| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| O D Howes, P Fusar-Poli, M Bloomfield, S Selvaraj, P McGuir. From the prodrome to chronic schizophrenia: the neurobiology underlying psychotic symptoms and cognitive impairments. Current pharmaceutical design. vol 18. issue 4. 2012-10-16. PMID:22239576. |
firstly they have consistently implicated presynaptic dopaminergic dysfunction in the disorder, finding that dopamine synthesis capacity, dopamine release and baseline dopamine levels are increased in the illness. |
2012-10-16 |
2023-08-12 |
Not clear |
| Hideaki Matsui, Roberto Gavinio, Ryosuke Takahash. Medaka fish Parkinson's disease model. Experimental neurobiology. vol 21. issue 3. 2012-10-12. PMID:23055787. |
despite the ubiquitous distribution of the inclusion bodies, the middle diencephalic dopaminergic neurons were particularly vulnerable to these toxins, supporting the idea that this dopamine cluster is similar to the human substantia nigra. |
2012-10-12 |
2023-08-12 |
human |
| Chih-Chun Huang, Yun-Hsuan Chang, Sheng-Yu Lee, Shiou-Lan Chen, Shih-Heng Chen, Chun-Hsien Chu, San-Yuan Huang, Nian-Sheng Tzeng, I Hui Lee, Tzung Lieh Yeh, Yen Kuang Yang, Ru-Band L. The interaction between BDNF and DRD2 in bipolar II disorder but not in bipolar I disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 159B. issue 5. 2012-10-11. PMID:22514151. |
the dopamine d2 receptor/ankyrin repeat and kinase domain containing 1 (drd2/ankk1), one of the dopaminergic pathways, as well as the brain-derived neurotrophic factor (bdnf) gene, were reported as candidate genes in the etiology of bipolar disorder. |
2012-10-11 |
2023-08-12 |
human |
| Chih-Cheng Chien, Yih-Jing Lee, Lir-Wan Fan, Ing-Kang Ho, Lu-Tai Tie. Naloxonazine, a specific mu-opioid receptor antagonist, attenuates the increment of locomotor activity induced by acute methamphetamine in mice. Toxicology letters. vol 212. issue 1. 2012-10-09. PMID:22564758. |
this study investigates the effects of naloxonazine, a specific mu-opioid receptor antagonist, on the locomotor behavioral response and phosphorylation pattern of dopamine and camp-regulated phosphoprotein of mr32 (darpp-32) in striatal dopaminergic transmissions induced by acute administration of meth to mice. |
2012-10-09 |
2023-08-12 |
mouse |
| Zuoli Sun, Jun Jia, Xiaoli Gong, Yanjun Jia, Jiahui Deng, Xuan Wang, Xiaomin Wan. Inhibition of glutamate and acetylcholine release in behavioral improvement induced by electroacupuncture in parkinsonian rats. Neuroscience letters. vol 520. issue 1. 2012-10-04. PMID:22583765. |
high-frequency ea stimulation at dazhui (gv14) and baihui (gv20) acupoints decreased rotational behavior induced by apomorphine (apo) and improved motor coordination, protected axotomized dopaminergic neurons from degeneration in the substantia nigra (sn), it did not increase striatal dopamine (da) levels. |
2012-10-04 |
2023-08-12 |
rat |
| Joel G Anderson, Paula T Cooney, Keith M Erikso. Inhibition of DAT function attenuates manganese accumulation in the globus pallidus. Environmental toxicology and pharmacology. vol 23. issue 2. 2012-10-02. PMID:17387379. |
to date, it remains elusive how and why mn targets dopaminergic neurons although recently the role of the dopamine transporter has been suggested. |
2012-10-02 |
2023-08-12 |
rat |
| D R McLean, M S Hafez, R R Duarte-Afara, M E Obei. Four cases of neuroleptic malignant syndrome. Annals of Saudi medicine. vol 12. issue 1. 2012-10-02. PMID:17589122. |
the syndrome is thought to result from acute dopaminergic blockage or dopamine depletion. |
2012-10-02 |
2023-08-12 |
Not clear |
| Florence Lev. Pharmacological and therapeutic directions in ADHD: Specificity in the PFC. Behavioral and brain functions : BBF. vol 4. 2012-10-02. PMID:18304369. |
a review of animal and human studies of pharmacological and therapeutic directions in adhd suggests that the d1 receptor is a specific site for dopaminergic regulation of the pfc, but optimal levels of dopamine (da) are required for beneficial effects on working memory. |
2012-10-02 |
2023-08-12 |
human |
| E C Wolters, C M Franco. Mental dysfunction in Parkinson's disease. Parkinsonism & related disorders. vol 4. issue 3. 2012-10-02. PMID:18591098. |
the pathological hallmark of parkinson's disease (pd) is a degeneration of the dopamine (da) producing cells in the substantia nigra and the ventral tegmentum, resulting in a dopamine deficiency in the dopaminergic projection areas with defective functioning of specific cortico-subcortical extrapyramidal circuits. |
2012-10-02 |
2023-08-12 |
Not clear |
| F Stocchi, A Desté. Co-administration of ropinirole and domperidone during rapid dose escalation of the dopamine agonist. Parkinsonism & related disorders. vol 4. issue 4. 2012-10-02. PMID:18591109. |
in patients naive to dopaminergic therapy, reducing the side-effects associated with dopamine agonist treatment will permit faster titration to effective therapeutic doses. |
2012-10-02 |
2023-08-12 |
Not clear |
| P C Goldsmith, K K Thind, T Song, E J Kim, J E Boggan. Location of the neuroendocrine dopamine neurons in the monkey hypothalamus by retrograde tracing and immunostaining. Journal of neuroendocrinology. vol 2. issue 2. 2012-10-02. PMID:19210380. |
however, considering the known locations of dopaminergic neurons and the large numbers of labeled cells, the results here are a reliable indication of the diverse origins of median eminence-directed dopamine neurons in the juvenile primate. |
2012-10-02 |
2023-08-12 |
rabbit |
| D E Dluzen, V D Ramire. Effects of orchidectomy on nigro-striatal dopaminergic function: behavioral and physiological evidence. Journal of neuroendocrinology. vol 1. issue 4. 2012-10-02. PMID:19210442. |
these results demonstrate that testicular hormones, most likely testosterone, have a markedly suppressive effect upon the nigro-striatal dopaminergic system as evidenced from changes in spontaneous behavioral activity and in vitro dopamine release. |
2012-10-02 |
2023-08-12 |
rat |
| J Zhang, C Chen, L A Kukstas, J D Vincent, J M Israe. Functional Lactotroph Heterogeneity in Lactating Rats and in vitro Modification by 17Beta-Estradiol. Journal of neuroendocrinology. vol 2. issue 6. 2012-10-02. PMID:19215424. |
from the above results, we suggest that: 1) lactotrophs in the lactating rat pituitary can be divided into two major subpopulations with regard to cellular size and density, prolactin production and responsiveness to trh and dopamine; 2) 17beta-estradiol pretreatment increases basal prolactin release from light fraction cells but does not affect basal prolactin release from heavy fraction cells in this way; 3) pretreatment with 17beta-estradiol enhances trh stimulation and reduces dopaminergic inhibition of prolactin release from lactotrophs. |
2012-10-02 |
2023-08-12 |
rat |
| J Demotes-Mainard, E Arnauld, J D Vincen. Estrogens Modulate the Responsiveness of in vivo Recorded Striatal Neurons to lontophoretic Application of Dopamine in Rats: Role of D and D2 Receptor Activation. Journal of neuroendocrinology. vol 2. issue 6. 2012-10-02. PMID:19215425. |
eighty-three spontaneously firing caudate neurons of ovariectomized female rats were extracellularly recorded during iontophoretic ejection of dopamine or dopaminergic agonists or antagonists. |
2012-10-02 |
2023-08-12 |
rat |
| J D Curlewis, A M Naylor, A S McNeill. Evaluation of a possible role for the dopamine d and d receptors in the steroid-dependent suppression of luteinizing hormone secretion in the seasonally anoestrous ewe. Journal of neuroendocrinology. vol 3. issue 4. 2012-10-02. PMID:19215481. |
abstract this study was undertaken to determine whether dopaminergic suppression of pulsatile luteinizing hormone (lh) secretion during seasonal anoestrus in the ewe is mediated via the dopamine d(1) or d(2) receptor. |
2012-10-02 |
2023-08-12 |
Not clear |
| M Baudry, J Costentin, H Marcais, M P Martres, P Protais, J C Schwart. Decreased responsiveness to low doses of apomorphine after dopamine agonists and the possible involvement of hyposensitivity of dopamine 'autoreceptors'. Neuroscience letters. vol 4. issue 3-4. 2012-10-02. PMID:19604945. |
thus, low stimulation of dopamine receptors can regulate the synthesis and release of dopamine even in the absence of impulse flow in dopaminergic neurons, and the initial stimulation of the receptors mediating such effects may lead to a state of hyposensitivity to further stimulation. |
2012-10-02 |
2023-08-12 |
mouse |
| R Weizman, D E Dar, S Landa, A Apter, M Gavis. "Peripheral" benzodiazepine receptor density is not altered by methylphenidate treatment in children with attention-deficit hyperactivity disorder. Journal of child and adolescent psychopharmacology. vol 3. issue 2. 2012-10-02. PMID:19630638. |
abstract "peripheral" benzodiazepine receptors (pbrs) are located in the central nervous system and the periphery, are involved in the release of dopamine, and are sensitive to agents active at the dopaminergic system. |
2012-10-02 |
2023-08-12 |
Not clear |
| S Dollfus, M Petit, J P Garnier, P Boudou, S Troupel, C Dreux, J F Menar. Catecholamines in autistic disorder: effects of amisulpride and bromocriptine in a controlled crossover study. Journal of child and adolescent psychopharmacology. vol 3. issue 3. 2012-10-02. PMID:19630674. |
this paradoxical decrease in hva levels suggests that both dopamine agonists and antagonists could act on autoreceptors or presynaptic dopaminergic receptors in the central nervous system. |
2012-10-02 |
2023-08-12 |
Not clear |
| S Dollfus, M Petit, J P Garnier, P Boudou, S Troupel, C Dreux, J F Menar. Catecholamines in autistic disorder: effects of amisulpride and bromocriptine in a controlled crossover study. Journal of child and adolescent psychopharmacology. vol 3. issue 3. 2012-10-02. PMID:19630674. |
the complementary clinical effects of a dopamine agonist and dopamine antagonist might speculatively be related to their similar action on dopamine autoreceptors, leading to a correction of the dopaminergic hyperactivity that has been postulated in autistic children. |
2012-10-02 |
2023-08-12 |
Not clear |
| João Paulo L Daher, Mingyao Ying, Rebecca Banerjee, Rebecca S McDonald, Myriam Dumas Hahn, Lichuan Yang, M Flint Beal, Bobby Thomas, Valina L Dawson, Ted M Dawson, Darren J Moor. Conditional transgenic mice expressing C-terminally truncated human alpha-synuclein (alphaSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons. Molecular neurodegeneration. vol 4. 2012-10-02. PMID:19630976. |
conditional transgenic mice expressing c-terminally truncated human alpha-synuclein (alphasyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons. |
2012-10-02 |
2023-08-12 |
mouse |