21310168. |
recently, we showed that pkcδ negatively regulates tyrosine hydroxylase (th), the rate-limiting enzyme in dopamine synthesis, by enhancing protein phosphatase-2a activity in dopaminergic neurons. |
2011-09-06 |
2023-08-12 |
Not clear |
| Danhui Zhang, Arthi Kanthasamy, Vellareddy Anantharam, Anumantha Kanthasam. Effects of manganese on tyrosine hydroxylase (TH) activity and TH-phosphorylation in a dopaminergic neural cell line. Toxicology and applied pharmacology. vol 254. issue 2. 2011-09-06. PMID:21310168. |
here, we report that mn exposure can affect the enzymatic activity of th, the rate-limiting enzyme in dopamine synthesis, by activating pkcδ-pp2a signaling pathway in a dopaminergic cell model. |
2011-09-06 |
2023-08-12 |
Not clear |
| Jung-Mi Choi, Jung-Hoon Hong, Min-Joo Chae, Phuoc Hung Ngyuen, Hyun-Sook Kang, Hyeo-Il Ma, Yun Joong Ki. Analysis of mutations and the association between polymorphisms in the cerebral dopamine neurotrophic factor (CDNF) gene and Parkinson disease. Neuroscience letters. vol 493. issue 3. 2011-09-01. PMID:21320571. |
the cerebral dopamine neurotrophic factor (cdnf) is a novel neurotrophic factor with strong trophic activity on dopaminergic neurons comparable to that of glial cell line-derived neurotrophic factor (gdnf). |
2011-09-01 |
2023-08-12 |
Not clear |
| Kenneth Blum, Yijun Liu, Richard Shriner, Mark S Gol. Reward circuitry dopaminergic activation regulates food and drug craving behavior. Current pharmaceutical design. vol 17. issue 12. 2011-08-30. PMID:21492092. |
individuals possessing a paucity of serotonergic and/or dopaminergic receptors and an increased rate of synaptic dopamine catabolism, due to high catabolic genotype of the comt gene, are predisposed to self-medicating any substance or behavior that will activate dopamine release including alcohol, opiates, psychostimulants, nicotine, glucose, gambling, sex, and even excessive internet gaming, among others. |
2011-08-30 |
2023-08-12 |
human |
| María Amparo Assis, Analía Valdomero, Constanza García-Keller, Claudia Sotomayor, Liliana Marina Cancel. Decrease of lymphoproliferative response by amphetamine is mediated by dopamine from the nucleus accumbens: influence on splenic met-enkephalin levels. Brain, behavior, and immunity. vol 25. issue 4. 2011-08-29. PMID:21237264. |
in this study, we investigated if a possible dopamine mechanism underlies these amphetamine-induced effects by administering d1 and d2 dopaminergic antagonists or a dopaminergic terminal neurotoxin before the drug. |
2011-08-29 |
2023-08-12 |
Not clear |
| Kristen A Kelps, Jadwiga Turchan-Cholewo, Erin R Hascup, Tiffany L Taylor, Don M Gash, Greg A Gerhardt, Luke H Bradle. Evaluation of the physical and in vitro protective activity of three synthetic peptides derived from the pro- and mature GDNF sequence. Neuropeptides. vol 45. issue 3. 2011-08-29. PMID:21507484. |
recently, a small 11-amino acid amidated peptide, dopamine neuron stimulating peptide-11 (dnsp-11), was shown to exert neurotrophic-like actions on primary dopaminergic neurons and in parkinsonian rat models. |
2011-08-29 |
2023-08-12 |
rat |
| Erin F Wolff, Xiao-Bing Gao, Katherine V Yao, Zane B Andrews, Hongling Du, John D Elsworth, Hugh S Taylo. Endometrial stem cell transplantation restores dopamine production in a Parkinson's disease model. Journal of cellular and molecular medicine. vol 15. issue 4. 2011-08-26. PMID:20406327. |
cells expressing cd90, platelet derived growth factor (pdgf)-rβ and cd146 but not cd45 or cd31 were differentiated in vitro into dopaminergic neurons that exhibited axon projections, pyramidal cell bodies and dendritic projections that recapitulate synapse formation; these cells also expressed the neural marker nestin and tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis. |
2011-08-26 |
2023-08-12 |
mouse |
| Alejandro Higuera-Matas, Fanny Botreau, Nuria Del Olmo, Miguel Miguéns, Oscar Olías, Gonzalo L Montoya, Carmen García-Lecumberri, Emilio Ambrosi. Periadolescent exposure to cannabinoids alters the striatal and hippocampal dopaminergic system in the adult rat brain. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 20. issue 12. 2011-08-26. PMID:20655181. |
we evaluated the levels of the dopamine transporter (dat), and the d1- (d1r) and d2-type (d2r) dopaminergic receptors, as well as tyrosine hydroxylase (th) mrna in dopaminergic areas of the adult, cocaine self-administered, rat brain that had been chronically exposed to cp or vehicle (vh) during periadolescence. |
2011-08-26 |
2023-08-12 |
human |
| Gunasingh J Masilamoni, James W Bogenpohl, David Alagille, Kristen Delevich, Gilles Tamagnan, John R Votaw, Thomas Wichmann, Yoland Smit. Metabotropic glutamate receptor 5 antagonist protects dopaminergic and noradrenergic neurons from degeneration in MPTP-treated monkeys. Brain : a journal of neurology. vol 134. issue Pt 7. 2011-08-26. PMID:21705423. |
these behavioural observations were consistent with in vivo positron emission tomography dopamine transporter imaging data, and with post-mortem stereological counts of midbrain dopaminergic neurons, as well as striatal intensity measurements of dopamine transporter and tyrosine hydroxylase immunoreactivity, which were all significantly higher in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/3-[(2-methyl-1,3-thiazol-4-yl) ethynyl] pyridine-treated animals than in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/vehicle-treated monkeys. |
2011-08-26 |
2023-08-12 |
monkey |
| Irina N Krasnova, Bruce Ladenheim, Amber B Hodges, Nora D Volkow, Jean Lud Cade. Chronic methamphetamine administration causes differential regulation of transcription factors in the rat midbrain. PloS one. vol 6. issue 4. 2011-08-25. PMID:21547080. |
when administered in large doses, meth can cause depletion of striatal dopamine terminals, with preservation of midbrain dopaminergic neurons. |
2011-08-25 |
2023-08-12 |
rat |
| Noelia Granado, Sara Ares-Santos, Idaira Oliva, Esther O'Shea, Eduardo D Martin, M Isabel Colado, Rosario Moratall. Dopamine D2-receptor knockout mice are protected against dopaminergic neurotoxicity induced by methamphetamine or MDMA. Neurobiology of disease. vol 42. issue 3. 2011-08-23. PMID:21303698. |
dopamine d2-receptor knockout mice are protected against dopaminergic neurotoxicity induced by methamphetamine or mdma. |
2011-08-23 |
2023-08-12 |
mouse |
| Zhishan Li, Alcmène Chalazonitis, Yung-Yu Huang, J John Mann, Kara Gross Margolis, Qi Melissa Yang, Dolly O Kim, Francine Côté, Jacques Mallet, Michael D Gersho. Essential roles of enteric neuronal serotonin in gastrointestinal motility and the development/survival of enteric dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 24. 2011-08-22. PMID:21677183. |
rings of sert-immunoreactive terminal axons surrounded myenteric dopaminergic neurons and sert knock-out increased intestinal levels of dopamine metabolites, implying that enteric dopaminergic neurons receive a serotonergic innervation. |
2011-08-22 |
2023-08-12 |
mouse |
| Zhi Dong Zhou, Yu Hong Lan, Eng King Tan, Tit Meng Li. Iron species-mediated dopamine oxidation, proteasome inhibition, and dopaminergic cell demise: implications for iron-related dopaminergic neuron degeneration. Free radical biology & medicine. vol 49. issue 12. 2011-08-18. PMID:20854902. |
iron species-mediated dopamine oxidation, proteasome inhibition, and dopaminergic cell demise: implications for iron-related dopaminergic neuron degeneration. |
2011-08-18 |
2023-08-12 |
Not clear |
| Zhi Dong Zhou, Yu Hong Lan, Eng King Tan, Tit Meng Li. Iron species-mediated dopamine oxidation, proteasome inhibition, and dopaminergic cell demise: implications for iron-related dopaminergic neuron degeneration. Free radical biology & medicine. vol 49. issue 12. 2011-08-18. PMID:20854902. |
in this study, we demonstrate that free iron ions (trivalent or bivalent) and iron ions in stable complex with cyanide ions (k(4)fe(cn)(6) and k(3)fe(cn)(6)) can induce dopamine (da) oxidation with different profiles and subsequently lead to proteasome inhibition and even dopaminergic mn9d cell demise via different mechanisms. |
2011-08-18 |
2023-08-12 |
Not clear |