| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fabrizio Stocch. Dopamine receptor agonists in the treatment of advanced Parkinson's disease. Parkinsonism & related disorders. vol 15 Suppl 4. 2010-09-30. PMID:20123558. |
there is now accumulating evidence that the progressive pathology of pd, the change in drug pharmaco-dynamics, and the pulsatile manner in which short-acting dopaminergic agents stimulate striatal dopamine receptors combine as key contributing factors to the priming of the basal ganglia for induction of motor complications. |
2010-09-30 |
2023-08-12 |
Not clear |
| Pengxiu Cao, Yiyuan Yuan, Elizabeth A Pehek, Alex R Moise, Ying Huang, Krzysztof Palczewski, Zhaoyang Fen. Alpha-synuclein disrupted dopamine homeostasis leads to dopaminergic neuron degeneration in Caenorhabditis elegans. PloS one. vol 5. issue 2. 2010-09-30. PMID:20174477. |
disruption of dopamine homeostasis may lead to dopaminergic neuron degeneration, a proposed explanation for the specific vulnerability of dopaminergic neurons in parkinson's disease. |
2010-09-30 |
2023-08-12 |
human |
| Pengxiu Cao, Yiyuan Yuan, Elizabeth A Pehek, Alex R Moise, Ying Huang, Krzysztof Palczewski, Zhaoyang Fen. Alpha-synuclein disrupted dopamine homeostasis leads to dopaminergic neuron degeneration in Caenorhabditis elegans. PloS one. vol 5. issue 2. 2010-09-30. PMID:20174477. |
we found that alpha-synuclein expression results in upregulation of dopamine synthesis and content, and redistribution of dopaminergic synaptic vesicles, which significantly contribute to dopaminergic neuron degeneration. |
2010-09-30 |
2023-08-12 |
human |
| Hiromi Shiotsuki, Kenji Yoshimi, Yasushi Shimo, Manabu Funayama, Yukio Takamatsu, Kazutaka Ikeda, Ryosuke Takahashi, Shigeru Kitazawa, Nobutaka Hattor. A rotarod test for evaluation of motor skill learning. Journal of neuroscience methods. vol 189. issue 2. 2010-09-28. PMID:20359499. |
on the other hand, apomorphine, an agonist of dopamine autoreceptor, a dopaminergic toxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) impaired the learning. |
2010-09-28 |
2023-08-12 |
mouse |
| Ricardo W Binfaré, Michela Mantovani, Josiane Budni, Adair Roberto S Santos, Ana Lúcia S Rodrigue. Involvement of dopamine receptors in the antidepressant-like effect of melatonin in the tail suspension test. European journal of pharmacology. vol 638. issue 1-3. 2010-09-27. PMID:20406627. |
was prevented by the pretreatment of mice with haloperidol (0.2mg/kg, i.p., a nonselective dopaminergic receptor antagonist), sch23390 (0.05 mg/kg, s.c., a selective dopamine d1 receptor antagonist), and sulpiride (50mg/kg, i.p., a selective dopamine d2 receptor antagonist). |
2010-09-27 |
2023-08-12 |
mouse |
| Ricardo W Binfaré, Michela Mantovani, Josiane Budni, Adair Roberto S Santos, Ana Lúcia S Rodrigue. Involvement of dopamine receptors in the antidepressant-like effect of melatonin in the tail suspension test. European journal of pharmacology. vol 638. issue 1-3. 2010-09-27. PMID:20406627. |
these results indicate that the antidepressant-like effect of melatonin in the tail suspension test is likely mediated by an interaction with the dopaminergic system, through an activation of dopamine d1 and d2 receptors. |
2010-09-27 |
2023-08-12 |
mouse |
| Andrea Varrone, Christer Halldi. Molecular imaging of the dopamine transporter. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 51. issue 9. 2010-09-27. PMID:20720060. |
the dopamine transporter (dat) is a transmembrane protein responsible for reuptake of dopamine from the synaptic cleft and termination of dopaminergic transmission. |
2010-09-27 |
2023-08-12 |
Not clear |
| Heather A O'Malley, Yanghae Park, Lori L Isom, Margaret E Gneg. PKCbeta co-localizes with the dopamine transporter in mesencephalic neurons. Neuroscience letters. vol 480. issue 1. 2010-09-24. PMID:20641161. |
the dopamine transporter (dat) is a critical regulator of dopaminergic neurotransmission. |
2010-09-24 |
2023-08-12 |
rat |
| Jacob Bendor, José E Lizardi-Ortiz, Robert I Westphalen, Markus Brandstetter, Hugh C Hemmings, David Sulzer, Marc Flajolet, Paul Greengar. AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release. The EMBO journal. vol 29. issue 16. 2010-09-24. PMID:20664521. |
of the five mammalian muscarinic acetylcholine (ach) receptors, m(5) is the only subtype expressed in midbrain dopaminergic neurons, where it functions to potentiate dopamine release. |
2010-09-24 |
2023-08-12 |
Not clear |
| Javier Fernández-Ruiz, Mariluz Hernández, José A Ramo. Cannabinoid-dopamine interaction in the pathophysiology and treatment of CNS disorders. CNS neuroscience & therapeutics. vol 16. issue 3. 2010-09-22. PMID:20406253. |
they also play a modulatory function on dopamine (da) transmission, although cb(1) receptors do not appear to be located in dopaminergic terminals, at least in the major brain regions receiving dopaminergic innervation, e.g., the caudate-putamen and the nucleus accumbens/prefrontal cortex. |
2010-09-22 |
2023-08-12 |
Not clear |
| Mohamed R Ahmed, Amandine Berthet, Evgeny Bychkov, Gregory Porras, Qin Li, Bernard H Bioulac, Yonatan T Carl, Bertrand Bloch, Seunghyi Kook, Incarnation Aubert, Sandra Dovero, Evelyne Doudnikoff, Vsevolod V Gurevich, Eugenia V Gurevich, Erwan Bezar. Lentiviral overexpression of GRK6 alleviates L-dopa-induced dyskinesia in experimental Parkinson's disease. Science translational medicine. vol 2. issue 28. 2010-09-20. PMID:20410529. |
parkinson's disease is caused primarily by degeneration of brain dopaminergic neurons in the substantia nigra and the consequent deficit of dopamine in the striatum. |
2010-09-20 |
2023-08-12 |
rat |
| Sohan Punia, Mitashree Das, Madhuri Behari, Bikash K Mishra, Asish K Sahani, Shyla T Govindappa, Sachi Jayaram, Uday B Muthane, Thelma B K, Ramesh C Juya. Role of polymorphisms in dopamine synthesis and metabolism genes and association of DBH haplotypes with Parkinson's disease among North Indians. Pharmacogenetics and genomics. vol 20. issue 7. 2010-09-20. PMID:20498626. |
in view of the biochemical evidence of depleted dopamine levels in the affected brains and also the most common and effective therapeutic modality of administration of levodopa in pd, genes from the dopaminergic pathway emerge as major determinants. |
2010-09-20 |
2023-08-12 |
Not clear |
| Jacob Eriksen, Walden Emil Bjørn-Yoshimoto, Trine Nygaard Jørgensen, Amy Hauck Newman, Ulrik Gethe. Postendocytic sorting of constitutively internalized dopamine transporter in cell lines and dopaminergic neurons. The Journal of biological chemistry. vol 285. issue 35. 2010-09-17. PMID:20551317. |
postendocytic sorting of constitutively internalized dopamine transporter in cell lines and dopaminergic neurons. |
2010-09-17 |
2023-08-12 |
Not clear |
| Chun-Hung Wu, Pao-Luh Tao, Eagle Yi-Kung Huan. Distribution of neuropeptide FF (NPFF) receptors in correlation with morphine-induced reward in the rat brain. Peptides. vol 31. issue 7. 2010-09-14. PMID:20381562. |
this implied a possible function of npff to modulate dopaminergic neurons directly and a possible indirect action of npff on gabaergic neurons to modulate dopamine release. |
2010-09-14 |
2023-08-12 |
rat |
| Mark F Lew, Robert A Hauser, Howard I Hurtig, William G Ondo, Joanne Wojcieszek, Tamar Goren, Cheryl J Fitzer-Atta. Long-term efficacy of rasagiline in early Parkinson's disease. The International journal of neuroscience. vol 120. issue 6. 2010-09-14. PMID:20504210. |
the majority of patients received a dopamine agonist prior to levodopa as the first additional dopaminergic agent. |
2010-09-14 |
2023-08-12 |
Not clear |
| Amal Alachkar, Jonathan M Brotchie, Owen T Jone. Binding of dopamine and 3-methoxytyramine as l-DOPA metabolites to human alpha(2)-adrenergic and dopaminergic receptors. Neuroscience research. vol 67. issue 3. 2010-09-13. PMID:20302892. |
binding of dopamine and 3-methoxytyramine as l-dopa metabolites to human alpha(2)-adrenergic and dopaminergic receptors. |
2010-09-13 |
2023-08-12 |
human |
| Amal Alachkar, Jonathan M Brotchie, Owen T Jone. Binding of dopamine and 3-methoxytyramine as l-DOPA metabolites to human alpha(2)-adrenergic and dopaminergic receptors. Neuroscience research. vol 67. issue 3. 2010-09-13. PMID:20302892. |
these data suggest that the effects of l-dopa in parkinson's disease may result from actions of its metabolites dopamine and 3-mt on both dopaminergic and non-dopaminergic receptors. |
2010-09-13 |
2023-08-12 |
human |
| Chie Seki, Hiroshi Ito, Tetsuya Ichimiya, Ryosuke Arakawa, Yoko Ikoma, Miho Shidahara, Jun Maeda, Akihiro Takano, Hidehiko Takahashi, Yuichi Kimura, Kazutoshi Suzuki, Iwao Kanno, Tetsuya Suhar. Quantitative analysis of dopamine transporters in human brain using [11C]PE2I and positron emission tomography: evaluation of reference tissue models. Annals of nuclear medicine. vol 24. issue 4. 2010-09-10. PMID:20364374. |
dopamine transporter (dat) is a reuptake carrier of dopamine at presynapse that regulates dopaminergic neural transmission. |
2010-09-10 |
2023-08-12 |
human |
| Stephan Heermann, Felipe Opazo, Björn Falkenburger, Kerstin Krieglstein, Björn Spitta. Aged Tgfbeta2/Gdnf double-heterozygous mice show no morphological and functional alterations in the nigrostriatal system. Journal of neural transmission (Vienna, Austria : 1996). vol 117. issue 6. 2010-09-08. PMID:20458508. |
loss of dopaminergic neurons in the substantia nigra pars compacta and the resulting decrease in striatal dopamine levels are the hallmarks of parkinson's disease. |
2010-09-08 |
2023-08-12 |
mouse |
| Orjan de Manzano, Simon Cervenka, Anke Karabanov, Lars Farde, Fredrik Ullé. Thinking outside a less intact box: thalamic dopamine D2 receptor densities are negatively related to psychometric creativity in healthy individuals. PloS one. vol 5. issue 5. 2010-09-07. PMID:20498850. |
here, we investigated the relationship between creative ability and dopamine d2 receptor expression in healthy individuals, with a focus on regions where aberrations in dopaminergic function have previously been associated with psychotic symptoms and a genetic liability to schizophrenia. |
2010-09-07 |
2023-08-12 |
Not clear |