| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thomas Steinkellner, Jae-Won Yang, Therese R Montgomery, Wei-Qiang Chen, Marie-Therese Winkler, Sonja Sucic, Gert Lubec, Michael Freissmuth, Ype Elgersma, Harald H Sitte, Oliver Kudlace. Ca(2+)/calmodulin-dependent protein kinase IIα (αCaMKII) controls the activity of the dopamine transporter: implications for Angelman syndrome. The Journal of biological chemistry. vol 287. issue 35. 2012-11-19. PMID:22778257. |
the dopamine transporter (dat) is a crucial regulator of dopaminergic neurotransmission, controlling the length and brevity of dopaminergic signaling. |
2012-11-19 |
2023-08-12 |
mouse |
| I G Sil'ki. [Possible mechanisms for orexin effects on the functioning of the hippocampus and spatial learning (analytical review)]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 62. issue 4. 2012-11-19. PMID:23035556. |
by enhancing the activity of dopaminergic neurons and increasing dopamine release, orexin can improve the functioning of reinforcing networks and facilitate spatial learning. |
2012-11-19 |
2023-08-12 |
Not clear |
| Tadashi Saigusa, Yuri Aono, Takuya Uchida, Koji Takada, Michel M M Verheij, Noriaki Koshikawa, Alexander R Cool. The α₁-, but not α₂-, adrenoceptor in the nucleus accumbens plays an inhibitory role upon the accumbal noradrenaline and dopamine efflux of freely moving rats. European journal of pharmacology. vol 688. issue 1-3. 2012-11-16. PMID:22617026. |
the present results show that (1) accumbal α(1)-adrenoceptors which are presynaptically located on noradrenergic nerve terminals inhibit the accumbal noradrenaline efflux, increasing thereby the accumbal dopamine efflux, (2) accumbal α(1)-adrenoceptors which are postsynaptically located on dopaminergic nerve terminals inhibit the accumbal dopamine efflux, and (3) accumbal α(2)-adrenoceptors play no major role in the regulation of accumbal efflux of noradrenaline and dopamine. |
2012-11-16 |
2023-08-12 |
rat |
| Sheila V Kusnoor, Michael Bubser, Ariel Y Deutc. The effects of nigrostriatal dopamine depletion on the thalamic parafascicular nucleus. Brain research. vol 1446. 2012-11-13. PMID:22353754. |
moreover, an antibody directed against dopamine revealed only very rare pf dopaminergic axons. |
2012-11-13 |
2023-08-12 |
rat |
| Luke S Poth, Bryan P O'Connell, Janet L McDermott, Dean E Dluze. Nomifensine alters sex differences in striatal dopaminergic function. Synapse (New York, N.Y.). vol 66. issue 8. 2012-11-09. PMID:22389194. |
taken together these results demonstrate the critical role played by catecholamine transporters in sex differences of dopaminergic function and suggest that this may involve the dopamine transporter, due to its high concentrations within the striatum. |
2012-11-09 |
2023-08-12 |
mouse |
| Xiqun Chen, Guanhui Wu, Michael A Schwarzschil. Urate in Parkinson's disease: more than a biomarker? Current neurology and neuroscience reports. vol 12. issue 4. 2012-11-08. PMID:22580741. |
although appreciation of pd as a multisystem disorder has grown, loss of dopaminergic neurons in the substantia nigra remains a pathological and neurochemical hallmark, accounting for the substantial symptomatic benefits of dopamine replacement therapies. |
2012-11-08 |
2023-08-12 |
Not clear |
| Patricia Szot, Allyn Franklin, Carl Sikkema, Charles W Wilkinson, Murray A Raskin. Sequential Loss of LC Noradrenergic and Dopaminergic Neurons Results in a Correlation of Dopaminergic Neuronal Number to Striatal Dopamine Concentration. Frontiers in pharmacology. vol 3. 2012-11-07. PMID:23129999. |
sequential loss of lc noradrenergic and dopaminergic neurons results in a correlation of dopaminergic neuronal number to striatal dopamine concentration. |
2012-11-07 |
2023-08-12 |
mouse |
| Patricia Szot, Allyn Franklin, Carl Sikkema, Charles W Wilkinson, Murray A Raskin. Sequential Loss of LC Noradrenergic and Dopaminergic Neurons Results in a Correlation of Dopaminergic Neuronal Number to Striatal Dopamine Concentration. Frontiers in pharmacology. vol 3. 2012-11-07. PMID:23129999. |
the loss of lc neurons did not affect the number of dopaminergic neurons in the sn and vta compared to control; however, lc 6ohda significantly reduced striatal dopamine (da; 29% reduced) but not norepinephrine (ne) concentration. |
2012-11-07 |
2023-08-12 |
mouse |
| Christopher J Martyniuk, Jason T Popesku, Brittany Chown, Nancy D Denslow, Vance L Trudea. Quantitative proteomics in teleost fish: insights and challenges for neuroendocrine and neurotoxicology research. General and comparative endocrinology. vol 176. issue 3. 2012-11-06. PMID:22202605. |
dopamine signaling altered the abundance of proteins that are binding partners of microfilaments, integrins, and intermediate filaments, consistent with data suggesting dopaminergic regulation of neuronal stability and structure. |
2012-11-06 |
2023-08-12 |
Not clear |
| Nicolas X Tritsch, Jun B Ding, Bernardo L Sabatin. Dopaminergic neurons inhibit striatal output through non-canonical release of GABA. Nature. vol 490. issue 7419. 2012-11-06. PMID:23034651. |
phasic activation of dopaminergic neurons in response to salient or reward-predicting stimuli is thought to modulate striatal output through the release of dopamine to promote and reinforce motor action. |
2012-11-06 |
2023-08-12 |
Not clear |
| A Bueno-Nava, R Gonzalez-Pina, A Alfaro-Rodriguez, A Avila-Luna, E Arch-Tirado, M Alonso-Spilsbur. The selective inhibition of the D₁ dopamine receptor results in an increase of metabolized dopamine in the rat striatum. Neurochemical research. vol 37. issue 8. 2012-11-05. PMID:22573387. |
our aim was to study the specific role of the postsynaptic d(1) receptors on dopaminergic response and analyze the metabolized dopamine (da) in the rat striatum. |
2012-11-05 |
2023-08-12 |
rat |
| Mary P Heyer, Amar K Pani, Richard J Smeyne, Paul J Kenny, Guoping Fen. Normal midbrain dopaminergic neuron development and function in miR-133b mutant mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 32. 2012-10-26. PMID:22875923. |
dopamine levels are unchanged in the striatum, while expression of dopaminergic genes, including pitx3, is also unaffected. |
2012-10-26 |
2023-08-12 |
mouse |
| Giovanni Hernandez, Ivan Trujillo-Pisanty, Marie-Pierre Cossette, Kent Conover, Peter Shizga. Role of dopamine tone in the pursuit of brain stimulation reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 32. 2012-10-26. PMID:22875936. |
whereas the effect of psychomotor stimulants on icss has long been attributed to dopaminergic action at early stages of the reward pathway, the results reported here imply that increased dopamine tone boosts reward pursuit by acting at or beyond the output of the circuitry that temporally and spatially summates the output of the directly stimulated neurons underlying icss. |
2012-10-26 |
2023-08-12 |
human |
| Evdoxia Tsigkaropoulou, Melpomeni Peppa, Christina Zompola, Emmanouil Rizos, Ioanna Xelioti, Sofia Chatziioannou, Anastasia Filippopoulou, Lefteris Lykoura. Hypogonadism due to hyperprolactinemia and subsequent first episode of psychosis. Gender medicine. vol 9. issue 1. 2012-10-24. PMID:22333523. |
dopamine is the most important prolactin-inhibiting factor, and dopaminergic hyperactivity has been implicated in the pathophysiology of psychosis. |
2012-10-24 |
2023-08-12 |
Not clear |
| Pabla Aguirre, Pamela Urrutia, Victoria Tapia, Monica Villa, Irmgad Paris, Juan Segura-Aguilar, Marco T Núñe. The dopamine metabolite aminochrome inhibits mitochondrial complex I and modifies the expression of iron transporters DMT1 and FPN1. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 25. issue 4. 2012-10-22. PMID:22302610. |
here, we present evidence showing that at low micromolar concentrations, the dopamine metabolite aminochrome inhibits complex i and atp production in sh-sy5y neuroblastoma cells differentiated into a dopaminergic phenotype. |
2012-10-22 |
2023-08-12 |
Not clear |
| Michele Raja, Anna Rita Bentivogli. Impulsive and compulsive behaviors during dopamine replacement treatment in Parkinson's Disease and other disorders. Current drug safety. vol 7. issue 1. 2012-10-22. PMID:22663960. |
impulsive and compulsive behaviors, including pathologic gambling, hypersexuality, compulsive shopping, compulsive eating, excessive engagement in hobbies, punding, and dopamine dysregulation syndrome (dds), are increasingly reported serious side-effects of dopaminergic medication, used in the treatment of parkinson's disease (pd) and other disorders. |
2012-10-22 |
2023-08-12 |
Not clear |
| Michele Raja, Anna Rita Bentivogli. Impulsive and compulsive behaviors during dopamine replacement treatment in Parkinson's Disease and other disorders. Current drug safety. vol 7. issue 1. 2012-10-22. PMID:22663960. |
dopamine neurotransmission along the meso-cortico-limbic pathway is a modulator of risk behavior and can be altered in pd and in the course of dopaminergic treatment. |
2012-10-22 |
2023-08-12 |
Not clear |
| Sheeja Navakkode, Sreedharan Sajikumar, Martin Korte, Tuck Wah Soon. Dopamine induces LTP differentially in apical and basal dendrites through BDNF and voltage-dependent calcium channels. Learning & memory (Cold Spring Harbor, N.Y.). vol 19. issue 7. 2012-10-22. PMID:22723051. |
the dopaminergic modulation of long-term potentiation (ltp) has been studied well, but the mechanism by which dopamine induces ltp (da-ltp) in ca1 pyramidal neurons is unknown. |
2012-10-22 |
2023-08-12 |
Not clear |
| Silvia Zoni, Giulia Bonetti, Roberto Lucchin. Olfactory functions at the intersection between environmental exposure to manganese and Parkinsonism. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 26. issue 2-3. 2012-10-18. PMID:22664337. |
changes in olfactory perception may be caused by a dopaminergic dysregulation, possibly related to changes at the level of dopamine receptors. |
2012-10-18 |
2023-08-12 |
Not clear |
| Thomas L Schwartz, Shilpa Sachdeva, Stephen M Stah. Genetic data supporting the NMDA glutamate receptor hypothesis for schizophrenia. Current pharmaceutical design. vol 18. issue 12. 2012-10-17. PMID:22280435. |
it is unclear if excess dopaminergic activity is the primary pathophysiology causing psychosis or if this dopamine excess is triggered by upstream, downstream or neurodevelopmental abnormalities. |
2012-10-17 |
2023-08-12 |
Not clear |