| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Perumal Gurusamy, Kaliappan Muthukumar, Seenivasan Rajesh, Gurusamy Muneeswaran, Subbu Perumal, Chandran Karunakara. Theoretical investigation of quinone metabolites of dopamine interaction with DNA--insights into toxicological effects. Journal of structural biology. vol 180. issue 1. 2013-02-21. PMID:22634727. |
dopamine (3,4-dihydroxyphenylethylamine, da), an important neurotransmitter, exists in the cell bodies of the dopaminergic neurons of the substantia nigra. |
2013-02-21 |
2023-08-12 |
Not clear |
| J C Shaw, Ø Øverl. Brain-encysting trematodes and altered monoamine activity in naturally infected killifish Fundulus parvipinnis. Journal of fish biology. vol 81. issue 7. 2013-02-21. PMID:23252735. |
a parasite density-associated decrease in serotonergic activity occurred in the hippocampus of naturally infected fish, as well as a decrease in dopaminergic activity in the raphe nuclei, suggesting that e. californiensis inhibits serotonin and dopamine signaling in naturally infected f. parvipinnis. |
2013-02-21 |
2023-08-12 |
Not clear |
| Saki Shimizu, Yukihiro Ohn. Improving the Treatment of Parkinson's Disease: A Novel Approach by Modulating 5-HT(1A) Receptors. Aging and disease. vol 4. issue 1. 2013-02-21. PMID:23423244. |
thus, 5-ht(1a) agonists improve the various motor disorders associated with dopaminergic deficits, dyskinesia induced by chronic l-dopa treatment, mood disturbances (anxiety and depression) and dopamine agonist-induced emesis. |
2013-02-21 |
2023-08-12 |
Not clear |
| Hiroshi Ito, Harumasa Takano, Ryosuke Arakawa, Hidehiko Takahashi, Fumitoshi Kodaka, Keisuke Takahata, Tsuyoshi Nogami, Masayuki Suzuki, Tetsuya Suhar. Effects of dopamine D2 receptor partial agonist antipsychotic aripiprazole on dopamine synthesis in human brain measured by PET with L-[β-11C]DOPA. PloS one. vol 7. issue 9. 2013-02-20. PMID:23029533. |
dopamine d(2) receptor partial agonist antipsychotic drugs can modulate dopaminergic neurotransmission as functional agonists or functional antagonists. |
2013-02-20 |
2023-08-12 |
human |
| Hiroshi Ito, Harumasa Takano, Ryosuke Arakawa, Hidehiko Takahashi, Fumitoshi Kodaka, Keisuke Takahata, Tsuyoshi Nogami, Masayuki Suzuki, Tetsuya Suhar. Effects of dopamine D2 receptor partial agonist antipsychotic aripiprazole on dopamine synthesis in human brain measured by PET with L-[β-11C]DOPA. PloS one. vol 7. issue 9. 2013-02-20. PMID:23029533. |
the effects of antipsychotics on presynaptic dopaminergic functions, such as dopamine synthesis capacity, might also be related to their therapeutic efficacy. |
2013-02-20 |
2023-08-12 |
human |
| Yukio Yamamura, Ryoma Morigaki, Jiro Kasahara, Hironori Yokoyama, Akie Tanabe, Shinya Okita, Hidetaka Koizumi, Shinji Nagahiro, Ryuji Kaji, Satoshi Got. Dopamine signaling negatively regulates striatal phosphorylation of Cdk5 at tyrosine 15 in mice. Frontiers in cellular neuroscience. vol 7. 2013-02-20. PMID:23420105. |
we here report that cdk5 with tyr15 phosphorylation (cdk5-ptyr15) is enriched in the mouse striatum, where dopaminergic stimulation inhibited phosphorylation of tyr15-cdk5 by acting through the d2 class dopamine receptors. |
2013-02-20 |
2023-08-12 |
mouse |
| David S Goldstein, Patti Sullivan, Adele Cooney, Yunden Jinsmaa, Rachel Sullivan, Daniel J Gross, Courtney Holmes, Irwin J Kopin, Yehonatan Sharab. Vesicular uptake blockade generates the toxic dopamine metabolite 3,4-dihydroxyphenylacetaldehyde in PC12 cells: relevance to the pathogenesis of Parkinson's disease. Journal of neurochemistry. vol 123. issue 6. 2013-02-14. PMID:22906103. |
parkinson's disease entails profound loss of nigrostriatal dopaminergic terminals, decreased vesicular uptake of intraneuronal catecholamines, and relatively increased putamen tissue concentrations of the toxic dopamine metabolite, 3,4-dihydroxyphenylacetaldehyde (dopal). |
2013-02-14 |
2023-08-12 |
Not clear |
| Mahomi Kuroiwa, Miho Hamada, Eriko Hieda, Takahide Shuto, Naoki Sotogaku, Marc Flajolet, Gretchen L Snyder, Joseph P Hendrick, Allen Fienberg, Akinori Nish. Muscarinic receptors acting at pre- and post-synaptic sites differentially regulate dopamine/DARPP-32 signaling in striatonigral and striatopallidal neurons. Neuropharmacology. vol 63. issue 7. 2013-02-12. PMID:22971543. |
the increase in darpp-32 phosphorylation was completely abolished either by a dopamine d(1) receptor antagonist (sch23390), tetrodotoxin, genetic deletion of m5 receptors, muscarinic toxins for m1 and m4 receptors, or 6-hydroxydopamine lesioning of dopaminergic neurons, whereas it was enhanced by nicotine. |
2013-02-12 |
2023-08-12 |
mouse |
| Mahomi Kuroiwa, Miho Hamada, Eriko Hieda, Takahide Shuto, Naoki Sotogaku, Marc Flajolet, Gretchen L Snyder, Joseph P Hendrick, Allen Fienberg, Akinori Nish. Muscarinic receptors acting at pre- and post-synaptic sites differentially regulate dopamine/DARPP-32 signaling in striatonigral and striatopallidal neurons. Neuropharmacology. vol 63. issue 7. 2013-02-12. PMID:22971543. |
the results demonstrate that muscarinic receptors, especially m5 receptors, act at presynaptic dopaminergic terminals, regulate the release of dopamine in cooperation with nicotinic receptors, and activate d(1) receptor/darpp-32 signaling in the striatonigral neurons. |
2013-02-12 |
2023-08-12 |
mouse |
| P Smittenaar, H W Chase, E Aarts, B Nusselein, B R Bloem, R Cool. Decomposing effects of dopaminergic medication in Parkinson's disease on probabilistic action selection--learning or performance? The European journal of neuroscience. vol 35. issue 7. 2013-02-05. PMID:22487043. |
we found that dopaminergic medication, consisting of levodopa and/or dopamine agonists taken at own dose, in 18 patients with mild parkinson's disease (hoehn and yahr < 2.5) potentiated reward-based approach in terms of both accuracy and reaction times, while leaving punishment-based avoidance unaffected. |
2013-02-05 |
2023-08-12 |
Not clear |
| Christoph Scherfler, Klaus Seppi, Katherina J Mair, Eveline Donnemiller, Irene Virgolini, Gregor K Wenning, Werner Poew. Left hemispheric predominance of nigrostriatal dysfunction in Parkinson's disease. Brain : a journal of neurology. vol 135. issue Pt 11. 2013-02-04. PMID:23043142. |
in addition, one-way analysis of variance revealed significant reductions of mean total putaminal [(123)i]β-cit binding of the parkinson's disease-right patients compared with parkinson's disease-left patients (p < 0.05).the preponderance of reduced left putaminal dopamine transporter availability strengthens clinical observations of a greater proportion of right-handed patients with parkinson's disease with predominantly right-sided motor signs and argues against a randomly distributed asymmetric vulnerability of substantia nigra dopaminergic neurons. |
2013-02-04 |
2023-08-12 |
Not clear |
| Christoph Scherfler, Klaus Seppi, Katherina J Mair, Eveline Donnemiller, Irene Virgolini, Gregor K Wenning, Werner Poew. Left hemispheric predominance of nigrostriatal dysfunction in Parkinson's disease. Brain : a journal of neurology. vol 135. issue Pt 11. 2013-02-04. PMID:23043142. |
the coexistence of a subgroup of right-handed patients with parkinson's disease with more severe and predominant ipsilateral putaminal dopamine transporter decline suggests that asymmetry of dopaminergic denervation and motor dysfunction in parkinson's disease cannot be fully explained by hemispheric dominance alone, but that other factors must be involved. |
2013-02-04 |
2023-08-12 |
Not clear |
| Lars Tönges, Tobias Frank, Lars Tatenhorst, Kim A Saal, Jan C Koch, Éva M Szego, Mathias Bähr, Jochen H Weishaupt, Paul Lingo. Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease. Brain : a journal of neurology. vol 135. issue Pt 11. 2013-02-04. PMID:23087045. |
furthermore, dopaminergic terminals were preserved as demonstrated by analysis of neurite network in vitro, striatal fibre density and by neurochemical analysis of the levels of dopamine and its metabolites in the striatum. |
2013-02-04 |
2023-08-12 |
mouse |
| Thorfinn T Riday, Elyse C Dankoski, Michael C Krouse, Eric W Fish, Paul L Walsh, Ji Eun Han, Clyde W Hodge, R Mark Wightman, Benjamin D Philpot, C J Malang. Pathway-specific dopaminergic deficits in a mouse model of Angelman syndrome. The Journal of clinical investigation. vol 122. issue 12. 2013-02-04. PMID:23143301. |
these deficits were not due to loss of dopaminergic neurons or impaired dopamine synthesis. |
2013-02-04 |
2023-08-12 |
mouse |
| Shan-shan Wang, Chun-ling Wei, Zhi-qiang Liu, Wei Re. [The influence of L-glutamate and carbachol on burst firing of dopaminergic neurons in ventral tegmental area]. Sheng li xue bao : [Acta physiologica Sinica]. vol 63. issue 1. 2013-01-31. PMID:21340431. |
burst firing of dopaminergic neurons in ventral tegmental area (vta) induces a large transient increase in synaptic dopamine (da) release and thus is considered the reward-related signal. |
2013-01-31 |
2023-08-12 |
rat |
| b' Ivana Timotijevi\\xc4\\x87, \\xc5\\xbdana Stankovi\\xc4\\x87, Mirjana Todorovi\\xc4\\x87, Srdjan Z Markovi\\xc4\\x87, Dragana A Kastratovi\\xc4\\x8. Serotonergic organization of the central nervous system. Psychiatria Danubina. vol 24 Suppl 3. 2013-01-24. PMID:23114811.' |
atypical antipsychotics which have low affinity for dopaminergic and high affinity for serotonergic receptors are seen through the dynamic relationship of serotonin, dopamine and noradrenalin in nigrostriatal, mezocortical, mezolimbic and tuberoinfudibular pathways. |
2013-01-24 |
2023-08-12 |
Not clear |
| Ishrat Ahmed, Yideng Liang, Sabitha Schools, Valina L Dawson, Ted M Dawson, Joseph M Savit. Development and characterization of a new Parkinson's disease model resulting from impaired autophagy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 46. 2013-01-21. PMID:23152632. |
this conditional impairment of autophagy results in the age-related loss of dopaminergic neurons and corresponding loss of striatal dopamine, the accumulation of low-molecular-weight α-synuclein, and the presence of ubiquitinated protein aggregates, recapitulating many of the pathologic features of pd. |
2013-01-21 |
2023-08-12 |
mouse |
| Dimitrios Kontis, Eirini Theochar. Dopamine in anorexia nervosa: a systematic review. Behavioural pharmacology. vol 23. issue 5-6. 2013-01-17. PMID:22854306. |
however, recent neuroimaging studies lend support to the increase in binding of dopaminergic receptors in the striatum, which favors the opposite theory that intrasynaptic dopamine is indeed decreased. |
2013-01-17 |
2023-08-12 |
Not clear |
| Joanna García, Thomas Carlsson, Máté Döbrössy, Guido Nikkhah, Christian Winkle. Impact of dopamine versus serotonin cell transplantation for the development of graft-induced dyskinesia in a rat Parkinson model. Brain research. vol 1470. 2013-01-15. PMID:22759908. |
the results extend prior knowledge of the role of dopaminergic grafts in the development of gid and show that, in the animal model, serotonin neurons within the graft suspension might be involved, but given sufficient dopamine cells, their impact on gid may be minor. |
2013-01-15 |
2023-08-12 |
rat |
| Massimo Grilli, Maria Summa, Alessia Salamone, Guendalina Olivero, Stefania Zappettini, Silvia Di Prisco, Marco Feligioni, Cesare Usai, Anna Pittaluga, Mario March. In vitro exposure to nicotine induces endocytosis of presynaptic AMPA receptors modulating dopamine release in rat nucleus accumbens nerve terminals. Neuropharmacology. vol 63. issue 5. 2013-01-14. PMID:22771975. |
here we provide functional and immunocytochemical evidence supporting the presence on nucleus accumbens (nac) dopaminergic terminals of cyclothiazide-sensitive, alfa-amino-3-hydroxy-5-methyl-4-isoxazolone propionate (ampa) receptors, which activation causes ca²⁺-dependent [³h]dopamine ([³h]da) exocytosis. |
2013-01-14 |
2023-08-12 |
rat |