| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanzhen Zhu, Jing Zhang, Yanjun Zen. Overview of tyrosine hydroxylase in Parkinson's disease. CNS & neurological disorders drug targets. vol 11. issue 4. 2012-12-03. PMID:22483316. |
parkinson's disease (pd) is characterized by severe loss of dopaminergic neurons and depletion of dopamine in substantia nigra. |
2012-12-03 |
2023-08-12 |
Not clear |
| Shams Tabrez, Nasimudeen R Jabir, Shazi Shakil, Nigel H Greig, Qamre Alam, Adel M Abuzenadah, Ghazi A Damanhouri, Mohammad A Kama. A synopsis on the role of tyrosine hydroxylase in Parkinson's disease. CNS & neurological disorders drug targets. vol 11. issue 4. 2012-12-03. PMID:22483313. |
a consistent neurochemical abnormality in pd is degeneration of dopaminergic neurons in substantia nigra pars compacta, leading to a reduction of striatal dopamine (da) levels. |
2012-12-03 |
2023-08-12 |
Not clear |
| Hajime Hirasawa, Rebecca A Betensky, Elio Raviol. Corelease of dopamine and GABA by a retinal dopaminergic neuron. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 38. 2012-12-03. PMID:22993444. |
retinal dopaminergic (daergic) amacrine cells synthesize both dopamine (da) and gaba. |
2012-12-03 |
2023-08-12 |
mouse |
| I V Romanova, A Iu Chesnokova, A L Mikhrin. [Immunohistochemical study of CART-peptide in striato-nigral projections at dopamine loss]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 98. issue 8. 2012-11-30. PMID:23155622. |
in both experiments data about activation of cartergic neurons in stria to-nigral projections testifies on participation of cart-peptide in compensatory brain mechanisms at dopamine loss and its role as modulator of dopaminergic brain neurons functional activity. |
2012-11-30 |
2023-08-12 |
rat |
| Feng Yue, Sien Zeng, Di Wu, Deqiao Yi, Y Alex Zhang, Piu Cha. Age-related decline in motor behavior and striatal dopamine transporter in cynomolgus monkeys. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 8. 2012-11-29. PMID:22327353. |
the function of the dopaminergic system was semi-quantitatively measured by (99m)tc-trodat-1 uptake rates, a dopamine transporter (dat) specific radiopharmaceutical with spect imaging. |
2012-11-29 |
2023-08-12 |
human |
| Feng Yue, Sien Zeng, Di Wu, Deqiao Yi, Y Alex Zhang, Piu Cha. Age-related decline in motor behavior and striatal dopamine transporter in cynomolgus monkeys. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 8. 2012-11-29. PMID:22327353. |
our results indicate that normal aging-related dopamine physiology influences certain aspects of motor behaviors and suggest that aging-associated dysfunction in the nigrostriatal dopaminergic system may be an important factor contributing to the decline of motor behaviors in aging cynomolgus monkeys. |
2012-11-29 |
2023-08-12 |
human |
| P Riederer, J Sian-Hülsman. The significance of neuronal lateralisation in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 8. 2012-11-29. PMID:22367437. |
the destruction of the dopaminergic neurons in the substantia nigra (sn) and consequent depletion of striatal dopamine elicits the main movement deficits related to parkinson's disease (pd). |
2012-11-29 |
2023-08-12 |
Not clear |
| Ayse Ulusoy, Tomas Björklund, Kerstin Buck, Deniz Kiri. Dysregulated dopamine storage increases the vulnerability to α-synuclein in nigral neurons. Neurobiology of disease. vol 47. issue 3. 2012-11-29. PMID:22659302. |
impairments in the capacity of dopaminergic neurons to handle cytoplasmic dopamine may be a critical factor underlying the selective vulnerability of midbrain dopamine neurons in parkinson's disease. |
2012-11-29 |
2023-08-12 |
mouse |
| Ayse Ulusoy, Tomas Björklund, Kerstin Buck, Deniz Kiri. Dysregulated dopamine storage increases the vulnerability to α-synuclein in nigral neurons. Neurobiology of disease. vol 47. issue 3. 2012-11-29. PMID:22659302. |
furthermore, toxicity of α-synuclein in dopaminergic neurons has been suggested to be mediated by direct interaction between dopamine and α-synuclein through formation of abnormal α-synuclein species, although direct in vivo evidence to support this hypothesis is lacking. |
2012-11-29 |
2023-08-12 |
mouse |
| Ayse Ulusoy, Tomas Björklund, Kerstin Buck, Deniz Kiri. Dysregulated dopamine storage increases the vulnerability to α-synuclein in nigral neurons. Neurobiology of disease. vol 47. issue 3. 2012-11-29. PMID:22659302. |
we found that overexpression of α-synuclein in nigral dopamine neurons in mice with deficient vesicular storage of dopamine led to a significant increase in dopaminergic neurodegeneration. |
2012-11-29 |
2023-08-12 |
mouse |
| S López-Pousa, C Lombardía-Fernández, J Garre Olmo, S Monserrat-Vila, J Vilalta-Franch, L Calvó-Perxa. Dopaminergic dysregulation, artistic expressiveness, and Parkinson's disease. Case reports in neurology. vol 4. issue 3. 2012-11-28. PMID:23185168. |
the most frequent behavioral manifestations in parkinson's disease (pd) are attributed to the dopaminergic dysregulation syndrome (dds), which is considered to be secondary to the iatrogenic effects of the drugs that replace dopamine. |
2012-11-28 |
2023-08-12 |
Not clear |
| Giovanni D'Andrea, Antonello D'Arrigo, Maurizio Dalle Carbonare, Alberta Leo. Pathogenesis of migraine: role of neuromodulators. Headache. vol 52. issue 7. 2012-11-27. PMID:22671857. |
the unbalanced levels of the neurotransmitters (dopamine and noradrenaline) and neuromodulators (eg, tyramine, octopamine, and synephrine) in the synaptic dopaminergic and noradrenergic clefts of the pain matrix pathways may activate, downstream, the trigeminal system that releases calcitonin gene-related peptide. |
2012-11-27 |
2023-08-12 |
Not clear |
| Anne Pankow, Astrid Knobel, Martin Voss, Andreas Hein. Neurobiological correlates of delusion: beyond the salience attribution hypothesis. Neuropsychobiology. vol 66. issue 1. 2012-11-27. PMID:22797275. |
based on studies revealing dopamine dysfunction in addiction research, it has been suggested that phasic or chaotic firing of dopaminergic neurons projecting to the (ventral) striatum attribute salience to otherwise irrelevant stimuli and thus contribute to delusional mood and delusion formation. |
2012-11-27 |
2023-08-12 |
Not clear |
| Shigeki Hirano, Hitoshi Shinotoh, David Eidelber. Functional brain imaging of cognitive dysfunction in Parkinson's disease. Journal of neurology, neurosurgery, and psychiatry. vol 83. issue 10. 2012-11-27. PMID:22807560. |
the mesocortical dopaminergic system is associated with executive functions which are frequently affected in pd and are influenced by local levodopa concentration, dopamine metabolism and baseline performance status. |
2012-11-27 |
2023-08-12 |
Not clear |
| Wenju Wang, Maosheng Sun, Hongjun Li, Wanpu Wang, Min Ya. The delivery of tyrosine hydroxylase accelerates the neurorestoration of Macaca Rhesus model of Parkinson's disease provided by Neurturin. Neuroscience letters. vol 524. issue 1. 2012-11-21. PMID:22766137. |
we hypothesized that the expression of ntn could provide neuroprotection to dopaminergic neurons and stop progressive neurodegeneration, while th enhanced the synthesis of dopamine and accelerated the recovery of parkinsonism. |
2012-11-21 |
2023-08-12 |
monkey |
| Sudarat Nimitvilai, Maureen A McElvain, Devinder S Arora, Mark S Brodi. Reversal of quinpirole inhibition of ventral tegmental area neurons is linked to the phosphatidylinositol system and is induced by agonists linked to G(q). Journal of neurophysiology. vol 108. issue 1. 2012-11-20. PMID:22490559. |
a d1-like dopaminergic agonist associated with pi turnover (skf83959), but not one linked to ac (skf83822), promoted reversal of inhibition produced by quinpirole, a dopamine d2-selective agonist. |
2012-11-20 |
2023-08-12 |
Not clear |
| Masato Asanuma, Ikuko Miyazaki, Yuri Kikkawa, Naotaka Kimoto, Mika Takeshima, Shinki Murakami, Ko Miyosh. Cyclooxygenase-independent neuroprotective effects of aspirin against dopamine quinone-induced neurotoxicity. Neurochemical research. vol 37. issue 9. 2012-11-20. PMID:22674083. |
aspirin and indomethacin did not affect the level of glutathione that exerts quenching dopamine quinone in dopaminergic cells. |
2012-11-20 |
2023-08-12 |
Not clear |
| Masato Asanuma, Ikuko Miyazaki, Yuri Kikkawa, Naotaka Kimoto, Mika Takeshima, Shinki Murakami, Ko Miyosh. Cyclooxygenase-independent neuroprotective effects of aspirin against dopamine quinone-induced neurotoxicity. Neurochemical research. vol 37. issue 9. 2012-11-20. PMID:22674083. |
the present results suggest that cyclooxygenase shows little contribution to dopamine oxidation in dopaminergic cells and that protective effects of aspirin against methyl l-dopa-induced dopamine quinone neurotoxicity are based on its cyclooxygenase-independent property. |
2012-11-20 |
2023-08-12 |
Not clear |
| Helga Nagy, Einat Levy-Gigi, Zsuzsanna Somlai, Annamária Takáts, Dániel Bereczki, Szabolcs Kér. The effect of dopamine agonists on adaptive and aberrant salience in Parkinson's disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 4. 2012-11-19. PMID:22089321. |
these results suggest that dopamine agonists may increase psychotic-like experiences in young patients with pd, possibly by facilitating dopaminergic transmission in the ventral striatum, which results in aberrant associations between conditioned stimuli and reward. |
2012-11-19 |
2023-08-12 |
Not clear |
| Jonghan Kim, Yuan Li, Peter D Buckett, Mark Böhlke, Khristy J Thompson, Masaya Takahashi, Timothy J Maher, Marianne Wessling-Resnic. Iron-responsive olfactory uptake of manganese improves motor function deficits associated with iron deficiency. PloS one. vol 7. issue 3. 2012-11-19. PMID:22479410. |
although tissue dopamine concentrations were similar in the striatum, dopamine transporter (dat) and dopamine receptor d(1) (d1r) levels were reduced and dopamine receptor d(2) (d2r) levels were increased in manganese-instilled rats, suggesting that manganese-induced changes in post-synaptic dopaminergic signaling contribute to the compensatory effect. |
2012-11-19 |
2023-08-12 |
rat |