| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sonia Gandhi, Annika Vaarmann, Zhi Yao, Michael R Duchen, Nicholas W Wood, Andrey Y Abramo. Dopamine induced neurodegeneration in a PINK1 model of Parkinson's disease. PloS one. vol 7. issue 5. 2012-12-13. PMID:22662171. |
parkinson's disease is a common neurodegenerative disease characterised by progressive loss of dopaminergic neurons, leading to dopamine depletion in the striatum. |
2012-12-13 |
2023-08-12 |
Not clear |
| Daniel T Omura, Damon A Clark, Aravinthan D T Samuel, H Robert Horvit. Dopamine signaling is essential for precise rates of locomotion by C. elegans. PloS one. vol 7. issue 6. 2012-12-13. PMID:22719914. |
we have found that reduced dopamine signaling can cause a distinct abnormality in the behavior of the nematode c. elegans, which has only eight dopaminergic neurons. |
2012-12-13 |
2023-08-12 |
caenorhabditis_elegans |
| Andrew M Dacks, Jeffrey A Riffell, Joshua P Martin, Stephanie L Gage, Alan J Nighor. Olfactory modulation by dopamine in the context of aversive learning. Journal of neurophysiology. vol 108. issue 2. 2012-12-12. PMID:22552185. |
in this study, we characterize the morphology of dopaminergic neurons that innervate each of the antennal lobes (als; the first synaptic neuropils of the olfactory system) of the moth manduca sexta and demonstrate with electrophysiology that dopamine enhances odor-evoked responses of the majority of al neurons while reducing the responses of a small minority. |
2012-12-12 |
2023-08-12 |
Not clear |
| Kohji Sat. Disruption of spine homeostasis causes dopaminergic compensatory up-regulation, resulting in schizophrenia. Medical hypotheses. vol 79. issue 3. 2012-12-12. PMID:22683237. |
this dopaminergic hyperactivity stimulates dopamine d2 receptors, leading to positive symptoms. |
2012-12-12 |
2023-08-12 |
Not clear |
| Elisa Belluzzi, Marco Bisaglia, Elisabetta Lazzarini, Leandro C Tabares, Mariano Beltramini, Luigi Bubacc. Human SOD2 modification by dopamine quinones affects enzymatic activity by promoting its aggregation: possible implications for Parkinson's disease. PloS one. vol 7. issue 6. 2012-12-12. PMID:22723845. |
a plausible source of oxidative stress, which could account for the selective degeneration of dopaminergic neurons, is the redox chemistry of dopamine (da) and leads to the formation of ros and reactive dopamine-quinones (daqs). |
2012-12-12 |
2023-08-12 |
human |
| Robin Patyal, Evan Y Woo, Stephanie L Borglan. Local hypocretin-1 modulates terminal dopamine concentration in the nucleus accumbens shell. Frontiers in behavioral neuroscience. vol 6. 2012-12-12. PMID:23226119. |
while it is known that hcrt action in the vta can increase dopamine in the nac, it has not been determined if hcrt released locally at dopaminergic terminals in the nacsh can modulate dopamine concentration. |
2012-12-12 |
2023-08-12 |
Not clear |
| Yun Li, Daishi Yui, Bryan W Luikart, Renée M McKay, Yanjiao Li, John L Rubenstein, Luis F Parad. Conditional ablation of brain-derived neurotrophic factor-TrkB signaling impairs striatal neuron development. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 38. 2012-12-10. PMID:22949667. |
furthermore, striatal-specific ablation of trkb, the gene encoding the high-affinity receptor for bdnf, is sufficient to elicit an array of striatal developmental abnormalities, including decreased anatomical volume, smaller neuronal nucleus size, loss of dendritic spines, reduced enkephalin expression, diminished nigral dopaminergic projections, and severe deficits in striatal dopamine signaling through darpp32. |
2012-12-10 |
2023-08-12 |
Not clear |
| Nicholas A Courtney, Aphroditi A Mamaligas, Christopher P For. Species differences in somatodendritic dopamine transmission determine D2-autoreceptor-mediated inhibition of ventral tegmental area neuron firing. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 39. 2012-12-10. PMID:23015441. |
the somatodendritic release of dopamine within the ventral tegmental area (vta) and substantia nigra pars compacta activates inhibitory postsynaptic d2-receptors on dopaminergic neurons. |
2012-12-10 |
2023-08-12 |
mouse |
| Kevin M Beaver, John Paul Wright, Matt DeLisi, Michael G Vaugh. Dopaminergic polymorphisms and educational achievement: results from a longitudinal sample of Americans. Developmental psychology. vol 48. issue 4. 2012-12-07. PMID:22081881. |
drawing on data from the national longitudinal study of adolescent health, in the current study, we examined the association between polymorphisms in three dopaminergic genes (dat1, drd2, and drd4), a dopamine index, and educational attainment. |
2012-12-07 |
2023-08-12 |
Not clear |
| Tasneem Peeraully, Eng-King Ta. Linking restless legs syndrome with Parkinson's disease: clinical, imaging and genetic evidence. Translational neurodegeneration. vol 1. issue 1. 2012-12-06. PMID:23211049. |
evidence pointing towards a link includes response to dopaminergic agents in pd and rls, suggestive of underlying dopamine dysfunction in both conditions. |
2012-12-06 |
2023-08-12 |
Not clear |
| Cristina Baiguera, Manuela Alghisi, Annalisa Pinna, Arianna Bellucci, Maria Antonietta De Luca, Lucia Frau, Micaela Morelli, Rosaria Ingrassia, Marina Benarese, Vanessa Porrini, Michele Pellitteri, Giuseppe Bertini, Paolo Francesco Fabene, Sandra Sigala, Maria Grazia Spillantini, Hsiou-Chi Liou, Pier Franco Spano, Marina Pizz. Late-onset Parkinsonism in NFκB/c-Rel-deficient mice. Brain : a journal of neurology. vol 135. issue Pt 9. 2012-12-05. PMID:22915735. |
nigral degeneration was accompanied by a significant loss of dopaminergic terminals and a significant reduction of dopamine and homovanillic acid levels in the striatum. |
2012-12-05 |
2023-08-12 |
mouse |
| Yannis Paloyelis, Mitul A Mehta, Stephen V Faraone, Philip Asherson, Jonna Kunts. Striatal sensitivity during reward processing in attention-deficit/hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry. vol 51. issue 7. 2012-12-04. PMID:22721595. |
attention-deficit/hyperactivity disorder (adhd) has been linked to deficits in the dopaminergic reward-processing circuitry; yet, existing evidence is limited, and the influence of genetic variation affecting dopamine signaling remains unknown. |
2012-12-04 |
2023-08-12 |
Not clear |
| Esther Nederhof, Jay Belsky, Johan Ormel, Albertine J Oldehinke. Effects of divorce on Dutch boys' and girls' externalizing behavior in Gene × Environment perspective: diathesis stress or differential susceptibility in the Dutch Tracking Adolescents' Individual Lives Survey study? Development and psychopathology. vol 24. issue 3. 2012-12-04. PMID:22781863. |
thus, this inquiry sought to determine whether select dopaminergic genes previously associated with externalizing behavior and/or found to moderate diverse environmental effects (dopamine receptors d2 and d4, catechol-o-methyltransferase) might moderate divorce effects on adolescent self-reported externalizing problems; and, if so, whether evidence of gene-environment (g × e) interaction would prove consistent with diathesis-stress or differential-susceptibility models of environmental action. |
2012-12-04 |
2023-08-12 |
Not clear |
| Megan L Fitzgerald, Eli Shobin, Virginia M Picke. Cannabinoid modulation of the dopaminergic circuitry: implications for limbic and striatal output. Progress in neuro-psychopharmacology & biological psychiatry. vol 38. issue 1. 2012-12-03. PMID:22265889. |
cannabinoid modulation of dopaminergic transmission is suggested by the ability of delta9-tetrahydrocanabinoid to affect motor and motivated behaviors in a manner similar to that produced by pharmacological manipulation of the nigrostriatal and mesocorticolimbic dopamine systems. |
2012-12-03 |
2023-08-12 |
Not clear |
| Supinder Kaur, Shreesh Raj Sammi, Pooja Jadiya, Aamir Nazi. RNAi of cat-2, a putative tyrosine hydroxylase, increases alpha synuclein aggregation and associated effects in transgenic C. elegans. CNS & neurological disorders drug targets. vol 11. issue 4. 2012-12-03. PMID:22483307. |
neurodegenerative parkinson's disease (pd) is a multifactorial disorder; effects like alpha synuclein aggregation, low dopamine levels and dopaminergic neurodegeneration are considered to be hallmarks of the disease. |
2012-12-03 |
2023-08-12 |
human |
| Marcelo M S Lima, Monica L Andersen, Angela B Reksidler, Anete C Ferraz, Maria A B F Vital, Sergio Tufi. Paradoxical sleep deprivation modulates tyrosine hydroxylase expression in the nigrostriatal pathway and attenuates motor deficits induced by dopaminergic depletion. CNS & neurological disorders drug targets. vol 11. issue 4. 2012-12-03. PMID:22483308. |
indeed, dopaminergic neurons in the ventral tegmental area were recently shown to fire in bursts during paradoxical sleep (ps), but little is known about the activity of the nigrostriatal dopamine (da) cells in relation to ps. |
2012-12-03 |
2023-08-12 |
mouse |
| Mohd Shahnawa Khan, Shams Tabrez, Medha Priyadarshini, Shubha Priyamvada, Mohd M Kha. Targeting Parkinson's - tyrosine hydroxylase and oxidative stress as points of interventions. CNS & neurological disorders drug targets. vol 11. issue 4. 2012-12-03. PMID:22483312. |
parkinson's disease (pd) is characterized by the progressive loss of the dopaminergic neurons leading to decrease in striatal dopamine (da) levels. |
2012-12-03 |
2023-08-12 |
rat |
| Christopher Tolleson, Daniel Claasse. The function of tyrosine hydroxylase in the normal and Parkinsonian brain. CNS & neurological disorders drug targets. vol 11. issue 4. 2012-12-03. PMID:22483314. |
treatment for pd has classically involved maximizing endogenous dopamine by medicinal options that either replace dopamine or augment the dopaminergic pathway. |
2012-12-03 |
2023-08-12 |
human |
| Christopher Tolleson, Daniel Claasse. The function of tyrosine hydroxylase in the normal and Parkinsonian brain. CNS & neurological disorders drug targets. vol 11. issue 4. 2012-12-03. PMID:22483314. |
gene therapy in pd is a burgeoning field which provides a way to augment dopamine production, and potentially protect the dopaminergic neurons from further degeneration. |
2012-12-03 |
2023-08-12 |
human |
| Robert B White, Meghan G Thoma. Moving beyond tyrosine hydroxylase to define dopaminergic neurons for use in cell replacement therapies for Parkinson's disease. CNS & neurological disorders drug targets. vol 11. issue 4. 2012-12-03. PMID:22483315. |
the gold standard marker in the identification of dopaminergic neurons is tyrosine hydroxylase (th), the rate limiting enzyme in dopamine synthesis, catalyzing the conversion of l-tyrosine to l-3,4-dihydroxyphenylalanine. |
2012-12-03 |
2023-08-12 |
Not clear |