| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Roger Cachope, Yolanda Mateo, Brian N Mathur, James Irving, Hui-Ling Wang, Marisela Morales, David M Lovinger, Joseph F Chee. Selective activation of cholinergic interneurons enhances accumbal phasic dopamine release: setting the tone for reward processing. Cell reports. vol 2. issue 1. 2013-03-04. PMID:22840394. |
here, we report that selective endogenous cholinergic activation achieved via in vitro optogenetic stimulation of nucleus accumbens, a terminal field of dopaminergic neurons, elicits real-time dopamine release. |
2013-03-04 |
2023-08-12 |
Not clear |
| T Witjas, A Eusebio, F Fluchère, J-P Azula. Addictive behaviors and Parkinson's disease. Revue neurologique. vol 168. issue 8-9. 2013-03-04. PMID:22921247. |
in parkinson's disease, the degeneration of the dopaminergic system and the longstanding exposure to dopamine replacement therapy (drt) may cause, in a group of vulnerable patients, dysregulation of the brain reward system. |
2013-03-04 |
2023-08-12 |
Not clear |
| Rita Perfeito, Teresa Cunha-Oliveira, Ana Cristina Reg. Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease--resemblance to the effect of amphetamine drugs of abuse. Free radical biology & medicine. vol 53. issue 9. 2013-03-04. PMID:22967820. |
the selective degeneration of dopaminergic neurons suggests that dopamine itself may contribute to the neurodegenerative process in pd. |
2013-03-04 |
2023-08-12 |
Not clear |
| Jiajie Xi, Yan Liu, Huisheng Liu, Hong Chen, Marina E Emborg, Su-Chun Zhan. Specification of midbrain dopamine neurons from primate pluripotent stem cells. Stem cells (Dayton, Ohio). vol 30. issue 8. 2013-02-28. PMID:22696177. |
by sequentially applying sonic hedgehog (c25ii) and chir99021 (gsk3β inhibitor) to induce the midbrain floor plate (fp) progenitors and fibroblast growth factor 8 (fgf8) to promote dopaminergic differentiation in a chemically defined medium, we have established a robust system for the generation of midbrain dopamine (da) neurons from human and rhesus monkey embryonic stem cells and induced pluripotent stem cells (pscs). |
2013-02-28 |
2023-08-12 |
human |
| Edita Navratilova, Jennifer Y Xie, Alec Okun, Chaoling Qu, Nathan Eyde, Shuang Ci, Michael H Ossipov, Tamara King, Howard L Fields, Frank Porrec. Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 50. 2013-02-28. PMID:23184995. |
using a model of experimental postsurgical pain we show that blockade of afferent input from the injury with local anesthetic elicits conditioned place preference, activates ventral tegmental dopaminergic cells, and increases dopamine release in the nucleus accumbens. |
2013-02-28 |
2023-08-12 |
Not clear |
| Edita Navratilova, Jennifer Y Xie, Alec Okun, Chaoling Qu, Nathan Eyde, Shuang Ci, Michael H Ossipov, Tamara King, Howard L Fields, Frank Porrec. Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 50. 2013-02-28. PMID:23184995. |
importantly, place preference is associated with increased activity in midbrain dopaminergic neurons and blocked by dopamine antagonists injected into the nucleus accumbens. |
2013-02-28 |
2023-08-12 |
Not clear |
| Nandakumar S Narayanan, Benjamin B Land, John E Solder, Karl Deisseroth, Ralph J DiLeon. Prefrontal D1 dopamine signaling is required for temporal control. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 50. 2013-02-28. PMID:23185016. |
rodents were trained to perform a fixed-interval timing task with an interval of 20 s. we report several results: first, that decreasing dopaminergic neurotransmission using virally mediated rna interference of tyrosine hydroxylase impaired temporal control, and second that pharmacological disruption of prefrontal d1 dopamine receptors, but not d2 dopamine receptors, impaired temporal control. |
2013-02-28 |
2023-08-12 |
Not clear |
| Hongyi Qi, Jia Zhao, Yifan Han, Allan S Y Lau, Jianhui Ron. Z-ligustilide potentiates the cytotoxicity of dopamine in rat dopaminergic PC12 cells. Neurotoxicity research. vol 22. issue 4. 2013-02-27. PMID:22451226. |
z-ligustilide potentiates the cytotoxicity of dopamine in rat dopaminergic pc12 cells. |
2013-02-27 |
2023-08-12 |
rat |
| Hongyi Qi, Jia Zhao, Yifan Han, Allan S Y Lau, Jianhui Ron. Z-ligustilide potentiates the cytotoxicity of dopamine in rat dopaminergic PC12 cells. Neurotoxicity research. vol 22. issue 4. 2013-02-27. PMID:22451226. |
we surprisingly found that z-ligustilide potentiated dopamine toxicity in a dopaminergic cell specific manner. |
2013-02-27 |
2023-08-12 |
rat |
| Hongyi Qi, Jia Zhao, Yifan Han, Allan S Y Lau, Jianhui Ron. Z-ligustilide potentiates the cytotoxicity of dopamine in rat dopaminergic PC12 cells. Neurotoxicity research. vol 22. issue 4. 2013-02-27. PMID:22451226. |
using rat dopaminergic cell line pc12 as a model, we demonstrated that dopamine and z-ligustilide in combination profoundly induced cell death, although these drugs alone, to a lesser extent, affected the cell viability in a concentration-dependent manner. |
2013-02-27 |
2023-08-12 |
rat |
| Nathalie Dehorter, Natalia Lozovaya, B Julius Mdzomba, François J Michel, Catherine Lopez, Vera Tsintsadze, Timur Tsintsadze, Michael Klinkenberg, Suzanna Gispert, Georg Auburger, Constance Hammon. Subthalamic lesion or levodopa treatment rescues giant GABAergic currents of PINK1-deficient striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 50. 2013-02-27. PMID:23238720. |
although 9- to 24-month-old pink1(-/-) mice show reduced striatal dopamine content and release, and impaired spontaneous locomotion, the relevance of this model to parkinson's disease has been questioned because mesencephalic dopaminergic neurons do not degenerate during the mouse lifespan. |
2013-02-27 |
2023-08-12 |
mouse |
| Nathalie Dehorter, Natalia Lozovaya, B Julius Mdzomba, François J Michel, Catherine Lopez, Vera Tsintsadze, Timur Tsintsadze, Michael Klinkenberg, Suzanna Gispert, Georg Auburger, Constance Hammon. Subthalamic lesion or levodopa treatment rescues giant GABAergic currents of PINK1-deficient striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 50. 2013-02-27. PMID:23238720. |
the similarity between the in vitro resting states of pink1 msns and those of fully dopamine (da)-depleted msns of 6-ohda-treated mice, together with the beneficial effect of levodopa treatment, strongly suggest that dysfunction of mesencephalic dopaminergic neurons in pink1(-/-) mice is more severe than expected. |
2013-02-27 |
2023-08-12 |
mouse |
| Xiqun Chen, Thomas C Burdett, Cody A Desjardins, Robert Logan, Sara Cipriani, Yuehang Xu, Michael A Schwarzschil. Disrupted and transgenic urate oxidase alter urate and dopaminergic neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 1. 2013-02-27. PMID:23248282. |
uox ko mice exhibit attenuated toxic effects of 6-ohda on nigral dopaminergic cell counts, striatal dopamine content, and rotational behavior. |
2013-02-27 |
2023-08-12 |
mouse |
| Hema Tharoor, R Padmavat. Tardive dyskinesia with low dose amisulpride. Indian journal of psychiatry. vol 55. issue 1. 2013-02-27. PMID:23440033. |
at low doses (50 mg), amisulpride preferentially blocks presynaptic auto receptors, enhances dopamine release, and therefore acts as a dopaminergic compound able to resolve the dopaminergic hypo activity that characterizes depression. |
2013-02-27 |
2023-08-12 |
Not clear |
| Keun-Sung Lee, Jin-Koo Lee, Hyung-Gun Kim, Hak Rim Ki. Differential Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on Motor Behavior and Dopamine Levels at Brain Regions in Three Different Mouse Strains. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 17. issue 1. 2013-02-27. PMID:23440908. |
however, susceptibilities of the mice to mptp were differed based on the degree of behavioral change, dopamine concentration in brain regions, and expression levels of tyrosine hydroxylase, with c57bl/6 and balb-c mice being more sensitive to the dopaminergic neuronal toxicity of mptp than icr mice. |
2013-02-27 |
2023-08-12 |
mouse |
| Ciara A Torres, David Sulze. Macroautophagy can press a brake on presynaptic neurotransmission. Autophagy. vol 8. issue 10. 2013-02-26. PMID:22767262. |
we generated mutant mice that were specifically deficient for macroautophagy in dopaminergic neurons by deleting the atg7 gene in cells that express the dopamine uptake transporter. |
2013-02-26 |
2023-08-12 |
mouse |
| Ciara A Torres, David Sulze. Macroautophagy can press a brake on presynaptic neurotransmission. Autophagy. vol 8. issue 10. 2013-02-26. PMID:22767262. |
acute rapamycin decreased dopaminergic synaptic vesicle density by ~25% and inhibited evoked dopamine release by ~25% in control mice, but not in the atg7 deficient mutants. |
2013-02-26 |
2023-08-12 |
mouse |
| Youren Tong, Jie She. Genetic analysis of Parkinson's disease-linked leucine-rich repeat kinase 2. Biochemical Society transactions. vol 40. issue 5. 2013-02-26. PMID:22988862. |
homozygous r1441c knockin mice exhibit no dopaminergic neurodegeneration or alterations in steady-state levels of striatal dopamine, but they show impaired dopamine neurotransmission, as was evident from reductions in amphetamine-induced locomotor activity and stimulated catecholamine release in cultured chromaffin cells as well as impaired dopamine d2 receptor-mediated functions. |
2013-02-26 |
2023-08-12 |
mouse |
| Frederico C Pereira, Teresa Cunha-Oliveira, Sofia D Viana, Ana S Travassos, Sara Nunes, Carlos Silva, Rui Daniel Prediger, A Cristina Rego, Syed F Ali, Carlos Alberto Fontes Ribeir. Disruption of striatal glutamatergic/GABAergic homeostasis following acute methamphetamine in mice. Neurotoxicology and teratology. vol 34. issue 5. 2013-02-25. PMID:22884891. |
this methamphetamine regimen also produced dopaminergic terminal degeneration in the striatum, as evidenced by dopamine and tyrosine hydroxylase depletion. |
2013-02-25 |
2023-08-12 |
mouse |
| Victoria S Dalton, Katerina Zavitsano. Rapid changes in d1 and d2 dopamine receptor binding in striatal subregions after a single dose of phencyclidine. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology. vol 9. issue 2. 2013-02-25. PMID:23429383. |
in rats, an acute dose of pcp increases dopaminergic activity and causes changes in dopamine related behaviours some of which are sexually dimorphic. |
2013-02-25 |
2023-08-12 |
rat |